Article
Biology
Huanqing Gao, Yiming Zhong, Liang Zhou, Sixiong Lin, Xiaoting Hou, Zhen Ding, Yan Li, Qing Yao, Huiling Cao, Xuenong Zou, Di Chen, Xiaochun Bai, Guozhi Xiao
Summary: Deletion of Kindlin-2 in hepatocytes leads to severe inflammation, liver fibrosis, and dysfunction by aberrantly activating the TNF pathway. Blocking the TNF signaling pathway restores liver function and prevents premature death caused by Kindlin-2 loss. Furthermore, overexpression of Kindlin-2 attenuates liver injury and death in mice.
Article
Food Science & Technology
Gloria Stephanie Villa-Jaimes, Fabio Alejandro Aguilar-Mora, Herson Antonio Gonzalez-Ponce, Francisco Javier Avelar-Gonzalez, Ma Consolacion Martinez Saldana, Manon Buist-Homan, Han Moshage
Summary: The study found that Opuntia spp-extracts can effectively protect against liver toxicity induced by diclofenac, reducing oxidative stress and inhibiting P53 to protect the liver.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Multidisciplinary Sciences
Takayuki Kondo, Kentaro Fujimoto, Kisako Fujiwara, Sae Yumita, Takamasa Ishino, Keita Ogawa, Miyuki Nakagawa, Terunao Iwanaga, Keisuke Koroki, Hiroaki Kanzaki, Masanori Inoue, Kazufumi Kobayashi, Soichiro Kiyono, Masato Nakamura, Naoya Kanogawa, Sadahisa Ogasawara, Shingo Nakamoto, Tetsuhiro Chiba, Jun Kato, Keiichi Fujiwara, Naoya Kato
Summary: The pathogenesis of acute liver failure (ALF) involves cell death, and necroptosis has been suggested as a newly identified programmed cell death. This study evaluated the role of cell death markers and cytokines in ALF. The results indicate that markers such as cCK18, CK18, and RIPK3 are associated with the severity of hepatitis, and RIPK3 may serve as a prognostic marker for acute liver injury.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, Research & Experimental
Guang-Peng Zhou, Shi-Peng Li, Yi-Zhou Jiang, Jie Sun, Yu-Le Tan, Zhi-Gui Zeng, Lin Wei, Wei Qu, Li-Ying Sun, Zhi-Jun Zhu
Summary: This study demonstrates that using explanted livers from patients with inherited metabolic liver diseases as a cell source for hepatocyte transplantation can effectively treat acute liver failure. This therapeutic strategy significantly reduces mortality, improves liver function, decreases inflammatory cytokine levels, reduces hepatocyte apoptosis, and successfully localizes human hepatocytes in injured mouse livers.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Engineering, Biomedical
Jiabin Zhang, Yanteng Xu, Chenya Zhuo, Run Shi, Haixia Wang, Zuquan Hu, Hon Fai Chan, Hae-Won Kim, Yu Tao, Mingqiang Li
Summary: Engineering hepatocytes as multicellular cell spheroids can improve their viability for rescuing acute liver failure. This study developed a magnetic system for generating functional hepatocyte spheroids, which showed superior hepatic functions and therapeutic effects in vivo. The magnetic system holds great potential for future clinical translation.
Article
Biochemistry & Molecular Biology
Vera Belousova, Oxana Svitich, Elena Timokhina, Irina Ignatko, Irina Bogomazova, Svetlana Pesegova, Tatiana Silaeva, Tatiana Kuzmina, Oxana Skorobogatova
Summary: This article presents the hypothesis that premature placenta apoptosis could be a potential cause of preterm birth, supported by evaluating gene expression. The study found that during pregnancy, the expression of apoptosis-related genes in the placenta is low, but the expression of the apoptosis inhibitor XIAP is high. However, at the onset of preterm labor, the expression of apoptosis-related genes increases significantly, potentially initiating preterm birth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Wan-feng Xu, Quan Zhang, Chu-jie Ding, Hui-yong Sun, Yuan Che, Hai Huang, Yun Wang, Jia-wei Wu, Hai-ping Hao, Li-juan Cao
Summary: This study developed a class of GSDME-derived inhibitors that can inhibit caspase-3 activity, preventing pyroptosis and apoptosis events, and alleviating liver injury in a mouse model.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Nanoscience & Nanotechnology
Lingli Qin, Jinxi Lu, Sun Ji
Summary: This study investigated the effect of astragaloside IV on liver Smac, Cyt-C and Caspase-3 expression in acute liver failure in mice. The results showed that astragaloside IV can reduce hepatocyte apoptosis and decrease the expression of hepatic Cyt-C. Additionally, astragaloside IV suppressed the activity of Caspase-3 and decreased hepatic Smac mRNA expression.
Review
Cell & Tissue Engineering
Samin Shokravi, Vitaliy Borisov, Burhan Abdullah Zaman, Firoozeh Niazvand, Raheleh Hazrati, Meysam Mohammadi Khah, Lakshmi Thangavelu, Sima Marzban, Armin Sohrabi, Amir Zamani
Summary: MSCs and their exosomes have shown promising therapeutic effects in the treatment of acute liver failure (ALF), promoting liver regeneration through various mechanisms. There is a wide range of MSCs-based strategies for ALF treatment, including the use of different types of MSCs and their derivatives in combination with other therapeutic molecules or modalities.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Engineering, Biomedical
Camille Le Guilcher, Gregory Merlen, Alessandra Dellaquila, Marie-Noeurolle Labour, Rachida Aid, Thierry Tordjmann, Didier Letourneur, Teresa Simon-Yarza
Summary: Porous pullulan-dextran hydrogel can be used to self-assemble hepatocytes and biliary-like cells into functional 3D microtissues, showing potential value in clinical applications.
MATERIALS TODAY BIO
(2023)
Review
Oncology
Mingxia Jiang, Ling Qi, Lisha Li, Yiming Wu, Dongfeng Song, Yanjing Li
Summary: Caspase-8 is a key player in cancer, involved in multiple programmed cell death modes and closely associated with tumor growth, invasion, therapeutic resistance, etc.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Multidisciplinary Sciences
Jia-xiang Chen, Jian-wen Zhi, Yi-ping Wang, Bo Ning
Summary: Through experimental verification, it was found that lncRNA-PEAK1 was significantly upregulated in the ICH cell models. Inhibiting lncRNA-PEAK1 can reduce the levels of inflammatory factors, promote cell proliferation, weaken cell apoptosis, and downregulate key protein levels involved in the apoptosis pathway. Further analysis revealed that lncRNA-PEAK1 binds to miR-466i-5p, and miR-466i-5p targets caspase 8. The study suggests that the lncRNA-PEAK1/miR-446i-5p/ caspase8 axis is closely related to neuronal cell apoptosis induced by ICH, and lncRNA-PEAK1 may be a potential target for ICH intervention.
Article
Biochemistry & Molecular Biology
Yinpeng Jin, Rongfeng Shi, Tangkai Qi, Qiang Li, Cong Chen, Shane Gao, Fengjuan Gao, Danjing Yang, Guangxi Sun, Jianqing Xu, Qingchun Fu, Jun Xu, Xiaoyan Zhang
Summary: Hepatocyte transplantation is hindered by limited resources, but mesenchymal stem cells (MSCs) can differentiate into hepatocyte-like cells (HLCs) and provide some hepatocyte functions. In this study, human adipose-derived stem cells (hADSCs) were found to have stronger hepatic differentiation ability compared to umbilical cord MSCs (hUCMSCs). The use of hADSCs-HLC or a combination of hADSCs and hADSCs-HLC had a better curative effect in treating acute liver failure, leading to hepatocyte regeneration, liver function recovery, reduced systemic inflammatory reaction, and improved survival rate.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Article
Engineering, Biomedical
Hongyan Wei, Fenfang Li, Tiantian Xue, Haixia Wang, Enguo Ju, Mingqiang Li, Yu Tao
Summary: This study demonstrated that the tetrahedral DNA (TDN) nanoplatform efficiently delivered liver-specific miR122 to human mesenchymal stem cells (hMSCs), inducing their differentiation into functional hepatocyte-like cells (HLCs), suggesting a new approach for cell-based therapy in acute liver failure.
BIOACTIVE MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Jun-Hyuk Han, Jooho Park, Tae-Bong Kang, Kwang-Ho Lee
Summary: Initially classified as an apoptotic caspase, caspase-8 has now been found to play significant roles in regulating inflammatory processes. Recent research has shown its involvement in modulating inflammatory responses, inflammasome activation, cell death, and cytokine induction. This review summarizes the latest advances in understanding how caspase-8 impacts inflammatory reactions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)