Article
Infectious Diseases
Shohra Qaderi, Masoud Mardani, Asghar Shah, Jaffer Shah, Narges Bazgir, Jalal Sayad, Ehsan Ghandchi, Majid Samsami, Javad Zebarjadi Bagherpour
Summary: The prevalence of CCHF is increasing in Afghanistan, with a majority of cases seeking medical care during the late phase of infection, which could negatively impact treatment efficacy. Impaired Alanine aminotransferase (ALT), hemorrhagic manifestations (including epistaxis), and impaired consciousness were factors associated with a higher mortality rate, potentially providing clues for early effective interventions.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Virology
Kubra Dogan, Serkan Bolat, Caner Oksuz, Seyit Ali Buyuktuna
Summary: Crimean-Congo hemorrhagic fever (CCHF) is a viral infection disease with unknown pathophysiology. This study investigated the levels of lipid mediators and cytokines in CCHF patients. The results showed lower 5-LO levels and higher ferritin and IL-6 levels in patients compared to healthy controls. No significant differences were found in CYSLT levels between patients and controls. The study suggests that changes in 5-LO enzyme and increased inflammation play a role in CCHF.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Infectious Diseases
Stella A. Atim, Shirin Ashraf, Sandra Belij-Rammerstorfer, Anna R. Ademun, Patrick Vudriko, Teddy Nakayiki, Marc Niebel, James Shepherd, Stephen Balinandi, Gladys Nakanjako, Andrew Abaasa, Paul C. D. Johnson, Steven Odongo, Martin Esau, Milton Bahati, Pontiano Kaleebu, Julius J. Lutwama, Charles Masembe, Teresa Lambe, Emma C. Thomson, Robert Tweyongyere
Summary: The study reveals a high prevalence of Crimean-Congo Haemorrhagic Fever (CCHF) in livestock farming communities in Uganda, with factors such as livestock farming, age, and collecting/eating engorged ticks associated with human seropositivity. This emphasizes the importance of further surveillance and control measures against the disease.
JOURNAL OF INFECTION
(2022)
Article
Pharmacology & Pharmacy
Sergio E. Rodriguez, David W. Hawman, Teresa E. Sorvillo, T. Justin O'Neal, Brian H. Bird, Luis L. Rodriguez, Eric Bergeron, Stuart T. Nichol, Joel M. Montgomery, Christina F. Spiropoulou, Jessica R. Spengler
Summary: This article reviews the progress in immunobiology research of Crimean-Congo hemorrhagic fever virus (CCHFV), including the relationship between different outcomes and disease severity, and provides recommendations for future research.
ANTIVIRAL RESEARCH
(2022)
Article
Infectious Diseases
Nikolay Tsapko, Anna S. Volynkina, Anna Yu Evchenko, Yana Lisitskaya, Ludmila Shaposhnikova
Summary: Crimean-Congo hemorrhagic fever (CCHF) plays a central role in tick-borne infections in southern Russia, with an expansion of the disease across regions. Ticks are the main vectors and reservoirs of the CCHF virus (CCHFV), which has been detected in 33 tick species. The study found the virus in various tick species, with H. marginatum being the main vector.
TICKS AND TICK-BORNE DISEASES
(2022)
Review
Microbiology
Aranzazu Portillo, Ana M. Palomar, Paula Santibanez, Jose A. Oteo
Summary: Crimean-Congo hemorrhagic fever virus (CCHFV) is a potentially fatal virus transmitted by ticks, widely distributed in Africa, Asia, and Europe. Recent cases in Western Europe and Spain suggest the possibility of virus transmission through ticks and migratory birds.
Article
Microbiology
Ayman Ahmed, Yousif Ali, Bashir Salim, Isabelle Dietrich, Jakob Zinsstag
Summary: This study reviewed the epidemiological reports of Crimean-Congo hemorrhagic fever (CCHF) in Sudan between 2010 and 2020. It identified 88 cases of CCHF, including 13 fatalities, with the majority concentrated in the Kordofan region. The study calls for the establishment of a genomic-based integrated One Health surveillance and response system.
Article
Virology
Serdal Arslan, Burcu Bayyurt, Aynur Engin, Mehmet Bakir
Summary: The study identified significant changes in miRNA expression in patients with Crimean Congo hemorrhagic fever, with some miRNAs showing differential expression in acute and severe cases. These miRNAs are associated with antiviral and proinflammatory pathways, suggesting potential therapeutic targets for the acute phase of the disease.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Review
Immunology
Hamid Sadeghi, Farhad Nikkhahi, Mohammad Reza Maleki, Aboutaleb Simiari, Mehdi Bakht, Saeideh Gholamzadeh Khoei
Summary: Crimean-Congo haemorrhagic fever (CCHF) is a re-emerging viral haemorrhagic fever that has caused outbreaks in Iran over the past 15 years. This systematic review and meta-analysis evaluated the prevalence of CCHF virus (CCHFV) in ticks. The findings showed a pooled prevalence of 6.0% with higher rates in regions with specific environmental characteristics. Given the importance of CCHF, further epidemiological studies on ticks are recommended in affected provinces and adjacent areas.
MICROBIAL PATHOGENESIS
(2023)
Article
Virology
Serdal Arslan, Mehmet Bakir, Burcu Bayyurt, Eylem Aydemir, Kenan Kinaci, Aynur Engin
Summary: This study investigated the lncRNA gene expression profiles in CCHF using microarray for the first time. Several lncRNAs were found to be significantly regulated in both case and fatal case groups. These lncRNAs could be considered as important therapeutic targets for further studies on CCHF.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Review
Medicine, General & Internal
Aykut Ozdarendeli
Summary: Crimean-Congo hemorrhagic fever virus (CCHFV) is a highly infectious virus transmitted to humans through tick bites or contact with infected animal blood, causing severe symptoms and a high mortality rate. The lack of effective medical countermeasures and its potential for global spread have made CCHFV a high-priority pathogen. Recent advances in biotechnology and suitable animal models have accelerated the development of CCHFV vaccines.
Letter
Immunology
Mohammad M. Obaidat, James C. Graziano, Maria Morales-Betoulle, Shelley M. Brown, Cheng-Feng Chiang, John D. Klena
Summary: The epidemiology of Rift Valley fever virus (RVFV) and Crimean-Congo hemorrhagic fever virus (CCHFV) in Jordan is unknown. A study found 3% of tested dairy cattle, sheep, and goats were RVFV seropositive and 14% were CCHFV seropositive. Ongoing surveillance is necessary to evaluate the risk to humans and protect public health.
EMERGING INFECTIOUS DISEASES
(2021)
Review
Virology
Mohammad Fereidouni, Dmitry A. Apanaskevich, David B. Pecor, Natalia Yu. Pshenichnaya, Gulzhan N. Abuova, Farida H. Tishkova, Yekaterina Bumburidi, Xiankun Zeng, Jens H. Kuhn, Maryam Keshtkar-Jahromi
Summary: This study summarizes the status of Crimean-Congo hemorrhagic fever (CCHF) in Central, Eastern, and South-eastern Asia. The risk and burden of CCHF were assessed based on case reports, antibody prevalence, and vector ticks isolation. The majority of cases were reported in Central Asia, while only China reported cases in Eastern Asia. No cases were reported in South-eastern Asia. Countries were classified into different levels based on evidence of CCHF, guiding the strengthening or establishment of CCHF surveillance systems.
Article
Parasitology
Stella A. Atim, Marc Niebel, Shirin Ashraf, Patrick Vudriko, Steven Odongo, Stephen Balinandi, Peace Aber, Ronald Bameka, Anna R. Ademun, Charles Masembe, Robert Tweyongyere, Emma C. Thomson
Summary: Following a human case of CCHF in Lyantonde district, Uganda, a detailed outbreak investigation in the animal population revealed a high circulation of CCHFV among cattle and goats, increasing the environmental risk for future human infections. Therefore, surveillance programs for CCHF in this area and the Ugandan cattle corridor are recommended to prevent and control further cases.
PARASITES & VECTORS
(2023)
Article
Immunology
Johan Espunyes, Oscar Cabezon, Lola Pailler-Garcia, Andrea Dias-Alves, Lourdes Lobato-Bailon, Ignasi Marco, Maria P. Ribas, Pedro E. Encinosa-Guzman, Marta Valldeperes, Sebastian Napp
Summary: A serosurvey in Catalonia, northeastern Spain, found high seroprevalence of Crimean-Congo hemorrhagic fever virus antibodies in southern Catalonia, indicating potential presence of competent virus vectors in the region.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Immunology
Shadi Aghamohammad, Hossein Ahangari Cohan, Ahmad Ghasemi, Ehsan Mostafavi, Mahdi Rohani
Summary: This study aimed to investigate the isolation of Francisella tularensis in different water samples from East Azerbaijan, Iran. Despite the unsuccessful isolation of F. tularensis, molecular testing indicated the presence of the bacteria in surface water, with the highest rate detected in injected mice based on molecular methods.
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
(2022)
Article
Immunology
Maryam Rahravani, Meysam Moravedji, Ehsan Mostafavi, Neda Baseri, Hamid Seyfi, Mehrdad Mohammadi, Amir Hossein Ziaei, Mohammad Mahdi Mozoum, Mina Latifian, Saber Esmaeili
Summary: The study detected Francisella tularensis in small ruminants and ticks in Kurdistan province, confirming the presence of the bacteria in ticks and suggesting the possibility of transmission to livestock and humans through tick bites in the region.
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Mina Latifian, Mohammad Khalili, Mehrdad Farrokhnia, Ehsan Mostafavi, Saber Esmaeili
Summary: This case report describes a patient in Iran who was diagnosed with Mediterranean spotted fever (MSF) caused by Rickettsia conorii. The study highlights the importance of identifying endemic areas for MSF in Iran.
BMC INFECTIOUS DISEASES
(2022)
Article
Immunology
Faranak Abdoli, Ehsan Mostafavi, Saber Esmaeili, Mahdi Rohani
Summary: This study investigated the prevalence of Rickettsia spp. in ticks in Southeastern Iran. The results showed that approximately 3.24% of the samples were positive for Rickettsia spp., with two samples closely related to R. rhipicephali and four samples closely related to R. massiliae. The findings are important for the detection and epidemiology of Rickettsia spp. in Iran, highlighting the necessity of prevention and control measures for rickettsiosis.
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
(2022)
Article
Veterinary Sciences
Maryam Rahravani, Meysam Moravedji, Ehsan Mostafavi, Mehrdad Mohammadi, Hamid Seyfi, Neda Baseri, Mohammad Mahdi Mozoun, Mina Latifian, Saber Esmaeili
Summary: This study investigated C. burnetii infection in small ruminants and their ticks in western Iran. Results showed the presence of C. burnetii DNA in the samples, indicating a possible role of ticks in the epidemiology of Q fever in Iran.
BMC VETERINARY RESEARCH
(2022)
Article
Parasitology
Saber Esmaeili, Ahmad Ghasemi, Parisa Esmaeili, Farshid Rezaie, Minoo Mohraz, Max Maurin, Ehsan Mostafavi
Summary: This article reports an unusual case of tularemia and highlights the neglect of this disease by the healthcare system in some countries. It emphasizes the need to increase awareness among physicians about tularemia.
Article
Public, Environmental & Occupational Health
Ali Mohammadi, Ehsan Mostafavi, Morteza Zaim, AhmadAli Enayati, Hamid Reza Basseri, AbdolReza Mirolyaei, Jamshid Poormozafari, Mohammad Mahdi Gouya
Summary: The study aimed to determine the sources and volume of tire imports in Iran and map the points of entry for entomological surveillance. The results showed that about one-third of Iran's annual tire requirements were imported from 15 countries, most of which were endemic to Aedes aegypti and Ae. albopictus. The majority of tire imports were made through southern ports and the main depot sites were located in four provinces, with special importance given to the border region with Pakistan.
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2022)
Article
Microbiology
Ashraf Mohabati Mobarez, Neda Baseri, Mohammad Khalili, Ehsan Mostafavi, John Stenos, Saber Esmaeili
Summary: This study evaluated the genetic diversity of Coxiella burnetii in Iran using the multi-spacer sequence typing (MST) method. The results revealed the circulation of five MST genotypes among Iranian domestic ruminants, including four novel genotypes. Understanding the genotypic profiles of C. burnetii is crucial for preventing Q fever outbreaks.
Article
Microbiology
Neda Baseri, Mostafa Salehi-Vaziri, Ehsan Mostafavi, Fahimeh Bagheri Amiri, Mina Latifian, John Stenos, Saber Esmaeili
Summary: This study investigated the prevalence of Rickettsia conorii among suspected Crimean-Congo hemorrhagic fever patients in Iran. The results showed that Rickettsia conorii is indeed present in Iran and can be misdiagnosed with other febrile syndromes.
Article
Multidisciplinary Sciences
Ahmad Ghasemi, Mina Latifian, Saber Esmaeili, Saied Reza Naddaf, Ehsan Mostafavi
Summary: This study conducted sample collection and molecular detection of ticks in northeastern Iran, finding multiple species of Rickettsia bacteria and suggesting the significant role of ticks in the transmission of these pathogens. The research findings are of great importance for understanding and preventing tick-borne diseases.
Article
Microbiology
Sana Eybpoosh, Alireza Biglari, Rahim Sorouri, Fatemeh Ashrafian, Mona Sadat Larijani, Vicente Verez-Bencomo, Maria Eugenia Toledo-Romani, Carmen Valenzuela Silva, Mostafa Salehi-Vaziri, Sarah Dahmardeh, Delaram Doroud, Mohammad Banifazl, Ehsan Mostafavi, Anahita Bavand, Amitis Ramezani
Summary: This study evaluated and compared the efficacy of PastoCovac Plus protein-subunit vaccine with ChAdOx1-S and BBIBP-CorV in volunteers who had been primed with two doses of ChAdOx1-S or BBIBP-CorV vaccines. The results showed that PastoCovac Plus effectively increased specific antibody levels and could be used in heterologous regimens to boost humoral immune responses.
Article
Public, Environmental & Occupational Health
Amin Doosti-Irani, Saiedeh Haji-Maghsoudi, Aliakbar Haghdoost, Sana Eybpoosh, Ehsan Mostafavi, Manoochehr Karami, Hossein Mahjub
Summary: This study aimed to determine the generation time of COVID-19 in Iran, find the best model for estimating the reproduction number, and calculate the basic and effective reproduction numbers. The results showed that the time-dependent model was the best fit for estimating the reproduction number in Iran. The epidemic situation varied greatly between February and December, with the worst weeks occurring before February and in October.
IRANIAN JOURNAL OF PUBLIC HEALTH
(2022)
Article
Parasitology
Ali Mohammadi, Arezoo Bozorgomid, Mohammad Mehdi Sedaghat, GholamReza Mowlavi, Mohammad Reza Abai, Ehsan Mostafavi
Summary: This study evaluated the rate of endoparasite infection among rodents in western regions of Iran and found a higher variety of rodents and worm parasites in these areas.
IRANIAN JOURNAL OF PARASITOLOGY
(2022)
Letter
Immunology
Saber Esmaeili, Mina Latifian, Mohammad Khalili, Mehrdad Farrokhnia, John Stenos, Mehdi Shafiei, Ehsan Mostafavi
Summary: A fatal case of Mediterranean spotted fever associated with septic shock was reported in a 61-year-old man living in a village in southeastern Iran. The patient had a history of tick bite a few days before symptom onset. Phylogenetic analysis confirmed infection by Rickettsia conorii subspecies israelensis.
EMERGING INFECTIOUS DISEASES
(2022)
Review
Psychology, Multidisciplinary
Hamid Sharif Nia, Mohammad Heidari, Navaz Naghavi, Rebecca H. Lehto, Ali Akbar Haghdoost, Azar Jafari-Koulaee, Yasaman Hatef Matbue, Ameneh Yaghoobzadeh, Amir Hossein Goudarzian, Saeed Pahlevan Sharif
Summary: This study analyzed the age changes in suicide behavior in Iran, and the results showed that the average age of suicide for men and women in Iran is 29.8 and 27.4 years old respectively. The eastern and central regions of Iran have the highest rates of completed suicide. The findings emphasize the critical importance of increasing awareness and reducing suicidal behavior in Iran through educational programs and public health campaigns.
OMEGA-JOURNAL OF DEATH AND DYING
(2022)