Article
Chemistry, Medicinal
Md Afjalus Siraj, Md Sariful Islam Howlader, Md Sohanur Rahaman, Jamil A. Shilpi, Veronique Seidel
Summary: The ethanol extract of Vernonia patula aerial parts demonstrated significant antinociceptive and sedative effects in animal tests, likely due to the presence of five phenolic compounds. Computational analysis revealed that vanillic acid and caffeic acid have high binding affinities towards the CB1 receptor.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Xiangzhong Liu, Wenjing Tian, Mi Zhou, Qiannan Xu, Jie Feng, Renjing Yang, Shoulun He, Guanghui Wang, Ting Lin, Haifeng Chen
Summary: The phytochemical assessment of Vernonia amygdalina led to the discovery of seven previously undescribed sesquiterpenes. These compounds showed anti-inflammatory activity by inhibiting the expression of iNOS and COX-2, and by modulating the PI3K/AKT/NF-κB signaling pathway.
Review
Biochemistry & Molecular Biology
Saniya Salathia, Maria Rosa Gigliobianco, Cristina Casadidio, Piera Di Martino, Roberta Censi
Summary: The nervous and immune systems are closely related in causing inflammation and pain. Macrophages play a crucial role in modulating inflammation to induce neuropathic pain. Varying the molecular weight of hyaluronic acid can resolve inflammation and relieve pain and inflammation by using HA-based drug delivery nanosystems.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Juan Rodriguez-Silverio, Maria Elena Sanchez-Mendoza, Hector Isaac Rocha-Gonzalez, Juan Gerardo Reyes-Garcia, Francisco Javier Flores-Murrieta, Yaraset Lopez-Lorenzo, Geovanna Nallely Quinonez-Bastidas, Jesus Arrieta
Summary: The study demonstrated significant antinociceptive, antiallodynic, and anti-inflammatory effects of Polyalthic acid. Additionally, it was found that there is synergy between Polyalthic acid and naproxen in treating hyperalgesia.
Article
Engineering, Chemical
Petra Obioma Nnamani, Edith Obioma Diovu, Ikechukwu Emmanuel Peter, Akachukwu Marytheresa Onwuka, Chiamaka Victory Ogbuanwu, Obiora Emmanuel Abonyi, Brigitta Loretz, Claus-Michael Lehr
Summary: This study investigated the characteristics and anti-inflammatory potency of herbal lipospheres formulated from Pentaclethra macrophylla. The results showed that the lipospheres had desirable particle size and morphology, and effectively inhibited edema in arthritis. These findings suggest that the herbal lipospheres have potential as a drug with better delivery system and reduced side effects.
Article
Plant Sciences
Gizzelle Delfino Araujo Ladeira, Thais Magalhaes Acacio, Felipe Fernandes Rodrigues, Juliana Mendes Amorim, Gustavo Pereira Cosenza, Maria Jose Nunes de Paiva, Renes Resende Machado, Rachel Oliveira Castilho
Summary: This study aimed to increase scientific knowledge on the ethnopharmacological use of Lippia lacunosa through the evaluation of its micromolecular composition and anti-inflammatory and antinociceptive activities. The chemical profile of the plant extracts and fractions were analyzed using chromatographic methods. Results showed that L. lacunosa has potential anti-inflammatory and analgesic effects, indicating its potential as a herbal medicine for treating inflammatory and painful conditions.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Plant Sciences
Jessica Leiras Mota Conegundes, Josiane Mello da Silva, Renata de Freitas Mendes, Maria Fernanda Fernandes, Nicolas de Castro Campos Pinto, Maycon Alcantara de Almeida, Paula Ribeiro Braga Dib, Rafaela de Oliveira Andrade, Matheus Nehrer Rodrigues, Maria Christina Marques Nogueira Castanon, Gilson Costa Macedo, Elita Scio
Summary: The research aimed to characterize the chemical constituents of Siparuna guianensis Aublet leaves and evaluate their antioxidant, anti-inflammatory, antinociceptive, and locomotor activities. The results showed that the dichloromethane fraction of the leaves had significant effects on inflammation and pain, supporting its ethnopharmacological uses.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Young-Seo Yoon, Han-Jun Hwang, Jae-Min Kim, Kyung-Sook Chung, Seo-Yun Jang, So-Won Heo, Su-Yeon Lee, Soo-Yeon Kim, Hyeon-A. Song, Seung-Jae Hong, Hyo-Jin An, Sang-Wook Park, Jhong-Jae Im, Dong-Ho Oh, Ah-Ram Lee, Kyung-Tae Lee
Summary: The aim of this study was to evaluate the synergic anti-nociceptive and anti-inflammatory effects of DW-1021, an ionic complex of pelubiprofen and tramadol, compared to the administration of pelubiprofen or tramadol alone. The results showed that DW-1021 exhibited strong synergistic antinociceptive efficacy in nociceptive and inflammation-induced nociceptive models. It had a better pain-relieving effect than pelubiprofen but not as much as tramadol, and a stronger anti-inflammatory effect than tramadol but less than pelubiprofen.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Feng Lei, Zhou Yan
Summary: Pain is becoming a major global health issue, affecting one in every five adults worldwide each year. In this study, the antinociceptive and anti-inflammatory effects of corynoline, a phytochemical compound isolated from Corydalis bungeana Turcz., were evaluated in experimental mice. The results showed that corynoline significantly reduced pain and inflammation in a dose-dependent manner.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2022)
Article
Plant Sciences
Glenda Laissa Oliveira de Melo Candeia, Wendao Kennedy Costa, Alisson Marcario de Oliveira, Thiago Henrique Napoleao, Patricia Maria Guedes Paiva, Magda Rhayanny Assuncao Ferreira, Luiz Alberto Lira Soares
Summary: Our study investigated the anti-inflammatory and analgesic activities of spray-dried extract and fractions from Eugenia uniflora leaves using in vivo pharmacological models in mice. The results suggest that the extract and ethyl acetate fraction exhibit peripheral and central antinociceptive activity, which may be related to the presence of flavonoids, mainly myricitrin, and the involvement of opioid receptors.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Qian Li, Yan Guo, Di Wei, Lvdong Gong, Liping Feng, Xun Dong, Tao Cui
Summary: Twenty-five grayanane diterpenoids, including six undescribed compounds (craibiodenoside A-F), were isolated from Craibiodendron yunnanense W. W. Smith leaves. The structures of the compounds were determined using 1D-NMR, 2D-NMR, and HR-ESI-MS analyses. The compounds were evaluated for their anti-inflammatory activities, and three undescribed compounds (craibiodenoside A, B, F) and three known compounds showed significant inhibition of interleukin-6 (IL-6) release. Additionally, the antinociceptive activities of the compounds were assessed, and Craibiodenoside D, grayanoside D, and rhodojaponins VI exhibited notable antinociceptive activities, with rhodojaponins VI having an inhibition percentage of 87.6%.
Article
Biochemistry & Molecular Biology
Xiangzhong Liu, Renjing Yang, Qiannan Xu, Mi Zhou, Jie Feng, Guanghui Wang, Ting Lin, Wenjing Tian, Haifeng Chen
Summary: This study identified new phytosterols from Vernonia amygdalina and evaluated their cytotoxic activities against HeLa cervical cancer cells. Compound 10 exhibited the most potent anti-cancer activity, inducing apoptosis in HeLa cells through caspase signaling pathway activation and cell cycle arrest in S phase.
BIOORGANIC CHEMISTRY
(2022)
Article
Immunology
Angel Josabad Alonso-Castro, Victor Arana-Argaez, Eunice Yanez-Barrientos, Mario Alberto Ramirez-Camacho, Katarzyna Wrobel, Julio Cesar Torres-Romero, Carolina Leon-Callejas, Kazimierz Wrobel
Summary: The ethanol extract from the leaves and stem of Cuphea aequipetala showed significant antinociceptive and anti-inflammatory effects, likely due to modulation of nitric oxide and ATP-sensitive K+ channels. CAE also increased IL-10 release, contributing to its anti-inflammatory effects both in vitro and in vivo.
INFLAMMOPHARMACOLOGY
(2021)
Article
Plant Sciences
Margaret O. Sofidiya, Johnbosco U. Ikechukwu, Victoria E. Nnah, Olubusola O. Olaleye, Kazeem Basheeru, Abimbola A. Sowemimo, Abayomi M. Ajayi
Summary: The study investigates the anti-inflammatory and antinociceptive properties of Daniellia oliveri plant and its possible mechanistic action. Results showed that the extract exhibited significant anti-inflammatory and antinociceptive effects, supporting its traditional use in the treatment of inflammatory and painful disorders.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Biology
Emadeldin Konozy, Makarim Osman, Amina Dirar
Summary: Lectins are carbohydrate-binding proteins/glycoproteins that have a wide range of applications, from purifying glycoproteins to potential antinociceptive, antiulcer, and anti-inflammatory agents. The glycosylated surface of the coronavirus provides a target for plant lectins, which could potentially block viral attachment and combat the virus, including SARS-CoV-2.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Cell Biology
Oscar Alejandro Santos Mayorga, Ygor Ferreira Garcia da Costa, Jucelia Barbosa da Silva, Elita Scio, Adriana Lucia Pires Ferreira, Orlando Vieira de Sousa, Maria Silvana Alves
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2019)
Article
Immunology
Ludmila S. Caputo, Maria Ines C. Campos, Herbert J. Dias, Antonio E. M. Crotti, Julia B. Fajardo, Chislene P. Vanelli, Alvaro C. D. Presto, Maria S. Alves, Fernando M. Aarestrup, Ana Claudia C. Paula, Ademar A. Da Silva Filho, Beatriz J. V. Aarestrup, Olavo S. Pereira Junior, Jose Otavio do A. Correa
INTERNATIONAL IMMUNOPHARMACOLOGY
(2020)
Article
Pharmacology & Pharmacy
Simone S. Valverde, Bruna Celeida S. Santos, Temistocles B. de Oliveira, Guilherme C. Goncalves, Orlando V. de Sousa
Summary: Solidagenone (SOL), a compound found in Solidago chilensis, shows promising anti-inflammatory activity in mouse ear edema models, reducing inflammatory parameters and interacting with COX-1 and prostaglandin-E(2)-9-reductase.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2021)
Article
Microbiology
Muhammad Mumtaz Khan, Maria S. Alves, Sadia Alam, Mohammad H. Khan, Muhammad Jahangir, Abdul Jabbar, Rehmat Zaman, Sajid Ali, Aisha Bibi, Mustafa Kamal
JUNDISHAPUR JOURNAL OF MICROBIOLOGY
(2020)
Article
Chemistry, Medicinal
Marina M. S. Andrade, Icaro F. Protti, Vinicius G. Maltarollo, Ygor F. G. da Costa, Wesley G. de Moraes, Nicole F. Moreira, Giovana G. Garcia, Gabriel F. Caran, Flaviano M. Ottoni, Ricardo J. Alves, Carolina P. S. Moreira, Helen R. Martins, Maria Silvana Alves, Renata B. de Oliveira
Summary: Bacterial infections are a serious health care problem due to antibiotic misuse, leading to the emergence of multidrug resistant bacterial strains. This study focuses on synthesizing arylfuran derivatives as potential antimicrobial agents, with compound 24 showing the most promising activity against both Gram-negative and Gram-positive bacteria. The in silico studies suggest that compound 24 is a druglike molecule with significant antibacterial potential and low similarity with known antibiotics, indicating its innovative aspect.
MEDICINAL CHEMISTRY RESEARCH
(2021)
Review
Microbiology
Arianna Pompilio, Marco Scocchi, Maria Luisa Mangoni, Samira Shirooie, Annalisa Serio, Ygor Ferreira Garcia da Costa, Maria Silvana Alves, Gokce Seker Karatoprak, Ipek Suntar, Haroon Khan, Giovanni Di Bonaventura
Summary: Most human infectious diseases are caused by microorganisms in biofilms, which have increased resistance to antibiotics and the immune system. Therefore, there is a need for new strategies to control biofilm-associated infections. Natural products with a wide range of chemical structures and biological activities have been explored as potential biofilm inhibitors. This review discusses the bioactive compounds isolated from various natural sources that have the potential to inhibit biofilm formation and disperse established biofilms. However, the exact mechanism of action of these compounds is often unclear.
CRITICAL REVIEWS IN MICROBIOLOGY
(2023)
Article
Biochemical Research Methods
Gilmar Alves de Mesquita Junior, Ygor Ferreira Garcia da Costa, Valeria de Mello, Fabiano Freire Costa, Mirian Pereira Rodarte, Juliana de Carvalho da Costa, Maria Silvana Alves, Fernanda Maria Pinto Vilela
Summary: This study evaluated the chemical composition and in vitro antibacterial activity of arabica coffee leaf extract. The results revealed the presence of bioactive compounds and demonstrated antibacterial properties against both Gram-positive and Gram-negative bacteria.
PHYTOCHEMICAL ANALYSIS
(2022)
Review
Biochemistry & Molecular Biology
Muhammad Ajmal Shah, Ayesha Hamid, Hafiza Ishmal Faheem, Azhar Rasul, Tourki A. S. Baokbah, Muhammad Haris, Rimsha Yousaf, Uzma Saleem, Shabnoor Iqbal, Maria Silvana Alves, Zahid Khan, Ghulam Hussain, Ifat Alsharfi, Haroon Khan, Philippe Jeandet
Summary: Polydatin, a component of Polygonum cuspidatum, has a variety of biological activities such as antioxidant, anti-inflammatory, anticancer effects. Studies have shown that PD can inhibit the migration and proliferation of ovarian and breast cancer cells, reduce malignancy of lung cancer cells, and prevent cervical cancer.
Article
Biochemistry & Molecular Biology
Franciane Campos Silva, Bruna Celeida Silva Santos, Pedro Possa de Castro, Giovanni Wilson Amarante, Orlando Vieira de Sousa
Summary: Synthetic amino acid derivatives have shown inhibitory effects on digestive enzymes, including pancreatic lipase, pancreatic alpha-amylase, and alpha-glucosidase, which suggests their potential therapeutic use in controlling metabolic disorders.
Article
Infectious Diseases
Jordana Damasceno Gitirana de Santana, Oscar Alejandro Santos-Mayorga, Jonatas Rodrigues Florencio, Mirella Chrispim Cerqueira de Oliveira, Luisa Maria Silveira de Almeida, Julianna Oliveira de Lucas Xavier, Danielle Cristina Zimmermann-Franco, Gilson Costa Macedo, Adriana Lucia Pires Ferreira, Orlando Vieira de Sousa, Ademar Alves da Silva Filho, Maria Silvana Alves
Summary: This study investigated the chemical constituents and antibacterial activity of the medicinal plant Vernonia polyanthes. The results showed that the V. polyanthes leaf rinse extract (Vp-LRE) contained glaucolide A, which exhibited significant antibacterial activity against MRSA strains. Additionally, other compounds in Vp-LRE were found to interact with beta-lactamase. These findings suggest that V. polyanthes could serve as a potential natural source of phytochemicals with antibiotic properties.
Article
Pharmacology & Pharmacy
Rodrigo Luiz Fabri, Lara Melo Campos, Jonatas Rodrigues Florencio, Luiz Gustavo Oliveira, Danielle Maria de Oliveira Aragao, Adriana Lucia Pires Ferreira, Jair Adriano Kopke de Aguiar, Ana Carolina Morais Apolonio, Maria Silvana Alves, Elita Scio
Summary: The methanolic extract from Mitracarpus frigidus (MFM) showed significant reduction in mice mortality from Salmonella infection, and did not cause liver function alterations. Inhibitions of inflammatory and oxidative stress mediators were possibly involved in the observed effects. Various compounds were identified in MFM, suggesting its potential as an alternative treatment for salmonellosis.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Filipe Soares Bertges, Maria da Penha Henriques do Amaral, Mirian Pereira Rodarte, Maria Jose Vieira Fonseca, Orlando Vieira Sousa, Fernanda Maria Pinto Vilela, Maria Silvana Alves
BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY
(2020)
Article
Public, Environmental & Occupational Health
Thiago Mauricio de Souza Pinto, Fabrini Luiz Alves Almeida, Julianna Oliveira de Lucas Xavier, Glauciemar Del-Vechio-Vieira, Ana Lucia Santos de Matos Araujo, Jose de Jesus Ribeiro Gomes de Pinho, Maria Silvana Alves, Orlando Vieira de Sousa
ACTA SCIENTIARUM-HEALTH SCIENCES
(2020)