Article
Chemistry, Multidisciplinary
Read F. Alserihi, Mohammed Razeeth Shait Mohammed, Mohammed Kaleem, Mohammad Imran Khan, Mario Sechi, Vanna Sanna, Torki A. Zughaibi, Adel M. Abuzenadah, Shams Tabrez
Summary: Polymeric epigallocatechin 3-gallate (EGCG)-loaded nanoparticles (NPs) coupled with folic acid (FA) were developed to target human folate receptor alpha (FOLR1) and prostate-specific membrane antigen (PSMA(+)) in prostate cancer (PCa) model. The targeted NPs showed significant reduction in spheroid size and enhanced anticancer activity against PCa cell lines.
NANOTECHNOLOGY REVIEWS
(2022)
Article
Cell Biology
Gu Li, Bo Pan, Lifei Liu, Xiaohui Xu, Weian Zhao, Qiuhong Mou, Narae Hwang, Su Wol Chung, Xiaoli Liu, Jie Tian
Summary: Decompensated cardiac hypertrophy is often accompanied by mitochondrial dysfunction. This study investigated the role of HDAC1-mediated NRF1 histone deacetylation in cardiac hypertrophy. The administration of the HDAC1 inhibitor EGCG restored cardiac function, reduced heart/body weight and fibrosis, and increased mtDNA/nDNA ratio in hypertrophic hearts. In hypertrophic cardiomyocytes, EGCG attenuated cell hypertrophy and increased LC3B II(+)MitoTracker(+) puncta and mtDNA/nDNA ratio. Intervention with EGCG also upregulated NRF1 and PGC-1 alpha expression and enhanced their interaction. Furthermore, EGCG inhibited HDAC1 expression and increased acH3K9 or acH3K14 binding to the promoters of PGC-1 alpha and NRF1. Overall, this study suggests that EGCG prevents NRF1 reduction through inhibiting HDAC1-mediated histone deacetylation, and acetylation of NRF1 histone may be crucial for maintaining mitochondrial homeostasis in cardiac hypertrophy.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Editorial Material
Endocrinology & Metabolism
Natalie Niemi
Summary: Previous studies suggested that acetylation of mitochondrial proteins occurs non-enzymatically, but a new research challenges this notion by demonstrating the involvement of a histone acetyltransferase in enhancing mitochondrial metabolism through acetylating a complex IV assembly factor.
Article
Chemistry, Applied
Manzar Alam, Sabeeha Ali, Ghulam Md Ashraf, Anwar L. Bilgrami, Dharmendra Kumar Yadav, Md Imtaiyaz Hassan
Summary: Epigallocatechin 3-gallate (EGCG), a polyphenolic component derived from green tea extract, possesses various biological functions, including anti-cancer and anti-inflammatory properties. It modulates multiple signaling pathways to inhibit tumor growth and induce cell death. EGCG also exhibits antioxidant, anti-angiogenic, and apoptotic effects. Therefore, EGCG shows potential in cancer treatment.
Article
Biochemistry & Molecular Biology
An-Ning Zhao, Zhan Yang, Dan-Dan Wang, Bei Shi, Hong Zhang, Yang Bai, Bo-Wen Yan, Yong Zhang, Jin-Kun Wen, Xiao-Lu Wang, Chang-Bao Qu
Summary: This study found that NLRP3 inflammasome-associated genes were upregulated in high-grade prostate cancer (PCa) and identified a circRNA, circAR-3, derived from the AR gene, which is involved in the AR-regulated inflammatory response and cell proliferation by activating the NLRP3 inflammatory pathway. Inhibiting NLRP3 acetylation or blocking inflammasome assembly could suppress the progression of PCa.
Article
Cell Biology
Munerah Hamed, Jihong Chen, Qiao Li
Summary: Dystroglycan, a key component for muscle membrane integrity, is regulated by retinoid X receptor signaling and plays a crucial role in myoblast differentiation. It is a target gene of the muscle master regulator MyoD and its expression is influenced by residue-specific histone acetylation. Our study provides new insights into the regulation and function of dystroglycan in myoblasts and suggests potential therapeutic approaches for muscle pathology.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Dingheng Lu, Yarong Song, Ying Yu, Decai Wang, Bing Liu, Liang Chen, Xuexiang Li, Yunxue Li, Lulin Cheng, Fang Lv, Pu Zhang, Yifei Xing
Summary: Abiraterone, a novel androgen synthesis inhibitor, is approved for treating castration-resistant prostate cancer(CRPC). However, patients often develop resistance to it, and the role of Lysine acetyltransferase 2 A (KAT2A) in this resistance was investigated. Higher KAT2A expression was found in abiraterone-resistant prostate cancer cells and in patients with poor clinical outcomes. Knocking down KAT2A partially resensitized resistant cells to abiraterone, while overexpressing it promoted resistance. These findings suggest KAT2A as a potential target for CRPC treatment.
CELL DEATH & DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Demitria M. Vasilatis, Christopher A. Lucchesi, Paramita M. Ghosh
Summary: Dogs naturally develop prostate cancer similar to aggressive forms found in humans. Prostate cancer samples in dogs often lack androgen receptor (AR), which can enhance our understanding of AR-indifferent prostate cancer in humans. This review highlights the molecular similarities between dog and human prostate cancer variants, suggesting the potential use of dogs as pre-clinical animal models for developing new therapies and diagnostics that can benefit both species.
Editorial Material
Cell Biology
Li Xin
Summary: EZH2 has been shown to promote the development of castration-resistant prostate cancer (CRPC) by interacting with the androgen receptor (AR) to reprogram its transcriptional activity, facilitating the transition of CRPC into a lineage infidelity state.
NATURE CELL BIOLOGY
(2021)
Article
Chemistry, Medicinal
David M. Carter, Edgar Specker, Piotr H. Malecki, Jessica Przygodda, Krystyna Dudaniec, Manfred S. Weiss, Udo Heinemann, Marc Nazare, Ulrich Gohlke
Summary: A benzyl-substituted variant of an inhibitor targeting KDM4 enzymes demonstrates improved potency, cell-permeability, and cytotoxicity against prostate cancer cells. The inhibition mechanism involves competition with Fe2+ at the active site and binding to a distal site on the enzyme surface. The inhibitor's cytostatic effect is attributed to direct intracellular inhibition of KDM4 enzymes, leading to altered gene expression and epigenetic changes in PCa cells.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Immunology
Yucheol Cheong, Minjin Kim, Jina Ahn, Hana Oh, Jongkwan Lim, Wonil Chae, Seung Won Yang, Min Seok Kim, Ji Eun Yu, Sanguine Byun, Yo Han Jang, Baik Lin Seong
Summary: The study investigated the potential use of catechins derived from green tea as adjuvants for subunit and inactivated vaccines, demonstrating their ability to enhance immune responses and provide protection against vaccines, including influenza virus.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biophysics
Yan Chen, Yunlei Zhou, Huanshun Yin
Summary: Histone acetylation, a crucial histone modification, is closely related to various diseases. Detection of HAT activity plays a significant role in disease discovery, prevention, and treatment, with recent research focusing on new methods combining different technologies.
BIOSENSORS & BIOELECTRONICS
(2021)
Review
Oncology
Chunguang Wang, Meiling Bai, Zhiguang Sun, Nan Yao, Aiting Zhang, Shengyu Guo, Zatollah Asemi
Summary: MicroRNAs (miRNAs) are small non-coding RNAs that affect gene expression and are inappropriately expressed in various cancers. Recent research shows that phytochemicals like EGCG can modulate miRNAs and have potential anticancer effects. Targeting specific miRNAs with EGCG can regulate cancer-related processes and improve current cancer treatments.
CANCER CELL INTERNATIONAL
(2023)
Review
Biochemistry & Molecular Biology
Victor Marin, Viviana Burgos, Rebeca Perez, Durvanei Augusto Maria, Paulo Pardi, Cristian Paz
Summary: Breast cancer is a highly prevalent cancer worldwide, with a high mortality rate despite treatment options such as surgery, radiotherapy, chemotherapy, and antibodies. Epigallocatechin-3-gallate (EGCG), found in green tea, has shown promising effects in controlling breast cancer by targeting various cellular processes. It has been proven to have synergistic effects when combined with traditional chemotherapy, increasing treatment efficacy. This review focuses on the impact of EGCG on breast tumor cells, the signaling pathways involved, the potential synergistic effects with current drugs, and the use of nanomaterials to enhance EGCG's bioavailability in breast cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Cristina Minnelli, Laura Cianfruglia, Emiliano Laudadio, Giovanna Mobbili, Roberta Galeazzi, Tatiana Armeni
Summary: The study evaluated the effect of EGCG on inhibiting NSCLC cell lines with EGFR activating mutations, demonstrating that EGCG polyphenol can inhibit cell proliferation and migration with varying efficacy and mechanisms. These findings may be of interest for evaluating the use of EGCG as an adjunct to NSCLC therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Min-Seok Kang, Hyun-Jin Park, Ki-Han You, Dae-Jung Choi, Chang-Won Park, Hoon-Jae Chung
Summary: This study compared the clinical outcomes of biportal endoscopic technique for primary and revision lumbar discectomy. The results showed that there were no significant differences in pain improvement between the two groups, and revision surgery had favorable clinical outcomes with less postoperative pain.
GLOBAL SPINE JOURNAL
(2023)
Article
Orthopedics
Hyun-Jin Park, Ki-Han You, Bingzhe Huang, Joon Hyeok Yoon, Hyong Nyun Kim
Summary: We investigated if 3D printed models can reduce operation time and improve the quality of reduction for calcaneal fractures. The study included 48 patients with unilateral intra-articular calcaneal fractures. The use of 3D printed models significantly reduced operation time and did not affect the radiological parameters or quality of fracture reduction compared to standard techniques.
JOURNAL OF FOOT & ANKLE SURGERY
(2023)
Article
Horticulture
Hyun-Jin Park, Gyu-Bin Lee, Young-Eun Park, Yong-Ik Jin, Jang-Gyu Choi, Jin-Hee Seo, Chung-Gi Cheon, Dong Chil Chang, Ji-Hong Cho, Jin-Ho Kang
Summary: The size of seed tubers affects the dormancy characteristics and yield of potatoes. Larger seed tubers have shorter dormancy periods, higher sprouting rates, better quality, and higher yields. Therefore, medium and large seed tubers are ideal choices for double-cropping in potato cultivation.
HORTICULTURE ENVIRONMENT AND BIOTECHNOLOGY
(2023)
Article
Microbiology
Yeon-Sook Kim, Seng-Ho Jeon, Junghee Kim, Jong Hoon Koh, Seung Won Ra, Ji Won Kim, Yeonjae Kim, Choon Kwan Kim, Yun Chul Shin, Beo Deul Kang, Seung ji Kang, Chul Hee Park, Boyoung Lee, Ji Yeon Lee, Chung Hoon Lee, Jae-phil Choi, Jin Yong Kim, Shi Nae Yu, Kyong Ran Peck, Sung-Han Kim, Jung Yeon Heo, Hyun ah Kim, Hyun-jin Park, JoungWon Choi, Jumi Han, JooHyun Kim, Hyoung jun Kim, Se Hee Han, Aeri Yoon, MiHee Park, SuJung Park, YuKyung Kim, Minji Jung, Myoung-don Oh
Summary: This study evaluated the efficacy of oral drug Camostat mesylate in treating mild to moderate COVID-19 patients. The results showed that patients in the Camostat group had a shorter time to symptom improvement compared to the placebo group, and it may be more effective in high-risk patients. Further clinical studies are needed to assess the efficacy of Camostat mesylate in high-risk patients.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Polymer Science
Li Jun Ren, Hui Yun Zhou, Pei Yan Hao, Hui Jie Zheng, Jia Nan Tong, Ya Wei Chen, Hyun Jin Park
Summary: In this study, l-lysine (Lys), l-glutamate (Glu), and l-glutamine (Gln) grafted-chitosan (CS) polymers (AA-g-CS) were prepared using EDC/NHS as coupling agents. AA-g-CS/GP hydrogel showed improved thermosensitivity and had a dense three-dimensional network structure. The hydrogel loaded with berberine hydrochloride (BBH) demonstrated sustained release, with BBH@Lys-g-CS/GP hydrogel showing the best sustained release effect.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Haishan Wu, Jian Nan, Liu Yang, Hyun Jin Park, Jinglei Li
Summary: Compared to subcutaneous injections, oral administration of insulin is preferred for diabetic patients. However, challenges such as early drug release and poor absorption hinder the effectiveness of liposomes and alginate hydrogels for oral delivery. This study presents a liposome-in-alginate hydrogel loaded with arginine-insulin complexes, demonstrating improved intestinal permeation and retention, controlled release, and hypoglycemic effects. Therefore, this strategy holds promise for oral insulin delivery.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Food Science & Technology
Yaxin Wen, Chhychhy Chao, Quang Tuan Che, Hyun Woo Kim, Hyun Jin Park
Summary: Plant-based meat analog production is a strategy to replace animal meat consumption, but faces challenges in terms of texture, nutrition, and sensory properties. 3D food printing can be used to produce customized food with different characteristics. Therefore, 3D-printed plant-based meat analogs have technical and commercial potential, but require further research.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2023)
Article
Orthopedics
Hyun-Jin Park, Jun-Young Choi, Woo Myung Lee, Sang-Min Park
Summary: This study examined the prevalence and associated factors of chronic low back pain in the South Korean population. The results showed that chronic low back pain was most common in the elderly and women. Age, gender, physical activity level, depressive symptoms, and comorbidities were found to be associated with chronic low back pain.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Food Science & Technology
Byungchan Cho, Korakot Charoensri, Hansol Doh, Hyun Jin Park
Summary: The colorimetric sensor array (CSA) system is used in food science to assess food quality by identifying undesirable volatile organic compounds. In this study, the quality of edible-coated food products was evaluated using both conventional and CSA methods, demonstrating that the CSA approach is a feasible alternative to conventional methods.
Article
Orthopedics
Woo-Myung Lee, Ki-Han You, Min-Seok Kang, Jun-Hyun Kim, Hyun-Jin Park
Summary: Oblique lumbar interbody fusion is a minimally invasive technique that can correct spinal alignment and achieve indirect neural decompression. However, it may be limited in patients with central canal lesions who require direct decompression. By combining it with biportal endoscopic spinal surgery, both alignment correction and direct decompression can be achieved.
ASIAN SPINE JOURNAL
(2023)
Article
Engineering, Marine
Taiji Tanaka, Yoshihiko Oishi, Hyun Jin Park, Yuji Tasaka, Yuichi Murai, Chiharu Kawakita
Summary: Frictional drag reduction using repetitive bubble injection in a turbulent boundary layer beneath a towing model ship was studied. The drag reduction ratio reached 24%, which was a 5% improvement compared to continuous bubble injection. The transition of bubble dispersion status was found to cause the streamwise decay of local drag reduction. Repetitive bubble injection improved the downstream persistence of the drag-reduction effect by a factor of 15. The estimation of full-scale performance indicated that repetitive bubble injection provided approximately 7 times the drag reduction of continuous bubble injection for long ship hulls exceeding 130m.
Article
Orthopedics
Min-Seok Kang, Hyun-Jin Park, Sang-Min Park, Ki-Han You, Won-Jik Ju
Summary: The study aimed to determine the learning curve for biportal full-endoscopic posterior cervical foraminotomy (BE-PCF). The learning curve was evaluated using a learning curve cumulative summation test (LC-CUSUM). The study found that the surgeon became competent after performing 20 operations, and there were no significant differences in operation time and clinical outcomes.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yuhui Jeong, Sun-Ho Lee, Jangho Lee, Min-Sun Kim, Yu-Geon Lee, Jin-Taek Hwang, Sang-Yoon Choi, Ho-Geun Yoon, Tae-Gyu Lim, Seung-Hyun Lee, Hyo-Kyoung Choi
Summary: This study investigated the effects of hot-water extract of Capsella bursa-pastoris (CBW) on doxorubicin-induced cardiotoxicity (DICT). The results showed that CBW can inhibit doxorubicin-induced cardiomyocyte death, increase SOD levels, reduce ROS production, and improve oxygen consumption rate. In mouse experiments, the combination of CBW and doxorubicin effectively restored various cardiac parameters and alleviated collagen accumulation and cell death in heart tissues. Furthermore, CBW improved the pathological electrophysiological features in human-induced pluripotent stem-cell-derived cardiomyocytes induced by doxorubicin. The study suggests that CBW has the potential to be a traditional therapeutic option for mitigating doxorubicin-induced cardiotoxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Orthopedics
Woo-Myung Lee, Ki-Han You, Min-Seok Kang, Jun-Hyun Kim, Hyun-Jin Park
Summary: Oblique lumbar interbody fusion (OLIF) is a minimally invasive procedure for degenerative lumbar disease, providing advantages of spinal alignment correction and indirect neural decompression. However, direct decompression is needed for some patients with central canal lesions, which can be achieved through biportal endoscopic spinal surgery. The combination of OLIF and biportal endoscopic spinal surgery allows for both alignment correction and direct decompression in multilevel lumbar lesions.
ASIAN SPINE JOURNAL
(2023)
Article
Clinical Neurology
Byung-Taek Kwon, Ho-Joong Kim, Sanghoon Lee, Sang-Min Park, Dae-Woong Ham, Hyun-Jin Park, Ohsang Kwon, Jin S. Yeom
Summary: This study compared the radiographic and clinical efficacy and safety between the BGS-7 spacer and PEEK cage in PLIF surgery. The results showed similar fusion rates and clinicoradiographic outcomes between the two groups, but the non-inferiority of the BGS-7 spacer was inconclusive. Safety concerns regarding fracture and migration of the BGS-7 spacer must be considered.
ACTA NEUROCHIRURGICA
(2023)
