Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 14, Issue 7, Pages 13129-13136Publisher
MDPI AG
DOI: 10.3390/ijms140713129
Keywords
immunohistochemistry; biopsy; desmoplastic reaction; early colorectal carcinoma; submucosal invasion
Funding
- Japanese Society for Cancer of the Colon and Rectum
- Dokkyo Medical University [2012-12-1]
- Japan Society for the Promotion of Science [24590429, 23590410]
- Grants-in-Aid for Scientific Research [25460413, 23590410] Funding Source: KAKEN
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The aim of our study was to evaluate the diagnosis of desmoplastic reaction (DR) by immunostaining for alpha-smooth muscle actin (alpha SMA) and desmin, for predicting the depth of submucosal invasion in biopsy specimens of early colorectal carcinomas (CRCs). Thirty-eight cases of non-pedunculated early CRCs were included in this study. Positive for DR was defined as alpha SMA-positive and desmin-negative stroma in the CRC. The depth of submucosal invasion was measured in endoscopically or surgically resected specimens and the lesions were subsequently divided into two groups: Group A (carcinoma in situ/intramucosal carcinoma and submucosal invasive carcinoma with a depth <1000 mu m) and Group B (submucosal invasion with a depth >= 1000 mu m). Twenty-one cases were DR-positive and 17 were DR-negative. No statistical significance was found between the DR with regard to tumor size, location and histological type. All DR-positive cases belonged to Group B whereas 14 (82.4%) DR-negative lesions belonged to Group A (p < 0.001). The sensitivity, specificity, positive and negative predictive values and accuracy of DR positivity for diagnosis of Group B were 87.5%, 100%, 100%, 82.4% and 92.1%, respectively. Conclusively, detection of DR in biopsy specimens with ancillary immunohistochemistry (aSMA/desmin) would help in preoperative diagnosis for the depth of submucosal invasion of early CRC.
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