Article
Anesthesiology
Lu Che, Xu Li, Xiuhua Zhang, Yue Lun Zhang, Jie Yi, Xia Ruan, Shuang Ma, Yuguang Huang
Summary: The study investigated perioperative allergic reactions among Chinese anesthesiologists, finding that such reactions are common but patients are rarely referred for further investigation by allergy specialists. There is variation in institutional support and management practices for perioperative allergic reactions. More standardized recommendations based on Chinese patient data are needed.
JOURNAL OF CLINICAL ANESTHESIA
(2021)
Article
Allergy
Witchaya Srisuwatchari, Charles A. Tacquard, Anna Borushko, Simon Viville, Rodolphe Stenger, Yoann Ehrhard, Jean-Marc Malinovsky, Paul-Michel Mertes, Pascal Demoly, Anca-Mirela Chiriac
Summary: The aim of this study was to determine the diagnostic performance of serum total tryptase (T-A) to differentiate positive from negative allergy testing suspected perioperative hypersensitivity reaction (POH), and also to analyze the diagnostic performance of serial tryptase levels using several formulas.
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)
Article
Pharmacology & Pharmacy
Giulia Liccioli, Gabriele Simonini, Federico Melani, Mattia Giovannini, Silvia Ricci, Lucrezia Sarti, Mara Cavallin, Simona Barni, Edoardo Marrani, Francesca Mori
Summary: Biological agents, including monoclonal antibodies, have seen increased usage in pediatric population in recent years. Adverse drug reactions, such as type I IgE-mediated hypersensitivity reactions, can occur. This report discusses two cases of anaphylaxis to rituximab in children, highlighting the importance of allergy investigations in differential diagnosis.
Review
Surgery
Jong Ha Hwang, Bo Wook Kim
Summary: A meta-analysis found no significant difference in the risk of perioperative lymphatic complications between robotic radical hysterectomy and lymph node dissection (RRHND) and laparoscopic radical hysterectomy and lymph node dissection (LRHND) for early uterine cervical cancer.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Medicine, General & Internal
Jae-Woo Ju, Nayoung Kim, Seong Mi Yang, Won Ho Kim, Ho-Jin Lee
Summary: The study aimed to investigate the incidence of sugammadex-induced anaphylaxis in a large Korean population. The estimated incidence of sugammadex-induced anaphylaxis was lower than previously reported rates in other countries, suggesting that concerns over anaphylaxis risk should not hinder its use in general anesthesia in Korea.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Xiao Zhang, Mengdan Zhao, Caihong Zheng
Summary: This study revealed a higher incidence rate of carboplatin-related drug fever associated with gynecologic cancer chemotherapy compared to previous studies, and identified younger age as a risk factor for this fever.
TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY
(2021)
Article
Oncology
M. Dupont, Claire Carlier, C. Gower-Rousseau, P. Barbier-Lider, D. Botsen, M. Brasseur, A. Burgevin, C. Chourbagi, R. D'Almeida, V Hautefeuille, M. Hentzien, A. Lambert, M. Lamuraglia, S. Lavau-Denes, A. Lopez, D. Parent, F. Slimano, M. Brugel, O. Bouche
Summary: This study found that patients treated in the French area with the highest incidence of Lyme disease are at a higher risk of CI-IRs, suggesting the need for increased attention to the risk of CI-IRs in these patients in those regions.
Article
Oncology
Yunxiao Zhang, Shuo Li, Chao Yang, Jiheng Chen, Fei Shan
Summary: For patients undergoing surgical resection for gastric cancer, the perioperative use of glucocorticoids and avoidance of intraoperative hypotension may decrease the incidence of postoperative infectious complications.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Oncology
Christine Barrett, Seon Jo Park, Lindsay Edmondson, Dulabh Monga
Summary: The incidence of hypersensitivity reactions in patients receiving oxaliplatin while on H1-receptor antagonists was lower than reported in previous literature, most reactions were mild, and patients were able to continue oxaliplatin-based therapy. More randomized controlled trials are needed to assess the effectiveness of H1RAs in preventing or delaying hypersensitivity reactions related to oxaliplatin.
JOURNAL OF ONCOLOGY PHARMACY PRACTICE
(2022)
Article
Allergy
Eric Macy, William W. Crawford, Myngoc T. Nguyen, John L. Adams, Elizabeth A. McGlynn, Thomas A. McCormick
Summary: This study aimed to investigate the association between the use of b-lactams sharing exact R1 side chains and allergic reactions. The research tracked all courses of ACC and trimethoprimsulfamethoxazole used by Kaiser Permanente California members in 2017 and 2018, comparing with sulfonamide antibiotic allergy.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Medicine, General & Internal
Duygu Hasan Dilber, Deniz Ozceker, Ozlem Terzi
Summary: Drug hypersensitivity reactions account for less than 15% of all drug reactions, and patients and their parents refer to any undesirable drug reactions as drug allergies. Only a small percentage of patients reported positive for drug reactions based on clinical history are actually confirmed to have drug allergies. The study aims to determine the frequency of drug allergies in children, the most common allergens, and evaluate demographic and clinical features.
MEDICAL BULLETIN OF SISLI ETFAL HOSPITAL
(2022)
Article
Medicine, General & Internal
Motohiro Ichikawa, Akira Kuriyama, Seigo Urushidani, Tetsunori Ikegami
Summary: The study revealed that 8.9% of adult patients with anaphylaxis experienced biphasic reactions, but biphasic reactions with significant abnormalities in vital signs were rare.
ACUTE MEDICINE & SURGERY
(2021)
Article
Oncology
Anyul Ferez-Pinzon, Samuel L. Corey, Haresh Rochani, Elena A. Rehl, William E. Burak Jr
Summary: This study found no significant difference in the number of harvested SLNs or in the time to transcutaneous localization when using Tilmanocept versus TSC as the radiolabeled mapping agents for intraoperative injection and mapping. These findings suggest that these two agents have similar performance and can be used interchangeably.
Review
Biotechnology & Applied Microbiology
Leticia de las Vecillas, Davide Caimmi, Ghislaine Annie Clarisse Isabwe, Ricardo Madrigal-Burgaleta, Ozge Soyer, Luciana Tanno, Alessandra Vultaggio, Mattia Giovannini, Francesca Mori
Summary: Hypersensitivity reactions to biologics in children are poorly understood, and there is a lack of knowledge on management and standardization of protocols. Recent publications have provided insights into managing these reactions and adapting desensitization protocols for pediatric populations. An international consensus is needed to improve personalized management and tailored desensitization in children.
EXPERT OPINION ON BIOLOGICAL THERAPY
(2023)
Article
Allergy
Anouchka Fillard, Amelia Licari, Nicolas Molinari, GianLuigi Marseglia, Pascal Demoly, Davide Caimmi
Summary: It is crucial to have a robust diagnosis of asthma in children to optimize patient care and reduce its burden. The recommended criterion of a 12% improvement in forced expiratory volume in 1 second (FEV1) after a bronchodilation test is rarely confirmed in clinical practice. This study found that a combination of clinical symptoms has a better sensitivity in diagnosing pediatric asthma compared to spirometric parameters.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Allergy
Subhabrata Moitra, Marzia Simoni, Sandra Baldacci, Sara Maio, Anna Angino, Patrizia Silvi, Giovanni Viegi, Stefania La Grutta, Franco Ruggiero, Gianni Bedini, Francesca Natali, Lorenzo Cecchi, Uwe Berger, Maria Prentovic, Amir Gamil, Nour Baiz, Michel Thibaudon, Samuel Monnier, Davide Caimmi, Luciana K. Tanno, Pascal Demoly, Simone Orlandini, Isabella Annesi-Maesano
Summary: Allergic rhinitis (AR) is a major non-communicable disease that affects patients' quality of life. This study found that AR patients with comorbid asthma have poorer HRQoL and symptom control, especially those with severe asthma. A comprehensive approach is important for the management of AR patients with comorbid allergic conditions.
CLINICAL AND TRANSLATIONAL ALLERGY
(2023)
Review
Medicine, General & Internal
E. Clark, M. Tabardel, Y. Bouderbala, P. Demoly, D. Caimmi
Summary: Pediatric asthma is a common chronic condition in childhood with an unsatisfactory definition. Diagnosis is based on clinical history, symptoms, and objective measures. Most children respond well to conventional treatments, but some require specialist consultation and potential biological therapy for severe asthma.
BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE
(2023)
Article
Allergy
Davide Caimmi, Pablo Rodriguez del Rio, Pilar Rico, Carmen Vidal, Carmen Moreno, Thomas B. Casale, Pascal Demoly, Moises A. Calderdon
Summary: Allergen immunotherapy (AIT) is the only etiological therapy for respiratory allergic diseases. The CHOICE-Global Survey aims to study the key parameters that drive the prescription of AIT by doctors and the acceptance of AIT by patients. This survey will provide academic information on the drivers of AIT prescription in real-life practice, improving understanding of this therapy.
WORLD ALLERGY ORGANIZATION JOURNAL
(2023)
Review
Health Care Sciences & Services
Antoine Magnan, Jean-Francois Nicolas, Davide Caimmi, Marc Vocanson, Thierry Haddad, Luc Colas, Silvia Scurati, Laurent Mascarell, Mohamed H. Shamji
Summary: Like in many fields of medicine, the concept of precision dosing has re-emerged in routine practice in allergology. Only one retrospective study on French physicians' practice has addressed this topic so far and generated preliminary data supporting dose adaptation, mainly based on experience, patient profile understanding and response to treatment. We focus on key immune cells involved in allergic disease and its resolution to further understand the effect of allergen immunotherapy (AIT) on these cells, and discuss the eligibility of a non/low-responder subset for dose adaptation.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Pediatrics
Arianna Giannetti, Alessandro Ruggi, Giampaolo Ricci, Giuliana Gianni, Carlo Caffarelli
Summary: Hazelnut allergy is the most common type of nut allergy in Europe, with symptoms ranging from mild to severe. Allergies to hazelnuts tend to persist throughout life, and there is currently no cure. Oral allergen immunotherapy (AIT) shows promise as a treatment option, and patients can be categorized based on their risk for severe reactions using various tests. This review provides an overview of the natural history of hazelnut allergy and new approaches for diagnosis and management.
Article
Pediatrics
Maria Beatrice De Felici Del Giudice, Carolina Calanca, Chiara Sassetti, Carlo Caffarelli, Claudio Feliciani, Susanna Esposito
Summary: We report a case of a 12-year-old boy with severe pemphigus vulgaris resistant to conventional therapies and an urticarial reaction to rituximab. This case highlights the importance of considering pemphigus vulgaris in children and the use of rituximab as a treatment option.
Article
Pediatrics
Bertrand Tchana, Carlo Caffarelli
Summary: Inhaled selective short-acting beta-2 agonists are commonly used to relieve acute asthma symptoms, but their safety is still debated due to the risk of cardiovascular events.
Article
Allergy
Davide Caimmi, Evangeline Clark, Paul Fogel, Nicolas Heddebaut, Michel Aubier, Pascal Demoly
Summary: In this study, we found that Puressentiel (R) nasal protection spray (SNPA) is effective in reducing nasal symptoms in patients with allergic rhinitis, providing a natural non-pharmacological option.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2023)
Review
Nutrition & Dietetics
Arianna Giannetti, Andrea Pession, Irene Bettini, Giampaolo Ricci, Giuliana Gianni, Carlo Caffarelli
Summary: Shellfish is a major cause of food allergy and anaphylaxis worldwide. Recent advancements in molecular characterization have improved our understanding of the allergen profile. There is a high serological cross-reactivity between shellfish species and between shellfish and house dust mites, although it doesn't always correlate accurately with clinical cross-reactions. Prompt clinical symptoms and perioral symptoms are typical features of shellfish allergy. Diagnosis involves skin prick tests and specific IgE, with double-blind placebo-controlled food challenge as the gold standard. Cross-reactivity between shellfish is common, necessitating complete avoidance. New immunotherapeutic strategies based on hypoallergens and other innovative approaches are emerging as the future of desensitization.
Article
Allergy
Evangeline Clark, Luciana Kase Tanno, Tram Vo, Brigitte Blanc, Pascal Demoly, Davide Caimmi
Summary: This study aimed to assess the appropriateness of epinephrine use in children with allergies in the emergency department, and identify factors associated with epinephrine administration, auto-injector prescription, and referral to an allergist. The study found that only 17% of children received epinephrine injections and 57.1% consulted an allergist after the acute episode. This highlights the need for improved management and care pathways for pediatric anaphylaxis.
CLINICAL AND TRANSLATIONAL ALLERGY
(2023)
Article
Allergy
Pablo Rodriguez del Rio, Davide Caimmi, Pilar Rico Nieto, Carmen Vidal, Carmen Moreno, Maria Teresa Gonzalez-Fernandez, Margarita Tomas-Perez, Ana Beristain, Isa Bosse, Hoai Bich Trinh, Thomas B. Casale, Pascal Demoly, Moises A. Calderon, on behalf of the C. H. O. I. C. E. Survey Team CHOICE Survey Team
Summary: This study investigated the drivers of prescription for allergen immunotherapy (AIT) for respiratory allergic diseases. The results showed that there are multiple drivers for AIT prescription, including the characteristics of doctors and patients as well as the disease characteristics.
WORLD ALLERGY ORGANIZATION JOURNAL
(2023)
Review
Medicine, General & Internal
Carlo Caffarelli, Serena Gracci, Giuliana Gianni, Roberto Bernardini
Summary: This review discusses the state of the art of prematurity-associated asthma in preterm infants, including the common occurrence of impaired pulmonary function and the risk factors such as viral respiratory tract infections and wheezing. The role of atopic sensitization, intestinal microbiome, and factors like diet and pollution are also examined. Understanding these factors can potentially improve the prediction of asthma development.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Carla Mastrorilli, Stefania Arasi, Simona Barni, Davide Caimmi, Fernanda Chiera, Pasquale Comberiati, Giulio Dinardo, Arianna Giannetti, Marco Gismondi, Serena Gracci, Francesco Paravati, Umberto Pelosi, Michele Miraglia Del Giudice, Roberto Bernardini, Luca Pecoraro
Summary: Fish allergy is one of the nine major triggers of allergic reactions. It affects less than 1% of the global population, but has a higher prevalence in children. Parvalbumin is the primary allergen found in fish muscles, and sensitization usually occurs through ingestion. Diagnosis involves history collection, prick tests, and measurement of serum-specific IgE. Clinical management includes avoidance of triggering species and having an action plan for accidental exposures.
MEDICINA-LITHUANIA
(2023)
