Journal
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
Volume 16, Issue 12, Pages E855-E859Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ijid.2012.07.013
Keywords
Biomarker; Diagnosis; IP-10; Tuberculosis
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Funding
- Korean Health Technology R&D Project, Ministry for Healthy, Welfare & Family Affairs, Republic of Korea [A101750]
- Korea Health Promotion Institute [A101750] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Objective: This study evaluated inducible protein 10 (IP-10) as a diagnostic biomarker for specific tuberculosis (TB) infection and evaluated the ability of IP-10 to distinguish between active TB and latent TB infection (LTBI). Methods: Forty-six patients with active pulmonary TB, 22 participants with LTBI, and 32 non-TB controls were enrolled separately. We measured IP-10 in serum and in supernatants from whole blood stimulated with TB-specific antigens. Results: TB antigen-dependent IP-10 secretion was significantly increased in the active TB patients and LTBI subjects compared with controls, but did not differ significantly between the active TB patients and LTBI subjects. Serum IP-10 levels were higher in active TB than in LTBI (174.9 vs. 102.7 pg/ml, p = 0.002). The respective rates of positive responders of TB antigen-dependent IP-10 were 97.8%, 90.9%, and 12.5% in active TB, LTBI, and non-TB controls, respectively. For serum IP-10, 87.5%, 45.5%, and 9.5% of responders were positive in the respective groups. Conclusions: The IP-10 response to TB antigen may constitute a specific biomarker for TB infection, but does not by itself distinguish between active TB and LTBI. Serum IP-10 may enhance the diagnostic performance when used in combination with another marker. (C) 2012 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
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