Dense genotyping of immune-related loci in idiopathic inflammatory myopathies confirms HLA alleles as the strongest genetic risk factor and suggests different genetic background for major clinical subgroups

UBE2L3 Polymorphism Amplifies NF-κB Activation and Promotes Plasma Cell Development, Linking Linear Ubiquitination to Multiple Autoimmune Diseases

(2015) Myles J. Lewis et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers

(2015) Suna Onengut-Gumuscu et al.   NATURE GENETICS

Immunochip Analysis Identifies Multiple Susceptibility Loci for Systemic Sclerosis

(2014) Maureen D. Mayes et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genotyping of immune-related genetic variants identifiesTYK2as a novel associated locus for idiopathic inflammatory myopathies

(2014) M Jani et al.   ANNALS OF THE RHEUMATIC DISEASES

GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region

(2014) D L Armstrong et al.   GENES AND IMMUNITY

Association between a C8orf13–BLK Polymorphism and Polymyositis/Dermatomyositis in the Japanese Population: An Additive Effect with STAT4 on Disease Susceptibility

(2014) Tomoko Sugiura et al.   PLoS One

Genome-Wide Association Study of Dermatomyositis Reveals Genetic Overlap With Other Autoimmune Disorders

(2013) Frederick W. Miller et al.   ARTHRITIS AND RHEUMATISM

Genetics of rheumatoid arthritis contributes to biology and drug discovery

(2013) Yukinori Okada et al.   NATURE

Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome

(2013) Christopher J Lessard et al.   NATURE GENETICS

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

(2013) Ashley H Beecham et al.   NATURE GENETICS

Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis

(2013) Jimmy Z Liu et al.   NATURE GENETICS

Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis

(2013) Anne Hinks et al.   NATURE GENETICS

188th ENMC International Workshop: Inclusion Body Myositis, 2–4 December 2011, Naarden, The Netherlands

(2013) M.R. Rose   NEUROMUSCULAR DISORDERS

Imputing Amino Acid Polymorphisms in Human Leukocyte Antigens

(2013) Xiaoming Jia et al.   PLoS One

ImmunoChip Study Implicates Antigen Presentation to T Cells in Narcolepsy

(2013) Juliette Faraco et al.   PLoS Genetics

Positive association betweenSTAT4polymorphisms and polymyositis/dermatomyositis in a Japanese population

(2012) Tomoko Sugiura et al.   ANNALS OF THE RHEUMATIC DISEASES

Annotation of functional variation in personal genomes using RegulomeDB

(2012) A. P. Boyle et al.   GENOME RESEARCH

Seven newly identified loci for autoimmune thyroid disease

(2012) Jason D. Cooper et al.   HUMAN MOLECULAR GENETICS

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis

(2012) Jimmy Z Liu et al.   NATURE GENETICS

High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis

(2012) Steve Eyre et al.   NATURE GENETICS

Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo

(2012) Ying Jin et al.   NATURE GENETICS

Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

(2012) Lam C Tsoi et al.   NATURE GENETICS

Evaluating the effective numbers of independent tests and significant p-value thresholds in commercial genotyping arrays and public imputation reference datasets

(2011) Miao-Xin Li et al.   HUMAN GENETICS

Deciphering the Clinical Presentations, Pathogenesis, and Treatment of the Idiopathic Inflammatory Myopathies

(2011) Lisa G. Rider   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The autoimmune disease–associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness

(2011) Jinyi Zhang et al.   NATURE GENETICS

Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease

(2011) Gosia Trynka et al.   NATURE GENETICS

Genevar: a database and Java application for the analysis and visualization of SNP-gene associations in eQTL studies

(2010) T.-P. Yang et al.   BIOINFORMATICS

Interstitial Lung Disease Associated With the Idiopathic Inflammatory Myopathies

(2010) Geoffrey R. Connors et al.   CHEST

Transcriptome genetics using second generation sequencing in a Caucasian population

(2010) Stephen B. Montgomery et al.   NATURE

A method and server for predicting damaging missense mutations

(2010) Ivan A Adzhubei et al.   NATURE METHODS

Inclusion body myositis

(2010) D. Hilton-Jones et al.   NEUROMUSCULAR DISORDERS

Genetics and Beyond – The Transcriptome of Human Monocytes and Disease Susceptibility

(2010) Tanja Zeller et al.   PLoS One

Shared molecular amino acid signature in the HLA-DR peptide binding pocket predisposes to both autoimmune diabetes and thyroiditis

(2010) F. Menconi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

(2009) Vesela Gateva et al.   NATURE GENETICS

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

(2009) Jeffrey C Barrett et al.   NATURE GENETICS

Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm

(2009) Prateek Kumar et al.   Nature Protocols

Common Regulatory Variation Impacts Gene Expression in a Cell Type-Dependent Manner

(2009) A. S. Dimas et al.   SCIENCE

The protein tyrosine phosphatase N22 gene is associated with juvenile and adult idiopathic inflammatory myopathy independent of the HLA 8.1 haplotype in British Caucasian patients

(2008) H. Chinoy et al.   ARTHRITIS AND RHEUMATISM

High-Resolution Mapping of Expression-QTLs Yields Insight into Human Gene Regulation

(2008) Jean-Baptiste Veyrieras et al.   PLoS Genetics