Aberrant Lipid Metabolism: An Emerging Diagnostic and Therapeutic Target in Ovarian Cancer

Cancer statistics, 2013

(2013) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Fatty acid synthase expression associated with NAC1 is a potential therapeutic target in ovarian clear cell carcinomas

(2012) M T Rahman et al.   BRITISH JOURNAL OF CANCER

Cancer and sphingolipid storage disease therapy using novel synthetic analogs of sphingolipids

(2012) Shimon Gatt et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Elevated and secreted phospholipase A2 activities as new potential therapeutic targets in human epithelial ovarian cancer

(2012) Qingchun Cai et al.   FASEB JOURNAL

Lysophosphatidic Acid Activates Lipogenic Pathways andde NovoLipid Synthesis in Ovarian Cancer Cells

(2012) Abir Mukherjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serum Autotaxin is not a Useful Biomarker for Ovarian Cancer

(2012) Kazuhiro Nakamura et al.   LIPIDS

The Rho/ROCK pathway for lysophosphatidic acid-induced proteolytic enzyme expression and ovarian cancer cell invasion

(2012) K J Jeong et al.   ONCOGENE

Measurement of Phospholipids May Improve Diagnostic Accuracy in Ovarian Cancer

(2012) Lian Shan et al.   PLoS One

Cancer metabolism: current perspectives and future directions

(2012) C Muñoz-Pinedo et al.   Cell Death & Disease

Dysregulation of sphingolipid metabolism in cancer

(2011) Lindsay K. Ryland et al.   CANCER BIOLOGY & THERAPY

Blockade of Fatty Acid Synthase Induces Ubiquitination and Degradation of Phosphoinositide-3-Kinase Signaling Proteins in Ovarian Cancer

(2011) K. Tomek et al.   MOLECULAR CANCER RESEARCH

p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase

(2011) Peng Jiang et al.   NATURE CELL BIOLOGY

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

(2011) Kristin M Nieman et al.   NATURE MEDICINE

LPA Receptors: Subtypes and Biological Actions

(2010) Ji Woong Choi et al.   Annual Review of Pharmacology and Toxicology

Lovastatin induces apoptosis of ovarian cancer cells and synergizes with doxorubicin: potential therapeutic relevance

(2010) Anna Martirosyan et al.   BMC CANCER

Autotaxin delays apoptosis induced by carboplatin in ovarian cancer cells

(2010) Susanne Vidot et al.   CELLULAR SIGNALLING

Low-Density Lipoprotein-Cholesterol/High-Density Lipoprotein-Cholesterol Ratio Predicts Lipid-Rich Coronary Plaque in Patients With Coronary Artery Disease

(2010) Takumi Kimura et al.   CIRCULATION JOURNAL

Sulfatides in ovarian tumors: clinicopathological correlates

(2010) A. M. Makhlouf et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Sphingosine Kinase Mediates Resistance to the Synthetic RetinoidN-(4-Hydroxyphenyl)retinamide in Human Ovarian Cancer Cells

(2010) Giuditta Illuzzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elevation of sulfatides in ovarian cancer: An integrated transcriptomic and lipidomic analysis including tissue-imaging mass spectrometry

(2010) Ying Liu et al.   Molecular Cancer

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

(2010) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of Fatty Acid Synthase Depends on NAC1 and Is Associated with Recurrent Ovarian Serous Carcinomas

(2010) Stefanie M. Ueda et al.   Journal of Oncology

ORIGINAL ARTICLE: Expression of Autotaxin, an Ectoenzyme that Produces Lysophosphatidic Acid, in Human Placenta

(2009) Yuki Iwasawa et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

The suppressive effect of Rho kinase inhibitor, Y-27632, on oncogenic Ras/RhoA induced invasion/migration of human bladder cancer TSGH cells

(2009) Horng-Rong Chang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Sp-1 and c-Myc Mediate Lysophosphatidic Acid-Induced Expression of Vascular Endothelial Growth Factor in Ovarian Cancer Cells via a Hypoxia-Inducible Factor-1-Independent Mechanism

(2009) Y. Song et al.   CLINICAL CANCER RESEARCH

Identification and Characterization of a Novel Lysophosphatidic Acid Receptor, p2y5/LPA6

(2009) Keisuke Yanagida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of StearoylCoA Desaturase-1 Inactivates Acetyl-CoA Carboxylase and Impairs Proliferation in Cancer Cells: Role of AMPK

(2009) Natalia Scaglia et al.   PLoS One

Two pathways for lysophosphatidic acid production

(2008) J AOKI   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

ATP Citrate Lyase: Activation and Therapeutic Implications in Non-Small Cell Lung Cancer

(2008) T. Migita et al.   CANCER RESEARCH

Inhibition of Lysophosphatidic Acid Receptor-2 Expression by RNA Interference Decreases Lysophosphatidic Acid-induced Urokinase Plasminogen Activator Activation, Cell Invasion, and Migration in Ovarian Cancer SKOV-3 Cells

(2008) Gui-li Wang et al.   CROATIAN MEDICAL JOURNAL

Targeting SphK1 as a New Strategy against Cancer

(2008) Dai Shida et al.   CURRENT DRUG TARGETS

Lysophosphatidic Acid Receptors Determine Tumorigenicity and Aggressiveness of Ovarian Cancer Cells

(2008) Shuangxing Yu et al.   JNCI-Journal of the National Cancer Institute

Phospholipase D Activity Regulates Integrin-mediated Cell Spreading and Migration by Inducing GTP-Rac Translocation to the Plasma Membrane

(2008) Young Chan Chae et al.   MOLECULAR BIOLOGY OF THE CELL

Positive Feedback between Vascular Endothelial Growth Factor-A and Autotaxin in Ovarian Cancer Cells

(2008) M. M. Ptaszynska et al.   MOLECULAR CANCER RESEARCH