Article
Biochemistry & Molecular Biology
Yonggang Zhang, Meng Zhu, Surapaneni Krishna Mohan, Zhi Hao
Summary: Crocin has been shown to inhibit the proliferation of follicular thyroid carcinoma cells and promote apoptosis in vitro. It achieves its anticancer effects by regulating oxidative stress, mitochondrial membrane potential, protease activity, and other pathways. Crocin may have potential as a therapeutic agent for thyroid cancer.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Endocrinology & Metabolism
Ming-Hsien Wu, Yi-Yin Lee, Yu-Ling Lu, Shu-Fu Lin
Summary: The study found that age and extrathyroidal invasion are significant risk factors for distant metastasis of FTC. Patients with metastatic FTC, especially when diagnosed on initial presentation, have dismal survival outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Yunjin Yao, Peiwei Xu, Tianxing Ying, Yue Wang, Xumeng Wang, Liqi Shu, Zhe Mo, Zhijian Chen, Xiaofeng Wang, Weibin Wang, Lisong Teng, Xiaoming Lou
Summary: This study conducted an integrative analysis of DNA methylation and RNA array data to identify thyroid cancer-specific DNA methylation markers, providing potential molecular markers for early diagnosis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Tomomi Kurashige, Mika Shimamura, Koichiro Hamada, Michiko Matsuse, Norisato Mitsutake, Yuji Nagayama
Summary: Oncocytic thyroid cancer is characterized by abnormal mitochondrial accumulation and oxidative phosphorylation defect. Metabolomics analysis revealed that XTC.UC1 cells, despite having higher glucose uptake than TPC1 cells, divert glycolytic intermediates to lipid metabolism and serine synthesis pathway. Glutamine is preferred for glutathione production in XTC.UC1 cells, while growth and survival depend on both glucose and glutamine. XTC.UC1 cells also have higher intracellular amino acids due to increased expression of ASCT2 and enhanced autophagy.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Shabnam Heydarzadeh, Ali Asghar Moshtaghie, Maryam Daneshpour, Mehdi Hedayati
Summary: This study investigates the potential of Apigenin, a plant derived flavonoid, in modulating tumor apoptosis by targeting GLUTs expression in anaplastic thyroid carcinoma. The results show that Apigenin treatment decreases the expression of GLUT1 and GLUT3 mRNA and protein levels in cancer cells, inhibiting cell migration and making them more susceptible to programmed cell death.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Oncology
Chenguang Liu, Fangqin Yu, Runsheng Ma, Lele Zhang, Gongbo Du, Dongpeng Niu, Detao Yin
Summary: The study showed that the expression level of Cep63 was significantly increased in papillary thyroid cancer tissues, and knocking out Cep63 could inhibit the proliferation, invasion, and migration abilities of PTC cells, as well as affect the cell cycle, possibly through inhibiting the JAK/STAT3 signaling pathway.
Article
Multidisciplinary Sciences
Yanyang Zhao, Tian Yu, Jie Sun, Feiliang Wang, Chaoze Cheng, Shurong He, Lan Chen, Donghui Xie, Liping Fu, Xuhuizi Guan, An Yan, Yao Li, Gang Miao, Xiaoquan Zhu
Summary: The study identified WDR77 mutations associated with predisposition to nonsyndromic familial papillary thyroid cancer, where a rare heterozygous missense mutation in one family impairs the interaction of WDR77 with PRMT5, and a splice-site mutation in another family results in a marked decrease in H4R3me2 levels. These findings provide new insights into the genetic factors influencing thyroid cancer susceptibility.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Eunmi Hwang, Woo Kyung Lee Doolittle, Yuelin Jack Zhu, Xuguang Zhu, Li Zhao, Yanlin Yu, Sheue-yann Cheng
Summary: It is found that the expression of thyroid hormone receptor α1 (TRα1) is lost in thyroid cancer. The study shows that TRα1 inhibits cell proliferation and induces apoptosis in thyroid cancer cells. Furthermore, TRα1 directly regulates the expression of PAX8 gene and shifts the cell landscape of thyroid cancer toward a differentiated state. Overall, TRα1 is identified as a regulator of thyroid differentiation and may serve as a potential therapeutic target for thyroid cancer patients.
Article
Medicine, Research & Experimental
Lina Lu, Jennifer Rui Wang, Ying C. Henderson, Shanshan Bai, Jie Yang, Min Hu, Cheng-Kai Shiau, Timothy Pan, Yuanqing Yan, Tuan M. Tran, Jianzhuo Li, Rachel Kieser, Xiao Zhao, Jiping Wang, Roza Nurieva, Michelle D. Williams, Maria E. Cabanillas, Ramona Dadu, Naifa Lamki Busaidy, Mark Zafereo, Nicholas Navin, Stephen Y. Lai, Ruli Gao
Summary: We investigated the transformation process of anaplastic thyroid cancer (ATC) from different subtypes of thyroid cancer using single-cell transcriptomic and genetic alteration data. The transformation included stress-responsive, inflammatory, mitotic-defective, and mesenchymal ATC cells. We identified important milestones including diploid and aneuploid stages, with corresponding phenotypic changes and interactions with other cell types, providing new therapeutic opportunities for ATC treatment.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Cell Biology
Carlos Frederico Lima Goncalves, Fabio Hecht, Juliana Cazarin, Rodrigo Soares Fortunato, Mario Vaisman, Denise Pires de Carvalho, Andrea Claudia Freitas Ferreira
Summary: The study evaluated the effects of quercetin on a papillary thyroid carcinoma cell line, showing that quercetin can be used as an adjuvant in thyroid cancer therapy by inducing apoptosis, reducing invasion, and increasing the efficacy of radioiodine therapy.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Review
Oncology
Jon Zugazagoitia, Luis Paz-Ares
Summary: Extensive-stage small-cell lung cancer is a challenging disease to treat, and despite improvements in first-line therapy, resistance remains a significant issue. Recent progress in understanding the molecular biology of SCLC holds potential for molecularly informed therapeutic strategies for patients with SCLC.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Eunah Shin, Ja Seung Koo
Summary: Thyroid cancer is the most common cancer in the endocrine system. The tumor microenvironment (TME) of thyroid cancer involves cancer associated fibroblasts (CAF) and immune cells. CAF contribute to tumor progression through cell proliferation and extracellular matrix remodeling, while immune cells contribute through cell proliferation, angiogenesis, epithelial-mesenchymal transition, and immune suppression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Lorenzo Allegri, Federica Baldan, Elisabetta Molteni, Catia Mio, Giuseppe Damante
Summary: This study compared the m6A-related RNA methylation profiles between a normal thyroid cell line and different thyroid cancer cell lines, identifying different patterns of m6A modification. By silencing METTL3, the impact of m6A modification on gene expression was evaluated in an anaplastic thyroid cancer model, leading to the identification of DDI2 as a gene specifically controlled by m6A modification.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Surgery
Anna C. Beck, Anand Rajan, Shannon Landers, Sarah Kelley, Andrew M. Bellizzi, Geeta Lal, Sonia L. Sugg, James R. Howe, Carlos H. Chan, Ronald J. Weigel
Summary: The study showed that the tall cell variant of papillary thyroid carcinoma has increased expression of cancer stem cell markers compared to classic papillary thyroid carcinoma. A gene signature similar to the tall cell variant identified a subtype of classic papillary thyroid carcinoma with worse recurrence-free survival.
Review
Oncology
Martin Reck, Jordi Remon, Matthew D. Hellmann
Summary: The past decade has seen significant progress in the treatment of metastatic non-small-cell lung cancer, with the development of specific antibodies leading to improved survival for many patients. Currently, nearly all mNSCLC patients receive PD-1 or PD-L1 therapy in the first-line setting, except those with targetable oncogenes.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Constanze Schanbacher, Michael Bieber, Yvonne Reinders, Deya Cherpokova, Christina Teichert, Bernhard Nieswandt, Albert Sickmann, Christoph Kleinschnitz, Friederike Langhauser, Kristina Lorenz
Summary: The activation or inhibition of the ERK1/2 signaling cascade has a significant impact on the outcome of ischemic stroke. This study found that overexpression of wild-type ERK2 worsened the infarct volume and neurological deficits, as well as increased blood-brain barrier leakage, inflammation, and apoptotic neurons. In contrast, inhibition of the Raf/MEK/ERK1/2 cascade provided protection against ischemic damage, primarily through anti-inflammatory signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Biochemistry & Molecular Biology
Daniela Grimm
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Biochemistry & Molecular Biology
Daniela Grimm
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Daniela Grimm, Herbert Schulz, Marcus Kruger, Jose Luis Cortes-Sanchez, Marcel Egli, Armin Kraus, Jayashree Sahana, Thomas J. Corydon, Ruth Hemmersbach, Petra M. Wise, Manfred Infanger, Markus Wehland
Summary: Cancer is a burdensome disease with high morbidity and mortality, and research in space under microgravity conditions has the potential to fight cancer and develop new therapies. Studies have shown that microgravity affects various aspects of cancer cells and can be used to create in vitro tumor models for drug development and studying cancer progression and metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Herbert Schulz, Dorothea Dietrichs, Markus Wehland, Thomas J. Corydon, Ruth Hemmersbach, Christian Liemersdorf, Daniela Melnik, Norbert Huebner, Kathrin Saar, Manfred Infanger, Daniela Grimm
Summary: This study conducted a parabolic flight experiment in real microgravity and analyzed metastatic prostate cancer cells, discovering a network of cytokines, chemokines, regulatory lncRNA, and microRNA related to prostate cancer. These findings contribute to a better understanding of prostate cancer and potential development of new diagnostic tools.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Linnea Hojer Wang, Markus Wehland, Petra M. M. Wise, Manfred Infanger, Daniela Grimm, Michael C. C. Kreissl
Summary: This manuscript investigates four tyrosine kinase inhibitors (TKIs), cabozantinib, vandetanib, pralsetinib, and selpercatinib, used for treating advanced and/or metastatic medullary thyroid cancer (MTC). The focus is on treatment-related hypertension, a well-known adverse effect (AE) of these TKIs. While TKI-induced hypertension is rarely a dose-limiting side effect, complications associated with hypertension can increase with longer patient survival without proper medication.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Justina Joksiene, Jayashree Sahana, Markus Wehland, Herbert Schulz, Jose Luis Cortes-Sanchez, Judit Prat-Duran, Daniela Grimm, Ulf Simonsen
Summary: A diabetogenic state induced by spaceflight causes stress and health problems in astronauts. Microgravity is a main stressor in space that leads to hyperglycaemia. The molecular pathways and synergistic effects of microgravity and hyperglycaemia are not fully understood.
Review
Cell Biology
Thomas J. Corydon, Herbert Schulz, Peter Richter, Sebastian M. Strauch, Maik Boehmer, Dario A. Ricciardi, Markus Wehland, Marcus Krueger, Gilmar S. Erzinger, Michael Lebert, Manfred Infanger, Petra M. Wise, Daniela Grimm
Summary: Microgravity has a significant impact on the health of space explorers, affecting cell proliferation, differentiation, and growth. With the planning of deep space exploration and the commercialization of space travel, researchers are focusing on gene regulation in cells and organisms exposed to real and simulated microgravity. Cancer and metastasis research in particular benefit from these findings.
Review
Biochemistry & Molecular Biology
Urjosee Sahana, Markus Wehland, Ulf Simonsen, Herbert Schulz, Daniela Grimm
Summary: Despite recent advances in HF therapy, CV mortality, morbidity, and HFH remain challenges. Vericiguat activates sGC to improve CV function and has shown efficacy in reducing CV death and HFH in HFrEF patients. However, it has no therapeutic effect on HFpEF. Common adverse events of vericiguat include hypotension, syncope, and anemia. Larger studies are needed to investigate the potential effect in HFpEF patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Biochemistry & Molecular Biology
Daniela Grimm
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Francesca Cialdai, Austin M. Brown, Cory W. Baumann, Debora Angeloni, Sarah Baatout, Alexandra Benchoua, Juergen Bereiter-Hahn, Daniele Bottai, Judith-Irina Buchheim, Marco Calvaruso, Eugenie Carnero-Diaz, Sara Castiglioni, Duccio Cavalieri, Gabriele Ceccarelli, Alexander Chouker, Gianni Ciofani, Giuseppe Coppola, Gabriella Cusella, Andrea Degl'Innocenti, Jean-Francois Desaphy, Jean-Pol Frippiat, Michael Gelinsky, Giada Genchi, Maria Grano, Daniela Grimm, Alain Guignandon, Christiane Hahn, Jason Hatton, Raul Herranz, Christine E. Hellweg, Carlo Saverio Iorio, Thodoris Karapantsios, Jack van Loon, Matteo Lulli, Jeanette Maier, Jos Malda, Emina Mamaca, Lucia Morbidelli, Angelique van Ombergen, Andreas Osterman, Aleksandr Ovsianikov, Francesco Pampaloni, Elizabeth Pavezlorie, Veronica Pereda-Campos, Cyrille Przybyla, Christopher Puhl, Petra Rettberg, Chiara Risaliti, Angela Maria Rizzo, Kate Robson-Brown, Leonardo Rossi, Giorgio Russo, Alessandra Salvetti, Daniela Santucci, Matthias Sperl, Felice Strollo, Kevin Tabury, Sara Tavella, Christiane Thielemann, Ronnie Willaert, Nathaniel J. Szewczyk, Monica Monici
Summary: This white paper presents the indications and recommendations of the SciSpacE Science Community on filling the gaps of knowledge regarding the effects of gravity alterations on animal and human systems at a cellular and tissue level. Despite previous studies, a comprehensive integrated model of the changes occurring at different system and functional levels is still lacking, making it difficult to predict the long-term consequences of human adaptation to the space environment and implement effective medical support plans.
Review
Biochemistry & Molecular Biology
Silvana Miranda, Shannon Marchal, Lina Cumps, Jenne Dierckx, Marcus Kruger, Daniela Grimm, Sarah Baatout, Kevin Tabury, Bjorn Baselet
Summary: The lunar dust problem arose from NASA's Apollo missions in 1969, as exposure to lunar dust became unavoidable. Several astronauts suffered allergy-like symptoms due to lunar dust inhalation. Research into the toxic effects of lunar dust gained significant interest and expanded to include other organ systems. With plans for future moon missions and potentially Mars missions, dust mitigation strategies are crucial for sustainable space exploration.
Review
Biochemistry & Molecular Biology
Niklas S. Jensen, Markus Wehland, Petra M. Wise, Daniela Grimm
Summary: Hypertension is a major global health burden, with an increasing prevalence due to aging populations and sedentary lifestyles. While there is evidence of the role of vitamin D in regulating blood pressure, its direct antihypertensive effect remains unclear. However, supplementing vitamin D in combination with other antihypertensive agents may have promising results.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jayashree Sahana, Jose Luis Cortes-Sanchez, Viviann Sandt, Daniela Melnik, Thomas J. Corydon, Herbert Schulz, Zexi Cai, Katja Evert, Daniela Grimm, Markus Wehland
Summary: This study cultured breast cancer cell lines MCF-7 and MDA-MB-231 under simulated microgravity conditions and investigated the gene expression pattern and cellular signaling pathways involved. The results showed that the engineered three-dimensional multicellular spheroid model can be used to study breast cancer cell behavior and evaluate the efficacy of drugs against breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Jose Luis Cortes-Sanchez, Daniela Melnik, Viviann Sandt, Stefan Kahlert, Shannon Marchal, Ian R. D. Johnson, Marco Calvaruso, Christian Liemersdorf, Simon L. Wuest, Daniela Grimm, Marcus Krueger
Summary: In the preparation of space and microgravity experiments, the use of ground-based facilities for initial experiments and feasibility studies is common. One approach to simulate microgravity conditions on Earth is to use a random positioning machine (RPM) as a rotary bioreactor. Combined with a suitable low-mass model system, such as cell cultures, these devices have been shown to produce results similar to those obtained in actual space experiments under real microgravity conditions. The RPM serves as a simulator of microgravity by randomizing the impact of Earth's gravity vector especially for suspended cells, and it also simulates physiological shear forces on the adherent cell layer.