Compound K, a Metabolite of Ginseng Saponin, Induces Mitochondria-Dependent and Caspase-Dependent Apoptosis via the Generation of Reactive Oxygen Species in Human Colon Cancer Cells

Ginseng saponin metabolite induces apoptosis in MCF-7 breast cancer cells through the modulation of AMP-activated protein kinase

(2010) Areum Daseul Kim et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Involvement of p38 MAPK- and JNK-modulated expression of Bcl-2 and Bax in Naja nigricollis CMS-9-induced apoptosis of human leukemia K562 cells

(2010) Ying-Jung Chen et al.   TOXICON

Reactive oxygen species mediate thymoquinone-induced apoptosis and activate ERK and JNK signaling

(2009) Nahed El-Najjar et al.   APOPTOSIS

Synthesis and pharmacological exploitation of clioquinol-derived copper-binding apoptosis inducers triggering reactive oxygen species generation and MAPK pathway activation

(2009) Hui-Ling Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Benzyl isothiocyanate-mediated generation of reactive oxygen species causes cell cycle arrest and induces apoptosis via activation of MAPK in human pancreatic cancer cells

(2009) Ravi P. Sahu et al.   CARCINOGENESIS

Surfactin induces apoptosis in human breast cancer MCF-7 cells through a ROS/JNK-mediated mitochondrial/caspase pathway

(2009) Xiao-hong Cao et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Compound K, Intestinal Metabolite of Ginsenoside, Attenuates Hepatic Lipid Accumulation via AMPK Activation in Human Hepatoma Cells

(2009) Do Yeon Kim et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Effect of Compound K, a Metabolite of Ginseng Saponin, Combined with γ-Ray Radiation in Human Lung Cancer Cells in Vitro and in Vivo

(2009) Sungwook Chae et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Compound K Induces Apoptosis via CAMK-IV/AMPK Pathways in HT-29 Colon Cancer Cells

(2009) Do Yeon Kim et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Altered expression of MUTYH and an increase in 8-hydroxydeoxyguanosine are early events in ulcerative colitis-associated carcinogenesis

(2009) Masaki Gushima et al.   JOURNAL OF PATHOLOGY

Arachidonic acid-induced apoptosis of human neuroblastoma SK-N-SH cells is mediated through mitochondrial alteration elicited by ROS and Ca2+-evoked activation of p38α MAPK and JNK1

(2009) Ku-Chung Chen et al.   TOXICOLOGY

Proapoptotic Ginsenosides Compound K and Rh2 Enhance Fas-induced Cell Death of Human Astrocytoma Cells Through Distinct Apoptotic Signaling Pathways

(2009) Kyungsun Choi et al.   Cancer Research and Treatment