Article
Endocrinology & Metabolism
Bjorn-Erik Bertelsen, Kristin Viste, Thomas Helland, Magnus Hagland, Havard Soiland, Jurgen Geisler, Tone Hoel Lende, Per Eystein Lonning, Jorn Sagen, Gunnar Mellgren, Bjorg Almas
Summary: This study developed a liquid chromatography-tandem mass spectrometry (MS/MS) method for simultaneous measurement of serum levels of third-generation aromatase inhibitors (AIs) and ultra-low levels of estrogens. The method is highly valuable for studying drug efficacy and compliance.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Multidisciplinary Sciences
Chitra Thakur, Yiran Qiu, Qian Zhang, Nicholas J. Carruthers, Miaomiao Yu, Zhuoyue Bi, Yao Fu, Priya Wadgaonkar, Bandar Almutairy, Akimasa Seno, Paul M. Stemmer, Fei Chen
Summary: This report provides evidence of diminished expression of the mineral dust-induced gene (mdig) in human triple negative breast cancer (TNBC). The study demonstrates that mdig promotes the growth of primary tumors but inhibits metastasis of TNBC cells. The findings also suggest a potential role of mdig in regulating genes related to cell motility, invasion, and metastasis.
Article
Biochemistry & Molecular Biology
Beata Filip-Psurska, Mateusz Psurski, Artur Anisiewicz, Patrycja Libako, Ewa Zbrojewicz, Magdalena Maciejewska, Michal Chodynski, Andrzej Kutner, Joanna Wietrzyk
Summary: Both the vitamin D active metabolite and synthetic analog can regulate the growth of not only estrogen receptor-positive cells, but also hormone-independent cancer cells, while combined with An, PRI-2191 and PRI-2205 significantly inhibit the tumor growth of MCF-7 cells. The potentiation of the antitumor activity in combined treatment of MCF-7 tumor-bearing mice is related to the reduced activity of aromatase and regulation of the expression of estrogen receptor ER alpha and VDR.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Melika Shirdarreh, Rossanna C. Pezo
Summary: Studies have shown that obesity may have a negative impact on the efficacy of aromatase inhibitors in early breast cancer patients, highlighting the need for further research on optimal endocrine therapies for obese women. However, there is insufficient evidence at present to recommend tailoring adjuvant endocrine therapy with specific AIs or dosing modifications in this patient population.
Article
Oncology
Cristina Ferreira Almeida, Natercia Teixeira, Maria Joao Valente, Anne Marie Vinggaard, Georgina Correia-da-Silva, Cristina Amaral
Summary: Estrogen receptor-positive (ER+) breast cancer accounts for 70-85% of cases and combining CBD with aromatase inhibitors (AIs) may improve treatment effectiveness. CBD potentiates the anti-tumor effects of exemestane (Exe) by modulating cell death and specific targets such as ERa and AR. This study highlights the potential benefits of combining CBD with Exe and suggests new therapeutic approaches using cannabinoids.
Article
Multidisciplinary Sciences
I. Blancas, C. Olier, V. Conde, J. L. Bayo, C. Herrero, I. Zarcos-Pedrinaci, F. Carabantes, J. M. Baena-Canada, J. Cruz, M. Ruiz-Borrego
Summary: The study evaluated the effectiveness of fulvestrant as first-line treatment for ER-positive ABC in real-world settings. Results showed that fulvestrant can prolong progression-free survival and is well tolerated, with patients who had an ECOG score of 0 at the start of treatment showing better clinical benefit and overall survival. The study's findings are in line with randomized clinical trials, demonstrating the continued clinical benefits of fulvestrant for postmenopausal women with ER-positive ABC.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Javier Garcia-Sanchez, Mayra Alejandra Mafla-Espana, Maria Dolores Torregrosa, Omar Cauli
Summary: This study aimed to evaluate the relationship between gonadal hormone concentrations in blood and frailty syndrome, as well as whether these hormone concentrations could predict the progression of frailty syndrome. The results showed that high androstenedione levels and low follicle-stimulating hormone (FSH) levels were significantly associated with the worsening of frailty syndrome. These hormone concentrations could be potential biomarkers to predict the progression of frailty syndrome.
Article
Obstetrics & Gynecology
Bryan D. Naelitz, Tommy Jiang, Carlos Munoz-Lopez, John Tucker Sigalos, Neilufar Modiri, Rosella Cannarella, Jesse N. Mills, Neel Parekh, Amy S. Nowacki, Sarah C. Vij, Sriram Eleswarapu, Scott D. Lundy
Summary: This study found that treatment with the aromatase inhibitor anastrozole can significantly improve semen parameters in infertile men. The treatment response is associated with pretreatment levels of luteinizing hormone, follicle-stimulating hormone, testosterone, and baseline semen parameters. Anastrozole treatment can help some patients achieve normal sperm levels and enable intrauterine insemination.
FERTILITY AND STERILITY
(2023)
Article
Pharmacology & Pharmacy
Angelo Di Vincenzo, Marnie Granzotto, Marika Crescenzi, Roberto Vettor, Marco Rossato
Summary: The activation of P2X7 receptor plays a crucial role in cellular inflammatory response. Obesity is associated with tissue-specific and systemic low-grade inflammation. The impact of sex hormones on adipose tissue inflammation and purinergic signaling modulation is still unclear.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Mohammadhadi Khorrami, Vidya Sakar Viswanathan, Priyanka Reddy, Nathaniel Braman, Siddharth Kunte, Amit Gupta, Jame Abraham, Alberto J. Montero, Anant Madabhushi
Summary: Imaging texture biomarkers before and after CDK4/6i therapy can predict early response and overall survival in MBC patients with liver metastases. Radiomic features can predict a lack of response earlier than standard anatomic/RECIST 1.1 assessment, highlighting the need for further study and clinical validation.
Article
Oncology
N. Lynn Henry, Sungjin Kim, Ron D. Hays, Marcio A. Diniz, Michael Luu, Reena S. Cecchini, Greg Yothers, Andre Rogatko, Patricia A. Ganz
Summary: The study analyzed the reasons for discontinuation of anastrozole and tamoxifen using clinician-reported adverse event and patient-reported outcome questionnaire data from the NSABP B-35 clinical trial. The findings showed that thrombosis and arthralgia were associated with discontinuation of both drugs, while other adverse events associated with discontinuation varied by drug. Baseline symptoms like pain interference, hot flashes, and unhappiness were specifically linked to tamoxifen discontinuation.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
Ho Tsoi, Johann Lok, Ellen P. S. Man, Cheuk-Nam Cheng, Man-Hong Leung, Chan-Ping You, Sum-Yin Chan, Wing-Lok Chan, Ui-Soon Khoo
Summary: This study revealed that overexpression of a novel splice variant BQ323636.1 is associated with resistance to the non-steroidal aromatase inhibitor anastrozole in ER+ post-menopausal breast cancer. Mechanistic studies showed that BQ overexpression enhances androgen receptor (AR) activity, leading to hyper-activation of AR signaling and increased cell proliferation. Targeting AR can overcome anastrozole resistance in breast cancer with BQ overexpression. Clinical study also demonstrated that high nuclear expression of both BQ and AR is significantly associated with poor survival in non-steroidal aromatase inhibitor-treated ER+ breast cancer patients.
JOURNAL OF PATHOLOGY
(2023)
Article
Oncology
Costanza Paoletti, William E. Barlow, Erin F. Cobain, Mattias Bergqvist, Rita S. Mehta, Julie R. Gralow, Gabriel N. Hortobagyi, Kathy S. Albain, Lajos Pusztai, Priyanka Sharma, Andrew K. Godwin, Alastair M. Thompson, Daniel F. Hayes, James M. Rae
Summary: The study found that in patients with MBC, sTK1 activity >= 200 Du/L was associated with poor prognosis. Patients with low sTK1 at baseline had comparable outcomes on single-agent or combination endocrine therapy.
CLINICAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Aikun Fu, Bingqing Yao, Tingting Dong, Yongyi Chen, Jia Yao, Yu Liu, Hang Li, Huiru Bai, Xiaoqin Liu, Yue Zhang, Chunhui Wang, Yajing Guo, Nan Li, Shang Cai
Summary: Tumor-resident intracellular microbiota plays an important role in promoting cancer metastasis, enhancing host-cell survival by increasing resistance to fluid shear stress. Furthermore, administration of intratumor bacteria can also promote tumor metastasis.
Article
Oncology
Jiao Zhang, Hui Lin, Lei Hou, Hui Xiao, Xilong Gong, Xuhui Guo, Xuchen Cao, Zhenzhen Liu
Summary: This study identified differentially expressed genes in DCIS and normal tissue and validated a six-core gene signature with potential for prognostic prediction in DCIS.