Kmup-1 Inhibits H441 Lung Epithelial Cell Growth, Migration and Proinflammation VIA Increased NO/CGMP and Inhibited RHO KINASE/VEGF Signaling Pathways

Rho-kinase mediates TNF-α-induced MCP-1 expression via p38 MAPK signaling pathway in mesangial cells

(2010) Keiichiro Matoba et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The xanthine derivative KMUP-1 inhibits models of pulmonary artery hypertension via increased NO and cGMP-dependent inhibition of RhoA/Rho kinase

(2010) Hui-Hsuan Chung et al.   BRITISH JOURNAL OF PHARMACOLOGY

Electrophilic nitro-fatty acids: anti-inflammatory mediators in the vascular compartment

(2010) Nicholas KH Khoo et al.   CURRENT OPINION IN PHARMACOLOGY

Fasudil protects hippocampal neurons against hypoxia-reoxygenation injury by suppressing microglial inflammatory responses in mice

(2010) Jing Ding et al.   JOURNAL OF NEUROCHEMISTRY

KMUP-1 ameliorates monocrotaline-induced pulmonary arterial hypertension through the modulation of Ca2+ sensitization and K+-channel

(2010) Zen-Kong Dai et al.   LIFE SCIENCES

KMUP-1 inhibits pulmonary artery proliferation by targeting serotonin receptors/transporter and NO synthase, inactivating RhoA and suppressing AKT/ERK phosphorylation

(2010) Hui-Hsuan Chung et al.   VASCULAR PHARMACOLOGY

Sildenafil in hypoxic pulmonary hypertension potentiates a compensatory up-regulation of NO-cGMP signaling

(2007) Mark Kirsch et al.   FASEB JOURNAL