Article
Medicine, General & Internal
Giorgia Sulis, Brice Batomen, Anita Kotwani, Madhukar Pai, Sumanth Gandra
Summary: The study indicates a significant increase in antibiotic sales, particularly azithromycin, during the peak phase of the first COVID-19 epidemic wave in India, highlighting the urgent need for antibiotic stewardship measures.
Review
Pharmacology & Pharmacy
Vincent J. Venditto, David J. Feola
Summary: Drug carriers for macrolide antibiotics show promise in treating inflammatory conditions and have the potential to improve drug stability and reduce adverse reactions.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Kiran Chaudhari, Anil Gohar, Stijn Claerhout, Rakesh Ganorkar
Summary: Controlling isomeric impurities in a key raw material is crucial for obtaining pure isomer-free targeted active pharmaceutical ingredient (API) in downstream processing. This study presents a scalable process for preparing substantially pure clarithromycin 9-(E)-oxime, with less than 1.2% of the (Z)-isomer, without the need for time-consuming purification steps. The pure clarithromycin 9-(E)-oxime can be converted into the pure 9a-lactam scaffold, and other impurities are also identified and controlled. The fine-tuned process allows for large-scale production of potential APIs derived from this scaffold.
Article
Microbiology
Nicole Acosta, Christina S. Thornton, Michael G. Surette, Ranjani Somayaji, Laura Rossi, Harvey R. Rabin, Michael D. Parkins
Summary: The study found that azithromycin treatment did not lead to significant changes in the CF microbiome structure. However, the baseline community structure was found to be associated with the subsequent response to azithromycin in CF adults.
Article
Infectious Diseases
Carlos F. Amabile-Cuevas
Summary: Biofilm formation by macrolide-resistant Staphylococcus aureus isolates can be induced by macrolides, especially in the early stages, suggesting that the empirical use of macrolides against infections caused by resistant S. aureus strains could lead to clinical failure or even enhance biofilm formation, making further treatment difficult.
Article
Medicine, Research & Experimental
Raghad K. Aldhahri, Shahad G. Gabb, Ohoud A. Shoaib, Reem M. Almadani, Khalid Eljaaly, Abrar K. Thabit
Summary: This study compared the effectiveness and safety of a combination of doxycycline with a beta-lactam and a combination of a macrolide with a beta-lactam in the treatment of non-severe community-acquired pneumonia. The results showed that there was no significant difference in clinical cure rate, time to clinical stability, and length of stay between the two groups. However, the combination of doxycycline with a beta-lactam had a better safety profile.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Review
Infectious Diseases
Georgia G. Kournoutou, George Dinos
Summary: This review evaluates the potential of azithromycin as a therapeutic agent for COVID-19 infection and discusses its antimicrobial, anti-inflammatory, and antiviral activity. The findings suggest that there is insufficient scientific evidence to support the use of azithromycin as a treatment for COVID-19, and discontinuing its use could prevent antibiotic resistance and preserve its value as an effective anti-infective therapeutic agent.
Review
Clinical Neurology
Leonard P. Rybak, Vickram Ramkumar, Debashree Mukherjea
Summary: This review summarizes the ototoxicity of non-aminoglycoside antibiotics, discussing antibiotics such as capreomycin, macrolides, and vancomycin that have been associated with hearing loss in animal studies and in patients, especially in neonates. It emphasizes the importance of being aware of the ototoxic potential of these antibiotics, given the extensive focus on the ototoxicity of aminoglycoside antibiotics in the literature.
FRONTIERS IN NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Goran Kragol, Victoria A. Steadman, Zorica Marusic Istuk, Ana Cikos, Martina Bosnar, Dubravko Jelic, Gabrijela Ergovic, Marija Trzun, Berislav Bosnjak, Ana Bokulic, Jasna Padovan, Ines Glojnaric, Vesna Erakovic Haber
Summary: This study reveals a novel azithromycin analog with good anti-inflammatory properties obtained via Barton-McCombie oxidation, which has the potential to treat chronic inflammatory diseases.
Article
Health Care Sciences & Services
Nour Baalbaki, Christopher Giuliano, Carrie L. Hartner, Pramodini Kale-Pradhan, Leonard Johnson
Summary: The study compared treatment failure in patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) receiving azithromycin or beta-lactams. Results showed that azithromycin was associated with less treatment failure, driven by lower readmission rates and prescription of new antimicrobials.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Review
Medicine, General & Internal
Gaber El-Saber Batiha, Marwa A. Zayed, Aya A. Awad, Hazem M. Shaheen, Suleiman Mustapha, Oscar Herrera-Calderon, Jorge Pamplona Pagnossa, Abdelazeem M. Algammal, Muhammad Zahoor, Achyut Adhikari, Ishan Pandey, Sara T. Elazab, Kannan R. R. Rengasamy, Natalia Cruz-Martins, Helal F. Hetta
Summary: Macrolides, including azithromycin, have shown potential as adjunctive therapy for COVID-19 due to their ability to decrease pro-inflammatory cytokines production and prevent SARS-CoV-2 infection by raising interferons and interferon-stimulated proteins levels, ultimately reducing virus replication and release.
FRONTIERS IN MEDICINE
(2021)
Article
Multidisciplinary Sciences
Fernando de Sa Del Fiol, Isaltino Pereira Andrade
Summary: The COVID-19 pandemic has led to a significant reduction in antibiotic prescriptions for children, indicating that the new sanitary behavior has contributed to better respiratory health control among children.
SCIENTIFIC REPORTS
(2022)
Article
Critical Care Medicine
Yiming Wang, Steven L. Taylor, Jocelyn M. Choo, Lito E. Papanicolas, Rebecca Keating, Kate Hindmarsh, Rachel M. Thomson, Lucy Morgan, Geraint B. Rogers, Lucy D. Burr
Summary: Does long-term macrolide use affect the carriage of resistance within the oropharyngeal microbiota in people with chronic respiratory conditions and the risk of onward transmission to their close contacts?
Article
Health Care Sciences & Services
Nikolaos Pyrpyris, Maria Kritikou, Xenofon Aggelidis, Ioanna Manolaraki, Michael Makris, Nikolaos G. Papadopoulos, Paraskevi Xepapadaki
Summary: This study analyzes the characteristics of anaphylaxis in a pediatric cohort in Greece and finds a low rate of adrenaline autoinjector administration by lay people. However, drug prescription and counseling after the reaction could help improve correct acute anaphylaxis management in the future.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Infectious Diseases
Lauri Ivaska, Alex-Mikael Barkoff, Jussi Mertsola, Qiushui He
Summary: This review summarizes the current understanding of the epidemiology, resistance mechanisms, and clinical implications of macrolide resistance in Bordetella pertussis. China has seen a high prevalence of macrolide-resistant B. pertussis, while sporadic cases have been reported in other parts of the world.