Article
Medicine, Research & Experimental
Sara Soleimani Asl, Alireza Gharebaghi, Siamak Shahidi, Simin Afshar, Fereshte Kalhori, Kimia Amiri, Fatemeh Mirzaei
Summary: Preconditioning stem cells with deferoxamine before transplantation can enhance the neuroprotective effects of stem cells, increase antioxidant capacity, and improve cell homing efficiency.
Article
Cell Biology
Muhammad Ikram, Myeung Hoon Jo, Kyonghwan Choe, Amjad Khan, Sareer Ahmad, Kamran Saeed, Min Woo Kim, Myeong Ok Kim
Summary: Cycloastragenol demonstrated positive effects against oxidative stress, neurogenic dysfunction, MAP kinase activation, mitochondrial apoptosis, and memory impairment in an A beta-induced mouse model of Alzheimer's disease.
Article
Biochemistry & Molecular Biology
Sareer Ahmad, Myeung Hoon Jo, Muhammad Ikram, Amjad Khan, Myeong Ok Kim
Summary: The study revealed that Luteolin has protective effects against amyloid-beta-induced neuroinflammation, amyloidogenesis, and synaptic dysfunction in mice, potentially through inhibition of JNK signaling and modulation of inflammatory and cell death markers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Bibin Anand, Qi Wu, Maryam Nakhaei-Nejad, Govindarajan Karthivashan, Lyudmyla Dorosh, Sara Amidian, Abhishek Dahal, Xiuju Li, Maria Stepanova, Holger Wille, Fabrizio Giuliani, Satyabrata Kar
Summary: Native PLGA nanoparticles show therapeutic potential in the treatment of Alzheimer's disease by suppressing aggregation of beta-amyloid peptides, triggering their disassembly, reducing phosphorylation of tau protein, enhancing neuronal viability, and attenuating memory deficits and A beta levels in animal models of AD.
BIOACTIVE MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Amjad Khan, Jun Sung Park, Min Hwa Kang, Hyeon Jin Lee, Jawad Ali, Muhammad Tahir, Kyonghwan Choe, Myeong Ok Kim
Summary: Caffeic acid has the potential to be used as a therapeutic agent for Alzheimer's disease due to its antioxidant and cognitive-enhancing effects. It reduces oxidative stress, regulates the expression of related proteins, decreases inflammation markers, enhances synaptic markers, and reduces the expression of Alzheimer's disease-related proteins.
Article
Biotechnology & Applied Microbiology
Pallabi Sil Paul, Jae-Young Cho, Qi Wu, Govindarajan Karthivashan, Emily Grabovac, Holger Wille, Mariana Kulka, Satyabrata Kar
Summary: The study found that native PLGA can inhibit the aggregation of A beta peptides and disassemble existing aggregates, protecting neurons from toxicity associated with Alzheimer's disease pathology at temperatures outside the physiological range. These findings support the unique therapeutic potential of PLGA nanoparticles in the treatment of AD.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Neurosciences
Yee Jie Yeap, Nagaendran Kandiah, Dean Nizetic, Kah-Leong Lim
Summary: Alzheimer's disease (AD) is the most common cause of dementia, affecting millions of elderly individuals worldwide. Despite extensive research, the cause of AD remains controversial and there is currently no cure. However, recent studies have identified the protease BACE2 as a potential therapeutic target for AD due to its non-amyloidogenic role in preventing the generation of toxic amyloid-beta peptides. This review discusses emerging evidence supporting the neuroprotective role of BACE2 in AD and provides an update on the identification of gene mutations linked to increased risk and earlier disease onset.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Teng Wan, Mingyuan Fu, Yan Jiang, Weiwei Jiang, Peiling Li, Shouhong Zhou
Summary: Alzheimer's disease is the most common type of dementia, and the number of cases is expected to increase. Apelin-13, a neuroprotective peptide, regulates cell activities to prevent the development of AD.
NEUROCHEMICAL RESEARCH
(2022)
Article
Neurosciences
Carolina Castillo, Gaston Bravo-Arrepol, Aline Wendt, Francisco Saez-Orellana, Camila Millar, Carlos F. Burgos, Javiera Gavilan, Carla Pacheco, Ramon Ahumada-Rudolph, Mariola Napiorkowska, Claudia Perez, Jose Becerra, Jorge Fuentealba, Jaime R. Cabrera-Pardo
Summary: Alzheimer's disease is characterized by cognitive impairment and memory loss due to the accumulation of amyloid-beta peptide. This study found that the compound Eu extracted from conifers has neuroprotective effects against A beta Os-induced synaptic failure.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Victor Valverde-Salazar, Daniel Ruiz-Gabarre, Vega Garcia-Escudero
Summary: Alzheimer's disease (AD) is a common form of dementia characterized by memory decline, cognitive impairment, and several pathological changes in the brain. Oxidative stress and inflammation play important roles in the development of AD. Green tea and its active compound EGCG have shown potential therapeutic effects in modulating AD through their antioxidative and anti-inflammatory properties. EGCG can regulate inflammatory processes, reduce protein aggregation, and promote neuronal survival pathways, making it a suitable candidate for the treatment of neurodegenerative disorders involving oxidative stress and inflammation.
Article
Biochemistry & Molecular Biology
Fernanda dos Santos Petry, Juliana Bender Hoppe, Caroline Peres Klein, Bernardo Gindri dos Santos, Regis Mateus Hozer, Felippo Bifi, Cristiane Matte, Christianne Gazzana Salbego, Vera Maria Treis Trindade
Summary: This study evaluated the protective effect of genistein against Aβ(1-42)-induced cognitive impairment and elucidated some possible mechanisms involved in its neuroprotective effects in the hippocampus, including attenuation of synaptotoxicity, prevention of Tau hyperphosphorylation, and inactivation of ERK.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Engineering, Biomedical
Bibin G. Anand, Qi Wu, Govindarajan Karthivashan, Kiran P. Shejale, Sara Amidian, Holger Wille, Satyabrata Kar
Summary: The study showed that surface-functionalized gold nanoparticles with mimosine can inhibit Aβ aggregation and stabilize it in its monomeric state, reducing neuronal toxicity associated with AD. Additionally, MimoAuNPs can trigger the disassembly of mature Aβ fibers, presenting a potential therapeutic effect on AD-related pathologies.
BIOACTIVE MATERIALS
(2021)
Article
Pharmacology & Pharmacy
Giuseppe Caruso, Margherita Grasso, Annamaria Fidilio, Sebastiano Alfio Torrisi, Nicolo Musso, Federica Geraci, Maria Rosaria Tropea, Anna Privitera, Fabio Tascedda, Daniela Puzzo, Salvatore Salomone, Filippo Drago, Gian Marco Leggio, Filippo Caraci
Summary: The study shows that depression is a risk factor for Alzheimer's disease. Antidepressants can reverse memory deficits and depressive-like phenotype induced by Aβ oligomers, as well as prevent Aβ-induced oxidative stress.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Behavioral Sciences
Alexander B. Pupyshev, Victor M. Belichenko, Michael V. Tenditnik, Alim A. Bashirzade, Nina I. Dubrovina, Marina V. Ovsyukova, Anna A. Akopyan, Larisa A. Fedoseeva, Tatiana A. Korolenko, Tamara G. Amstislavskaya, Maria A. Tikhonova
Summary: By comparing the effects of rapamycin and trehalose in the treatment of Alzheimer's disease, it was found that trehalose can effectively induce autophagy and improve AD-related behavioral and neuronal deficits, with the best outcomes achieved with the combined treatment.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2022)
Article
Food Science & Technology
Srijan Shrestha, Jae Sue Choi, Wei Zhang, Scott D. Smid
Summary: Phlorotannins exhibit neuroprotective activity against oxidative stress and amyloid beta exposure, with fucofuroeckol-type phlorotannins showing broader neuroprotective effects.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2022)