Review
Pharmacology & Pharmacy
Hongrui Wang, Yingying Su, Duoduo Chen, Qi Li, Shuyou Shi, Xin Huang, Mingli Fang, Ming Yang
Summary: Inhibitory oligodeoxynucleotides (ODNs) are short DNA strands capable of binding to various targets. They have potential therapeutic applications in immune-mediated inflammatory diseases (IMIDs) due to their immunomodulatory activity. Inhibitory ODNs can target RNAs or proteins, reducing or increasing protein expression and regulating the immune activation state. They have also been used to treat inflammatory disorders and autoimmune diseases, with several drugs already approved on the market. This review discusses the chemical modifications, action mechanisms, and applications of inhibitory ODNs in the precise treatment of IMIDs.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cell Biology
Li-Bo Dai, Jiang-Tao Zhong, Li-Fang Shen, Shui-Hong Zhou, Zhong-Jie Lu, Yang-Yang Bao, Jun Fan
Summary: This study demonstrated that curcumin and GLUT1 siRNA, either alone or in combination, sensitized laryngeal carcinoma cells to radiation by inducing autophagy. Inhibition of autophagy promoted apoptosis after radiation or treatment with curcumin and GLUT1 siRNA. The combined treatment of curcumin, GLUT1 siRNA and an autophagy inhibitor 3-MA provided the strongest sensitization in vivo, indicating a potential therapeutic strategy for laryngeal carcinoma.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Manuela Carvalheiro, Margarida Ferreira-Silva, Denys Holovanchuk, H. Susana Marinho, Joao Nuno Moreira, Helena Soares, M. Luisa Corvo, Maria Eugenia M. Cruz
Summary: This study evaluated the ability of antagonist G to improve the targeting and internalization of liposomal formulations to small cell lung carcinoma (SCLC) cell lines. The results showed that covalent attachment of antagonist G increased cellular association and internalization of liposomes via receptor-mediated and clathrin-dependent endocytosis. Biodistribution studies in mice demonstrated preferential lung accumulation of antagonist G-targeted liposomes, indicating their potential as delivery vectors for SCLC treatment.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Oncology
Xiao-Hong Chen, Ding-Li Yu, Jiang-Tao Zhong, Shui-Hong Zhou, Jun Fan, Zhong-Jie Lu
Summary: Inhibition of HK-II by siRNA enhances radiosensitivity of laryngeal carcinoma Tu212 cells by inhibiting glycolysis and partially inhibiting oxidative phosphorylation.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Chemistry, Medicinal
Yan Liu, Jiaqing Huang, Min Wu, Bi Liu, Qiaofa Lin, Jingjing Wu, Yuhua Ouyang, Xin Guo, Ruyi Huang, Yongmin Zhang, Jianhua Xu
Summary: Six positional isomers of triptolide-glucose conjugates (TG1 alpha, TG1 beta, TG2, TG3, TG4 and TG6) were synthesized and showed improved water solubility. Among them, TG2, formed by triptolide and D-glucose, exhibited the strongest cytotoxicity to tumor cells and the lowest toxicity to non-tumor cells, resulting in the highest relative therapeutic index and the most powerful selective antitumor activity in vitro.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Maha M. Shouman, Rania M. Abdelsalam, Mahmoud M. Tawfick, Sanaa A. Kenawy, Mona M. El-Naa
Summary: The study found that blocking TF expression with TFAS injection improved inflammatory and fibrotic changes associated with CCl4+DEN intoxication. TFAS also decreased expression of molecules related to liver fibrosis like α-SMA, TGF-1β, TNF-α, offering a new direction for treating liver fibrosis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Mariana Morais, Francisca Dias, Ines Nogueira, Anabela Leao, Nuno Goncalves, Luis Araujo, Sara Granja, Fatima Baltazar, Ana L. Teixeira, Rui Medeiros
Summary: Renal cell carcinoma (RCC) is a metabolic associated cancer, and this study investigated the potential role of hsa-miR-144-5p and hsa-miR-186-3p in ccRCC glycolysis status and as biomarkers. Circulating hsa-miR-144-5p and hsa-miR-186-3p could be potential biomarkers of ccRCC prognosis.
Article
Otorhinolaryngology
Karlijn van den Bovenkamp, Bert van der Vegt, Gyorgy B. Halmos, Lorian Slagter-Menkema, Johannes A. Langendijk, Boukje A. C. van Dijk, Ed Schuuring, Bernard F. A. M. van der Laan
Summary: This study examined the predictive value of various tumor markers in patients with advanced-stage laryngeal squamous cell carcinoma, and found that overexpression of HIF-1α was associated with locoregional recurrence.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Endocrinology & Metabolism
Hui Chen, Xiongze Zhang, Nanying Liao, Yuying Ji, Lan Mi, Yuhong Gan, Yongyue Su, Feng Wen
Summary: This study investigated the expression of GLP-1R, SGLT1, SGLT2, GLUT1, and GLUT2 in DR patients and found that GLP-1R and SGLT2 were significantly decreased in PDR patients. Their decrease was associated with an increased level of expression of TNF-alpha and IFN-gamma, suggesting a potential correlation between defective GLP-1R and SGLT2 signaling and immune response cytokines in PDR patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biophysics
Kaijing Wang, Congcong Zhang, Han Zhou, Hongshuai Wei, Liping Yin, Tingting Zhang, Yunqing Zhi, Jun Zhou, Bingkai Han, Zhenguo Zhang, Xin Du
Summary: In this study, an electrochemical platform for detecting GLUT-1 on living cells was developed using a composite of reduced graphene oxide-multi-wall carbon nanotube. The sensor demonstrated good performance in detecting GLUT-1 expression on cells and showed consistency with traditional detection methods. It has the potential to assess malignancy level and glucose uptake pathways in tumor cells while reducing medical costs.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Endocrinology & Metabolism
Maria Anna Bantounou, Panagiotis Sardellis, Rosa Thuemmler, Daniel Black Boada, Justyna Kaczmarek, Ribeya Mahmood, Josip Plascevic, Sam Philip
Summary: This study investigated the renal safety profile of sotagliflozin, a new inhibitor of sodium-glucose co-transporter-1 and -2, in patients with type 1 and type 2 diabetes. The results showed that sotagliflozin did not adversely affect renal function and did not change the risk of key renal outcomes, even in patients with pre-existing renal impairment.
DIABETES OBESITY & METABOLISM
(2023)
Article
Otorhinolaryngology
Izabela Bronikowska, Elzbieta Swietochowska, Robert Morawski, Pawel Sowa, Eugeniusz Czecior
Summary: This study evaluated the concentration of HIF-1, GLUT1, and VEGF in tissue samples and blood serum, and their correlation with tumor size, nodal disease, pathologic differentiation, and patient data in laryngeal carcinoma patients. The results showed significantly higher levels of HIF-1 alpha, GLUT1, and VEGF in cancer tissue samples compared to normal tissue and benign lesions, and significantly lower levels in the control group. Furthermore, there was a significant difference in HIF-1 alpha concentration in cancer samples and serum between T2 and T4 stages. The findings indicate that high levels of HIF-1 alpha, GLUT1, and VEGF may suggest a carcinogenic process and could aid in the early detection of malignancy in laryngeal lesions.
ACTA OTO-LARYNGOLOGICA
(2022)
Article
Microbiology
Kenshi Hirai, Takuya Idemoto, Shiho Kato, Akihiko Ichiishi, Fumiyasu Fukumori, Makoto Fujimura
Summary: L-Sorbose induces hyperbranching of hyphae and colonial growth in Neurospora crassa. The sor-4 gene, a glucose sensor involved in carbon catabolite repression (CCR), has been identified as a sorbose resistance gene. In this study, we found that the col-26 gene, an AmyR-like transcription factor involved in CCR, also displayed sorbose resistance. Deletion mutants of other CCR genes (hxk-2, prk-10, cre-1) showed no sorbose resistance. Double mutant analysis showed that the deletion of hxk-2, prk-10, and cre-1 did not affect the sorbose resistance of the col-26 mutant.
Article
Multidisciplinary Sciences
Naoto Mukada, Masahiko Tosaka, Nozomi Matsumura, Rei Yamaguchi, Masanori Aihara, Koji Isoda, Tetsuya Higuchi, Yoshito Tsushima, Hideaki Yokoo, Yuhei Yoshimoto
Summary: Papillary craniopharyngiomas are characterized by the BRAF V600E mutation, with enhanced glucose metabolism possibly related to this mutation. GLUT-1 and HK-II expressions were significantly higher in papillary type samples compared to adamantinomatous type samples, indicating a more prominent glucose metabolism in the former.
SCIENTIFIC REPORTS
(2021)
Article
Agriculture, Multidisciplinary
Hui-jun Jiao, Hong-wei Wang, Kun Ran, Xiao-chang Dong, Ran Dong, Shu-wei Wei, Shao-min Wang
Summary: In this study, the PbrAGPs expressed in pear pollen were identified and their influences on pollen tube growth were explored. Among the 187 PbrAGPs, 38 were specifically expressed in pollen. Their expression patterns were validated and functional genes related to pollen tube growth were identified. Recombinant proteins of 19 PbrAGPs were tested and 11 of them promoted pear pollen tube growth. The expression levels of PbrAGP1 and PbrAGP5 were found to inhibit pollen tube growth. PbrAGP1 and PbrAGP5 were localized in the plasma membrane and did not alter the distribution of pectin in the pollen tube. Overall, this study provides insights into the functions of PbrAGPs in pollen tube growth.
JOURNAL OF INTEGRATIVE AGRICULTURE
(2023)
