Article
Biotechnology & Applied Microbiology
Wenxue Ma, Tingting Zhong, Junqiu Chen, Xiao Ke, Huihua Zuo, Qiang Liu
Summary: This study aimed to investigate the effect of exogenous hydrogen sulfide (H2S) on high glucose-induced injury in endothelial progenitor cells (EPCs) and its underlying mechanisms. The results showed that H2S reversed the inhibitory effects of high glucose on EPCs proliferation, migration, and tube formation, promoting autophagic flux and reducing reactive oxygen species (ROS) production.
Article
Pharmacology & Pharmacy
Qingjie Mu, Kaixuan Lv, Jielun Yu, Shangmin Chu, Lichun Zhang, Lingyu Kong, Linlin Zhang, Yan Tian, Xiaopeng Jia, Benhong Liu, Youzhen Wei, Nana Yang
Summary: This study found that hydrogen can repair the proliferation, migration, and tube formation dysfunctions of lipopolysaccharide (LPS)-induced bone marrow-derived endothelial progenitor cells (EPCs). This repairment is mediated by the PI3K/AKT/eNOS signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Si-Lu Zhu, Mei-Ling Wang, Yue-Teng He, Shu-Wen Guo, Ting-Ting Li, Wei-Jie Peng, Dan Luo
Summary: Capsaicin elevates SIRT1 levels through TRPV1 pathway and suppresses IHG-induced endothelial cell senescence.
Review
Biochemistry & Molecular Biology
Yunna Lee, Eunok Im
Summary: Natural antioxidants play a crucial role in combating cardiovascular diseases, potentially exerting cardioprotective effects through various mechanisms. Research suggests that miRNAs are key players in regulating oxidative stress in cardiovascular diseases, affecting endothelial function by targeting eNOS and SIRT1.
Article
Biochemistry & Molecular Biology
Qiang Tu, Lingling Xu, Hufei Zhang, Yumin Qiu, Zhefu Liu, Bing Dong, Jun Tao
Summary: This study demonstrates the effect and mechanism of Andrographolide (AGP), a traditional Chinese patent medicine, on the function of endothelial progenitor cells (EPCs) in hypertension. AGP improves the dysfunction of EPCs through SIRT1-mediated anti-apoptotic effects, providing a new therapeutic strategy for treating vascular damage in hypertension.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Sarah E. Basehore, Samantha Bohlman, Callie Weber, Swathi Swaminathan, Yuji Zhang, Cholsoon Jang, Zoltan Arany, Alisa Morss Clyne
Summary: The study found that steady laminar flow reduces eNOS O-GlcNAcylation by limiting glycolysis and the availability of UDP-GlcNAc, leading to increased eNOS phosphorylation and NO production. This research demonstrates for the first time that O-GlcNAcylation is regulated by mechanical stimuli, which has implications for cardiovascular disease.
CIRCULATION RESEARCH
(2021)
Article
Food Science & Technology
Xuan Chen, Liufeng Zheng, Bing Zhang, Zeyuan Deng, Hongyan Li
Summary: This research showed that the combination of quercetin and lycopene can prevent endothelial oxidative stress by reducing reactive oxygen species and inhibiting the expression of Nox4. The combination also downregulates inflammatory genes induced by H2O2 and activates SIRT1 deacetyl activity.
CURRENT RESEARCH IN FOOD SCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Keita Horitani, Masayoshi Iwasaki, Hiroshi Kishimoto, Kensaku Wada, Miyuki Nakano, Haengnam Park, Yasushi Adachi, Daisuke Motooka, Daisuke Okuzaki, Ichiro Shiojima
Summary: The combination of hyperglycemia and hypertriglyceridemia is associated with an increased risk of atherosclerotic cardiovascular disease. In humans, hypertriglyceridemia may enhance the negative impact of hyperglycemia on the number of circulating endothelial progenitor cells. In mice, metabolic stress induced by glucose and triglyceride spikes results in senescence-like phenotypes of bone marrow stem/progenitor cells via H3K27me3 demethylase-mediated epigenetic regulation.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Kai Wang, Shiyue Sun, Guigui Zhang, Zixian Lu, Hui Chen, Xia Fan, Chunjie Gu, Xiaohong Pan, Qian Lin, Oscar Chen, Lu Cai, Xiaozhen Dai, Xiao Wang, Chaosheng Lu, Xiaoqing Yan, Yi Tan
Summary: The CXCR7 agonist TC14012 can improve the function of EPCs under diabetic conditions and promote the mobilization of EPCs and diabetic ischemic angiogenesis through the CXCR7/Akt signaling pathway.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Review
Biochemistry & Molecular Biology
Klara Komici, Angelica Perna, Germano Guerra
Summary: Frailty is a clinical condition characterized by a decline in biological reserves, physiological mechanism failure, and vulnerability to stressors. This review focuses on the role of endothelial progenitor cells (EPCs) in frailty, highlighting their impaired function, number, and survival in the elderly. It also discusses the modification of EPCs in age-related diseases such as atherosclerosis, hypertension, and diabetes mellitus. The review concludes by exploring interventions that may restore EPCs expression and function in frail individuals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Jidong Zhou, Hang Li, Liying Xun, Lei Wang, Qitao Zhao
Summary: This study aims to explore the role of hyperlipidemia in the mobilization of bone marrow endothelial progenitor cells induced by acute myocardial ischemia. The results showed that hyperlipidemia may attenuate the mobilization of BM EPCs induced by AMI via the VEGF/eNOS/NO/MMP-9 signal pathway, which hampers the repairs of AMI-induced cardiac injury to some extent.
Article
Medicine, Research & Experimental
Tongshuai Chen, Chang Ma, Guanqi Fan, Hui Liu, Xie Lin, Jingyuan Li, Na Li, Shujian Wang, Mei Zeng, Yun Zhang, Peili Bu
Summary: Hyperglycemia accelerates endothelial cell dysfunction and vascular complications by inducing ECs senescence, with molecular mechanisms involving SIRT3-p53 pathway.
Article
Nutrition & Dietetics
Tays Amanda Felisberto Goncalves, Viviane Silva Lima, Arthur Jose Pontes Oliveira de Almeida, Alinne Villar de Arruda, Ana Caroline Meneses Ferreira Veras, Thais Trajano Lima, Evyllen Myllena Cardoso Soares, Adhonias Correia dos Santos, Maria Eduarda Costa de Vasconcelos, Mathania Silva de Almeida Feitosa, Robson Cavalcante Veras, Isac Almeida de Medeiros
Summary: This study demonstrated the regulatory effects of carvacrol on endothelial repair in spontaneously hypertensive rats. Results showed that carvacrol promoted the migration and proliferation of endothelial progenitor cells, increased eNOS expression and activity, reduced reactive oxygen species production and cellular senescence, and improved vascular function.
Article
Engineering, Biomedical
Duanwen Cao, Huihua Zuo, Mingjin Jiang, Yiteng Huang, Liang Li, Fengxia Lin, Yue Liu
Summary: Recent studies have shown that GNR@MSNs@PEI loaded with pcDNA3.1-CXCR4 and miR-126 can protect EPCs against high glucose-induced injury efficiently. These nano-carriers exhibit high loading capacity, biocompatibility, cell internalization efficiency, and controllable release ability, making them promising for gene delivery in treating diabetic macroangiopathy.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2022)
Article
Multidisciplinary Sciences
June Seok Heo, Sinyoung Kim
Summary: This study found that human adipose mesenchymal stem cell-derived exosomes have anti-inflammatory and pro-angiogenic effects. Exosomes inhibit inflammation by activating ROCK1 and PTEN expression, and promote angiogenesis by releasing miR-132 and miR-146a.
SCIENTIFIC REPORTS
(2022)