Article
Immunology
Kerstin Muelling, Alexa Josephine Fischer, Elena Siakaeva, Mathis Richter, Sharareh Bordbari, Ilona Spyra, Christian Koester, Dirk M. Hermann, Matthias Gunzer, Ursula Felderhoff-Mueser, Ivo Bendix, Jadwiga Jablonska, Josephine Herz
Summary: This study found that neutrophils in the neonatal brain are rapidly activated after experimental hypoxia-ischemia, producing reactive oxygen species and showing an increased proportion of hyperactivated/aged cells compared to peripheral neutrophils. Delayed neutrophil depletion led to reduced cellular neurodegeneration and decreased microglial and astroglial activation, offering new possibilities for therapeutic approaches in post-hypoxic brain injury.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Oncology
Fengyun Ren, Xing Liu, Xiaoxue Liu, Yanli Cao, Lantao Liu, Xingjiang Li, Yingjun Wu, Shudi Du, Guozhong Tian, Jing Hu
Summary: The study demonstrated that taurine can alleviate ischemic damage by promoting its synthesis and transport, thereby inhibiting apoptosis and calcium ion overload.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Jia Wang, Yuanyuan Wang, Wei Zheng, Xianxian Yuan, Cheng Liu, Ya Zhang, Wei Song, Xiaoxin Wang, Shengnan Liang, Xu Ma, Guanghui Li
Summary: This study aimed to observe the dynamic changes of serum taurine during pregnancy and investigate its relationship with gestational diabetes mellitus (GDM) in early pregnancy. The results showed that low serum taurine concentration in the first trimester was significantly associated with the development of GDM, but the association disappeared as the pregnancy progressed. This may be related to the inhibition of taurine transporter (TauT) activity by high glucose.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Yader Sandoval, Bradley R. Lewis, Ramila A. Mehta, Olatunde Ola, Jonathan D. Knott, Laura De Michieli, Ashok Akula, Ronstan Lobo, Eric H. Yang, S. Michael Gharacholou, Marshall Dworak, Erika Crockford, Nicholas Rastas, Eric Grube, Swetha Karturi, Scott Wohlrab, David O. Hodge, Tahir Tak, Charles Cagin, Rajiv Gulati, Allan S. Jaffe
Summary: Using a single hs-cTnT below the limit of quantitation of 6 ng/L is a safe and rapid method to identify a substantial number of patients at very low risk for acute myocardial injury and infarction.
Article
Multidisciplinary Sciences
Jae Heon Kim, Hee Jo Yang, Sung Sik Choi, Seung U. Kim, Hong J. Lee, Yun Seob Song
Summary: Transplanting hMSCs into the bladder wall can increase micro-vessel formation, decrease collagen deposition and detrusor muscle apoptosis, and improve underactive bladder. Overexpression of HGF in hMSCs further enhances these effects.
Article
Biochemistry & Molecular Biology
Sharif A. Sabe, Cynthia M. Xu, Brittany A. Potz, Akshay Malhotra, Mohamed Sabra, Dwight D. Harris, Mark Broadwin, M. Ruhul Abid, Frank W. Sellke
Summary: Hypoxia-modified extracellular vesicle (EV) therapy enhances contractility, capillary density, and angiogenic signaling pathways in chronic myocardial ischemia compared to normoxia serum-starved EV therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Lina Bai, Junhua Yang, Hong Zhang, Wei Liao, Yunguang Cen
Summary: The study found that the knockdown of APPL1 in myocardial ischemia leads to increased apoptosis and inflammation, while overexpression of APPL1 can inhibit myocardial ischemia/hypoxia-reperfusion injury by inactivating the APAF-1/Caspase9 signaling pathway. The findings suggest that APPL1 may be a promising target for the treatment of myocardial ischemia.
Article
Anatomy & Morphology
Asari Marquez Garcia, Victor Salazar, Lucimey Lima Perez
Summary: The colocalization of taurine and zinc transporters in the retina has been explored in this study. The distribution and localization of TAUT and ZnTs were evaluated using immunohistochemistry. The results indicate the interaction of taurine and zinc in the retina and the importance of maintaining zinc homeostasis for the function of the taurine system.
MICROSCOPY RESEARCH AND TECHNIQUE
(2022)
Review
Biochemistry & Molecular Biology
Dorota Stary, Marek Bajda
Summary: Cancer cells show uncontrolled growth, proliferation, and impaired apoptosis. The altered expression and function of SLC6 family solute carrier proteins are associated with severe diseases, including cancers. This article discusses the potential role of taurine (SLC6A6) and creatine (SLC6A8) transporters in cancer development and the therapeutic potential of their inhibitors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Olesya G. Bernikova, Alena S. Tsvetkova, Alexey O. Ovechkin, Marina M. Demidova, Jan E. Azarov, Pyotr G. Platonov
Summary: This study evaluated the effects of melatonin treatment on ECG parameters in myocardial ischemia and found that melatonin can prevent excessive prolongation of QRS and Tpeak-Tend intervals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Liang Wen, Qing-Hui Yang, Xiao-Lei Ma, Ting Li, Sa Xiao, Chao-Feng Sun
Summary: The study demonstrates that inhibition of TNFAIP1 plays a crucial role in ameliorating myocardial I/R injury by reducing cardiomyocyte apoptosis, oxidative stress, and inflammatory response via activation of the Nrf2 signaling pathway. knockdown of TNFAIP1 potentiates Nrf2 signaling through the modulation of the Akt/GSK-3 beta pathway, highlighting TNFAIP1 as a potential therapeutic target for myocardial I/R injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Obstetrics & Gynecology
Hua Wu, Xinyue Zhang, Jihong Yang, Ting Feng, Yao Chen, Ruizhi Feng, Hui Wang, Yun Qian
Summary: The study revealed that taurine content was lower in spermatozoa from patients with recurrent pregnancy loss without heartbeat, while TAUT expression was lower in patients with teratozoospermia. Functional analysis in mice demonstrated that abnormal spermatozoa increased after interference, and supplementation with 5% beta-alanine worsened the defect but 5% taurine improved it.
HUMAN REPRODUCTION
(2022)
Article
Cell & Tissue Engineering
Martta Hakli, Joose Kreutzer, Antti-Juhana Maki, Hannu Valimaki, Reeja Maria Cherian, Pasi Kallio, Katriina Aalto-Setala, Mari Pekkanen-Mattila
Summary: In this study, human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) were used to model acute ischemia-reperfusion, revealing that hypoxia decreases cell beating frequency and field potential amplitude, while reoxygenation further deteriorates morphological and structural changes. This research indicates the usefulness of hiPSC-CMs as a human-based model for studying acute cardiac ischemia-reperfusion.
STEM CELLS INTERNATIONAL
(2022)
Review
Pharmacology & Pharmacy
Corrado De Marco, Thierry Charron, Guy Rousseau
Summary: Adenosine has the potential benefits in the treatment of acute myocardial infarction by inhibiting the pathophysiological processes leading to reperfusion injury. However, the heterogenous evidence regarding its effects has resulted in limited uptake in clinical practice. Therefore, studying the dose, route, timing, and site of administration of adenosine is crucial for its efficacy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Joachim Neumann, Konrad Boedicker, Igor B. Buchwalow, Constanze Schmidbaur, Gustavo Ramos, Stefan Frantz, Ulrich Hofmann, Ulrich Gergs
Summary: Calsequestrin (CSQ2) is found to have significant impacts on cardiac function and inflammation. Lack of CSQ2 leads to reduced cardiac performance and increased fibrosis in mice. Additionally, the effects of CSQ2 on cardiac function vary with age.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)