Article
Cardiac & Cardiovascular Systems
Maha A. Al-Mohaissen
Summary: There is growing interest in the use of echocardiography in the evaluation of primary microvascular angina, which is attributed to primary coronary microvascular dysfunction. Adequate echocardiographic techniques can facilitate diagnosis, follow-up, research, and therapy evaluation. However, there is a lack of sufficient data and limitations in the interpretation of available literature. Various echocardiographic techniques can assess primary coronary microvascular dysfunction, but the diagnosis requires excluding obstructive coronary artery disease. While certain techniques show diagnostic and prognostic potential, there is no consensus on criteria and limited expertise. Therefore, the appraisal of current echocardiographic literature is important for clinical recognition and future research.
TRENDS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Bernard De Bruyne, Nico H. J. Pijls, Emanuele Gallinoro, Alessandro Candreva, Stephane Fournier, Danielle C. J. Keulards, Jeroen Sonck, Marcel Van't Veer, Emanuele Barbato, Jozef Bartunek, Marc Vanderheyden, Eric Wyffels, Annemiek De Vos, Mohamed El Farissi, Pim A. L. Tonino, Olivier Muller, Carlos Collet, William F. Fearon
Summary: This study proposes microvascular resistance reserve (MRR) as a specific index for assessing coronary microvascular function, independent of autoregulation and myocardial mass, based on absolute values of coronary flow and pressure. The research found a strong correlation between continuous thermodilution-derived MRR and Doppler MRR, suggesting MRR as a specific, quantitative, and operator-independent metric for quantifying coronary microvascular dysfunction.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Hugo Rodriguez-Zanella, Rosina Arbucci, Juan Francisco Fritche-Salazar, Xochitl Arely Ortiz-Leon, Domenico Tuttolomondo, Diego Haber Lowenstein, Karina Wierzbowska-Drabik, Quirino Ciampi, Jaroslaw D. Kasprzak, Nicola Gaibazzi, Jorge Lowenstein, Edith Liliana Posada-Martinez, Jose Antonio Arias-Godinez, Juan C. de la Fuente-mancera, Eugenio Picano
Summary: This study aimed to investigate the cardiac mechanics in patients with INOCA and reduced CVFR during stress. The results showed that during peak stress, patients with normal CVFR had lower global longitudinal strain and higher mechanical dispersion.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Kentaro Kakuta, Kaoru Dohi, Takayuki Yamamoto, Naoki Fujimoto, Takahiro Shimoyama, Satoru Umegae, Masaaki Ito
Summary: Inflammatory bowel disease (IBD) is associated with coronary microvascular dysfunction (CMD), which improves after surgical resection of the diseased intestines.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Cardiac & Cardiovascular Systems
Jakob Schroder, Eva Prescott
Summary: Echocardiographic evaluation is crucial for diagnosing cardiovascular disease, with TTDE CFVR being a valuable tool for assessing coronary microvascular dysfunction. However, its clinical use is limited, leading to underdiagnosis of CMD. Low CFVR remains an important prognostic marker in both men and women, despite potential gender differences in angina patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Maria Cristina Pasqualetto, Domenico Tuttolomondo, Antonio Cutruzzola, Giampaolo Niccoli, Damini Dey, Alessandro Greco, Chiara Martini, Concetta Irace, Fausto Rigo, Nicola Gaibazzi
Summary: A new imaging metric using CCTA, PCAT CT attenuation, provides information on coronary inflammation; the study found a significant inverse relationship between PCAT CT attenuation and CFVR-lad in subjects without overt or mild CAD.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Review
Medicine, General & Internal
Fabio Mangiacapra, Michele Mattia Viscusi, Giuseppe Verolino, Luca Paolucci, Annunziata Nusca, Rosetta Melfi, Gian Paolo Ussia, Francesco Grigioni
Summary: The critical role of the coronary microvascular compartment and its invasive functional assessment have been recognized. However, the diagnosis of coronary microvascular dysfunction (CMD) is challenging due to its small dimensions. Several diagnostic tools are available for assessing the coronary microvascular function, which, when combined with physiological indices, can provide a comprehensive evaluation of the coronary circulation. Physiological-guided management of CMD may offer symptom improvement among patients with angina and ischemic heart disease.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Zhihua Yang, Shanshan Lin, Yangxi Liu, Qiuan Ren, Zhao Ge, Ci Wang, Yingfei Bi, Xianliang Wang, Jingyuan Mao
Summary: Coronary microvascular disease (CMVD) is common in patients with cardiovascular risk factors and is associated with an increased risk of adverse cardiovascular events. Traditional Chinese medicine (TCM), with its clinical advantages of syndrome differentiation and individualized treatment, shows potential efficacy and action mechanisms for CMVD. However, there are still many scientific issues and gaps in the research of CMVD.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Stefanos Drakos, Grigorios Chatzantonis, Michael Bietenbeck, Georg Evers, Arik Bernard Schulze, Michael Mohr, Helena Fonfara, Claudia Meier, Ali Yilmaz
Summary: COVID-19 patients may experience coronary microvascular disease, resulting in persistent symptoms of exercise dyspnea and fatigue.
SCIENTIFIC REPORTS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Liu Yang, Peng Peng Xu, U. Joseph Schoepf, Christian Tesche, Balakrishnan Pillai, Rock H. Savage, Chun Xiang Tang, Fan Zhou, Hao Dong Wei, Zhong Qiang Luo, Qing Gen Wang, Chang Sheng Zhou, Meng Jie Lu, Guang Ming Lu, Long Jiang Zhang
Summary: Fractional flow reserve and plaque progression assessed by serial coronary CT angiography predicted the risk of future major adverse cardiovascular events (MACE), demonstrating better accuracy compared to traditional assessment markers.
EUROPEAN RADIOLOGY
(2021)
Article
Dermatology
Stefano Piaserico, Evangelia Papadavid, Annagrazia Cecere, Gloria Orlando, Konstantrinos Theodoropoulos, Pelagia Katsimbri, George Makavos, Penelope Rafouli-Stergiou, Sabino Iliceto, Mauro Alaibac, Francesco Tona, Ignatios Ikonomidis
Summary: Severe psoriasis is associated with an increased cardiovascular risk, and coronary microvascular dysfunction (CMD) has been shown to predict a poor cardiovascular prognosis. This study evaluated the prevalence and predictors of CMD in a large cohort of patients with psoriasis without clinical cardiovascular disease. The results showed that higher PASI, longer disease duration, the presence of psoriatic arthritis, and hypertension were independently associated with CMD.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Mathematical & Computational Biology
Jucheng Zhang, Minwen Ma, Huajun Li, Zhaoxia Pu, Haipeng Liu, Tianhai Huang, Huan Cheng, Yinglan Gong, Yonghua Chu, Zhikang Wang, Jun Jiang, Ling Xia
Summary: This study investigates the diagnostic performance of myocardial contrast echocardiography (MCE) for coronary microvascular dysfunction (CMD). It finds that MCE has high sensitivity and specificity in diagnosing CMD, showing strong agreement with thermodilution. However, the correlation coefficient is not high.
MATHEMATICAL BIOSCIENCES AND ENGINEERING
(2023)
Article
Cardiac & Cardiovascular Systems
Diana M. Lopez, Sanjay Divakaran, Ankur Gupta, Navkaranbir S. Bajaj, Michael T. Osborne, Wunan Zhou, Jon Hainer, Courtney F. Bibbo, Hicham Skali, Sharmila Dorbala, Viviany R. Taqueti, Ron Blankstein, Marcelo F. Di Carli
Summary: This study aimed to evaluate the sensitivity and specificity of exercise treadmill testing (ETT) in the diagnosis of coronary microvascular disease (CMD) and the prognostic implications of ETT results in CMD patients. The study found that ETT has limited sensitivity in detecting CMD, but a positive ETT with ischemic changes lasting at least 1 minute into recovery and the absence of obstructive coronary artery disease may indicate the presence of CMD.
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Masahiro Hoshino, Seokhun Yang, Tomoyo Sugiyama, Jinlong Zhang, Yoshihisa Kanaji, Rikuta Hamaya, Masao Yamaguchi, Masahiro Hada, Tomoki Horie, Kai Nogami, Hiroki Ueno, Toru Misawa, Taishi Yonetsu, Doyeon Hwang, Joo Myung Lee, Eun-Seok Shin, Joon-Hyung Doh, Chang-Wook Nam, Bon-Kwon Koo, Tetsuo Sasano, Tsunekazu Kakuta
Summary: This study found that the prevalence of coronary microvascular dysfunction (CMD) in patients with intermediate epicardial stenosis is about one-third. CMD was significantly associated with greater lumen volume, fibrofatty and necrotic component volume, and epicardial fat volume.
EUROPEAN RADIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Ashkan Eftekhari, Tim P. van de Hoef, Masahiro Hoshino, Joo Myung Lee, Coen K. M. Boerhout, Guus A. de Waard, Ji-Hyun Jung, Seung Hun Lee, Hernan Mejia-Renteria, Mauro Echavarria-Pinto, Martijn Meuwissen, Hitoshi Matsuo, Maribel Madera-Cambero, Mohamed A. Effat, Koen Marques, Joon-Hyung Doh, Rupak Banerjee, Chang-Wook Nam, Giampaolo Niccoli, Tadashi Murai, Masafumi Nakayama, Nobuhiro Tanaka, Eun-Seok Shin, Paul Knaapen, Niels van Royen, Javier Escaned, Bon Kwon Koo, Steven A. J. Chamuleau, Tsunekazu Kakuta, Jan J. Piek, Evald Hoj Christiansen
Summary: This study investigated the association between changes in microvascular resistance (MR) and target vessel failure (TVF) in patients undergoing percutaneous coronary intervention (PCI). The results showed that increased MR post-PCI was associated with lesions of less severe hemodynamic influence at baseline and higher rates of TVF at follow-up.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Meeting Abstract
Immunology
Nuretdin Suna, Digdem Ozer Etik, Serkan Ocal, Haldun Selcuk, Ulku Dagli, Fatih Hilmioglu, Sedat Boyacioglu, Mehmet Haberal
Meeting Abstract
Immunology
Digdem Ozer Etik, Nuretdin Suna, Serkan Ocal, Haldun Selcuk, Ulku Dagli, Turan Colak, Fatih Hilmioglu, Sedat Boyacioglu, Mehmet Haberal
Meeting Abstract
Immunology
Ulku Dagli, Digdem Ozer Etik, Aydincan Akdur, Haldun Selcuk, Fatih Hilmioglu, Sedat Boyacioglu, Gokhan Moray, Mehmet Haberal
Meeting Abstract
Immunology
Fatih Boyvat, Mehmet Haberal, Ali Harman, Aydincan Akdur, Umut Ozyer, Haldun Selcuk, Gokhan Moray
Article
Transplantation
Digdem Ozer Etik, Nuretdin Suna, Serkan Ocal, Haldun Selcuk, Ulku Dagli, Turan Colak, Fatih Hilmioglu, Ahmet Sedat Boyacioglu, Mehmet Haberal
EXPERIMENTAL AND CLINICAL TRANSPLANTATION
(2019)
Article
Transplantation
Nuretdin Suna, Digdem Ozer Etik, Serkan Ocal, Haldun Selcuk
EXPERIMENTAL AND CLINICAL TRANSPLANTATION
(2019)
Article
Cardiac & Cardiovascular Systems
Murat Gunday, Ozgur Ciftci
HEART SURGERY FORUM
(2020)
Article
Peripheral Vascular Disease
Omer Faruk Baycan, Fatma Betul Celik, Tolga Sinan Guvenc, Adem Atici, Yusuf Yilmaz, Oguz Konal, Mehmet Ali Agirbasli, Seref Kul, Hakan Gullu, Mustafa Caliskan
Summary: Patients with an exaggerated blood pressure response to exercise exhibit coronary microvascular dysfunction, as well as endothelial dysfunction and subclinical atherosclerosis. This finding may explain the increased risk of coronary artery disease and cardiovascular mortality in these patients.
HYPERTENSION RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Saadet Demirtas Inci, Murat Tulmac, Cagatay Tunca, Tolgahan Efe, Hakan Gullu
Summary: In this case report, a patient with ventricular septal defect (VSD) detected after transcatheter aortic valve implantation (TAVI) was successfully treated with percutaneous closure, resulting in significant improvement in symptoms.
JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Saadet Demirtas Inci, Murat Tulmac, Cagatay Tunca, Tolgahan Efe, Hakan Gullu
Summary: This report presents a case of VSD detected and successfully treated after TAVI. The patient complained of shortness of breath one month after the procedure, and a VSD causing left-to-right shunt was identified. Following interventional treatment, the patient showed significant improvement in symptoms.
JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Saadet Demirtas Inci, Mustafa Agah Tekindal, Meltem Altinsoy, Nail Burak Ozbeyaz, Hamza Sunman, Alperen Tas, Sabiye Yilmaz, Sebahat Tekeli Sengul, Cihan Altin, Hakan Gullu
Summary: This study aimed to evaluate the predictive value of heart rate-corrected QT interval prolongation in combination with the Global Registry of Acute Coronary Events risk score for early mortality in patients with non-ST segment elevation acute coronary syndrome. The study found that both the corrected QT interval and the risk score independently predicted early mortality, and their combination improved the predictive value.
TURK KARDIYOLOJI DERNEGI ARSIVI-ARCHIVES OF THE TURKISH SOCIETY OF CARDIOLOGY
(2022)
Review
Gastroenterology & Hepatology
Serkan Ocal, Nuretdin Suna, Digdem Ozer Etik, Fatih Boyvat, Haldun Selcuk
GASTROENTEROLOGY NURSING
(2019)
Article
Cardiac & Cardiovascular Systems
Aynur Acibuca, Sefa Okar, Tuba Canpolat, Zafer Koc, Hakan Gullu
ANATOLIAN JOURNAL OF CARDIOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Aynur Acibuca, Mahmut Yeral, Nazim Emrah Kocer, Zafer Koc, Hakan Gullu
ANATOLIAN JOURNAL OF CARDIOLOGY
(2019)
Meeting Abstract
Gastroenterology & Hepatology
U. Dagli, D. Ozer Etik, N. Demir, S. Ocal, H. Selcuk, F. Hilmioglu, S. Boyacioglu
JOURNAL OF CROHNS & COLITIS
(2018)
Article
Peripheral Vascular Disease
Jingting Yao, Justin D. Sprick, Jinhee Jeong, Jeanie Park, David A. Reiter
Summary: This study used time-frequency spectral analysis of resting near-infrared spectroscopy (NIRS) signals to evaluate the regulation of peripheral microvascular perfusion in CKD patients. The findings suggest that CKD patients have impaired neurogenic and endothelial functions, which may be associated with increased sympathetic activity and reduced endothelial function in CKD.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Yoh Sugawara, Yusuke Mizuno, Shinya Oku, Yuri Sawada, Takahisa Goto
Summary: This study investigated the role of Protein kinase D (PKD) in aortic contraction and hemodynamics, finding that PKD1 plays a crucial role in these processes through phosphorylation of MYPT1 and actin polymerization in a calcium-independent manner.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Xuenan Zhuang, Guiqin He, Yunkao Zeng, Miaoling Li, Yongyue Su, Xuelin Chen, Yining Zhang, Yuhong Gan, Feng Wen, Xiongze Zhang
Summary: This study assessed the impact of acute, heavy alcohol consumption on the ocular microvasculature. The findings suggest that excessive alcohol consumption leads to vasoconstriction in ocular arterioles and vasodilation in capillaries, particularly evident 1-hour post-consumption.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Ayuki Nakano, Akane Morita, Shiho Arima, Tohru Nagamitsu, Tsutomu Nakahara
Summary: This study examines the preventative and therapeutic effects of inhibiting mammalian target of rapamycin complex 1 (mTORC1) on abnormal retinal blood vessels in a rat model of retinopathy of prematurity (ROP). The results suggest that mTORC1 activation in proliferating endothelial cells contributes to the appearance and progression of ROP-like retinal blood vessels. Inhibition of mTORC1 may be a promising approach for selectively targeting abnormal retinal blood vessels in ROP.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Bing Wang, Xiaohong Song, Xu Zhang, Yuan Li, Mengting Xu, Xueting Liu, Bingwei Li, Sunjing Fu, Hao Ling, Yingyu Wang, Xiaoyan Zhang, Ailing Li, Mingming Liu
Summary: This study found that glycine supplementation can improve pancreatic microcirculation in T1DM mice and reverse the production of inflammatory cytokines. Furthermore, glycine supplementation also alleviates damage to pancreatic islet and vascular tissues, suggesting a potential therapeutic effect for T1DM.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Merve Erkisa Genel, Kaan Adacan, Selin Selvi, Deniz Erol Kutucu, Ayca Uvez, Elif Ilkay Armutak, Abdurrahman Sengul, Engin Ulukaya, Ebru Gurel Gurevin
Summary: This study investigated the anti-growth/cytotoxic effect of a dinuclear Pd(II) complex on breast cancer cell lines and confirmed its anti-migration and antiangiogenic properties. The results suggest the potential of this complex in the treatment of breast cancer.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Cedric Mueller, Christoph Hauser, Justin Carrard, Konstantin Gugleta, Timo Hinrichs, Arno Schmidt-Trucksass, Henner Hanssen, Lukas Streese
Summary: This study aimed to evaluate the differences in microvascular health between normotensive individuals and patients with arterial hypertension and to assess the effects of short-term high-intensity interval training (HIIT) on microvascular health in patients with arterial hypertension. The study found that short-term HIIT can ameliorate hypertension-induced retinal microvascular abnormalities in patients with arterial hypertension.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Yuyang Hou, Wenjing Du, Qiong Wu, Xinyu Chai, Yinan Wang, Yingqian Mi, Yuan Tian, Mengyan Tang, Jun Li, Dongmei Yan
Summary: This study identified a prognostic signature consisting of four genes in bladder cancer patients and utilized angiogenesis-related genes and molecular subtypes to construct this signature, which could help predict survival outcomes. The study also evaluated immune cell infiltration and predicted chemotherapeutic responses, confirming the effectiveness of this prognostic signature.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Sean D. Mcgarry, Cynthia Adjekukor, Suchit Ahuja, Jasper Greysson-Wong, Idy Vien, Kristina D. Rinker, Sarah J. Childs
Summary: The article introduces a software tool called Vessel Metrics for analyzing developmental vascular microscopy images, which can expedite the analysis process and ensure consistency between research groups. The tool includes a segmentation algorithm that accurately quantifies different image types and has been validated in zebrafish and mouse models.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Y. P. Latul, C. Ince, N. E. van Trommel, A. van den Brandhof-van den Berg, J. P. W. R. Roovers, A. W. Kastelein
Summary: This study evaluated the real-time detection capability of handheld vital microscopy (HVM) for cervical intraepithelial neoplasia (CIN) and cervical cancer (CC). The results showed that HVM enables easy, real-time, and non-invasive assessment of cervical lesions through the detection of microvascular alterations. This method has the potential to be used for point-of-care screening, reducing unnecessary surgical interventions.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Zhifei Liu, Jieqiong Zhang, Xue Li, Qiumei Hu, Xi Chen, Linlin Luo, Liqianyu Ai, Jian Ye
Summary: The study revealed that astrocytic YAP can alleviate retinal pathological angiogenesis by inhibiting overactivation of astrocytes, thereby suppressing excessive VEGF-A production and neuroinflammation.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Robert G. Hahn
Summary: The fast-exchange interstitial fluid compartment is directly connected to the circulating blood, while the slow-exchange compartment is not.
MICROVASCULAR RESEARCH
(2024)
Review
Peripheral Vascular Disease
Nadia Hamjane, Mohcine Bennani Mechita, Naima Ghailani Nourouti, Amina Barakat
Summary: Gut microbiota dysbiosis plays a crucial role in the development of obesity-related metabolic abnormalities, including insulin resistance, type 2 diabetes, and cardiovascular diseases. Inflammation is a major mechanism linking gut microbiota dysbiosis to obesity-associated metabolic complications.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Guangzhen Zhou, Yan Gao, Yanbin Shi, Shengnan Qiu, Guimei Lin, Xinbing Ding, Wenguang Wang, Yihua Feng, Fei Wang, Jinwei Qiao
Summary: This study utilized an in vitro biomimetic experimental system to investigate the transvascular transport of nano-preparations, and found that the pressure gradient between vascular fluid pressure and interstitial fluid pressure determines the existence of the enhanced penetration and retention effect of nanopreparations.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Kenji Chamoto, Barry C. Gibney, Willi L. Wagner, Maximilian Ackermann, Hassan A. Khalil, Steven J. Mentzer
Summary: In the study, the process of angiogenesis in adult regenerating tissue was investigated by grafting portions of the regenerating lung onto the chick chorioallantoic membrane. The results showed peri-graft angiogenesis, particularly in the cardiac lobe. Functional vascular connections were observed between the cardiac lobe and the chick chorioallantoic membrane vascular network. Elevated gene expression levels were found in the cardiac lobe compared to other lobes.
MICROVASCULAR RESEARCH
(2024)
