Article
Biochemical Research Methods
Qinpei Deng, Lixiu He, Fangyan Xu, Qiaochun Deng, Tongze Xu, Junkai Jiang, Zhenxiang Hu, Jiaming Yang
Summary: Human chorionic gonadotropin (hCG), a glycoprotein hormone, is used for infertility treatment. The beta (0-) subunit determines its specificity, while the alpha (a-) subunit is shared by gonadotropin family. Analysis showed that the beta (0-) subunit has two variants, 01 and 02, with different glycosylation patterns at Asn 13 and Asn 30.
ANALYTICAL BIOCHEMISTRY
(2023)
Article
Medicine, General & Internal
Yi Zhong, Xing Chen, Yan Huang, Yi Jiang, Ting Chen, Xianglin Nie, Wenjun Cheng
Summary: This case report describes a 50-year-old woman diagnosed with ovarian high-grade serous carcinoma with elevated beta-hCG, which was insensitive to chemotherapeutic drugs and had a poor prognosis.
Article
Multidisciplinary Sciences
Yuanfeng Zhang, Zhuangyong Xu, Shaoxu Wu, Tianxiang Zhu, Xuwei Hong, Zepai Chi, Rujan Malla, Jingqi Jiang, Yi Huang, Qingchun Xu, Zhiping Wang, Yonghai Zhang
Summary: The objective of this study was to construct a 3D and 2D contrast-enhanced computed tomography (CECT) radiomics model to predict CGB3 levels and assess its prognostic abilities in bladder cancer patients. Transcriptome data and CECT images were used to extract radiomics features. The study found that CGB3 expression level is an important prognosis factor for bladder cancer patients, and both 3D and 2D CECT radiomics are effective in predicting CGB3 expression levels.
Article
Multidisciplinary Sciences
Yane Liu, Duo Wang, Zhijun Li, Xinwei Li, Mengdi Jin, Ningning Jia, Xingyao Cui, Guoyan Hu, Tongyu Tang, Qiong Yu
Summary: This study provides a comprehensive analysis of the role of PIK3R1 and PIK3R2 in various cancers. The results show that PIK3R1 is lowly expressed in most tumors while PIK3R2 is highly expressed and associated with immune infiltration levels. Mutations and dysregulation of PIK3R1 and PIK3R2 are found to be detrimental to the survival of most cancer patients.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, Research & Experimental
Tianyu Cao, Yuanyuan Lu, Qi Wang, Hongqiang Qin, Hongwei Li, Hao Guo, Minghui Ge, Sarah E. Glass, Bhuminder Singh, Wenyao Zhang, Jiaqiang Dong, Feng Du, Airong Qian, Ye Tian, Xin Wang, Cunxi Li, Kaichun Wu, Daiming Fan, Yongzhan Nie, Robert J. Coffey, Xiaodi Zhao
Summary: De novo and acquired resistance are major impediments to cancer therapy. A study identified CGA as a prognostic biomarker and therapeutic target in chemoresistant gastric cancer (GC). High levels of CGA were found in chemoresistant GC cells and tissues, and elevated plasma CGA levels were correlated with reduced chemotherapy responsiveness and poor survival. CGA promoted survival and activated EGFR signaling in GC cells. Targeting CGA with anti-EGFR therapies or microRNAs restored chemotherapy sensitivity.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Biochemistry & Molecular Biology
Jia-Mei Luo, Tong-Tong Zhang, Yu-Ying He, Hui-Na Luo, Yu-Qi Hong, Zeng-Ming Yang
Summary: Decidualization is crucial for early pregnancy in rodents and humans. Disturbed decidualization can lead to implantation failure, spontaneous abortion, and preeclampsia. This study demonstrates that IL4I1-catalyzed metabolites of Trp enhance human decidualization through the AHR-Epiregulin pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Pengcheng Wang, Dunqiang Ren, Caihong Guo, Xiaoqian Ding, Yiwei Cao, Peige Zhao, Qiang Wang, Wenjuan Xu
Summary: Pulmonary embolism caused by choriocarcinoma is rare and difficult to diagnose and treat. A case study of a 21-year-old female diagnosed with primary pulmonary artery choriocarcinoma using PET/CT and successfully treated with chemotherapy was reported.
Review
Medicine, Research & Experimental
Yiming Chen, Yijie Chen, Xue Wang, Xuelian Chu, Wenwen Ning, Linyuan Gu, Liyao Li, Zhen Xie, Caihe Wen
Summary: Maternal serum D-dimer (DD) levels in the second trimester are associated with hypertensive disorders of pregnancy, with DD potentially being the best individual marker for predicting HDP. The risk calculation model constructed with DD+free beta-hCG+AFP had the greatest diagnostic value for severe preeclampsia (SPE).
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Shrabanti Chowdhury, Jacob J. Kennedy, Richard G. Ivey, Oscar D. Murillo, Noshad Hosseini, Xiaoyu Song, Francesca Petralia, Anna Calinawan, Sara R. Savage, Anna B. Berry, Boris Reva, Umut Ozbek, Azra Krek, Weiping Ma, Felipe da Veiga Leprevost, Jiayi Ji, Seungyeul Yoo, Chenwei Lin, Uliana J. Voytovich, Yajue Huang, Sun-Hee Lee, Lindsay Bergan, Travis D. Lorentzen, Mehdi Mesri, Henry Rodriguez, Andrew N. Hoofnagle, Zachary T. Herbert, Alexey I. Nesvizhskii, Bing Zhang, Jeffrey R. Whiteaker, David Fenyo, Wilson McKerrow, Joshua Wang, Stephan C. Schuer, Vasileios Stathias, X. Steven Chen, Mary Helen Barcellos-Hoff, Timothy K. Starr, Boris J. Winterhoff, Andrew C. Nelson, Samuel C. Mok, Scott H. Kaufmann, Charles Drescher, Marcin Cieslik, Pei Wang, Michael J. Birrer, Amanda G. Paulovich
Summary: To enhance our understanding of chemo-refractory high-grade serous ovarian cancers (HGSOCs), we analyzed the proteogenomic landscape of 242 HGSOCs and identified a 64-protein signature that accurately predicts a subgroup of HGSOCs refractory to initial platinum-based therapy. We also found a significant association between the lack of Ch17 loss of heterozygosity (LOH) and chemo-refractoriness, and identified 5 clusters of HGSOC based on pathway protein expression, which may represent different mechanisms of refractoriness and potential therapeutic vulnerabilities.
Article
Medical Laboratory Technology
Caroline E. Franks, Jieli Li, Magen Martinez, Christopher W. Farnsworth, Patricia M. Jones, David G. Grenache, Qing H. Meng, Ann M. Gronowski
Summary: This study assessed the utility of 5 quantitative hCG immunoassays for use as tumor markers in trophoblastic and non-trophoblastic disease. Results suggest that all 5 immunoassays are adequate for using hCG as a tumor marker in gestational trophoblastic disease and select germ cell tumors. Further studies are needed to assess the utility of quantitative hCG as a tumor marker in other malignant diseases.
CLINICAL CHEMISTRY
(2023)
Review
Medicine, Research & Experimental
Javier Gonzalez Fernandez, Javier Moncayo Arlandi, Ana Ochando, Carlos Simon, Felipe Vilella
Summary: Embryo-maternal cross-talk is crucial for embryo development and implantation, involving secreted factors and extracellular vesicles (EVs). EV cargo influences target cells and prepares them for reproductive stages like embryo development and implantation. Recent research suggests that EVs and their cargo can be used as a powerful, non-invasive tool to assess the quality of embryos and maternal tissues in assisted reproduction treatments. This review focuses on intercellular cross-talk between embryos and maternal tissues, examining human biology and signaling mechanisms identified in animal models.
Article
Chemistry, Analytical
Hatem Mohamed Elsheikh, Shadia Abdel-Hamid Fathy, Nahed Hassan Ebeid, Khaled Mohamed Sallam, Ahmed Sami El-bayoumy, Nagy Lahzy Mehany, Germine Mohsen Hamdy
Summary: The main objective of this study was to prepare and evaluate primary reagents for the liquid phase human chorionic gonadotropin-radioimmunoassay (HCG-RIA) kit. Polyclonal antibodies were found to be specific and valid, while monoclonal antibodies were more specific. The developed in-house HCG-RIA method showed high sensitivity, specificity, precision, and accuracy, making it suitable for quantifying HCG in human sera for pregnancy monitoring and diagnosis of gestational trophoblastic diseases.
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
(2023)
Article
Medical Laboratory Technology
Yang Li, Jiaou Zhang, Kemei Zhang, Ensheng Wang, Jing Shu
Summary: This retrospective study on 200 early pregnancy women found that the ongoing pregnancy group had significantly higher levels of E2 and beta-HCG from the 5th to 10th week of pregnancy compared to the inevitable abortion group. The growth rates of E2 and beta-HCG play an important role in predicting pregnancy outcomes.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Endocrinology & Metabolism
M. Kirshenbaum, O. Gil, J. Haas, R. Nahum, E. Zilberberg, O. Lebovitz, R. Orvieto
Summary: This study compared the effects of different sources of LH on treatment outcomes in IVF, revealing differences in the number of mature oocytes and fertilized oocytes between different LH preparations. However, there were no significant differences in other indicators and pregnancy rates between the treatment cycles.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Ying Liu, Xiao-Ya Ren, Ya-Guang Peng, Shao-Ke Chen, Xin-Ran Cheng, Miao Qin, Xiao-Ling Wang, Yan-Ning Song, Li-Jun Fan, Chun-Xiu Gong
Summary: The study demonstrated that hCG/hMG therapy is feasible and effective for treating male adolescents with CHH, with the initial 3 months of treatment showing the strongest effects. Results from the extended time-period also showed positive outcomes at the 1-year mark, indicating the potential of hCG/hMG regimen, although further research is needed to assess its long-term effectiveness and limitations.
CHINESE MEDICAL JOURNAL
(2021)
