Mass spectrometric fragmentation behaviour of cAMP analogues

The mass spectrometric fragmentation of a number of analogues of the biological second messenger, adenosine 3',5'-cyclic monophosphate (cAMP), was undertaken in order to study the effects of modifications of the naturally-occuring compound on the tandem mass spectrometry data obtained. Such analogues are being investigated as biomedical treatments and also as experimental research tools; the data reported here will assist the structural elucidation of novel cAMP analogues produced in the future by acting as a reference guide as to the effect of different modifications on the mass spectrometric fragmentation patterns. (C) 2010 Elsevier B.V. All rights reserved.