Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 13, Issue 4, Pages 5010-5018Publisher
MDPI
DOI: 10.3390/ijms13045010
Keywords
Orophea enterocarpa; Anonaceae; aristolactam; human colon adenocarcinoma cells; cytotoxicities
Funding
- Center for Innovation in Chemistry (PERCH-CIC), Commission on Higher Education, Ministry of Education
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A new aristolactam, named enterocarpam-III (10-amino-2,3,4,6-tetramethoxy phenanthrene-1-carboxylic acid lactam, 1) together with the known alkaloid stigmalactam (2), were isolated from Orophea enterocarpa. Their structures were elucidated on the basis of interpretation of their spectroscopic data. Compounds 1 and 2 exhibited significant cytotoxicities against human colon adenocarcinoma (HCT15) cell line with IC50 values of 1.68 and 1.32 mu M, respectively.
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