Prodrugs of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs), More Than Meets the Eye: A Critical Review

NOSH–aspirin (NBS-1120), a novel nitric oxide- and hydrogen sulfide-releasing hybrid is a potent inhibitor of colon cancer cell growth in vitro and in a xenograft mouse model

(2012) Mitali Chattopadhyay et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Synthesis and evaluation of fluorobenzoylated di- and tripeptides as inhibitors of cyclooxygenase-2 (COX-2)

(2012) Sai Kiran Sharma et al.   BIOORGANIC & MEDICINAL CHEMISTRY

NOSH-Aspirin: A Novel Nitric Oxide–Hydrogen Sulfide-Releasing Hybrid: A New Class of Anti-inflammatory Pharmaceuticals

(2012) Ravinder Kodela et al.   ACS Medicinal Chemistry Letters

Hydrogen sulfide-releasing NSAIDs inhibit the growth of human cancer cells: A general property and evidence of a tissue type-independent effect

(2011) Mitali Chattopadhyay et al.   BIOCHEMICAL PHARMACOLOGY

Prescription patterns and appropriateness of NSAID therapy according to gastrointestinal risk and cardiovascular history in patients with diagnoses of osteoarthritis

(2011) Angel Lanas et al.   BMC Medicine

Nitroxide derivatives of non-steroidal anti-inflammatory drugs exert anti-inflammatory and superoxide dismutase scavenging properties in A459 cells

(2011) Wilmarie Flores-Santana et al.   BRITISH JOURNAL OF PHARMACOLOGY

Chemotherapeutic Properties of Phospho-Nonsteroidal Anti-Inflammatory Drugs, a New Class of Anticancer Compounds

(2011) L. Huang et al.   CANCER RESEARCH

Aspirin Analogues as Dual Cyclooxygenase-2/5-Lipoxygenase Inhibitors: Synthesis, Nitric Oxide Release, Molecular Modeling, and Biological Evaluation as Anti-Inflammatory Agents

(2011) Jatinder Kaur et al.   ChemMedChem

Quinone Methides and their Prodrugs: A Subtle Equilibrium Between Cancer Promotion, Prevention, and Cure

(2011) F. Dufrasne et al.   CURRENT MEDICINAL CHEMISTRY

A Prodrug Approach to Improve the Physico-Chemical Properties and Decrease the Genotoxicity of Nitro Compounds

(2011) Man Chin Chung et al.   CURRENT PHARMACEUTICAL DESIGN

Rational Design and Development of Colon-Specific Prodrugs

(2011) Suneela S. Dhaneshwar et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

A promising codrug of nicotinic acid and ibuprofen for managing dyslipidemia. I: Synthesis andin vitroevaluation

(2011) Fatima Z. Abu Zanat et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Cyclooxygenase-2 inhibitors and cardiovascular risk in a nation-wide cohort study after the withdrawal of rofecoxib

(2011) M. Back et al.   EUROPEAN HEART JOURNAL

Synthesis, characterization and in vitro hydrolysis of a gemfibrozil-nicotinic acid codrug for improvement of lipid profile

(2011) Amjad M. Qandil et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Nitroxides prevent exacerbation of indomethacin-induced gastric damage in adjuvant arthritis rats

(2011) Hisato Deguchi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Chemical and in vitro enzymatic stability of newly synthesized celecoxib lipophilic and hydrophilic amides

(2011) Amjad M. Qandil et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Investigation of anticholinergic and non-steroidal anti-inflammatory prodrugs which reduce chemically induced skin inflammation

(2011) Sherri C. Young et al.   JOURNAL OF APPLIED TOXICOLOGY

Ethanesulfohydroxamic Acid Ester Prodrugs of Nonsteroidal Anti-inflammatory Drugs (NSAIDs): Synthesis, Nitric oxide and Nitroxyl Release, Cyclooxygenase Inhibition, Anti-inflammatory, and Ulcerogenicity Index Studies

(2011) Zhangjian Huang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of Amyloidogenesis by Nonsteroidal Anti-inflammatory Drugs and Their Hybrid Nitrates

(2011) Isaac T. Schiefer et al.   JOURNAL OF MEDICINAL CHEMISTRY

New Nitric Oxide or Hydrogen Sulfide Releasing Aspirins

(2011) Loretta Lazzarato et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel Analgesic/Anti-Inflammatory Agents: Diarylpyrrole Acetic Esters Endowed with Nitric Oxide Releasing Properties

(2011) Mariangela Biava et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nitric Oxide Release Is Not Required to Decrease the Ulcerogenic Profile of Nonsteroidal Anti-inflammatory Drugs

(2011) Sarthak Jain et al.   JOURNAL OF MEDICINAL CHEMISTRY

Oxidative Stress Mediates through Apoptosis the Anticancer Effect of Phospho-Nonsteroidal Anti-Inflammatory Drugs: Implications for the Role of Oxidative Stress in the Action of Anticancer Agents

(2011) Y. Sun et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Phospho-Ibuprofen (MDC-917) Is a Novel Agent against Colon Cancer: Efficacy, Metabolism, and Pharmacokinetics in Mouse Models

(2011) G. Xie et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Prodrugs--from Serendipity to Rational Design

(2011) K. M. Huttunen et al.   PHARMACOLOGICAL REVIEWS

Synthesis and Preliminary Pharmacological Evaluation of Aryl Dithiolethiones with Cyclooxygenase-2-Selective Inhibitory Activity and Hydrogen Sulfide-Releasing Properties

(2010) Shannon D. Zanatta et al.   AUSTRALIAN JOURNAL OF CHEMISTRY

Peripheral site acetylcholinesterase inhibitors targeting both inflammation and cholinergic dysfunction

(2010) Sherri Young et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The novel phospho-non-steroidal anti-inflammatory drugs, OXT-328, MDC-22 and MDC-917, inhibit adjuvant-induced arthritis in rats

(2010) L Huang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Phospho-sulindac (OXT-922) inhibits the growth of human colon cancer cell lines: a redox/polyamine-dependent effect

(2010) Liqun Huang et al.   CARCINOGENESIS

Prodrug Design to Improve Pharmacokinetic and Drug Delivery Properties: Challenges to the Discovery Scientists

(2010) S. Jana et al.   CURRENT MEDICINAL CHEMISTRY

Synthesis and pharmacological characterization of a novel nitric oxide-releasing diclofenac derivative containing a benzofuroxan moiety

(2010) Paulo Sérgio de Carvalho et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Codrug: An efficient approach for drug optimization

(2010) N. Das et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Synthesis and Biological Effects of Hydrogen Sulfide (H2S): Development of H2S-Releasing Drugs as Pharmaceuticals

(2010) Giuseppe Caliendo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Prodrugs: Some Thoughts and Current Issues

(2010) Valentino J. Stella   JOURNAL OF PHARMACEUTICAL SCIENCES

Comparison between 3-Nitrooxyphenyl acetylsalicylate (NO-ASA) and O2-(acetylsalicyloxymethyl)-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (NONO-ASA) as Safe Anti-Inflammatory, Analgesic, Antipyretic, Antioxidant Prodrugs

(2010) M. Chattopadhyay et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Inducible COX-2 dominates over COX-1 in prostacyclin biosynthesis: Mechanisms of COX-2 inhibitor risk to heart disease

(2010) Cheng-Huai Ruan et al.   LIFE SCIENCES

Pain market

(2010) Irena Melnikova   NATURE REVIEWS DRUG DISCOVERY

NO synthase: Structures and mechanisms

(2010) Simon Daff   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Oral bioavailability, efficacy and gastric tolerability of P2026, a novel nitric oxide-releasing diclofenac in rat

(2010) Asif R. Pathan et al.   INFLAMMOPHARMACOLOGY

Dinitroglyceryl and diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of aspirin, indomethacin and ibuprofen: Synthesis, biological evaluation and nitric oxide release studies

(2009) Khaled R.A. Abdellatif et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

NO-NSAIDs: Gastric-sparing nitric oxide-releasable prodrugs of non-steroidal anti-inflammatory drugs

(2009) Kumar V.S. Nemmani et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Mechanisms of Cyclooxygenase-2 Inhibition and Cardiovascular Side Effects--The Plot Thickens

(2009) L. J. Marnett   Cancer Prevention Research

Phosphoaspirin (MDC-43), a novel benzyl ester of aspirin, inhibits the growth of human cancer cell lines more potently than aspirin: a redox-dependent effect

(2009) W. Zhao et al.   CARCINOGENESIS

Prodrug Approaches for Enhancing the Bioavailability of Drugs with Low Solubility

(2009) Christa E. Müller   CHEMISTRY & BIODIVERSITY

Prodrugs: bridging pharmacodynamic/pharmacokinetic gaps

(2009) Bernard Testa   CURRENT OPINION IN CHEMICAL BIOLOGY

Medicinal Chemistry and Anti-Inflammatory Activity of Nitric Oxide-Releasing NSAI Drugs

(2009) Esra Koc et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Prodrug Designing of NSAIDs

(2009) Parmeshwari Halen et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Synthesis of Piperazinylalkyl Ester Prodrugs of Ketorolac and their In Vitro Evaluation for Transdermal Delivery

(2008) Amjad Qandil et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Control of Gastric Acid Secretion in Health and Disease

(2008) Mitchell L. Schubert et al.   GASTROENTEROLOGY

Second-Generation Aspirin and Indomethacin Prodrugs Possessing anO2-(Acetoxymethyl)-1-(2-carboxypyrrolidin-1-yl)diazenium-1,2-diolate Nitric Oxide Donor Moiety: Design, Synthesis, Biological Evaluation, and Nitric Oxide Release Studies

(2008) Carlos A. Velázquez et al.   JOURNAL OF MEDICINAL CHEMISTRY

Progress in Drug Delivery to the Central Nervous System by the Prodrug Approach

(2008) Barbara Pavan et al.   MOLECULES

Prodrugs: design and clinical applications

(2008) Jarkko Rautio et al.   NATURE REVIEWS DRUG DISCOVERY

NCX 4040, an NO-donating acetylsalicylic acid derivative: Efficacy and mechanisms of action in cancer cells

(2008) Anna Tesei et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Role of nitric oxide in the gastrointestinal tract

(2008) Angel Lanas   ARTHRITIS RESEARCH & THERAPY