Review
Cell & Tissue Engineering
Oldouz Shareghi-oskoue, Leili Aghebati-Maleki, Mehdi Yousefi
Summary: Premature ovarian failure (POF) is a problem for women before the age of 40, characterized by symptoms such as amenorrhea and low estrogen levels. The current treatment approach involves stem cell therapy, particularly HUCMSC transplantation, which has shown to effectively improve ovarian function and treat infertility.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Cell Biology
Yufeng Shang, Haotong Guan, Fuling Zhou
Summary: Umbilical cord mesenchymal stem cells (UC-MSCs) have the characteristics of inhibiting tumor cell proliferation and migration, supporting hematopoietic microenvironment, and suppressing the immune system, showing great potential in the treatment of hematologic diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell & Tissue Engineering
Reinhard Dolp, Gertraud Eylert, Christopher Auger, Ayesha Aijaz, Yufei Andy Chen, Saeid Amini-Nik, Alexandra Parousis, Andrea-Kaye Datu, Marc G. Jeschke
Summary: This study compared the cell characteristics of burned skin-derived mesenchymal stromal/stem cells with umbilical cord mesenchymal stromal/stem cells, revealing differences in mesenchymal differentiation capacity and cytokine secretion. However, other aspects like population doubling time, colony formation, cell proliferation, and immune markers showed no significant differences, indicating potential for cell therapy and skin regeneration.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Multidisciplinary Sciences
Romina Marcoccia, Salvatore Nesci, Barbara Merlo, Giulia Ballotta, Cristina Algieri, Alessandra Pagliarani, Eleonora Iacono
Summary: This study compared the characteristics of canine adipose tissue and umbilical cord matrix MSCs, finding no significant differences in cell proliferation, migration, spheroid formation ability, and differentiation potential. ATP production pathways were also evaluated, with mitochondrial respiration being the main pathway for both types of MSCs. Mitochondrial respiration and ATP turnover were higher in UC-MSCs compared to AT-MSCs, but both had 100% coupling efficiency, indicating a potential for differentiation.
Article
Biotechnology & Applied Microbiology
Jingyue Zhang, Shiheng Zhang, Yueming Yang, Ling Liu
Summary: The study found that umbilical cord blood-derived mesenchymal stem cells (UCBMSCs) can effectively treat adriamycin-induced cardiomyopathy by restoring myocardial function and alleviating inflammatory response.
Article
Cell & Tissue Engineering
Wei Zhang, Qing Ling, Bin Wang, Kai Wang, Jianbo Pang, Jing Lu, Yan Bi, Dalong Zhu
Summary: Both UC-MSCs and BM-MSCs showed comparable therapeutic effects in improving T1D, with similar results in lowering blood glucose levels and preserving beta-cell function.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Veterinary Sciences
Eva Punzon, Maria Garcia-Castillo, Miguel A. Rico, Laura Padilla, Almudena Pradera
Summary: This study aimed to evaluate the safety of intra-articular administration of equine umbilical cord mesenchymal stem cells (EUC-MSC) in young healthy dogs under field conditions. The safety profile of allogenic canine adipose derived mesenchymal stem cells (CAD-MSC) and placebo was also compared. The results show that the intra-articular administration of equine umbilical cord mesenchymal stem cells in dogs is safe.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Review
Cell Biology
Yuelong Zhang, Huangming Zhuang, Xunshan Ren, Fuze Jiang, Panghu Zhou
Summary: Osteoarthritis is a common and disabling disease, and surgical treatment is the main approach. Human umbilical cord mesenchymal stem cells (hUC-MSCs) are self-regenerative pluripotent cells that promote cartilage regeneration through the secretion of various trophic factors. The combination of hUC-MSCs with other substances also shows a significant synergistic effect on osteoarthritis treatment. Some scholars have suggested transplanting stem cells into damaged cartilage to slow down the progression of osteoarthritis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Liming Li, Jiafu Mu, Yu Zhang, Chenyang Zhang, Teng Ma, Lu Chen, Tianchen Huang, Jiahe Wu, Jian Cao, Shiqing Feng, Youzhi Cai, Min Han, Jianqing Gao
Summary: This study found that exosomes derived from hypoxic preconditioned human umbilical vein endothelial cells can stimulate angiogenic MSCs, showing great potential in the treatment of traumatic spinal cord injury.
Article
Reproductive Biology
Meriem Baouche, Agnieszka Krawczenko, Maria Paprocka, Aleksandra Klimczak, Pascal Mermillod, Yann Locatelli, Malgorzata Ochota, Wojciech Nizanski
Summary: This study investigates whether cells derived from the feline umbilical cord exhibit mesenchymal stromal/stem cells (MSCs) characteristics. The results show that MSCs derived from Wharton's jelly have the best proliferation ability, pluripotency gene expressions, and differentiation potential, making them the most valuable for feline regenerative medicine.
Article
Cell & Tissue Engineering
Chuan He, Chao Yang, Qiang Zeng, Zhigang Liu, Fangfang Wang, Qiang Chen, Ting Liu
Summary: Umbilical cord-derived MSCs cultured in different media showed the general characteristics of MSCs. HGF, ANG-1, and TGF-beta 1 secretion by MSCs in the MCL was higher than in the other media, while PGE2 secretion was lower in the MCL. MSCs in the MCL inhibited IFN-gamma and TNF-alpha more effectively. MSC treatment promoted recovery of peripheral blood cells, increased Treg ratio and VEGF level, and significantly improved bone marrow.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell Biology
Xiaobo Li, Qijing Huang, Xiangxiang Zhang, Changfeng Xie, Muyun Liu, Yueming Yuan, Jianjia Feng, Haoyu Xing, Li Ru, Zheng Yuan, Zhiyong Xu, YaoXiang Yang, Yan Long, Chengfeng Xing, Jianping Song, Xiang Hu, Qin Xu
Summary: The study evaluated the effects of intravenous injection of hUC-MSCs on reproduction and development in rats, finding no significant adverse effects within a certain dosage range, but high doses may lead to mortality in pregnant female rats, highlighting the importance of cautious use.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Oncology
Jiasheng Wang, Leland Metheny
Summary: Cord blood is an important source for allogeneic hematopoietic cell transplantation and is also being developed for cell therapy products. The unique cellular composition of cord blood, including higher percentages of hematopoietic stem cells and progenitor cells, offers advantages in immune tolerance and off-the-shelf cell therapy development. In addition, cord blood-derived mesenchymal stem cells have potential in regenerative medicine and inflammatory/autoimmune conditions. This review focuses on recent clinical development of cord blood-derived therapies in oncology.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cell & Tissue Engineering
Giacomo Lanzoni, Elina Linetsky, Diego Correa, Shari Messinger Cayetano, Roger A. Alvarez, Dimitrios Kouroupis, Ana Alvarez Gil, Raffaella Poggioli, Phillip Ruiz, Antonio C. Marttos, Khemraj Hirani, Crystal A. Bell, Halina Kusack, Lisa Rafkin, David Baidal, Andrew Pastewski, Kunal Gawri, Clarissa Lenero, Alejandro M. A. Mantero, Sarah W. Metalonis, Xiaojing Wang, Luis Roque, Burlett Masters, Norma S. Kenyon, Enrique Ginzburg, Xiumin Xu, Jianming Tan, Arnold Caplan, Marilyn K. Glassberg, Rodolfo Alejandro, Camillo Ricordi
Summary: The study confirmed safety of UC-MSC infusions in patients with COVID-19 ARDS. By reducing inflammatory cytokines, significant improvement was observed in UC-MSC-treated patients on day 6. The treatment markedly increased patient survival rate, SAE-free survival, and time to recovery.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Santhosh Kacham, Tejal Sunil Bhure, Sindhuja D. Eswaramoorthy, Gaurav Naik, Subha Narayan Rath, Sreenivasa Rao Parcha, Sayan Basu, Virender Singh Sangwan, Sachin Shukla
Summary: Umbilical cord-derived mesenchymal stem cells promote the repair of injured corneal epithelium by stimulating the proliferation of corneal epithelial cells, potentially serving as a non-ocular source of stem cells for treating injury-induced bilateral corneal diseases.