Article
Biotechnology & Applied Microbiology
Jian Zhang, Chi Huang, Zehan Liu, Shuai Ren, Zilong Shen, Kecheng Han, Weiguang Xin, Guanyi He, Jianyu Liu
Summary: This study identified potential biomarkers in the peripheral serum of patients with steroid-induced osteonecrosis of the femoral head (SONFH) by analyzing gene expression profile data. GYPA, TMCC2, and BPGM were found to be potential biomarkers and may affect the development of SONFH by regulating erythrocytes and immunity.
Review
Oncology
Kaichi Kaneko, Hao Chen, Matthew Kaufman, Isaak Sverdlov, Emily M. Stein, Kyung-Hyun Park-Min
Summary: Osteonecrosis is a complex and devastating complication of systemic lupus erythematosus, with variable prevalence in SLE patients. The use of high-dose glucocorticoid therapy is strongly associated with the development of osteonecrosis in SLE patients, although the exact pathophysiology and risk factors for osteonecrosis in this population are not fully understood.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Genetics & Heredity
Ju'an Yue, Huachen Yu, Pei Liu, Pengfei Wen, Haojun Zhang, Wanshou Guo, Qidong Zhang
Summary: The study found that Icariin (ICA) can effectively prevent steroid-induced osteonecrosis of the femoral head (ONFH) in rats; by regulating the expression of miRNA-335 and improving the migration and angiogenesis abilities of BMECs, ICA has a protective effect against steroid-induced BMECs injury.
Article
Pharmacology & Pharmacy
Q. -R. Wang, Z. -Y. Yang, W. -L. Zhang, Q. -H. LI, P. -D. Kang
Summary: This study used a rat model to investigate the association between glucocorticoid-induced osteonecrosis of the femoral head (GC-ONFH) and abnormal chondrocyte hyperplasia in articular surface cartilage. The results suggest that the abnormal chondrocyte hyperplasia may be related to glucocorticoid-induced overactivation of autophagy.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Chemistry, Medicinal
Daoyu Zhu, Hongping Yu, Pei Liu, Qianhao Yang, Yixuan Chen, Pengbo Luo, Changqing Zhang, Youshui Gao
Summary: The study demonstrated the beneficial effects of calycosin in glucocorticoid-induced osteonecrosis of the femoral head. Calycosin could promote bone formation, inhibit inflammatory responses, and improve pathological manifestations. The results suggest that calycosin may become a potential candidate for pharmaceutical prevention of this intractable disease.
PHYTOTHERAPY RESEARCH
(2021)
Review
Immunology
Qingyu Zhang, Wei Sun, Tengqi Li, Fanxiao Liu
Summary: Glucocorticoid-induced osteonecrosis of the femoral head (GIONFH) is a debilitating disease with high mortality in China. The involvement of macrophages in osteoimmunology and their cross-talk with other cells play a crucial role in maintaining bone homeostasis. In GIONFH, M1 polarized macrophages promote chronic inflammation, while M2 macrophages have an anti-inflammatory effect. The TLR4/NF-kappa B signal pathway activation and metabolic transformation of macrophages contribute to the development of GIONFH. Interventions to regulate the polarization of macrophages or inhibit their adoption of the M1 phenotype may be potential strategies for preventing or treating GIONFH.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Review
Surgery
Bin Lv, Zhangrong Cheng, Yajie Yu, Yuhang Chen, Weikang Gan, Shuai Li, Kangcheng Zhao, Cao Yang, Yukun Zhang
Summary: Exosomes play important roles in both physiological and pathological processes, including those related to bone. They affect the biology of target cells, produced and secreted by chondrocytes, osteoblasts, synovial fibroblasts, and bone marrow mesenchymal stem cells. Additionally, in the development of glucocorticoid-induced osteoarthrosis, exosomes are also widely involved. Thus, exosomes may have therapeutic potential for the treatment of osteoarthrosis and play a regulatory role in tumors.
FRONTIERS IN SURGERY
(2022)
Article
Rheumatology
Neslihan Gokcen, Andac Komac, Fatma Tuncer, Gizem Kocak Buyuksutcu, Ozlem Ozdemir Isik, Ayten Yazici, Ayse Cefle
Summary: The study found that in patients with TA, AVN is associated with higher CRP levels and male gender. Patients with type IIb TA are more likely to develop AVN, while those with type V TA are less likely to have AVN. AVN patients are often found to have involvement of the descending aorta and thoracic aorta.
RHEUMATOLOGY INTERNATIONAL
(2022)
Article
Plant Sciences
Fang Cao, Kai-Rong Qin, Kai Kang, Guoshuang Zheng, Weidan Wang, Xiuzhi Zhang, Dewei Zhao
Summary: Ginkgo biloba L. extract (EGb) has been widely used for its diverse pharmacological properties. This study aimed to investigate the effect and mechanism of EGb in preventing steroid-induced necrosis of the femoral head (SINFH).
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Yesel Kim, Jeong-Kui Ku
Summary: This study successfully established a MRONJ rat model on the calvaria, which mimicked the characteristics of MRONJ and can be used for developing treatments for MRONJ.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Shanhong Fang, Zhaoliang Liu, Songye Wu, Xinjie Chen, Mengqiang You, Yongfeng Li, Fuhui Yang, Shuhuan Zhang, Yiqun Lai, Peiyao Liu, Weijiawen Jiang, Peng Chen
Summary: This study reveals the important role of miR-21-5p delivered by hucMSC-Exos in promoting angiogenesis and osteogenesis in ONFH.
CELL DEATH DISCOVERY
(2022)
Article
Engineering, Biomedical
Chi Ma, Graham Andre, David Edwards, Harry K. W. Kim
Summary: The study successfully established a clinically relevant model of osteonecrosis on rats, which can be used for efficient and cost-effective testing of new treatment strategies. The model mimicked the pathological features and progression of osteonecrosis in humans, making it a valuable tool for the development and testing of innovative biological therapeutics.
ACTA BIOMATERIALIA
(2021)
Article
Immunology
Yannan Cheng, Hui Chen, Ping Duan, Hao Zhang, Yongle Yu, Jiadong Yu, Zirui Yu, Lin Zheng, Xin Ye, Zhenyu Pan
Summary: M1 macrophages play a crucial role in the pathogenesis of GA-ONFH by promoting inflammation and cellular apoptosis, exacerbating disease progression. Clearance of M1 macrophages can attenuate the development of GA-ONFH, presenting a promising therapeutic strategy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Marta Zola, Dan Mejlachowicz, Raquel Gregorio, Marie-Christine Naud, Frederic Jaisser, Min Zhao, Francine Behar-Cohen
Summary: This study explores the link between hypothalamic-pituitary-adrenal axis (HPA) brake and central serous chorioretinopathy (CSCR). The results show that HPA axis brake leads to a decrease in intraocular corticosterone levels and activation of the MR pathway in the RPE/choroid, which may contribute to the occurrence of CSCR.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Tengqi Li, Yadi Liu, Qingyu Zhang, Wei Sun, Yiyang Dong
Summary: Bone microvascular endothelial cells (BMECs) play a central role in the development of steroid-induced osteonecrosis of the femoral head and can be cultured on a microfluidic organ-on-a-chip platform. The study showed that BMECs have better viability than HUVECs and that hydroxyapatite (HA) can promote BMECs growth. Glucocorticoids were found to cause damage to BMECs by inducing cleaved caspase 3/7, which was then protected by icariin on the microfluidic organ-on-a-chip platform.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)