Article
Biochemistry & Molecular Biology
Rong-San Jiang, I-Chieh Chen, Yi-Ming Chen, Tzu-Hung Hsiao, Yi-Chen Chen
Summary: This study found that polygenic risk scores developed from European populations can be applied to the Taiwanese population to predict the risk of chronic rhinosinusitis, especially for female patients with nasal polyps.
Review
Biochemistry & Molecular Biology
Junhu Tai, Jae-Min Shin, Jaehyung Park, Munsoo Han, Tae Hoon Kim
Summary: Oxidative stress is caused by an imbalance between reactive oxygen species production and the body's antioxidant defense system. It plays a crucial role in regulating the immune response and can contribute to various diseases. Recent studies have found that oxidative stress is important in the pathogenesis and persistence of chronic rhinosinusitis (CRS), attracting the attention of researchers. The relationship between reactive oxygen species and nasal polyp pathology is a key topic of interest. This article reviews the role of oxidative stress in respiratory diseases, specifically CRS, and introduces potential antioxidant therapies for targeted treatment.
Article
Allergy
Julie A. Poposki, Aiko Klingler, Whitney W. Stevens, Lydia A. Suh, Bruce K. Tan, Anju T. Peters, Hiam Abdala-Valencia, Leslie C. Grammer, Kevin C. Welch, Stephanie S. Smith, David B. Conley, Robert C. Kern, Robert P. Schleimer, Atsushi Kato
Summary: This study found that neutrophils accumulate and are highly activated in CRSwNP in Western populations, playing a significant role in the inflammation. This finding has important implications for the pathogenesis and treatment of CRSwNP in Western countries.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Otorhinolaryngology
Lauren T. Roland, Alan Regenberg, Amber U. Luong, Sarah K. Wise, Elina Toskala, Kent K. Lam, Joshua M. Levy, Christine B. Franzese, Kristine Smith, Jean Kim
Summary: Biologics have been approved for use in chronic rhinosinusitis with nasal polyps patients, showing effectiveness in controlling the disease in both subjective and objective short-term outcomes. However, the high costs of biologics may pose a burden for the healthcare system with widespread and prolonged use. Cost-effectiveness analyses are needed to determine appropriate usage, along with addressing patient preferences, counseling on side effects, and healthcare economics.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Florent Carsuzaa, Emilie Bequignon, Xavier Dufour, Guillaume de Bonnecaze, Jean-Claude Lecron, Laure Favot
Summary: This review summarizes the current state of knowledge regarding the cytokine signature in CRSwNP, as well as the role of cytokines in the pathogenesis of the disease and in intercellular communication between epithelial cells, fibroblasts, and inflammatory cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Jian-Wen Ruan, Jie-Fang Zhao, Xue-Li Li, Bo Liao, Li Pan, Ke-Zhang Zhu, Qi-Miao Feng, Jin-Xin Liu, Zi-E Yu, Jia Song, Hai Wang, Zheng Liu
Summary: In chronic rhinosinusitis with nasal polyps (CRSwNP), tissue neutrophilia is associated with higher levels of inflammatory mediators and lower percentages of apoptotic neutrophils. Neutrophil-high nasal polyps predominantly exhibit type 1 and type 3 endotypes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Allergy
Junqin Bai, Julia H. Huang, Caroline P. E. Price, Jacob M. Schauer, Lydia A. Suh, Regan Harmon, David B. Conley, Kevin C. Welch, Robert C. Kern, Stephanie Shintani-Smith, Anju T. Peters, Whitney W. Stevens, Atsushi Kato, Robert P. Schleimer, Bruce K. Tan
Summary: This study aimed to evaluate the impact of polyp recurrence (PR) on disease severity post-ESS and quantify the prognostic value of various clinical variables and biomarkers. The study found a significant association between PR and radiographic and sinonasal test scores post-ESS. A combined model incorporating clinical and biomarker factors accurately predicted PR.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Allergy
Yan Zhao, Junru Chen, Yun Hao, Boqian Wang, Yue Wang, Qinghua Liu, Jinming Zhao, Ying Li, Ping Wang, Xiangdong Wang, Peng Zhang, Luo Zhang
Summary: The study found that altered nasal microbiota constituents can be used as biomarkers to predict CRSwNP recurrence, providing new insights for the prognosis of nasal polyp patients. The nasal microbiome is an understudied source of clinical variation in CRSwNP and represents a novel therapeutic target for future prevention and treatment.
Article
Biochemistry & Molecular Biology
Maria Sandra Dominguez-Sosa, Maria Soledad Cabrera-Ramirez, Miriam del Carmen Marrero-Ramos, Delia Davila-Quintana, Carlos Cabrera-Lopez, Teresa Carrillo-Diaz, Jesus Javier Benitez del Rosario
Summary: This study aimed to evaluate the efficacy of mepolizumab in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) in real-life settings. A retrospective observational study was conducted on severe CRSwNP patients treated with mepolizumab. The results showed significant improvements in symptoms, polyp scores, blood eosinophils, and corticosteroid use, leading to enhanced health-related quality of life in patients with severe CRSwNP, regardless of the presence of asthma or aspirin exacerbated respiratory disease (AERD).
Article
Allergy
Aiko I. Klingler, Whitney W. Stevens, Bruce K. Tan, Anju T. Peters, Julie A. Poposki, Leslie C. Grammer, Kevin C. Welch, Stephanie S. Smith, David B. Conley, Robert C. Kern, Robert P. Schleimer, Atsushi Kato
Summary: Different inflammatory endotypes in CRSsNP are controlled by distinct molecular mechanisms, and biomarkers in nasal lavage fluids may help distinguish tissue endotypes in CRSsNP, allowing for more precise and personalized medical treatments.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hyunjae Yu, Dong-Kyu Kim
Summary: Machine-learning algorithms were used to investigate the factors associated with the recurrence of CRSwNP following sinus surgery. Neutrophil inflammation was found to be an important factor affecting surgical outcomes, with tissue neutrophilia being the most important variable in determining recurrence. The study suggests that increased neutrophilic inflammation is associated with poor surgical outcomes in patients with difficult-to-treat CRSwNP.
Review
Immunology
Shudi Guo, Ming Tian, Yunping Fan, Xiangyang Zhang
Summary: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a complex and heterogeneous disease diagnosed through endoscopy and computed tomography, and treated with glucocorticoid or surgery. Proteomics and metabolomics have shown potential in elucidating the mechanisms underlying CRSwNP using mass spectrometry as a powerful tool. Recent advances in non-invasive samples, exosomes, and metabolomics research have paved the way for further understanding of CRSwNP.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Allergy
A. Wautlet, C. Bachert, M. Desrosiers, Peter W. Hellings, Anju T. Peters
Summary: Chronic rhinosinusitis with nasal polyps is a prevalent condition that has significant implications for both patients and society. The development of biologic medications has proven to be effective in treating this condition, leading to improvements in patient outcomes and quality of life. This review examines the treatment options and explores the available evidence regarding patient selection, monitoring after treatment initiation, and comparisons with other treatment options such as sinus surgery.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Immunology
Ying Zhu, Xiwen Sun, Shaolin Tan, Chunyu Luo, Jiayao Zhou, Shiyao Zhang, Zhipeng Li, Hai Lin, Weitian Zhang
Summary: This study identified 92 differentially expressed genes associated with M2 macrophages in CRSwNP, primarily enriched in immune responses and extracellular matrix structure. A total of 18 hub genes related to M2 macrophages were identified through PPI network analysis, which may play pivotal roles in the pathogenesis of CRSwNP. AIF1, C1QA, C1QB, C3AR1, CCR1, CD163, CD4, CD53, CD86, CSF1R, CYBB, FCER1G, FCGR3A, IL10RA, ITGB2, LAPTM5, PLEK, TYROBP were confirmed as potential M2 macrophage-related biomarkers for CRSwNP after verification. These findings provide new insights into the hub genes and mechanisms involved in the pathogenesis of CRSwNP.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Allergy
Tanya M. Laidlaw, Joaquim Mullol, Katharine M. Woessner, Nikhil Amin, Leda P. Mannent
Summary: Patients with CRSwNP and asthma often have severe and recurrent disease with tissue eosinophilia and high IgE levels. The shared pathophysiology between upper and lower airways highlights the importance of systemic treatment targeting type 2 inflammatory pathways.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Infectious Diseases
Lang Gong, Jie Li, Qingfeng Zhou, Ying Lin, Jianru Qin, Chunyi Xue, Yongchang Cao
INFECTION GENETICS AND EVOLUTION
(2018)
Article
Infectious Diseases
Z. Wen, J. Li, Y. Zhang, Q. Zhou, L. Gong, C. Xue, Y. Cao
TRANSBOUNDARY AND EMERGING DISEASES
(2018)
Article
Virology
Liangliang He, Jie Li, Yun Zhang, Jun Luo, Yongchang Cao, Chunyi Xue
Article
Multidisciplinary Sciences
Qiong Wang, Guopei He, Mengmeng Hou, Liutao Chen, Shangwu Chen, Anlong Xu, Yonggui Fu
SCIENTIFIC REPORTS
(2018)
Article
Biochemistry & Molecular Biology
Yonggui Fu, Liutao Chen, Chengyong Chen, Yutong Ge, Mingjing Kang, Zili Song, Jingwen Li, Yuchao Feng, Zhanfeng Huo, Guopei He, Mengmeng Hou, Shangwu Chen, Anlong Xu
Article
Biochemical Research Methods
Han Zhang, Yonggui Fu, Lei Wang, Anwen Liang, Shangwu Chen, Anlong Xu
JOURNAL OF PROTEOMICS
(2019)
Article
Virology
Ying Wei, Jie Li, Yun Zhang, Chunyi Xue, Yongchang Cao
Correction
Virology
Liangliang He, Jie Li, Yun Zhang, Jun Luo, Yongchang Cao, Chunyi Xue
Article
Microbiology
Yunping Du, Zhichao Xu, Guolian Yu, Wei Liu, Qingfeng Zhou, Dehong Yang, Jie Li, Li Chen, Yun Zhang, Chunyi Xue, Yongchang Cao
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Microbiology
Jiating Qian, Qiao Meng, Yifan Feng, Xuanxuan Mao, Yayue Ling, Jie Li
CURRENT MICROBIOLOGY
(2020)
Article
Infectious Diseases
Liangliang He, Jie Li, Peng Peng, Jingsong Nie, Jun Luo, Yongchang Gao, Chunyi Xue
INFECTION GENETICS AND EVOLUTION
(2020)
Letter
Virology
Jiating Qian, Yifan Feng, Jie Li
JOURNAL OF MEDICAL VIROLOGY
(2020)
Article
Cell Biology
Zhijie Hu, Mengxia Li, Zhanfeng Huo, Liutao Chen, Susu Liu, Ke Deng, Xin Lu, Shangwu Chen, Yonggui Fu, Anlong Xu
Summary: Alternative splicing and alternative polyadenylation (APA) are crucial for gene regulation in eukaryotic cells. While the U1 snRNP complex can suppress proximal APA sites, the free proteins of this complex actually promote the usage of these sites, indicating a contrasting role.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2022)
Article
Cell Biology
Susu Liu, Runze Wu, Liutao Chen, Ke Deng, Xin Ou, Xin Lu, Mengxia Li, Chao Liu, Shangwu Chen, Yonggui Fu, Anlong Xu
Summary: CPSF6 undergoes liquid-liquid phase separation (LLPS) to regulate alternative polyadenylation in cancer cells. CLK2 kinase disrupts CPSF6 LLPS, affecting the length of 3'UTRs of cell-cycle-related genes and cell proliferation.
Proceedings Paper
Engineering, Biomedical
Jie Li, Jiating Qian, Xuanxuan Mao, Chunyi Xue, Yongchang Cao
PROCEEDINGS OF 2019 IEEE 7TH INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND COMPUTATIONAL BIOLOGY (ICBCB 2019)
(2019)