Article
Oncology
Ishani Banik, Adhideb Ghosh, Erin Beebe, Blaz Burja, Mojca Frank Bertoncelj, Christopher M. M. Dooley, Enni Markkanen, Reinhard Dummer, Elisabeth M. M. Busch-Nentwich, Mitchell P. P. Levesque
Summary: NRAS mutations are common in melanoma but lack targeted therapies. This study demonstrates that p38 acts as a tumor suppressor in NRAS mutant melanoma by regulating mTOR phosphorylation, autophagy, and actin remodeling. Pharmacologically available small molecules can modulate p38 and its downstream targets, providing a potential strategy for treating NRAS mutant melanoma. Combining these compounds with FDA-approved drugs like MEK inhibitors may offer a novel approach for targeting NRAS-mutant melanoma.
Article
Oncology
Ishani Banik, Phil F. Cheng, Christopher M. Dooley, Jana Travnickova, Munise Merteroglu, Reinhard Dummer, Elizabeth E. Patton, Elisabeth M. Busch-Nentwich, Mitchell P. Levesque
Summary: The study demonstrates that activating the P38 alpha-MAPK14 pathway can inhibit the onset of NRAS-mutant melanoma, indicating a potential biological difference between BRAF and NRAS mutations in melanoma. The translational benefit of the study is highlighted by the use of anisomycin to activate the pathway, showing promise for clinical applications.
PIGMENT CELL & MELANOMA RESEARCH
(2021)
Article
Oncology
Ishani Banik, Phil F. Cheng, Christopher M. Dooley, Jana Travnickova, Munise Merteroglu, Reinhard Dummer, Elizabeth E. Patton, Elisabeth M. Busch-Nentwich, Mitchell P. Levesque
Summary: The study demonstrates that activating the P38 alpha-MAPK14 pathway can effectively suppress the initiation and growth of NRAS-mutant melanoma, and reduce the viability of MEK inhibitor resistant melanoma cells. These findings suggest a biological difference between BRAF and NRAS-mutant melanoma.
PIGMENT CELL & MELANOMA RESEARCH
(2021)
Article
Oncology
Sitong Zhou, Wen Ouyang, Xi Zhang, Lexi Liao, Xiaobing Pi, Ronghua Yang, Baiqiang Mei, Huaiyuan Xu, Shijian Xiang, Jiehua Li
Summary: Utrophin, a tumor suppressor gene, showed decreased expression in melanoma and was associated with poorer prognosis. Experimental evidence supported that up-regulated utrophin expression could inhibit melanoma cell proliferation. The inhibition of melanoma growth by utrophin was mediated through p38 and JNK1/c-Jun pathways.
CANCER CELL INTERNATIONAL
(2021)
Article
Pharmacology & Pharmacy
Weixiao Zhou, Dongjiang Cai
Summary: This study demonstrated that midazolam retards I/R-induced cardiomyocyte apoptosis by inhibiting the JNK/p38 MAPK signaling pathway, thereby reducing heart injury and infarction. These findings provide new insight into the treatment of myocardial I/R injury.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Michael A. Fawzy, Sherif A. Maher, Sally M. Bakkar, Mahmoud A. El-Rehany, Moustafa Fathy
Summary: This study demonstrated the protective effect of pantoprazole on renal ischemia/reperfusion injury in rats for the first time, by suppressing apoptosis, reducing pro-inflammatory cytokines levels, and impacting intracellular signaling pathways. Moreover, multiple doses of pantoprazole showed a greater therapeutic effect than a single dose.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Zhuoying Lin, Yu Lei, Mingyao Wen, Qin He, Dean Tian, Huaping Xie
Summary: Gene fusions caused by cytogenetic aberrations are important in cancer development. The MTAP-ANRIL fusion gene, with a frequency of over 7% in melanoma, downregulates wild-type MTAP and promotes a process similar to epithelial-mesenchymal transition through JNK and p38 MAPK activation. This suggests that MTAP-ANRIL is a potential prognostic biomarker and therapeutic target for melanoma.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Li Chen, Xuantong Zhou, Xiangyi Kong, Zhaohui Su, Xiangyu Wang, Sen Li, Aiping Luo, Zhihua Liu, Yi Fang, Jing Wang
Summary: The study found that the expression of p-JNK in breast cancer patients is related to prognosis, with higher levels associated with significantly longer survival times. p-JNK expression is an important prognostic factor that can effectively predict survival in breast cancer patients undergoing NACT. Additionally, treatment with the JNK agonist anisomycin can induce apoptosis and lead to changes in p-JNK and p-STAT3 expression levels.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Wen Ding, Hong Feng, Wen-Jing Li, Hai-Han Liao, Nan Zhang, Zi-Ying Zhou, Shan-Qi Mou, Zheng Lin, Na-Zi Xia-He, Hao Xia, Qi-Zhu Tang
Summary: The study found that APO treatment effectively improved cardiac function, reduced cardiac hypertrophy and fibrosis, and decreased oxidative stress in DCM. Mechanistically, APO suppressed apoptosis through inhibiting the ASK1-p38/JNK signaling pathway. In vitro experiments also showed that APO could inhibit NRCM apoptosis and CF activation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Immunology
Yanwen Luo, Jiefu Zhu, Fan Zhao, Lang Shi, Yuzhen Li, Xiongfei Wu
Summary: This study investigated the role of PIM1 in renal ischemia-reperfusion injury (IRI) and its downstream regulatory mechanism. The study found that PIM1 expression was significantly upregulated in renal IRI mouse model and in renal tubular cell HR model. Overexpression of PIM1 ameliorated renal IRI, possibly through the ASK1-MAPK pathway. Therefore, PIM1 may be a potential therapeutic target for renal IRI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Lesley Jia Wei Pua, Chun-Wai Mai, Felicia Fei-Lei Chung, Alan Soo-Beng Khoo, Chee-Onn Leong, Wei-Meng Lim, Ling-Wei Hii
Summary: JNK and p38 MAPK signaling pathways play important roles in nasopharyngeal carcinoma (NPC), promoting tumor processes such as cell proliferation, apoptosis, inflammation, metastasis, and angiogenesis. Although the underlying mechanisms are not fully understood, further research on JNK and p38 MAPK could provide important insights for diagnosis, prognosis, and treatment decision-making in NPC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Lea-Marie Jenster, Karl-Elmar Lange, Sabine Normann, Anja vom Hemdt, Jennifer D. Wuerth, Lisa D. J. Schiffelers, Yonas M. Tesfamariam, Florian N. Gohr, Laura Klein, Ines H. Kaltheuner, Stefan Ebner, Dorothee J. Lapp, Jacob Mayer, Jonas Moecking, Hidde L. Ploegh, Eicke Latz, Felix Meissner, Matthias Geyer, Beate M. Kuemmerer, Florian I. Schmidt
Summary: This study describes how p38 signaling activates human NLRP1 by direct phosphorylation, integrating various cellular stress signals relevant to the skin.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Zhangshuo Yang, Hao Zhang, Maohui Yin, Zhixiang Cheng, Ping Jiang, Maohui Feng, Bo Liao, Zhisu Liu
Summary: This study found that NTF3 is significantly downregulated in human hepatocellular carcinoma (HCC) and its low expression is associated with shorter survival and poor clinical outcomes. NTF3 inhibits the progression of HCC cells by activating the p75NTR and JNK/P38 MAPK pathways to induce apoptosis. Therefore, NTF3 may serve as a potential treatment molecule for HCC.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Dermatology
Muhammad Mubashshir, Nabeel Ahmad, Helen Nilsson Skoeld, Mohd Ovais
Summary: Melatonin affects mammalian coat color, hair follicle pigmentation, and retinal cell responses. Its direct effects on melanocytes and human skin pigmentation are still uncertain. Melatonin acts as a free radical scavenger and inhibits cancer cell growth. Melanocytes and melanoma cells can be used as in vitro test models for pharmacological applications.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Cell Biology
Xue-Hua Du, Shao-Bo Ke, Xin-Yi Liang, Jie Gao, Xiao-Xiao Xie, Lin-Zhi Qi, Xue-Yi Liu, Guo-Yuan Xu, Xiao-Dong Zhang, Run-Lei Du, Shang-Ze Li
Summary: Our study demonstrates that USP14 functions as a deubiquitinase that interacts and stabilizes JNK, promoting MAPK/JNK signaling and colorectal carcinogenesis. Increased expression of USP14 is associated with elevated levels of JNK protein and downstream gene expression in colorectal cancer patients. Inhibition of USP14 reduces cancer cell proliferation and tumorigenesis by downregulating the activation of the MAPK/JNK pathway.
CELL DEATH & DISEASE
(2023)
Article
Cell Biology
Nirali Talati, Danielle Kamato, Terrence J. Piva, Peter J. Little, Narin Osman
CELLULAR SIGNALLING
(2018)
Article
Endocrinology & Metabolism
Genia F. Burchall, Dodie S. Pouniotis, Helena J. Teede, Sanjeeva Ranasinha, Kirsty A. Walters, Terrence J. Piva
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2019)
Article
Integrative & Complementary Medicine
Siat Yee Fong, Dilani Wimalasiri, Terrence Piva, Chaitali Dekiwadia, Sylvia Urban, Tien Huynh
JOURNAL OF HERBAL MEDICINE
(2019)
Article
Biochemistry & Molecular Biology
Elham Shahhoseini, Bryce N. Feltis, Masao Nakayama, Terrence J. Piva, Dodie Pouniotis, Salem S. Alghamdi, Moshi Geso
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Masao Nakayama, Clare L. Smith, Bryce N. Feltis, Terrence J. Piva, Farnaz Tabatabaie, Peter D. Harty, Frank M. Gagliardi, Kirsten Platts, Sarah Otto, Anton Blencowe, Kenta Morita, Moshi Geso
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
(2020)
Review
Biochemistry & Molecular Biology
Ava Bachari, Terrence J. Piva, Seyed Alireza Salami, Negar Jamshidi, Nitin Mantri
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Kanika Singh, Negar Jamshidi, Roby Zomer, Terrence J. Piva, Nitin Mantri
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Elham Shahhoseini, Masao Nakayama, Terrence J. Piva, Moshi Geso
Summary: The study found that the effects of gold nanoparticles and ionizing radiation on cancer cells and normal cells differ, which may be attributed to radiation-induced adhesiveness and metabolic differences between tumor cells and their non-cancerous counterparts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Kanika Singh, Nazim Nassar, Ava Bachari, Ellen Schanknecht, Srinivasareddy Telukutla, Roby Zomer, Terrence J. Piva, Nitin Mantri
Summary: Prostate cancer is the second most commonly diagnosed cancer in males, and recent evidence suggests that cannabinoids may serve as powerful regulators of cell growth and differentiation. Research over the past two decades has shown that cannabinoids not only have palliative effects, but also hold promising potential as antitumor agents in a variety of cancers, including prostate cancer. This analysis may offer insights into the selection and development of specific cannabinoids for use in antitumor drugs for the treatment of prostate cancer.
Article
Acoustics
Giulia Mccorkell, Masao Nakayama, Bryce Feltis, Terrence Piva, Moshi Geso
Summary: Recent in vivo studies have shown impressive results using ultrasound-stimulated microbubbles as a localized radiosensitizer. This study investigated the effect of combining ultrasound-stimulated microbubbles with radiation on cell killing using two carcinoma cell lines and human umbilical vein endothelial cells. The results demonstrated a decreased cell survival rate, with significant effects observed in NCI-H727 cells.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Article
Chemistry, Medicinal
Dao Nguyen, Jessica Holien, Chaitali Dekiwadia, Thilini Thrimawithana, Terrence Piva, Tien Huynh
Summary: Momordica cochinchinensis is a herbal medicine that shows promising antimelanoma properties and this study focused on optimizing the bioactivity of its seed extract. The aqueous extract was found to be the most effective, exhibiting higher cytotoxicity towards melanoma cells compared to other solvents. The mechanism of action involved MAPK signaling pathways, TNFR1 activation, reduced NF-kB expression, and suppression of BRAF/MEK. These findings suggest that M. cochinchinensis seed extracts could be a potential adjunctive therapy for metastatic melanoma.
Article
Cell Biology
Ava Bachari, Nazim Nassar, Srinivasareddy Telukutla, Roby Zomer, Chaitali Dekiwadia, Terrence J. Piva, Nitin Mantri
Summary: Melanoma, an aggressive form of skin cancer, is resistant to advanced cancer treatments. Studies have shown that Cannabis sativa extracts exhibit potential anticancer effects against melanoma cells. However, further research is needed to evaluate their safety, efficacy, and clinical applications.
Review
Medicine, Research & Experimental
Ava Bachari, Nazim Nassar, Ellen Schanknecht, Srinivasareddy Telukutla, Terrence Jerald Piva, Nitin Mantri
Summary: This article provides an overview of the pathophysiology of melanoma, current pharmacotherapy, and the challenges associated with different pharmacological approaches. It also highlights the utility of cannabinoids as an additive remedy for melanoma.
WIRES MECHANISMS OF DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Ellen Schanknecht, Ava Bachari, Nazim Nassar, Terrence Piva, Nitin Mantri
Summary: Melanoma is a deadly and physically impairing disease with ongoing treatment deficiencies. Current treatment regimens face pitfalls, with low five-year survival rates for patients with advanced metastatic invasion. Polyphenolic compounds, including cannabinoids, terpenoids, and flavonoids, show promising potential for anti-cancer, anti-inflammatory, and palliative utility. Cannabis sativa, with its medicinal compounds, could offer considerable relief for melanoma sufferers and should be further evaluated pharmacologically.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Integrative & Complementary Medicine
Dilani Wimalasiri, Chaitali Dekiwadia, Siat Yee Fong, Terrence J. Piva, Tien Huynh
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2020)