Article
Immunology
Sofia R. Gardeta, Eva M. Garcia-Cuesta, Gianluca D'Agostino, Blanca Soler Palacios, Adriana Quijada-Freire, Pilar Lucas, Jorge Bernardino de la Serna, Carolina Gonzalez-Riano, Coral Barbas, Jose Miguel Rodriguez-Frade, Mario Mellado
Summary: The local lipid environment plays an important role in regulating CXCR4 organization and function, and modulating chemokine-triggered directed cell migration. Treatment of T cells with bacterial sphingomyelinase alters the lipid composition of the cell membrane, affecting membrane fluidity and CXCR4 nanoclustering and dynamics.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Cameron R. Bastow, Mark D. Bunting, Ervin E. Kara, Duncan R. McKenzie, Adriana Caon, Sapna Devi, Lynn Tolley, Scott N. Mueller, Ian H. Frazer, Natasha Harvey, Mark R. Condina, Clifford Young, Peter Hoffmann, Shaun R. McColl, Iain Comerford
Summary: This study reveals the mechanism by which ACKR4 controls DC migration in barrier tissues, identifying the existence of two forms of CCL21 in steady-state conditions and their regulation by ACKR4. It enhances understanding of functional chemokine gradient formation by showing how ACKR4 affects CCL21 gradients in barrier tissues and downstream lymph nodes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Neurosciences
Chiara Ossola, Nereo Kalebic
Summary: The development of the cerebral cortex is a complex process, and disturbances in the characteristics of neural progenitor cells are associated with cortical developmental abnormalities that can lead to neurodevelopmental disorders.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Zhen-Hong Yang, Si-Jia Zhang, Hai-Ping Zhao, Fang-Fang Li, Zhen Tao, Yu-Min Luo, Rong-Liang Wang
Summary: This study investigated the effects of erythropoietin (EPO) on the differentiation of neural stem cells (NSCs)/neural progenitors (NPs) in hypoxic-ischemic injury. Results showed that EPO promoted the differentiation of NSCs/NPs into oligodendrocytes and astrocytes, while inhibiting neuronal differentiation. The EPO receptor/β common receptor heterodimer was found to be present on the surface of fetal NSCs/NPs and involved in glial differentiation. The study provides insights into the potential mechanisms of EPO in treating hypoxic-ischemic injury.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Immunology
Paris M. M. Kollis, Lisa M. M. Ebert, John Toubia, Cameron R. R. Bastow, Rebecca J. J. Ormsby, Santosh I. I. Poonnoose, Sakthi Lenin, Melinda N. N. Tea, Stuart M. M. Pitson, Guillermo A. A. Gomez, Michael P. P. Brown, Tessa Gargett
Summary: This study characterized the chemokine receptor and integrin expression profiles of endogenous glioblastoma-infiltrating T cells and identified potential homing receptor-ligand pairs that could enhance the tumour-homing properties of future T-cell immunotherapies for glioblastoma.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chia-Chu Hsieh, Szu-Chun Hsu, Ming Yao, Dong-Ming Huang
Summary: The study found that ionomycin stimulated the expression of exosomal CD9 in human MSCs, but it could not affect melanoma cell migration through hMSCs. Furthermore, ionomycin reduced chemokine CCL21 expression and secretion in hMSCs, leading to decreased chemoattraction and migration of cancer cell lines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Yanan Wang, Jing Wang, Xinyi Yang, Jinlong Yang, Panpan Lu, Lin Zhao, Bokang Li, Hanyu Pan, Zhengtao Jiang, Xiaoting Shen, Zhiming Liang, Yue Liang, Huanzhang Zhu
Summary: The study demonstrates that CAR T cells combined with chemokine receptors have superior anti-tumor abilities in treating non-small-cell lung carcinoma, showing better therapeutic outcomes through enhanced migration and infiltration into tumor tissue.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Sivakamasundari Vijayakumar, Roberta Sala, Gugene Kang, Angela Chen, Michelle Ann Pablo, Abidemi Ismail Adebayo, Andrea Cipriano, Jonas L. Fowler, Danielle L. Gomes, Lay Teng Ang, Kyle M. Loh, Vittorio Sebastiano
Summary: A simplified monolayer protocol is developed to differentiate and purify primordial germ cell-like cells (PGCLCs) from human pluripotent stem cells (hPSCs). Single-cell RNA-sequencing reveals the specific features of PGCLCs and their transcriptional similarities with fetal PGCs.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Tyler J. Dause, Jiyeon K. Denninger, Bryon M. Smith, Elizabeth D. Kirby
Summary: This review focuses on investigating the autocrine and paracrine functions of the endogenous NSC secretome across life. Evidence shows that the NSC secretome is critical for how endogenous NSCs regulate themselves and their niche, but there are gaps in current literature, particularly in the clinically-relevant domain of endogenous NSC paracrine function in the injured CNS.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Oncology
Zixi Qin, Weiye Liang, Zixuan Zhang, Peiwen Li, Tianyu Wang, Qianyu Chen, Baoyin Guo, Ying Zhong, Hui Kang, Lihui Wang
Summary: The activation of KRAS gene can transform normal NPCs into GSC-like cells and lead to aggressive tumor formation. Additionally, KRAS activation also causes abnormal structure in ESC-derived brain organoids. This study provides a simple cellular model to investigate gliomagenesis.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
So-Yeon Park, Da-Seul Kim, Hyun-Mun Kim, Jun-Kyu Lee, Dong-Youn Hwang, Tae-Hyung Kim, Seungkwon You, Dong Keun Han
Summary: Mesenchymal stem cells (MSCs) have been used in clinical studies due to their versatility and low immunogenicity. However, safety issues remain a concern. Recently, extracellular vesicles (EVs) derived from MSCs have been explored as an alternative. EVs are nano-sized particles released by cells and have similar biological functions as their origin cells. They carry bioactive molecules and facilitate tissue regeneration. EVs derived from adipose-derived MSCs (ADMSC) also have neuroprotective and neurogenesis effects. This study aimed to enhance the neural differentiation ability of ADMSC-derived EVs by investigating the neurogenic-differentiation process. The results showed that differentiated EVs (dEVs) obtained from neurogenesis conditioned media increased neurogenic ability by altering microRNA expression and cytokine composition. dEVs promoted neuronal differentiation of neural progenitor cells in vitro, indicating their potential in EV-based therapy for neurological disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Marc Artinger, Oliver J. Gerken, Vladimir Purvanov, Daniel F. Legler
Summary: Chemokine-guided leukocyte migration is an important immune response mechanism. This study used fluorescently labeled chemokines to study the formation and changes of chemokine gradients in a 3D matrix, and found that dendritic cells can sense and respond differently to different gradient shapes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
M. Kouwenberg, W. P. C. Pulskens, L. Diepeveen, M. Bakker-van Bebber, C. A. Dinarello, M. G. Netea, L. B. Hilbrands, J. van der Vlag
Summary: The study evaluated the influence of IL-37 on DC-T cell interaction, finding that IL-37 did not affect mouse DC phenotype or subsequent T cell stimulatory capacity, but did reduce CXCL1 production. Additionally, CXCL1 did not have an effect on T cell proliferation or differentiation.
Review
Immunology
Hanli Xu, Shuye Lin, Ziyun Zhou, Duoduo Li, Xiting Zhang, Muhan Yu, Ruoyi Zhao, Yiheng Wang, Junru Qian, Xinyi Li, Bohan Li, Chuhan Wei, Keqiang Chen, Teizo Yoshimura, Ji Ming Wang, Jiaqiang Huang
Summary: Over the past thirty years, the importance of chemokines and their receptors has been recognized in various immune processes and disease pathogenesis. The genetic and nongenetic regulation of chemokines and receptors leads to functional heterogeneity and their imbalances contribute to various diseases. Understanding the molecular basis and interactions of chemokines and receptors will advance the application of precision medicine.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Review
Immunology
Masanori A. Murayama, Jun Shimizu, Chie Miyabe, Kazuo Yudo, Yoshishige Miyabe
Summary: Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammation and bone destruction in multiple joints. Inflammatory cytokines, such as IL-6 and TNF-alpha, play crucial roles in RA development. Biological therapies targeting these cytokines have revolutionized RA treatment, but non-responsiveness is still a challenge. This review focuses on the pathogenic roles of chemokines and their receptors in RA and discusses their potential as therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2023)
