Article
Infectious Diseases
Shohra Qaderi, Masoud Mardani, Asghar Shah, Jaffer Shah, Narges Bazgir, Jalal Sayad, Ehsan Ghandchi, Majid Samsami, Javad Zebarjadi Bagherpour
Summary: The prevalence of CCHF is increasing in Afghanistan, with a majority of cases seeking medical care during the late phase of infection, which could negatively impact treatment efficacy. Impaired Alanine aminotransferase (ALT), hemorrhagic manifestations (including epistaxis), and impaired consciousness were factors associated with a higher mortality rate, potentially providing clues for early effective interventions.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Virology
Kubra Dogan, Serkan Bolat, Caner Oksuz, Seyit Ali Buyuktuna
Summary: Crimean-Congo hemorrhagic fever (CCHF) is a viral infection disease with unknown pathophysiology. This study investigated the levels of lipid mediators and cytokines in CCHF patients. The results showed lower 5-LO levels and higher ferritin and IL-6 levels in patients compared to healthy controls. No significant differences were found in CYSLT levels between patients and controls. The study suggests that changes in 5-LO enzyme and increased inflammation play a role in CCHF.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Infectious Diseases
Stella A. Atim, Shirin Ashraf, Sandra Belij-Rammerstorfer, Anna R. Ademun, Patrick Vudriko, Teddy Nakayiki, Marc Niebel, James Shepherd, Stephen Balinandi, Gladys Nakanjako, Andrew Abaasa, Paul C. D. Johnson, Steven Odongo, Martin Esau, Milton Bahati, Pontiano Kaleebu, Julius J. Lutwama, Charles Masembe, Teresa Lambe, Emma C. Thomson, Robert Tweyongyere
Summary: The study reveals a high prevalence of Crimean-Congo Haemorrhagic Fever (CCHF) in livestock farming communities in Uganda, with factors such as livestock farming, age, and collecting/eating engorged ticks associated with human seropositivity. This emphasizes the importance of further surveillance and control measures against the disease.
JOURNAL OF INFECTION
(2022)
Article
Pharmacology & Pharmacy
Sergio E. Rodriguez, David W. Hawman, Teresa E. Sorvillo, T. Justin O'Neal, Brian H. Bird, Luis L. Rodriguez, Eric Bergeron, Stuart T. Nichol, Joel M. Montgomery, Christina F. Spiropoulou, Jessica R. Spengler
Summary: This article reviews the progress in immunobiology research of Crimean-Congo hemorrhagic fever virus (CCHFV), including the relationship between different outcomes and disease severity, and provides recommendations for future research.
ANTIVIRAL RESEARCH
(2022)
Article
Infectious Diseases
Nikolay Tsapko, Anna S. Volynkina, Anna Yu Evchenko, Yana Lisitskaya, Ludmila Shaposhnikova
Summary: Crimean-Congo hemorrhagic fever (CCHF) plays a central role in tick-borne infections in southern Russia, with an expansion of the disease across regions. Ticks are the main vectors and reservoirs of the CCHF virus (CCHFV), which has been detected in 33 tick species. The study found the virus in various tick species, with H. marginatum being the main vector.
TICKS AND TICK-BORNE DISEASES
(2022)
Review
Microbiology
Aranzazu Portillo, Ana M. Palomar, Paula Santibanez, Jose A. Oteo
Summary: Crimean-Congo hemorrhagic fever virus (CCHFV) is a potentially fatal virus transmitted by ticks, widely distributed in Africa, Asia, and Europe. Recent cases in Western Europe and Spain suggest the possibility of virus transmission through ticks and migratory birds.
Article
Microbiology
Ayman Ahmed, Yousif Ali, Bashir Salim, Isabelle Dietrich, Jakob Zinsstag
Summary: This study reviewed the epidemiological reports of Crimean-Congo hemorrhagic fever (CCHF) in Sudan between 2010 and 2020. It identified 88 cases of CCHF, including 13 fatalities, with the majority concentrated in the Kordofan region. The study calls for the establishment of a genomic-based integrated One Health surveillance and response system.
Review
Medicine, General & Internal
Aykut Ozdarendeli
Summary: Crimean-Congo hemorrhagic fever virus (CCHFV) is a highly infectious virus transmitted to humans through tick bites or contact with infected animal blood, causing severe symptoms and a high mortality rate. The lack of effective medical countermeasures and its potential for global spread have made CCHFV a high-priority pathogen. Recent advances in biotechnology and suitable animal models have accelerated the development of CCHFV vaccines.
Letter
Immunology
Mohammad M. Obaidat, James C. Graziano, Maria Morales-Betoulle, Shelley M. Brown, Cheng-Feng Chiang, John D. Klena
Summary: The epidemiology of Rift Valley fever virus (RVFV) and Crimean-Congo hemorrhagic fever virus (CCHFV) in Jordan is unknown. A study found 3% of tested dairy cattle, sheep, and goats were RVFV seropositive and 14% were CCHFV seropositive. Ongoing surveillance is necessary to evaluate the risk to humans and protect public health.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Aadil A. Patel, Yagnya D. Dalal, Amrita Parikh, Rajkamal Gandhi, Anand Shah
Summary: Crimean-Congo hemorrhagic fever (CCHF) is an emerging zoonotic disease caused by the CCHF virus. It is endemic in Africa, the Balkans, the Middle East, and Asia, with more than 1000 human cases reported annually. The CCHF virus has the widest geographic range among tick-borne viruses that infect humans. Diagnosis of CCHF remains a challenge, especially in non-endemic areas, due to its resemblance with other hemorrhagic fevers.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Review
Virology
Mohammad Fereidouni, Dmitry A. Apanaskevich, David B. Pecor, Natalia Yu. Pshenichnaya, Gulzhan N. Abuova, Farida H. Tishkova, Yekaterina Bumburidi, Xiankun Zeng, Jens H. Kuhn, Maryam Keshtkar-Jahromi
Summary: This study summarizes the status of Crimean-Congo hemorrhagic fever (CCHF) in Central, Eastern, and South-eastern Asia. The risk and burden of CCHF were assessed based on case reports, antibody prevalence, and vector ticks isolation. The majority of cases were reported in Central Asia, while only China reported cases in Eastern Asia. No cases were reported in South-eastern Asia. Countries were classified into different levels based on evidence of CCHF, guiding the strengthening or establishment of CCHF surveillance systems.
Article
Parasitology
Stella A. Atim, Marc Niebel, Shirin Ashraf, Patrick Vudriko, Steven Odongo, Stephen Balinandi, Peace Aber, Ronald Bameka, Anna R. Ademun, Charles Masembe, Robert Tweyongyere, Emma C. Thomson
Summary: Following a human case of CCHF in Lyantonde district, Uganda, a detailed outbreak investigation in the animal population revealed a high circulation of CCHFV among cattle and goats, increasing the environmental risk for future human infections. Therefore, surveillance programs for CCHF in this area and the Ugandan cattle corridor are recommended to prevent and control further cases.
PARASITES & VECTORS
(2023)
Article
Pharmacology & Pharmacy
Jessica R. Spengler, Stephen R. Welch, Florine E. M. Scholte, Sergio E. Rodriguez, Jessica R. Harmon, Joann D. Coleman-McCray, Stuart T. Nichol, Joel M. Montgomery, Eric Bergeron, Christina F. Spiropoulou
Summary: The VRP vaccine provides complete protection against CCHFV when administered 28 days before challenge, and also shows efficacy in protecting mice at different intervals relative to challenge. This supports the utility of the VRP vaccine for rapid vaccination protocols to mitigate CCHFV spread and severe outcomes.
ANTIVIRAL RESEARCH
(2021)
Article
Immunology
Johan Espunyes, Oscar Cabezon, Lola Pailler-Garcia, Andrea Dias-Alves, Lourdes Lobato-Bailon, Ignasi Marco, Maria P. Ribas, Pedro E. Encinosa-Guzman, Marta Valldeperes, Sebastian Napp
Summary: A serosurvey in Catalonia, northeastern Spain, found high seroprevalence of Crimean-Congo hemorrhagic fever virus antibodies in southern Catalonia, indicating potential presence of competent virus vectors in the region.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Virology
Serdal Arslan, Burcu Bayyurt, Aynur Engin, Mehmet Bakir
Summary: The study identified significant changes in miRNA expression in patients with Crimean Congo hemorrhagic fever, with some miRNAs showing differential expression in acute and severe cases. These miRNAs are associated with antiviral and proinflammatory pathways, suggesting potential therapeutic targets for the acute phase of the disease.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Medicine, General & Internal
Hirawati Deval, Dimpal A. Nyayanit, Shailendra Kumar Mishra, Pragya D. Yadav, Kamran Zaman, Prem Shankar, Brij R. Misra, Sthita Pragnya Behera, Niraj Kumar, Abhinendra Kumar, Pooja Bhardwaj, Gaurav Raj Dwivedi, Rajeev Singh, Anita M. Shete, Priyanka Pandit, Ashok K. Pandey, Girijesh Kumar Yadav, Shashi Gupta, Manoj Kumar, Asif Kavathekar, Ravi Shankar Singh, Sanjay Prajapati, Rajni Kant
Summary: This study sequenced and analyzed the genomes of SARS-CoV-2 in Uttar Pradesh, India, and found different evolutionary patterns and variants between the first and second waves of the virus. The introduction of more variants of concern in the second wave has important implications for vaccine and drug development.
FRONTIERS IN MEDICINE
(2022)
Letter
Infectious Diseases
Pragya D. Yadav, Rima R. Sahay, Sachee Agrawal, Anita Shete, Balkrishna Adsul, Srikanth Tripathy, Dimpal A. Nyayanit, Manish Manrai, Deepak Y. Patil, Sanjay Kumar, Vikas Marwah, Gajanan N. Sapkal, Jayanthi Shastri, Rajlakshmi Viswanathan, Priyanka Pandit, Yogendra Mishra, Smita Chavan, Yash Joshi, T. Ajai Kumar, Triparna Majumdar, Abhinendra Kumar, Savita Patil, Renuka Munshi, Unnati Desai, Himanshu Kaushal, Annasaheb Suryawanshi, Manisha Dudhmal, Pranita Gawande, Rajlaxmi Jain, Ashwini Waghmare, Kaumudi Kalele, Pratiksha Vedpathak, Jyoti Yemul, Poonam Bodke, Tejashri Kore, A. L. Kakrani, Prachi Athavale, Poonam Suryawanshi, Sudhir Patsute, Vikram Padbidri, Pradip Awate, Priya Abraham
JOURNAL OF INFECTION
(2022)
Article
Virology
Pragya D. Yadav, Dimpal A. Nyayanit, Nivedita Gupta, Jayanthi Shastri, Rima R. Sahay, Deepak Y. Patil, Anita M. Shete, Alpana Razdan, Sachee Agrawal, Abhinendra Kumar, Triparna Majumdar, Savita Patil, Prasad Sarkale, Shreekant Baradkar, Manisha Dudhmal, Harmanmeet Kaur, Neeraj Aggarwal
Summary: International travel has been identified as the main cause of the rapid spread of new SARS-CoV-2 variants worldwide. Genomic surveillance of SARS-CoV-2 revealed that out of 212 positive clinical specimens, 90 had complete SARS-CoV-2 genomes, including 14 with the Eta variant from international travelers and local residents in India. The detection of the Eta variant with the lethal E484K mutation highlights the importance of ongoing genomic surveillance and preventive measures.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Public, Environmental & Occupational Health
Jeromie Wesley Vivian Thangaraj, Muthusamy Santhosh Kumar, C. P. Girish Kumar, Pragya Yadav, D. Sudha Rani, T. Karunakaran, Manoj Murhekar
Summary: This study in Chennai, India examined the second wave of COVID-19 cases and found that reinfection was not a major reason for the surge in cases. The presence of IgG antibodies in unvaccinated COVID-19 patients could provide early indications of the extent of reinfections in the area.
FRONTIERS IN PUBLIC HEALTH
(2022)
Letter
Infectious Diseases
Anita M. Shete, Pragya D. Yadav, Abhinendra Kumar, Savita Patil, Deepak Y. Patil, Yash Joshi, Triparna Majumdar, Vineet Relhan, Rima R. Sahay, Meenakshy Vasu, Pranita Gawande, Ajay Verma, Arbind Kumar, Shivram Dhakad, Anukumar Bala Krishnan, Shubin Chenayil, Suresh Kumar, Priya Abraham
JOURNAL OF INFECTION
(2023)
Article
Virology
Vineet Relhan, Rima R. Sahay, Anita M. Shete, Pragya D. Yadav, Bijaylaxmi Sahoo, Deepak Y. Patil, Suresh Kumar, Kannan Sabarinath Premachandran Syamaladevi, Lalit Dar, Sreelekshmy Mohandas, Priya Abraham
Summary: This study describes the clinical and demographic characteristics of five confirmed cases of monkeypox in New Delhi, India, without international travel history. The study examines the viral load and clearance kinetics in various samples and highlights the underdiagnosed monkeypox infection in the community. The findings emphasize the importance of active surveillance in high-risk populations.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Letter
Infectious Diseases
Rima R. Sahay, Deepak Y. Patil, Gajanan N. Sapkal, Anita M. Shete, Pragya D. Yadav
INFECTIOUS DISEASES
(2023)
Article
Virology
Pragya D. Yadav, Sanjay Kumar, Kshitij Agarwal, Mukul Jain, Dilip R. Patil, Kapil Maithal, Basavaraj Mathapati, Suresh Giri, Sreelekshmy Mohandas, Anita Shete, Gajanan Sapkal, Deepak Y. Patil, Ayan Dey, Harish Chandra, Gururaj Deshpande, Nivedita Gupta, Priya Abraham, Himanshu Kaushal, Rima R. Sahay, Anuradha Tripathy, Dimpal Nyayanit, Rajlaxmi Jain, Abhimanyu Kumar, Prasad Sarkale, Shreekant Baradkar, Chozhavel Rajanathan, Hari Prasad Raju, Satish Patel, Niraj Shah, Pankaj Dwivedi, Dharmendra Singh
Summary: The development of a needle-free injection system (NFIS) has addressed concerns about injection site pain, bloodborne pathogen transmission, and mass immunization. This study evaluated the efficacy of NFIS and needle injection system (NIS) for delivering the DNA vaccine candidate ZyCoV-D in rhesus macaques against SARS-CoV-2 infection. The results showed that the 2 mg dose delivered by NFIS induced significant IgG and neutralizing antibody titers, with further increases after virus challenge. NFIS also stimulated increased lymphocyte proliferation and cytokine response. This study demonstrated the efficiency of NFIS in delivering the 2 mg ZyCoV-D vaccine candidate.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Rima R. Sahay, Pragya D. Yadav, Ashok Nandapurkar, Rutuja Dhawde, Annasaheb Suryawanshi, Deepak Y. Patil, Anita M. Shete, Gajanan N. Sapkal, Milind Kulkarni, Yogesh K. Gurav, Gururaj R. Deshpande, Jagdevi S. Ghodke, Rajlaxmi Jain, Raj Hawale, Kaumudi Kalele, Jyoti Yemul, Pranita Gawande, Priya Abraham
Summary: This study evaluated the immune response of two doses of Covaxin given one month apart in two adult populations (COVID-19 naive-vaccinated individuals and COVID-19 recovered individuals). The study observed a sustained immune response with the presence of antibodies for up to six months after vaccination. The findings highlight the importance of a booster dose after six months of vaccination.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2023)
Letter
Virology
Pragya D. Yadav, Meenakshy Vasu, Fazil Abubaker, Rima R. Sahay, Aravind Reghukumar, Anukumar Bala Krishnan, Kavya Prabha, Asha Konipparambil Papu, Lakshmi Geetha Gopalakrishnan, Nizamuddin Mundangalam, Aboobaker Siddiq, Deepak Y. Patil, Anita M. Shete, Priya Abraham, Anoop Rajendra Prasad, Anoop Thavakara Koolothuvalappil, Kavya Karunakaran
JOURNAL OF MEDICAL VIROLOGY
(2023)
Letter
Virology
Anita M. Shete, Deepak Y. Patil, Rajlaxmi Jain, Rima R. Sahay, Shubin Chenayil, Sreelekshmy Mohandas, Pragya D. Yadav
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Infectious Diseases
Ashok Munivenkatappa, Pragya D. Yadav, Rima R. Sahay, S. K. Kiran, Anita M. Shete, Deepak Y. Patil, Sreelekshmy Mohandas, Rajlaxmi Jain, Savita Patil, Diamond P. Sinha, Manjunatha M. Jayaswamy
Summary: This study investigated suspected human cases of Kyasanur Forest Disease (KFD) in Karnataka state, India from December 2018 to June 2019. It found endemicity of KFD in many districts and confirmed the presence of KFDV for the first time in two new districts, i.e. Hassan and Mysore. The study also analyzed the KFDV infection among vaccinated and non-vaccinated populations, finding insignificant differences.
INFECTIOUS DISEASES
(2023)
