Journal
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
Volume 28, Issue -, Pages 74-79Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ijid.2014.06.021
Keywords
Campylobacter; Salmonella; Yersinia; Miscarriage; Preterm birth; Small for gestational age (SGA)
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Funding
- Pharmacy Foundation
- Egmont Foundation
- March of Dimes Birth Defects Foundation
- Augustinus Foundation
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Background: The aim of this study was to determine antibody titres against Campylobacter, Salmonella, and Yersinia in a population-based cohort of pregnant women in Denmark in order to evaluate adverse pregnancy outcomes (miscarriage, preterm birth, and small for gestational age) in relation to occupational exposure to animals in women exposed to food producing animals. Methods: We used data and blood samples from the Danish National Birth Cohort. Serum samples collected during the first trimester from 192 pregnant women who were occupationally exposed to domestic animals and 188 randomly selected unexposed pregnant women were analysed for IgG, IgM, and IgA antibodies against Campylobacter, Salmonella, and Yersinia. Pregnancy outcomes of interest were identified through the Danish National Patient Register. Results: Women with occupational exposure to animals had significantly higher IgG antibody concentrations against Campylobacter, Salmonella, and Yersinia, whereas they had lower concentrations of IgM and IgA antibodies. Conclusions: Serological markers were not identified as risk factors for adverse pregnancy outcomes, with the exception of elevated concentrations of Salmonella antibodies, which were found to be associated with an increased risk of preterm birth. (C) 2014 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
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