Article
Oncology
Xiang Shu, Qin Zhou, Xiaohui Sun, Michelle Flesaker, Xingyi Guo, Jirong Long, Mark E. Robson, Xiao-Ou Shu, Wei Zheng, Jonine L. Bernstein
Summary: This study identified 98 proteins that may have potential causal associations with the risk of breast cancer subtypes. The associations of ICAM1, PLA2R1, and TXNDC12 varied significantly across the subtypes. These findings contribute to understanding the heterogeneity in the etiology of different subtypes of breast cancer and may aid in personalized risk assessment of the disease.
BRITISH JOURNAL OF CANCER
(2022)
Article
Cell Biology
Eun-Ji Lim, Jae-Hyeok Kang, Yeon-Ju Kim, Seungmo Kim, Su-Jae Lee
Summary: ICAM-1 is a potential therapeutic target for colorectal cancer (CRC) that enhances treatment effectiveness by promoting the c-MET-SRC signaling axis. Treatment with antibodies targeting ICAM-1 can reduce metastasis and angiogenesis in CRC.
CELL DEATH & DISEASE
(2022)
Article
Medicine, Legal
Mizuho Nosaka, Yuko Ishida, Yumi Kuninaka, Akiko Ishigami, Akira Taruya, Emi Shimada, Yumiko Hashizume, Hiroki Yamamoto, Akihiko Kimura, Fukumi Furukawa, Toshikazu Kondo
Summary: The study used a mouse deep vein thrombosis model to investigate the intrathrombotic expression of AQP-1 and AQP-3, finding that the changes in AQP-1 and AQP-3 within the thrombus at different time points could help determine the age of the thrombus.
INTERNATIONAL JOURNAL OF LEGAL MEDICINE
(2021)
Review
Biology
Cameron D. Haydinger, Liam M. Ashander, Alwin Chun Rong Tan, Justine R. Smith
Summary: Intercellular adhesion molecule 1 (ICAM-1) is a transmembrane protein that plays important roles in the immune system and is involved in various diseases. It mediates cellular adhesive interactions and is upregulated in inflammation. This review provides a comprehensive summary of the structure and regulation of ICAM1 gene and the ICAM-1 protein, discusses its functions in the immune system and diseases, and explores current therapeutics and future advancements.
Article
Neurosciences
Jonathan D. Drake, Alison B. Chambers, Brian R. Ott, Lori A. Daiello
Summary: The study found that plasma-based vascular biomarkers, particularly VCAM-1 and ICAM-1, were associated with Alzheimer's disease (AD) and clinical impairment. VCAM-1 was linked with clinical dementia rating sum-of-boxes (CDR-SB) scores, with the APOE epsilon 4 genotype modifying this relationship. Additionally, combining VCAM-1 and cerebrospinal fluid (CSF) biomarkers showed independent associations with AD-related clinical impairment.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Taichi Matsumoto, Junichi Matsumoto, Yuka Matsushita, Moeno Arimura, Kentaro Aono, Mikiko Aoki, Kazuki Terada, Masayoshi Mori, Yutaka Haramaki, Takuya Imatoh, Atsushi Yamauchi, Keisuke Migita
Summary: This study investigated the effect of bortezomib (BTZ) on vascular permeability and expression of cell-cell junction molecules in human pulmonary microvascular endothelial cells. The findings showed that clinically relevant concentrations of BTZ increased the permeability of endothelial cell monolayers and downregulated the expression of claudin-5, occludin, and VE-cadherin at both protein and mRNA levels. This suggests that BTZ-induced pulmonary toxicity may be mediated by increased vascular permeability caused by the downregulation of these cell-cell junction molecules.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Ophthalmology
Natalia I. Khramenko, Natalia V. Konovalova, Volodymyr Ya. Usov, Liudmyla M. Velychko, Olexandra V. Bogdanova
Summary: The parameters of the T-cell link of the immune response and the parameters of humoral immunity were different between patients with uncomplicated recurrent anterior uveitis (AU) and those with recurrent AU complicated by uveitic macular edema (UME). The patients with UME had increased T-cell immune response parameters and decreased humoral immunity parameters. The relative numbers of natural killer cells and phagocytic neutrophils were also different between the two groups. The expression levels of ICAM-1 and CD5 seem to play a role in uveitic macular edema.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Immunology
Jae-Young Park, Hyo-Min Park, Seonhwa Kim, Kyeong-Bae Jeon, Chae-Min Lim, Jin Tae Hong, Do-Young Yoon
Summary: IL-32 theta A94V, a mutant isoform, can inhibit monocyte-endothelial adhesion by binding to integrins aVb3 and aVb6, thus reducing the early step of atherosclerosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Vladana Domazetovic, Irene Falsetti, Caterina Viglianisi, Kristian Vasa, Cinzia Aurilia, Maria Stio, Stefano Menichetti, Teresa Iantomasi
Summary: The study found that tocopherol derivatives can prevent TNFα-induced oxidative stress and inhibit the increase of ICAM-1 and Cl-2 expression. Among them, (δ-Toc)2S and (δ-Toc)2S-2 were more effective than δ-Toc and α-Toc.
Article
Clinical Neurology
Xue-Bing Chen, Dong Qu, Qing Zhang, Xia Yue, Dong-Fang Qiao
Summary: This case study reports the death of a 30-year-old man due to acute pulmonary edema during rt-pa thrombolytic therapy, emphasizing the importance of closely monitoring vital sign changes and being aware of the risk of pulmonary edema during thrombolysis.
Article
Oncology
Jing Zhang, Rongrong Zhang, Zhenhong Zhao
Summary: Clinical treatment can significantly reduce the levels of autoantibodies and ICAM-1 in patients with Graves disease, improve thyroid function, and alleviate inflammation. Detection of these indicators can provide guidance for disease progression and treatment.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Oncology
Bing Zhu, Xinyan Wang, Takaya Shimura, Andrew C. Huang, Nana Kong, Yujie Dai, Jianmin Fang, Peng Guo, Jie-Er Ying
Summary: This preclinical study reports two effective targeted therapeutics for the treatment of cholangiocarcinoma. By conjugating ICAM1 antibodies with different cytotoxic payloads, tumor growth was successfully attenuated. This study paves the road for developing a promising targeted therapeutic candidate for clinical treatment of cholangiocarcinoma.
NPJ PRECISION ONCOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Weiwei Cao, Yu Chen, Wei Han, Juzheng Yuan, Weimin Xie, Kun Liu, Yan Qiu, Xudan Wang, Xiao Li
Summary: This study found that patients with normal or normalized AFP and sICAM-1 levels in liver cancer had lower tumor recurrence rates and better survival rates, while those with elevated levels of both markers had poorer outcomes. AFP and ICAM-1 play crucial roles in the diagnosis, prognostic prediction, and immunotherapy of HCC, and their combined application can improve predictive accuracy.
Article
Biochemistry & Molecular Biology
Jia Guo, Zeyu Xu, Rachel C. Gunderson, Baohui Xu, Sara A. Michie
Summary: In this study, the researchers found that ICAM-1 is expressed on the sinus endothelia of lymph nodes, but not on the lymphatic vessels of peripheral tissues. Memory CD4(+) T cells migrated to lymph nodes from peripheral tissues more efficiently than from blood vessels. ICAM-1 deficiency significantly inhibited the migration of lymphocytes from peripheral tissues into lymph nodes, and the absence of ICAM-1 or LFA-1 reduced the number of memory T cells in lymph nodes.
Article
Medicine, Legal
Dong Qu, Na Chen, Dong-Fang Qiao, Hui-Jun Wang, Xiao-Hui Tan
Summary: This case study details the death of a 32-year-old man due to bilateral re-expansion pulmonary edema following the insertion of a chest tube for unilateral spontaneous pneumothorax. Despite various treatments being administered, the patient ultimately succumbed to acute cardiac and respiratory failure. The findings from autopsy emphasize the importance of integrating death investigation, pathological findings, and clinical courses in the diagnosis of RPE in forensic pathology.
FORENSIC SCIENCE MEDICINE AND PATHOLOGY
(2021)