Journal
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
Volume 10, Issue 2, Pages 171-175Publisher
IVYSPRING INT PUBL
DOI: 10.7150/ijms.5312
Keywords
Biodegradable Conduit; Epineurial Neurorrhaphy; Peripheral Nerve Mutilation; Small Gap; Tubulization
Categories
Funding
- Chinese National Natural Science Fund for Outstanding Youth [30625036]
- Chinese National Natural Science Fund [31171150, 31271284, 30801169, 81171146, 30971526]
- Beijing City Science & Technology New Star Classification [A-2008-10]
- Chinese Ministry of Education for Doctor Position New Teacher [20070001780]
- Chinese Educational Ministry New Century Excellent Talents Support Project [BMU20110270]
- Peking University People's Hospital Project [RDB2009-01]
- Chinese 973 Project Planning [2005CB522604]
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Nerve regeneration and re-innervation are usually difficult after peripheral nerve injury. Epineurium neurorrhaphy to recover the nerve continuity is the traditional choice of peripheral nerve mutilation without nerve defects, whereas the functional recovery remains quite unsatisfactory. Based on previous research in SD rats and Rhesus Monkeys, a multiple centers clinical trial about biodegradable conduit small gap tubulization for peripheral nerve mutilation to substitute traditional epineurial neurorrhaphy was carried out. Herein, the authors reviewed the literature that focused on peripheral nerve injury and possible clinical application, and confirmed the clinical possibilities of biodegradable conduit small gap tubulization to substitute traditional epineurial neurorrhaphy for peripheral nerve mutilation. The biodegradable conduit small gap tubulization to substitute traditional epineurial neurorrhaphy for peripheral nerve mutilation may be a revolutionary innovation in peripheral nerve injury and repair field.
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