Article
Endocrinology & Metabolism
Domenico Corica, Giorgia Pepe, Tommaso Aversa, Monica Curro, Selenia Curatola, Alessandra Li Pomi, Angela Alibrandi, Riccardo Ientile, Malgorzata Wasniewska
Summary: The study found that postprandial asprosin levels significantly change in non-diabetic children and adolescents with obesity, and are associated with metabolic variables related to diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zahra Nadimi Shahraki, Hanie Azimi, Nasrin Ilchi, Mina Rohani Borj, Hossein Pourghadamyari, Saeedeh Mosallanejad, Kazem Abbaszadeh-Goudarzi, Amirhossein Sahebkar
Summary: CAD is a major cause of death globally, and its association with inflammation is known. Recent research shows that CTRP12 has strong anti-inflammatory effects, and this study aimed to assess its levels in relation to CAD severity.
Article
Genetics & Heredity
Xiaoyan Chen, Zhaoming Liu, Jingen Cui, Xiaolan Chen, Jing Xiong, Wei Zhou
Summary: The study did not provide robust evidence supporting the causal role of common circulating adipokine levels in PET, but genetically predicted PET may affect PAI-1 levels. Therefore, PAI-1 may be a useful biomarker for monitoring PET diagnosis or therapy, rather than a therapeutic target for PET.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Stephan Wueest, Eleonora Seelig, Katharina Timper, Mark P. Lyngbaek, Kristian Karstoft, Marc Y. Donath, Helga Ellingsgaard, Daniel Konrad
Summary: Blocking IL-6 receptor increases circulating adiponectin levels and decreases leptin levels in obese individuals, positively impacting insulin sensitivity.
Review
Biochemistry & Molecular Biology
Yangxue Yin, Shuangshuang Xie, Qin Xu, Lingyun Liao, Hongqin Chen, Rong Zhou
Summary: This meta-analysis examined the association between circulating chemerin levels in pregnant women with preeclampsia (PE). The results showed that chemerin levels were significantly higher in PE patients compared to controls, indicating its potential use as a marker for diagnosing PE. Subgroup analysis revealed consistent findings across different conditions, while meta-regression did not identify any factors significantly impacting the overall estimate.
LIPIDS IN HEALTH AND DISEASE
(2023)
Review
Physiology
Md. Sahab Uddin, Md. Motiar Rahman, Mohammad Abu Sufian, Philippe Jeandet, Ghulam Md. Ashraf, May N. Bin-Jumah, Shaker A. Mousa, Mohamed M. Abdel-Daim, Muhammad Furqan Akhtar, Ammara Saleem, Md. Shah Amran
Summary: Alzheimer's disease is the most common form of dementia, with obesity being a common risk factor associated with dysregulation of adipokine and adipocyte dysfunction. Dysfunction of adipose tissue in obesity is connected with various brain issues and cognitive decline.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Stephanie Brandt, Julia von Schnurbein, Christian Denzer, Wolfgang Kratzer, Martin Wabitsch
Summary: Circulating leptin levels in pre-pubertal children with obesity are negatively associated with steatosis hepatis, and children with low leptin levels have higher triglyceride, fasting insulin, and c-peptide levels.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Nutrition & Dietetics
Mousa Khalafi, Mohammad Hossein Sakhaei, Shokoufeh Kheradmand, Michael E. Symonds, Sara K. Rosenkranz
Summary: This meta-analysis compared the effects of exercise training (Ex) with those of dietary interventions (DIs) and the effects of the combination of Ex and DI (Ex + DI) with those of Ex or DI alone on circulating leptin and adiponectin in individuals who are overweight and those with obesity. The results showed that DI decreased leptin concentration and increased adiponectin concentration compared with Ex alone, and Ex + DI achieved similar effects. However, Ex + DI did not increase adiponectin concentration and had inconsistent effects on leptin concentration compared with DI alone. Age, BMI, intervention duration, supervision type, study quality, and energy restriction were sources of heterogeneity.
ADVANCES IN NUTRITION
(2023)
Article
Endocrinology & Metabolism
Kunxia Xie, Lujie Liu, Chunyan Yin, Min Li, Liming Wang, Weicheng Lv, Yinan Chang, Yanfeng Xiao
Summary: This study found that serum levels of FAM19A5 and FSTL1 were decreased in obese children, and these proteins likely play important roles in glucose metabolism in obese children. Furthermore, FAM19A5 was identified as a predictor of insulin resistance in obese children.
ANNALS OF NUTRITION AND METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Michihiro Kon, Yuko Tanimura
Summary: Aerobic exercise is an effective therapeutic strategy for managing metabolic disorders, but its underlying mechanisms are not fully understood. This study investigated the effects of acute aerobic exercise on the levels of CTRP1, CTRP3, CTRP5, and CTRP9 in human participants. The results suggest that acute aerobic exercise may enhance the secretion of CTRP1, CTRP3, CTRP5, and CTRP9 in healthy adults.
Review
Medicine, Research & Experimental
Yingying Xie, Ling Liu
Summary: There is a close correlation between obesity and vascular dysfunction, but the specific mechanisms are unclear. The chemerin/chemR23 axis has multifarious impacts on vascular function regulation.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Medical Laboratory Technology
Xia Deng, Zhicong Zhao, Li Zhao, Chenxi Wang, Yanyan Li, Zhensheng Cai, Haoxiang Li, Tian Gu, Yue Xia, Zheng Zhang, Dong Wang, Ling Yang, Guoyue Yuan
Summary: The study found that serum asprosin levels are significantly higher in patients with type 2 diabetes mellitus (T2DM) who have carotid plaques. Serum asprosin is positively correlated with obesity, insulin resistance, and other indicators. Furthermore, asprosin remains significantly correlated with carotid plaques in T2DM patients and can serve as a predictive marker for carotid plaque formation.
CLINICAL BIOCHEMISTRY
(2022)
Article
Environmental Sciences
Pilar Requena, Celia Perez-Diaz, Vicente Mustieles, Francisco M. Peinado, Josefa Leon, Francisco M. Perez-Carrascosa, Hanne Frederiksen, Inmaculada Salcedo-Bellido, Rocio Barrios-Rodriguez, Juan Pedro Arrebola
Summary: This study investigates the associations between human phthalate exposure and the onset of chronic diseases with an immunological component. The results suggest that certain phthalates are correlated with cytokines and acute phase proteins, indicating potential subclinical immuno-inflammatory actions of these pollutants.
ENVIRONMENTAL RESEARCH
(2023)
Review
Endocrinology & Metabolism
Kainan Lin, Xiaoting Sun, Xiao Wang, Hanchu Wang, Xia Chen
Summary: This meta-analysis indicates that levels of circulating adiponectin are significantly decreased in nonobese PCOS patients while levels of chemerin, leptin, resistin, and visfatin are significantly increased. There were no significant changes in the levels of apelin, irisin, omentin, or vaspin. This suggests that dysregulated levels of circulating adipokines may play crucial roles in the development of PCOS regardless of obesity status.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Genetics & Heredity
Weizhong Xiao, Jian Li, Tianyuyi Feng, Long Jin
Summary: This study used Mendelian randomization analysis to determine the effects of BMI, adiponectin, leptin, PAI-1, MCP-1, leptin receptor, and RETN levels on VTE, DVT, and PE. It found that higher BMI and circulating leptin levels increase the risk of VTE, DVT, and PE, and circulating leptin might mediate the risk of PE caused by BMI. Adiponectin has a potential protective effect on both VTE and PE.
FRONTIERS IN GENETICS
(2023)
