Journal
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
Volume 10, Issue 6, Pages 691-698Publisher
IVYSPRING INT PUBL
DOI: 10.7150/ijms.6170
Keywords
Wnt10b; Wnt/beta-catenin signaling; Hair follicle; Melanocyte; Differentiation
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Funding
- National Natural Science Foundation of China [81071309]
- Natural Science Foundation of Chongqing [cstc2012jjA0335]
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Previous research has revealed that Wnt10b activates canonical Wnt signaling, which is integral to melanocyte differentiation in hair follicles (HFs). However, the function of Wnt10b in HF melanocytes remains poorly understood. We determined using Dct-LacZ transgenic mice that Wnt10b is mainly expressed near and within melanocytes of the hair bulbs during the anagen stage of the hair cycle. We also found that Wnt10b promotes an increase in melanocyte maturation and pigmentation in the hair bulbs of the mouse HF. To further explore the potential functions of Wnt10b in mouse HF melanocytes, we infected iMC23 cells with Ad-Wnt10b to overexpress Wnt10b. We demonstrated that Wnt10b promotes the differentiation of melanocytes by activating canonical Wnt signaling in melanocytes.
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