Article
Pharmacology & Pharmacy
Andre Lopes Saraiva, Allisson Benatti Justino, Rodrigo Rodrigues Franco, Heitor Cappato Guerra Silva, Felipe dos Santos Arruda, Sandra Gabriela Klein, Mara Rubia Nunes Celes, Luiz Ricardo Goulart, Foued Salmen Espindola
Summary: In this study, the antioxidant and anti-inflammatory activities of polyphenols-rich fractions from Annona muricata L. leaves were investigated. The fractions reduced the generation of reactive oxygen species and secretion of inflammatory markers in immune cells. Furthermore, these fractions attenuated oxidative damage and inflammation in experimental acute lung injury. These findings suggest that these fractions might be explored for the development of new therapies for inflammatory conditions.
Article
Chemistry, Applied
Caroline Zanella Cagnini, Angelica Barbosa Dias, Mariana Rodrigues Vilas Boas, Fabiana Pacheco Reis Batista, Maria Graciela Iecher Faria, Jasmina Glamoclija, Marina Sokovic, Vele Tesevic, Ederlan de Souza Ferreira, Nelson Barros Colauto, Giani Andrea Linde, Zilda Cristiani Gazim
Summary: This study investigated the antimicrobial activity and chemical composition of Annona muricata leaf oleoresin extracted by supercritical CO2. The oleoresin showed high bactericidal activity against various bacteria, but low fungicidal activity. Promising applications in food, cosmetic, and pharmaceutical industries were suggested for the leaf oleoresin of A. muricata.
NATURAL PRODUCT RESEARCH
(2022)
Article
Medicine, Research & Experimental
Casimiro Cardenas, Jose Antonio Torres-Vargas, Abel Cardenas-Valdivia, Nuria Jurado, Ana R. Quesada, Melissa Garcia-Caballero, Beatriz Martinez-Poveda, Miguel Angel Medina
Summary: Extracts from Annona muricata leaves contain 33 bioactive compounds and have potential as anti-angiogenic agents.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Oncology
Suganya Ilango, Dipak Kumar Sahoo, Biswaranjan Paital, Kavibharathi Kathirvel, Jerrina Issac Gabriel, Kalyani Subramaniam, Priyanka Jayachandran, Rajendra Kumar Dash, Akshaya Kumar Hati, Tapas Ranjan Behera, Pragnyashree Mishra, Ramalingam Nirmaladevi
Summary: This review article introduces the medicinal properties of Annona muricata and its potential role in cancer treatment. The active phytochemicals identified in A. muricata have the potential to be used as anti-cancer agents and can modulate cellular proliferation, reduce cancer cell invasion and metastasis, and destroy cancer cells.
Article
Plant Sciences
Nimcy Noemi Meza-Gutierrez, Paola Magallon-Servin, Rosendo Balois-Morales, Iza Fernanda Perez-Ramirez, Graciela Guadalupe Lopez-Guzman, Guillermo Berumen-Varela, Pedro Ulises Bautista-Rosales
Summary: The effect of soursop leaf extracts on the growth, motility, and biofilm formation of Lactobacillus casei were investigated. The extracts showed both growth-promoting and inhibitory effects, with different compounds being related to growth. The extracts also affected the motility of L. casei and inhibited biofilm formation.
Article
Biochemistry & Molecular Biology
Rehab H. Abdallah, Muneera S. M. Al-Saleem, Wael M. Abdel-Mageed, Al-Sayed R. Al-Attar, Youssef M. Shehata, Doaa M. Abdel-Fattah, Rahnaa M. Atta
Summary: Annona muricate is a tropical plant with edible fruits that have therapeutic properties. The plant extracts were analyzed using LCMS/MS, resulting in the identification of 388 components, including new compounds. The extracts showed potential anticancer properties against Ehrlich ascites carcinoma in mice.
Article
Plant Sciences
Natalia Carnevalli Miranda, Ester Cristina Borges Araujo, Allisson Benatti Justino, Yusmaris Cariaco, Caroline Martins Mota, Layane Alencar Costa-Nascimento, Foued Salmen Espindola, Neide Maria Silva
Summary: This study evaluated the activity of ethanolic extract and its fractions from Annona muricata against Toxoplasma gondii, showing that ethanolic extract has good anti-Toxoplasma activity and can improve survival rates in small intestine and lung infections.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Saniya Salathia, Maria Rosa Gigliobianco, Cristina Casadidio, Piera Di Martino, Roberta Censi
Summary: The nervous and immune systems are closely related in causing inflammation and pain. Macrophages play a crucial role in modulating inflammation to induce neuropathic pain. Varying the molecular weight of hyaluronic acid can resolve inflammation and relieve pain and inflammation by using HA-based drug delivery nanosystems.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Food Science & Technology
Ivone Lima Santos, Antonio Manoel da Cruz Rodrigues, Edna Regina Amante, Luiza Helena Meller da Silva
Summary: This study discusses the chemical composition of soursop fruit and its by-products, as well as potential applications such as soursop powder, bioactive compounds, oil, biochar, biodiesel, and bio-oil. These by-products are rich in phytochemicals and have the potential to reduce environmental impact and generate income.
Article
Food Science & Technology
Carolina Lopes Leivas, Thaisa Moro Cantu-Jungles, Bruna Barbosa da Luz, Maria Fernanda de Paula Werner, Marcello Iacomini, Lucimara M. C. Cordeiro
Summary: This study investigated the structural features and biological activities of dietary fibers from soursop fruits. The soluble fibers were found to have type II arabinogalactan and a highly methyl esterified homogalacturonan, while the insoluble fibers were mainly composed of pectic arabinan, a xylan-xyloglucan complex, and a glucuronoxylan. These fibers showed potential for pain relief and anti-inflammatory effects.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Goon-Tae Kim, Kyung-Hee Cho, Amitesh Sharma, Shivani Devi, Tae-Sik Park
Summary: Graviola leaf extracts can alleviate chronic diseases by downregulating fatty acid oxidation and synthesis genes. In vivo experiments in mice fed a high-fat diet showed significant weight loss and improvement in liver condition in response to treatment with graviola leaf extracts, particularly ethanol extract.
Review
Biochemistry & Molecular Biology
Mutakin Mutakin, Rizky Fauziati, Fahrina Nur Fadhilah, Ade Zuhrotun, Riezki Amalia, Yuni Elsa Hadisaputri
Summary: This review discusses the traditional use, chemical content, and pharmacological activities of Soursop (Annona muricata Lin.). Studies have shown that Soursop has various activities, including anticancer, antiulcer, and antidiabetic effects. The plant contains chemicals such as acetogenins, alkaloids, flavonoids, and vitamins, which are predicted to be responsible for its biological activity.
Article
Chemistry, Multidisciplinary
Gabriela Aguilar-Hernandez, Brandon A. Lopez-Romero, Alejandro Perez-Larios, Jose M. Ruvalcaba-Gomez, Inkar Castellanos-Huerta, Guillermo Tellez-Isaias, Victor M. Petrone-Garcia, Luis M. Anaya-Esparza, Efigenia Montalvo-Gonzalez
Summary: This study evaluated the antimicrobial effect of crude extract (CE) and purified acetogenins (P-ACGs) from the endosperm of A. muricata seeds against Gram-positive and Gram-negative microorganisms. The results showed that P-ACGs had strong antibacterial activity against several microorganisms, with a minimum inhibitory concentration ranging from 0.009 to 12.50 μg/mL. Additionally, P-ACGs caused significant sub-lethal damage in certain bacteria.
APPLIED SCIENCES-BASEL
(2023)
Article
Chemistry, Multidisciplinary
Houefa Egidia Fallon Adido, Cristian Kallahan Silva Chagas, Gleison Goncalves Ferreira, Mirian Leticia Carmo Bastos, Maria Fani Dolabela
Summary: As life expectancy increases, the number of people affected by cancer is increasing. This study evaluated the antitumor potential of acetogenins isolated from Annona muricata. The results showed that muricatacin and cis-uvariamicin IV have promising antitumor activity.
FRONTIERS IN CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Shashanka K. Prasad, Sushma Pradeep, Chandan Shimavallu, Shiva Prasad Kollur, Asad Syed, Najat Marraiki, Chukwuebuka Egbuna, Mihnea-Alexandru Gaman, Olga Kosakowska, William C. Cho, Kingsley Chukwuemeka Patrick-Iwuanyanwu, Joaquin Ortega Castro, Juan Frau, Norma Flores-Holguin, Daniel Glossman-Mitnik
Summary: Annona muricata, a tropical plant with extensive medicinal use, exhibits significant antiviral properties and selective cytotoxicity against tumorigenic cells. Researchers have developed a unique library of bioactive compounds exclusive to A. muricata for in silico evaluations against the SARS-CoV-2 spike protein. The Acetogenins from A. muricata show promising potential as anti-SARS-CoV-2 agents and warrant further in vitro and in vivo studies.
FRONTIERS IN CHEMISTRY
(2021)
Article
Cell Biology
Oscar Alejandro Santos Mayorga, Ygor Ferreira Garcia da Costa, Jucelia Barbosa da Silva, Elita Scio, Adriana Lucia Pires Ferreira, Orlando Vieira de Sousa, Maria Silvana Alves
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2019)
Article
Immunology
Ludmila S. Caputo, Maria Ines C. Campos, Herbert J. Dias, Antonio E. M. Crotti, Julia B. Fajardo, Chislene P. Vanelli, Alvaro C. D. Presto, Maria S. Alves, Fernando M. Aarestrup, Ana Claudia C. Paula, Ademar A. Da Silva Filho, Beatriz J. V. Aarestrup, Olavo S. Pereira Junior, Jose Otavio do A. Correa
INTERNATIONAL IMMUNOPHARMACOLOGY
(2020)
Article
Pharmacology & Pharmacy
Simone S. Valverde, Bruna Celeida S. Santos, Temistocles B. de Oliveira, Guilherme C. Goncalves, Orlando V. de Sousa
Summary: Solidagenone (SOL), a compound found in Solidago chilensis, shows promising anti-inflammatory activity in mouse ear edema models, reducing inflammatory parameters and interacting with COX-1 and prostaglandin-E(2)-9-reductase.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2021)
Article
Microbiology
Muhammad Mumtaz Khan, Maria S. Alves, Sadia Alam, Mohammad H. Khan, Muhammad Jahangir, Abdul Jabbar, Rehmat Zaman, Sajid Ali, Aisha Bibi, Mustafa Kamal
JUNDISHAPUR JOURNAL OF MICROBIOLOGY
(2020)
Article
Chemistry, Medicinal
Marina M. S. Andrade, Icaro F. Protti, Vinicius G. Maltarollo, Ygor F. G. da Costa, Wesley G. de Moraes, Nicole F. Moreira, Giovana G. Garcia, Gabriel F. Caran, Flaviano M. Ottoni, Ricardo J. Alves, Carolina P. S. Moreira, Helen R. Martins, Maria Silvana Alves, Renata B. de Oliveira
Summary: Bacterial infections are a serious health care problem due to antibiotic misuse, leading to the emergence of multidrug resistant bacterial strains. This study focuses on synthesizing arylfuran derivatives as potential antimicrobial agents, with compound 24 showing the most promising activity against both Gram-negative and Gram-positive bacteria. The in silico studies suggest that compound 24 is a druglike molecule with significant antibacterial potential and low similarity with known antibiotics, indicating its innovative aspect.
MEDICINAL CHEMISTRY RESEARCH
(2021)
Review
Microbiology
Arianna Pompilio, Marco Scocchi, Maria Luisa Mangoni, Samira Shirooie, Annalisa Serio, Ygor Ferreira Garcia da Costa, Maria Silvana Alves, Gokce Seker Karatoprak, Ipek Suntar, Haroon Khan, Giovanni Di Bonaventura
Summary: Most human infectious diseases are caused by microorganisms in biofilms, which have increased resistance to antibiotics and the immune system. Therefore, there is a need for new strategies to control biofilm-associated infections. Natural products with a wide range of chemical structures and biological activities have been explored as potential biofilm inhibitors. This review discusses the bioactive compounds isolated from various natural sources that have the potential to inhibit biofilm formation and disperse established biofilms. However, the exact mechanism of action of these compounds is often unclear.
CRITICAL REVIEWS IN MICROBIOLOGY
(2023)
Article
Biochemical Research Methods
Gilmar Alves de Mesquita Junior, Ygor Ferreira Garcia da Costa, Valeria de Mello, Fabiano Freire Costa, Mirian Pereira Rodarte, Juliana de Carvalho da Costa, Maria Silvana Alves, Fernanda Maria Pinto Vilela
Summary: This study evaluated the chemical composition and in vitro antibacterial activity of arabica coffee leaf extract. The results revealed the presence of bioactive compounds and demonstrated antibacterial properties against both Gram-positive and Gram-negative bacteria.
PHYTOCHEMICAL ANALYSIS
(2022)
Review
Biochemistry & Molecular Biology
Muhammad Ajmal Shah, Ayesha Hamid, Hafiza Ishmal Faheem, Azhar Rasul, Tourki A. S. Baokbah, Muhammad Haris, Rimsha Yousaf, Uzma Saleem, Shabnoor Iqbal, Maria Silvana Alves, Zahid Khan, Ghulam Hussain, Ifat Alsharfi, Haroon Khan, Philippe Jeandet
Summary: Polydatin, a component of Polygonum cuspidatum, has a variety of biological activities such as antioxidant, anti-inflammatory, anticancer effects. Studies have shown that PD can inhibit the migration and proliferation of ovarian and breast cancer cells, reduce malignancy of lung cancer cells, and prevent cervical cancer.
Article
Biochemistry & Molecular Biology
Franciane Campos Silva, Bruna Celeida Silva Santos, Pedro Possa de Castro, Giovanni Wilson Amarante, Orlando Vieira de Sousa
Summary: Synthetic amino acid derivatives have shown inhibitory effects on digestive enzymes, including pancreatic lipase, pancreatic alpha-amylase, and alpha-glucosidase, which suggests their potential therapeutic use in controlling metabolic disorders.
Article
Infectious Diseases
Jordana Damasceno Gitirana de Santana, Oscar Alejandro Santos-Mayorga, Jonatas Rodrigues Florencio, Mirella Chrispim Cerqueira de Oliveira, Luisa Maria Silveira de Almeida, Julianna Oliveira de Lucas Xavier, Danielle Cristina Zimmermann-Franco, Gilson Costa Macedo, Adriana Lucia Pires Ferreira, Orlando Vieira de Sousa, Ademar Alves da Silva Filho, Maria Silvana Alves
Summary: This study investigated the chemical constituents and antibacterial activity of the medicinal plant Vernonia polyanthes. The results showed that the V. polyanthes leaf rinse extract (Vp-LRE) contained glaucolide A, which exhibited significant antibacterial activity against MRSA strains. Additionally, other compounds in Vp-LRE were found to interact with beta-lactamase. These findings suggest that V. polyanthes could serve as a potential natural source of phytochemicals with antibiotic properties.
Article
Pharmacology & Pharmacy
Rodrigo Luiz Fabri, Lara Melo Campos, Jonatas Rodrigues Florencio, Luiz Gustavo Oliveira, Danielle Maria de Oliveira Aragao, Adriana Lucia Pires Ferreira, Jair Adriano Kopke de Aguiar, Ana Carolina Morais Apolonio, Maria Silvana Alves, Elita Scio
Summary: The methanolic extract from Mitracarpus frigidus (MFM) showed significant reduction in mice mortality from Salmonella infection, and did not cause liver function alterations. Inhibitions of inflammatory and oxidative stress mediators were possibly involved in the observed effects. Various compounds were identified in MFM, suggesting its potential as an alternative treatment for salmonellosis.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Filipe Soares Bertges, Maria da Penha Henriques do Amaral, Mirian Pereira Rodarte, Maria Jose Vieira Fonseca, Orlando Vieira Sousa, Fernanda Maria Pinto Vilela, Maria Silvana Alves
BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY
(2020)
Article
Public, Environmental & Occupational Health
Thiago Mauricio de Souza Pinto, Fabrini Luiz Alves Almeida, Julianna Oliveira de Lucas Xavier, Glauciemar Del-Vechio-Vieira, Ana Lucia Santos de Matos Araujo, Jose de Jesus Ribeiro Gomes de Pinho, Maria Silvana Alves, Orlando Vieira de Sousa
ACTA SCIENTIARUM-HEALTH SCIENCES
(2020)