4.7 Letter

Sickle-cell erythrocytes in the placentas of dengue-infected women

Journal

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
Volume 16, Issue 1, Pages E72-E72

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.ijid.2011.09.005

Keywords

-

Ask authors/readers for more resources

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Infectious Diseases

Post-acute COVID-19 syndrome after reinfection and vaccine breakthrough by the SARS-CoV-2 Gamma variant in Brazil

Stephanie L. S. Penetra, Michele F. B. da Silva, Paola Resende, Anielle Pina-Costa, Heloisa F. P. Santos, Lusiele Guaraldo, Guilherme A. Calvet, Maria Ogrzewalska, Ighor Arantes, Ketiuce Zukeram, Mia F. de Araujo, Ana Beatriz Machado Lima, Renata Serrano Lopes, Larissa R. Lira-Silva, Isabella Moraes, Mayumi D. Wakimoto, Trevon L. Fuller, Claudia Raja Gabaglia, Otavio M. Espindola, Myrna C. Bonaldo, Claudio Tadeu Daniel-Ribeiro, Jimmy Whitworth, Chris Smith, Karin Nielsen-Saines, Alex Pauvolid-Correa, Marilda M. Siqueira, Patricia Brasil

Summary: We report a case of prolonged COVID-19 caused by the SARS-CoV-2 Gamma variant in a fully vaccinated healthcare worker. Infections were confirmed by whole-genome sequencing and detection of neutralizing antibodies. Considering multiple factors, the healthcare worker may have benefited from an additional dose of a heterologous vaccine.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2022)

Article Immunology

Early Predictors of Poor Neurologic Outcomes in a Prospective Cohort of Infants With Antenatal Exposure to Zika Virus

Sophia Finn Tiene, Jessica S. Cranston, Karin Nielsen-Saines, Tara Kerin, Trevon Fuller, Zilton Vasconcelos, Peter B. Marschik, Dajie Zhang, Marcos Pone, Sheila Pone, Andrea Zin, Elizabeth Brickley, Dulce Orofino, Patricia Brasil, Kristina Adachi, Ana Carolina C. da Costa, Maria Elisabeth Lopes Moreira

Summary: This study aimed to identify early predictors of poor neurodevelopment in infants with antenatal Zika virus exposure. The findings suggest that smaller head circumference and auditory abnormalities are associated with poor neurodevelopment in these infants. Language delay is the most prominent developmental concern.

PEDIATRIC INFECTIOUS DISEASE JOURNAL (2022)

Article Immunology

Longitudinal Evaluation of Antibody Persistence in Mother-Infant Dyads After Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Pregnancy

Mary C. Cambou, Christine M. Liu, Thalia Mok, Viviana Fajardo-Martinez, Sophia G. Paiola, Francisco J. Ibarrondo, Tara Kerin, Trevon Fuller, Nicole H. Tobin, Gustavo Garcia, Debika Bhattacharya, Grace M. Aldrovandi, Vaithilingaraja Arumugaswami, Suan-Sin Foo, Jae U. Jung, Zilton Vasconcelos, Patricia Brasil, Michelle Brendolin, Otto O. Yang, Rashmi Rao, Karin Nielsen-Saines

Summary: Vaccination in pregnant women with COVID-19 can boost antibodies in mother-infant dyads. Antibody levels in infants were higher at birth but decreased after 6 months.

JOURNAL OF INFECTIOUS DISEASES (2023)

Article Immunology

Circulation of Vaccine-derived Rotavirus G1P[8] in a Vulnerable Child Cohort in Rio de Janeiro

Denise Cotrim da Cunha, Trevon Fuller, Carina Pacheco Cantelli, Marcia Terezinha Baroni de Moraes, Jose Paulo Gagliardi Leite, Filipe Anibal Carvalho-Costa, Patricia Brasil

Summary: This study aimed to evaluate the shedding of rotavirus vaccine strain and acute diarrheal disease (ADD) before and after immunization through 24 months of age. The results showed that the shedding of vaccine strain still occurred in unvaccinated individuals, but the vaccine strains remained at a low level after immunization, supporting the high effectiveness of rotavirus vaccines.

PEDIATRIC INFECTIOUS DISEASE JOURNAL (2023)

Article Virology

Ecological, Genetic, and Phylogenetic Aspects of YFV 2017-2019 Spread in Rio de Janeiro State

Ieda Pereira Ribeiro, Edson Delatorre, Filipe Vieira Santos de Abreu, Alexandre Araujo Cunha dos Santos, Nathalia Dias Furtado, Anielly Ferreira-de-Brito, Anielle de Pina-Costa, Maycon Sebastiao Alberto Santos Neves, Marcia Goncalves de Castro, Monique de Albuquerque Motta, Patricia Brasil, Ricardo Lourenco-de-Oliveira, Myrna Cristina Bonaldo

Summary: A study analyzed the yellow fever virus in the Rio de Janeiro region of Brazil and found that the genetic diversity and spatial distribution of the virus originated from multiple introductions and dissemination chains. This has important implications for predicting, controlling, and preventing yellow fever outbreaks.

VIRUSES-BASEL (2023)

Article Medicine, General & Internal

Neuromotor repertoires in infants exposed to maternal COVID-19 during pregnancy: a cohort study

Viviana Fajardo Martinez, Dajie Zhang, Sophia Paiola, Thalia Mok, Mary C. Cambou, Tara Kerin, Rashmi Rao, Patricia Brasil, Fatima Ferreira, Trevon Fuller, Debika Bhattacharya, Suan-Sin Foo, Weiqiang Chen, Jae Jung, Christa Einspieler, Peter B. Marschik, Karin Nielsen-Saines

Summary: This longitudinal cohort study evaluated neuromotor development in infants exposed to antenatal COVID-19. It found that compared to pre-pandemic controls, infants exposed to COVID-19 were more likely to have suboptimal neuromotor development.

BMJ OPEN (2023)

Article Infectious Diseases

Clinical markers of post-Chikungunya chronic inflammatory joint disease: A Brazilian cohort

Carolina dos Santos Lazari, Mariana Severo Ramundo, Felipe ten-Caten, Clarisse S. Bressan, Ana Maria Bispo de Filippis, Erika Regina Manuli, Isabella de Moraes, Geovana Maria Pereira, Marina Farrel Cortes, Darlan da Silva Candido, Alexandra L. Gerber, Ana Paula Guimaraes, Nuno Rodrigues Faria, Helder I. Nakaya, Ana Tereza R. Vasconcelos, Patricia Brasil, Glaucia Paranhos-Baccala, Ester Cerdeira Sabino

Summary: This study provides important insights into the prognostic evaluation of CHIKF, identifying sub-acute disease as a relevant predictor of evolution to chronic arthritis. Joint pain, edema, and multiple joint involvement were found to be risk factors for chronification.

PLOS NEGLECTED TROPICAL DISEASES (2023)

Article Microbiology

Histopathological and immunological characteristics of placentas infected with chikungunya virus

Natalia Salomao, Kissila Rabelo, Elyzabeth Avvad-Portari, Carlos Basilio-de-Oliveira, Rodrigo Basilio-de-Oliveira, Fatima Ferreira, Luiz Ferreira, Thiara Manuele de Souza, Priscila Nunes, Monique Lima, Anna Paula Sales, Regina Fernandes, Luiz Jose de Souza, Laura Dias, Patricia Brasil, Flavia dos Santos, Marciano Paes

Summary: This study investigates the role of placenta in the transmission of CHIKV and the effects of infection on the maternal-fetal interface. Results show that CHIKV infection disrupts placental homeostasis, leading to histopathological alterations and increased cellularity and cytokine release, creating an altered and harmful environment for the pregnant woman and fetus.

FRONTIERS IN MICROBIOLOGY (2022)

Article Infectious Diseases

Accuracy of saliva for SARS-CoV-2 detection in outpatients and their household contacts during the circulation of the Omicron variant of concern

Guilherme Calvet, Maria Ogrzewalska, Wagner Tassinari, Lusiele Guaraldo, Paola Resende, Trevon Fuller, Stephanie Penetra, Michele Borges, Anielle Pina-Costa, Ezequias Martins, Isabella Moraes, Heloisa Santos, Luana Damasceno, Fernando Medeiros-Filho, Otavio Espindola, Fernando Mota, Valeria Nacife, Alex Pauvolid-Correa, Jimmy Whitworth, Chris Smith, Marilda Siqueira, Patricia Brasil

Summary: Saliva is a reliable sample for detecting SARS-CoV-2, especially in symptomatic children and adolescents during the circulation of the Omicron variant.

BMC INFECTIOUS DISEASES (2023)

Article Virology

Infectious SARS-CoV-2 Particles from Rectal Swab Samples from COVID-19 Patients in Brazil

Ieda Pereira Ribeiro, Lilian Goncalves do Nascimento, Luis Fernando Lopez Tort, Elisa Cavalcante Pereira, Lidiane Souza Raphael Menezes, Fabio Correia Malta, Barbara Cristina Euzebio Pereira Dias de Oliveira, Joao Paulo Rodrigues, Pedro Paulo de Abreu Manso, Marcelo Pelajo, Myrna Cristina Bonaldo, Paola Cristina Resende Silva, Marilda Mendonca Siqueira, Patricia Brasil, Tulio Machado Fumian

Summary: The study investigated the dynamic of SARS-CoV-2 viral excretion in rectal swab, saliva, and nasopharyngeal swab samples from symptomatic patients and asymptomatic contacts. It also evaluated the replication potential of SARS-CoV-2 in the gastrointestinal tract and the excretion of infectious SARS-CoV-2 from feces. The presence of replicating SARS-CoV-2 was found in a small percentage of rectal swab samples, while infectious SARS-CoV-2 was identified in only one sample. The study highlights the need for further research on fecal-oral transmission of SARS-CoV-2.

VIRUSES-BASEL (2023)

Article Multidisciplinary Sciences

SARS-CoV-2 intra-host diversity, antibody response, and disease severity after reinfection by the variant of concern Gamma in Brazil

Felipe Gomes Naveca, Valdinete Alves Nascimento, Fernanda Nascimento, Maria Ogrzewalska, Alex Pauvolid-Correa, Mia Ferreira Araujo, Ighor Arantes, erika Rocha Batista, Alessandro alvares Magalhas, Fernando Vinhal, Tirza Peixoto Mattos, Irina Riediger, Maria do Carmo Debur, Beatriz Grinsztejn, Valdilea G. Veloso, Patricia Brasil, Rodrigo Ribeiro Rodrigues, Darcita Buerger Rovaris, Sandra Bianchini Fernandes, Cristiano Fernandes, Joao Hugo Abdalla Santos, Ligia Fernandes Abdalla, Rubens Costa-Filho, Marineide Silva, Victor Souza, Agatha Araujo Costa, Matilde Mejia, Maria Julia Brandao, Luciana Fe Goncalves, George Allan Silva, Michele Silva de Jesus, Karina Pessoa, Andre de Lima Guerra Corado, Debora Camila Gomes Duarte, Ana Beatriz Machado, Ketiuce de Azevedo Zukeram, Natalia Valente, Renata Serrano Lopes, Elisa Cavalcante Pereira, Luciana Reis Appolinario, Alice Sampaio Rocha, Luis Fernando Lopez Tort, Tsuyoshi Sekizuka, Kentaro Itokawa, Masanori Hashino, Makoto Kuroda, Filipe Zimmer Dezordi, Gabriel Luz Wallau, Edson Delatorre, Tiago Graf, Marilda Mendonca Siqueira, Gonzalo Bello, Paola Cristina Resende

Summary: The rapid spread of the SARS-CoV-2 Variant of Concern (VOC) Gamma in Amazonas during early 2021 fueled a second large COVID-19 epidemic wave and raised concern about the potential role of reinfections. Here we describe 25 cases of SARS-CoV-2 reinfection in Brazil, confirming that individuals were infected with distinct viral lineages during primo-infection and reinfection. Our findings suggest that individuals reinfected with the VOC Gamma may have higher viral loads in the upper respiratory tract, contributing to viral transmission.

SCIENTIFIC REPORTS (2023)

Article Multidisciplinary Sciences

Reduced ability to neutralize the Omicron variant among adults after infection and complete vaccination with BNT162b2, ChAdOx1, or CoronaVac and heterologous boosting

Otavio Melo Espindola, Trevon L. Fuller, Mia Ferreira de Araujo, Luis Fernando Lopez Tort, Lusiele Guaraldo, Guilherme Calvet, Paola Resende, Myrna Bonaldo, Jimmy Whitworth, Chris Smith, Marilda Siqueira, Patricia Brasil

Summary: COVID-19 vaccines have reduced rates of severe infection requiring hospitalization but are less effective against SARS-CoV-2 variants in preventing symptomatic infection. This study examined the antibodies generated after complete vaccination and boosting, finding that binding antibodies decayed slowly in individuals under 60 with hybrid immunity. Neutralizing antibodies against Omicron BA.1 were lower compared to other variants. The response to the first booster dose was stronger than the response to the second booster dose. Monitoring the effects of SARS-CoV-2 mutations on disease severity and therapeutic effectiveness is important.

SCIENTIFIC REPORTS (2023)

Article Infectious Diseases

Challenges of acute febrile illness diagnosis in a national infectious diseases center in Rio de Janeiro: 16-year experience of syndromic surveillance

Clarisse da Silveira Bressan, Maria de Lourdes Benamor Teixeira, Maria Isabel Fragoso da Silveira Gouvea, Anielle de Pina-Costa, Heloisa Ferreira Pinto Santos, Guilherme Amaral Calvet, Otilia Lupi, Andre Machado Siqueira, Rogerio Valls-de-Souza, Clarissa Valim, Patricia Brasil

Summary: This study describes the most common etiologies of acute febrile illnesses observed over a 16-year period in a national reference center for tropical diseases research in Rio de Janeiro, Brazil. Parasitic diseases and tropical infections were found to be the most common diagnoses, with limited accuracy in clinical symptoms and traditional diagnostic methods. Therefore, there is a need for improvement in diagnostic technologies and surveillance capacity.

PLOS NEGLECTED TROPICAL DISEASES (2023)

Article Health Care Sciences & Services

Risk of adverse outcomes in offspring with RT-PCR confirmed prenatal Zika virus exposure: an individual participant data meta-analysis of 13 cohorts in the Zika Brazilian Cohorts Consortium

Ricardo Arraes de Alencar Ximenes, Democrito de Barros Miranda-Filho, Elizabeth B. Brickley, Thalia Velho Barreto de Araujo, Ulisses Ramos Montarroyos, Marilia Rosa Abtibol-Bernardino, Marisa M. Mussi-Pinhata, Geraldo Duarte, Conrado Milani Coutinho, Silvia Fabiana Biason de Moura Negrini, Maria das Gracas Costa Alecrim, Luciola de Fatima Albuquerque de Almeida Peixoto, Maria Elisabeth Lopes Moreira, Andrea Zin, Jose Paulo Pereira Junior, Karin Nielsen-Saines, Celina Maria Turchi Martelli, Laura Cunha Rodrigues, Wayner Vieira de Souza, Liana O. Ventura, Consuelo Silva de Oliveira, Haroldo de Matos, Emilene Monteiro Furtado Serra, Luna Thais Souza Gomes, Mauricio L. Nogueira, Cassia Estofolete, Denise Cristina Vaz-Oliani, Saulo Duarte Passos, Antonio Moron, Maria Manoela Duarte Rodrigues, Stephanno Gomes Pereira Sarmento, Marilia Dalva Turchi, Luiza Emylce Pela Rosado, Ana Laura de Sene Amancio Zara, Maria Barbara Franco Gomes, Lavinia Schuler-Faccini, Juliana Herrero-Silva, Melania M. Amorim, Adriana Oliveira Melo, Antonio Jose Ledo Alves da Cunha, Arnaldo Prata-Barbosa, Joffre Amim Jr, Jorge Rezende-Filho, Juan Ignacio Calcagno, Luiz Carlos Junior Alcantara, Breno Lima de Almeida, Cristina Barroso Hofer, Elizabeth S. Machado, Isadora Cristina de Siqueira, Flor Ernestina Martinez-Espinosa, Patricia Brasil

Summary: This study conducted an individual participant data meta-analysis using data from the Zika Brazilian Cohorts Consortium, and found that Zika virus infection during pregnancy may lead to miscarriage, stillbirth, prematurity, low birth weight, small for gestational age (SGA), microcephaly, neuroimaging abnormalities, ophthalmic abnormalities, auditory abnormalities, arthrogryposis, and dysphagia. This study provides the most robust evidence to date on the risks of congenital Zika virus infections.

LANCET REGIONAL HEALTH-AMERICAS (2023)

Article Public, Environmental & Occupational Health

Early diagnostic indicators of dengue versus other febrile illnesses in Asia and Latin America (IDAMS study): a multicentre, prospective, observational study

Kerstin D. Rosenberger, Lam Phung Khanh, Frank Tobian, Ngoun Chanpheaktra, Varun Kumar, Lucy Chai See Lum, Jameela Sathar, Ernesto Pleite's Sandoval, Gabriela M. Maron, Ida Safitri Laksono, Yodi Mahendradhata, Malabika Sarker, Ridwanur Rahman, Andrea Caprara, Bruno Souza Benevides, Ernesto T. A. Marques, Tereza Magalhaes, Patricia Brasil, Guilherme Amaral Calvet, Adriana Tami, Sarah E. Bethencourt, Tam Dong Thi Hoai, Kieu Nguyen Tan Thanh, Ngoc Tran Van, Nam Nguyen Tran, Viet Do Chau, Sophie Yacoub, Kinh Nguyen Van, Maria G. Guzman, Pedro A. Martinez, Quyen Nguyen Than Ha, Cameron P. Simmons, Bridget A. Wills, Ronald B. Geskus, Thomas Jaenisch

Summary: This study aimed to improve the early diagnosis of dengue, especially in resource-limited settings where distinguishing dengue from other febrile illnesses is crucial. The study found that platelet count and white blood cell count were strongly associated with dengue, and the importance of serial measurements over time was highlighted.

LANCET GLOBAL HEALTH (2023)

No Data Available