Article
Biochemistry & Molecular Biology
Hui-Yu Ye, Zhen-Zi Shang, Feng-Yun Zhang, Xue-Qiang Zha, Qiang-Ming Li, Jian-Ping Luo
Summary: This study aimed to explore the potential mechanism of Dendrobium huoshanense stem polysaccharide (cDHPS) in ameliorating alcohol-induced gastric ulcer (GU) by strengthening the gastric mucosal barrier and reducing inflammation. The results showed that cDHPS effectively increased mucus secretion and tight junction protein expression in normal rats, while it alleviated alcohol-induced gastric mucosal injury and inflammation in GU rats by strengthening the gastric mucosal barrier. Furthermore, cDHPS activated Nrf2 signaling and promoted antioxidant enzymes activities in both normal and GU rats. These findings suggest that cDHPS pretreatment can protect the gastric mucosa from oxidative stress and inflammation by strengthening the gastric mucosal barrier through the activation of Nrf2 signaling.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Zhen-Zi Shang, Dan-Yang Qin, Qiang-Ming Li, Xue-Qiang Zha, Li-Hua Pan, Dai-Yin Peng, Jian-Ping Luo
Summary: The study showed that Dendrobium huoshanense stem polysaccharide has a beneficial effect on rheumatoid arthritis in mice, alleviating symptoms and rebalancing immune cells while inhibiting inflammatory pathways.
CARBOHYDRATE POLYMERS
(2021)
Article
Food Science & Technology
Jiao Yu, Junwei Zhao, Huiqun Xie, Ming Cai, Liang Yao, Jinmiao Li, Lan Han, Weidong Chen, Nianjun Yu, Daiyin Peng
Summary: The therapeutic effect of Dendrobium huoshanense polysaccharides (DHP) on ulcerative colitis (UC) is confirmed in this study. Through metabolomics and gut flora analysis, it was found that DHP alleviates UC symptoms by improving colonic mucosal barrier function, reducing inflammation, and modulating the composition of gut microbiota.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Plant Sciences
Jing Wu, Xiaoxi Meng, Weimin Jiang, Zhaojian Wang, Jing Zhang, Fei Meng, Xiaoyan Yao, Mengjuan Ye, Liang Yao, Longhai Wang, Nianjun Yu, Daiyin Peng, Shihai Xing
Summary: This study conducted a comprehensive analysis of crotonylated proteins in Dendrobium huoshanense cells using high-resolution liquid chromatography-mass spectrometry (LC-MS). A total of 1,591 proteins and 4,726 lysine crotonylation sites were identified, and bioinformatic analyses revealed their association with drought stress response and multiple metabolic pathways.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Physiology
Yiheng Liang, Guangrong Liu, Lingna Xie, Kewen Su, Xia Chang, Yani Xu, Junsong Chen, Zhenyuan Zhu, Kaiye Yang, Huixiong Chen, Zhiyun Du
Summary: This study verified the effect of Dendrobium candidum polysaccharides (DCP) on atopic dermatitis (AD) and found that DCP improved AD symptoms and histological damage through modulating the intestinal microbiome composition and homeostasis imbalance.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Nutrition & Dietetics
Li Wang, Yi-gui Mao, Xiang Zeng, Na Liu, Chao-fei Niu, Xin-xin Li, Bing-ji Ma, Lan-ping Guo, Xiao-long Yang
Summary: In this study, a novel polysaccharide (DHPs-1) was extracted from Dendrobium huoshanense and its structure and bioactivity were investigated. The analysis revealed that DHPs-1 had a weight-average molecular weight of 5.0 x 10(4) Da and consisted mainly of glucose, mannose, galactose, galacturonic acid, rhamnose, and xylose. It showed immunomodulatory activity by enhancing transcript levels of cytokines and exhibited good antioxidant activity. These findings suggest that DHPs-1 could be developed as a safe immunomodulatory agent and antioxidant for pharmacological or functional food applications.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Ailing Hui, Weiqin Xu, Jinghe Wang, Jie Liu, Shaohuan Deng, Baoyi Xiong, Wencheng Zhang, Zeyu Wu
Summary: In this study, pectic polysaccharides (FDP and DDP) were obtained from fresh and dried Dendrobium officinale by extraction and purification. FDP had stronger scavenging capacity against radicals than DDP and both attenuated alcohol-induced liver injury in mice. FDP-treated mice showed lower transaminase levels, inflammatory cytokine expression, and higher antioxidant enzyme activities compared to DDP-treated mice. The results suggest that D. officinale pectin can protect the liver and fresh pectin with specific structural characteristics is more promising.
Article
Food Science & Technology
Feng Li, Lei-Lei Zhu, Lei-Lei Gao, Ying Pan, Bang-Xing Han, Ling-Dong Kong
Summary: Dendrobium huoshanense is an edible medicinal herb that has been shown to alleviate hepatic injury. In this study, it was found that high fructose decreased RIP2 expression and increased the expression of IRE1α and XBP1s, leading to lipid accumulation in hepatocytes. However, treatment with DHP reversed these effects and protected against lipid accumulation by downregulating miR-429 and upregulating RIP2 expression.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Bing Liu, Qiang-Ming Li, Zhen-Zi Shang, Xue-Qiang Zha, Li-Hua Pan, Jian-Ping Luo
Summary: The study found that homogeneous cultivated Dendrobium huoshanense stem polysaccharide can effectively inhibit gastric cancer in vivo, and its anti-gastric cancer activity is closely related to its molecular weight and O-acetyl group. Experiments showed that polysaccharides with different molecular weights and O-acetyl groups have different inhibitory effects on murine forestomach carcinoma tumors.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Qinyao Zheng, Xuewei Zhao, Ye Huang, Meng-Meng Zhang, Xin He, Shijie Ke, Yuanyuan Li, Cuili Zhang, Sagheer Ahmad, Siren Lan, Minghe Li, Zhong-Jian Liu
Summary: This study identified DchYABBYs, DhuYABBYs, and DnoYABBYs from the genome databases of three Dendrobium species and found that they were unevenly distributed on different chromosomes. It was discovered that DchYABBY2 plays a crucial role in ovary and early petal development, DchYABBY5 is essential for lip development, and DchYABBY6 is crucial for early sepal formation. Additionally, DchYABBY1 primarily regulates sepals during blooming, and there is potential involvement of DchYABBY2 and DchYABBY5 in gynostemium development. This comprehensive genome-wide study provides important clues for future functional investigations and pattern analyses of YABBY genes in the Dendrobium species.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yonggang Xu, Rong Fang, Jie Shao, Zihao Cai
Summary: Erianin inhibits the proliferation of TNBC cells and induces cell cycle arrest and apoptosis by suppressing the activation of the PI3K/Akt pathway.
BIOSCIENCE REPORTS
(2021)
Article
Plant Sciences
Yujuan Wang, Jun Dai, Rui Chen, Cheng Song, Peipei Wei, Yongping Cai, Yulong Wang, Bangxing Han
Summary: The study identified a total of 211 miRNAs in drought-treated Dendrobium huoshanense, of which 36 conserved and 33 novel miRNAs were differentially expressed between drought and control samples. Target prediction and functional enrichment analysis indicated that drought-regulated miRNAs in Dendrobium may play roles in response to drought stress by targeting stress-related genes. Furthermore, integrated analysis of miRNA transcriptome and qRT-PCR detection suggested that specific miRNAs could regulate their targets to respond to hormone signaling, thus affecting plant morphological and physiological responses to drought stress.
JOURNAL OF PLANT GROWTH REGULATION
(2022)
Article
Medicine, Research & Experimental
Songwen Ren, You Gao, Luanjin Wang, Ce Qiu, Lingtao Yang, Li Li, Yueyue Xiao, Nengming Xiao, Lixin Liao, Zhenghong Zuo, Chunyan Yang, Chengyong He
Summary: The study demonstrated that Sacran could alleviate symptoms in AD mice, reduce skin inflammation induced by DNCB, potentially through inhibiting Th2 cell activation and decreasing IgE release.
Article
Agricultural Engineering
Yingyu Zhang, Wenwu Zhang, Muhammad Aamir Manzoor, Irfan Ali Sabir, Pengfei Zhang, Yunpeng Cao, Cheng Song
Summary: This study identified 64 WRKY genes in the genome of Dendrobium huoshanense and revealed their involvement in responding to both biotic and abiotic stresses. The subcellular localization analysis showed that most of the WRKY genes were located in the nucleus. The evolutionary analysis provided insights into the origin and duplication events of the WRKY genes in Dendrobium species, and identified DhWRKY42 as a key regulator involved in the regulation of jasmonic-acid-responsive genes.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Nutrition & Dietetics
Fang-Li Gu, Xiao-Mei He, Ren-Shu Huang
Summary: Skin aging is a natural process that can be slowed down by polysaccharides from Dendrobium huoshanense, which increase skin hygroscopicity, moisturizing effect, and inhibit tyrosinase activity. These polysaccharides may serve as excellent raw materials for the development of antiaging cosmetics.
CURRENT TOPICS IN NUTRACEUTICAL RESEARCH
(2021)