Review
Agronomy
Sarana Rose Sommano, Ratchuporn Suksathan, Thanarat Sombat, Pimjai Seehanam, Sasithorn Sirilun, Warintorn Ruksiriwanich, Sutee Wangtueai, Noppol Leksawasdi
Summary: Medicinal mushrooms, including those containing psilocybin, have diverse chemical constituents and therapeutic potential. They are used for treating addiction, depression, anxiety, and other mental health concerns. However, there is a lack of comprehensive documentation on the agronomic aspects and biotechnology approaches for producing active ingredients from these mushrooms.
Article
Food Science & Technology
Michele O'Sullivan, Elaine Dempsey, Sarah Case, Emer E. Hackett, Anna E. Ledwith, Hannah Prendeville, Tara O'Brien, Faye Lewis, Dearbhla M. Murphy, Supriya Yadav, Jude Wilson, Sinead C. Corr, Frederick J. Sheedy
Summary: Mushrooms have been valued as an edible and medical resource for thousands of years. Research on powdered A. bisporus mushrooms shows that they can attenuate immune signaling triggered by microbial ligands and inhibit the development of colitis in vivo. This study highlights the importance of mushrooms in developing complementary approaches to modulate chronic inflammation and disease.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Multidisciplinary Sciences
Ayaz Shahid, Matthew Huang, Mandy Liu, Md Abdullah Shamim, Cyrus Parsa, Robert Orlando, Ying Huang
Summary: This study suggests that Ganoderma lucidum, a medicinal mushroom, prevents skin cancer by attenuating UV-induced immunosuppression. In both in vitro and in vivo models, a commercial product containing spore and fruiting body extracts showed potential in inhibiting cancer cell transformation and reducing skin tumor incidence.
Review
Biochemistry & Molecular Biology
Sechul Chun, Judy Gopal, Manikandan Muthu
Summary: This article discusses the medicinal properties and bioactivity of mushrooms, focusing on the antioxidant and antiviral properties of mushroom polysaccharides. It also points out the relatively limited research on mushroom polysaccharides compared to overall mushroom studies.
Review
Food Science & Technology
Janos Vetter
Summary: Carbohydrates, especially glucans, play an important role in the fungal cell wall and have positive biological effects on animals and humans. Different mushrooms contain different types of glucans, with molecular weights ranging from 10^4 to 10^5 Da. The biological effects of glucans are related to the integrity of their tertiary structure.
Article
Food Science & Technology
Guohua Zhang, Xianghui Yan, Jiaheng Xia, Zhihong Zhang, Dongsheng Wang, Ping Sheng, Ping Yu, Zheling Zeng
Summary: This study aimed to investigate the anti-inflammatory activity of ethanol extracts (EE) of C. camphora seed and the changes after digestion and hydrolysis. The results showed that EE, digested ethanol extracts (dEE), and hydrolysed ethanol extracts (hEE) exhibited cell protection function and significantly reduced pro-inflammatory mediators and cytokines secretion and expression. Although the anti-inflammatory activity of EE was decreased, most of it was retained after digestion and hydrolysis. The findings suggest that the anti-inflammatory activity of EE is relatively stable and may facilitate the processing and consumption of related products.
Article
Biochemistry & Molecular Biology
Teresa Quynh Tram Nguyen, Frederik Wendelboe Lund, Ali Asghar Hakami Zanjani, Himanshu Khandelia
Summary: The active hallucinogen psilocin is being repurposed to treat nicotine addiction and treatment-resistant depression. Recent evidence suggests that psilocin may exert its effects through a membrane-mediated receptor-binding mechanism. Both psilocin and serotonin have similar impacts on lipid membranes, but psilocin's effect is limited by its chemical structure.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2022)
Article
Environmental Sciences
Dalia H. El-Kashef, Maha H. Sharawy
Summary: Nicorandil protects against acetaminophen-induced liver damage by reducing liver function indicators, inhibiting oxidative stress and inflammation, and improving cell survival.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Ojwang D. Otieno, Mulaa F. Jakim, Obiero George, Midiwo Jacob
Summary: The current study focused on optimizing key process parameters for mushroom hydrolysis using crude enzymatic extract. The enzyme was prepared by solid-state fermentation of pineapple peels with Aspergillus niger. The study found that optimal conditions for glucose yield were pH 6.5, temperature 50 degrees C, enzyme loading 5% (v/v), and reaction time 12 h. Mushroom hydrolysis under these conditions increased glucose yield by 10%. Adding Tween-80 and yeast extract to the fermentation medium significantly improved hydrolytic efficiency of the crude enzyme extract by 2.2-fold.
Review
Oncology
Santhosshi Narayanan, Aline Rozman de Mores, Lorenzo Cohen, Mohammed Moustapha Anwar, Felippe Lazar, Rachel Hicklen, Gabriel Lopez, Peiying Yang, Eduardo Bruera
Summary: The systematic review focused on clinical studies of mushroom supplements in cancer care conducted in the past 10 years. The studies showed that mushroom preparations can have positive effects in reducing chemotherapy toxicity, improving quality of life, promoting immune response, and possibly improving clinical outcomes. However, the current evidence is inconclusive to recommend the routine use of mushrooms for cancer patients, and more trials are needed to explore their use during and after cancer treatment.
CURRENT ONCOLOGY REPORTS
(2023)
Article
Endocrinology & Metabolism
Chenyuan Luo, Yuming Wei, Shuzhen Li, Chunjun Li, Honglai Zheng
Summary: This study found that various solvent extracts from the rhizome of Imperata cylindrica possess antioxidant capacity and anti-inflammatory activity, which may be provoked by suppressing the NF-kappa B and activating the Nrf2. Therefore, the rhizome of Imperata cylindrica has the potential to develop new therapeutic agents for treating inflammatory diseases.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Gastroenterology & Hepatology
Tobias Riedl, Suzanne Faure-Dupuy, Maude Rolland, Svenja Schuehle, Zohier Hizir, Silvia Calderazzo, Xiaodong Zhuang, Jochen Wettengel, Martin Alexander Lopez, Romain Barnault, Valbona Mirakaj, Sandra Prokosch, Danijela Heide, Corinna Leuchtenberger, Martin Schneider, Bernd Hessling, Benjamin Stottmeier, Isabel M. Wessbecher, Peter Schirmacher, Jane A. McKeating, Ulrike Protzer, David Durantel, Julie Lucifora, Emmanuel Dejardin, Mathias Heikenwalder
Summary: The stabilization of HIF1 alpha was found to inhibit the expression of APOBEC3B and its antiviral effects against HBV. Inhibiting the expression or stabilization of HIF1 alpha could serve as an anti-HBV strategy. High levels of HIF1 alpha may provide a reservoir for HBV survival in immune-active patients, and therefore should be considered as a constraining factor in the development of immune therapies.
Article
Pharmacology & Pharmacy
Shang Xian Bo, Wang Yan Jie, Cai De Chao, Ma Sai, Wang Zhe, Zhu Ya Kun, Guo Hui Hui, Wang Chen, Ma Xiao, Hu Zhong Yao, Yu Hao Ran, Zhang Ji Sen, Cheng Wen Dan
Summary: The study demonstrated that compound 22o effectively inhibited the inflammatory response and catabolism of chondrocytes, reducing articular cartilage injury in a rat OA model induced by ACLT. The compound showed potential as a disease-modifying OA drug.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Joao Victor Silva-Silva, Carla J. Moragas-Tellis, Maria S. S. Chagas, Paulo Victor R. Souza, Davyson L. Moreira, Celeste S. F. de Souza, Kerolain F. Teixeira, Arthur R. Cenci, Aldo S. de Oliveira, Fernando Almeida-Souza, Maria D. Behrens, Katia S. Calabrese
Summary: This study evaluated the leishmanicidal activity of a crude extract and anthocyanidin-rich fractions from Arrabidaea chica, as well as three isolated anthocyanidins. The results showed promising anti-leishmanial effects of these compounds, indicating their potential as therapeutic agents for leishmaniasis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Chemistry, Medicinal
Rina Das, Dinesh Kumar Mehta, Meenakshi Dhanawat
Summary: Nuclear factor-kappa B (NF-kappa B) is a transcription factor that controls gene expression and plays a crucial role in regulating cell signaling. The constitutive activity of NF-kappa B signaling has been reported in various cancer cells, making it a desirable target for cancer treatment. Plant-derived compounds, such as flavonoids and polyphenols, have been evaluated as potential inhibitors of NF-kappa B signaling and have shown promising anticancer effects.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2022)