Article
Microbiology
Anjna Kumari, Isha Pahuja, Kriti Negi, Antara Ghoshal, Suparba Mukopadhyay, Meetu Agarwal, Babu Mathew, Jaswinder Singh Maras, Shivam Chaturvedi, Ashima Bhaskar, Ved Prakash Dwivedi
Summary: This study explores the immunomodulatory potential of withaferin A (WA) as an immunotherapeutic against tuberculosis (TB). WA can restrict the growth of Mycobacterium tuberculosis by enhancing host immune responses and can be used in combination with isoniazid. WA directs host macrophages towards defensive polarization and enhances T(H)1 and T(H)17 immune responses against M. tuberculosis infection.
MICROBIOLOGY SPECTRUM
(2023)
Article
Immunology
Jinbiao Lu, Xiaonan Guo, Chunhua Wang, Weixin Du, Xiaobing Shen, Cheng Su, Yongge Wu, Miao Xu
Summary: This study evaluated the therapeutic effect of a novel subunit vaccine AEC/BC02 after chemotherapy in a tuberculosis (TB) relapse model, showing that the vaccine could reduce bacterial loads and induce antigen-specific cellular immune responses.
Article
Multidisciplinary Sciences
Anneliese S. Ashhurst, Matt D. Johansen, Joshua W. C. Maxwell, Skye Stockdale, Caroline L. Ashley, Anupriya Aggarwal, Rezwan Siddiquee, Stefan Miemczyk, Duc H. Nguyen, Joel P. Mackay, Claudio Counoupas, Scott N. Byrne, Stuart Turville, Megan Steain, James A. Triccas, Philip M. Hansbro, Richard J. Payne, Warwick J. Britton
Summary: Current vaccines against SARS-CoV-2 reduce mortality but are less effective in preventing infection. In this study, the authors demonstrate that intranasal vaccination with a subunit vaccine containing a TLR2-stimulating adjuvant can induce strong neutralizing antibody and T-cell responses against SARS-CoV-2 in the lungs, providing protection against infection. This highlights the potential of mucosal vaccination to improve protection in the respiratory tract against SARS-CoV-2.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
C. Robert Horsburgh, Youngji Jo, Brooke Nichols, Helen E. Jenkins, Colin A. Russell, Laura F. White
Summary: Background modeling studies have found that most tuberculosis infections result from reinfection. The annual rate of infection (ARI) may not accurately reflect the risk of infection among previously infected individuals. Using a simulation model, we found that ARI underestimates the true risk of infection, especially in populations with heterogeneous risk. These findings suggest that the true force of tuberculosis infection in a community may be greater than previously appreciated.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Cell Biology
Taylor W. Foreman, Christine E. Nelson, Keith D. Kauffman, Nickiana E. Lora, Caian L. Vinhaes, Danielle E. Dorosky, Shunsuke Sakai, Felipe Gomez, Joel D. Fleegle, Melanie Parham, Shehan R. Perera, Cecilia S. Lindestam Arlehamn, Alessandro Sette, Jason M. Brenchley, Artur T. L. Queiroz, Bruno B. Andrade, Juraj Kabat, Laura E. Via, Daniel L. Barber
Summary: HIV/Mycobacterium tuberculosis (Mtb) co-infected individuals have an increased risk of tuberculosis before the loss of peripheral CD4 T cells. This study used rhesus macaques to investigate the early effects of simian immunodeficiency virus (SIV) co-infection on pulmonary granulomas. The results showed that Mtb-specific CD4 T cells were dramatically depleted from granulomas two weeks after SIV inoculation in Mtb-infected macaques, before CD4 T cell loss in blood, airways, and lymph nodes. The study also revealed reduced motility of intralesional CD4 T cells after SIV co-infection. These findings suggest that CD4 T cells in granulomas may be decimated before the onset of acute HIV infection symptoms.
Article
Oncology
Nawid Albinger, Rita Pfeifer, Marcus Nitsche, Sarah Mertlitz, Julia Campe, Katja Stein, Hermann Kreyenberg, Ralf Schubert, Melissa Quadflieg, Dina Schneider, Michael W. M. Kuhn, Olaf Penack, Congcong Zhang, Nina Moeker, Evelyn Ullrich
Summary: This study introduced the generation of CD33-targeted CAR-modified NK cells using BaEV-LVs, demonstrating enhanced cytotoxic activity against AML cells in vitro and potential anti-leukemic effects in xenograft mouse models.
BLOOD CANCER JOURNAL
(2022)
Article
Medicine, General & Internal
Yuya Sugiyama, Nobuhiro Ueno, Shion Tachibana, Yu Kobayashi, Yuki Murakami, Takahiro Sasaki, Aki Sakatani, Keitaro Takahashi, Katsuyoshi Ando, Shin Kashima, Kentaro Moriichi, Hiroki Tanabe, Toshikatsu Okumura, Mikihiro Fujiya
Summary: Screening for latent tuberculosis (TB) infection is important before initiating anti-tumor necrosis factor (anti-TNF) alpha agents to prevent TB reactivation. However, reactivation of latent TB infection can still occur, and the ideal therapeutic strategy for inflammatory bowel disease (IBD) patients who develop active TB infection has not been established. Vedolizumab (VDZ) has a good safety profile, but its safety in patients with latent TB infection reactivation associated with anti-TNF-alpha agents is unclear.
Article
Immunology
Xiaonan Guo, Jinbiao Lu, Junli Li, Weixin Du, Xiaobing Shen, Cheng Su, Yongge Wu, Aihua Zhao, Miao Xu
Summary: A latent tuberculosis infection (LTBI) is a major source of active tuberculosis, and vaccines as an adjunct to chemotherapy can protect populations with an LTBI. In this study, a novel subunit vaccine, AEC/BC02, showed a promising protective effect in a guinea pig latent infection model.
Article
Immunology
Alessandro Marins-Dos-Santos, Jackline de Paula Ayres-Silva, Dina Antunes, Carlos Jose de Carvalho Moreira, Marcelo Pelajo-Machado, David Alfaro, Agustin G. Zapata, Adriana Cesar Bonomo, Wilson Savino, Juliana de Meis, Desio Aurelio Farias-de-Oliveira
Summary: This study demonstrates that Trypanosoma cruzi causes high tissue parasitism during the acute phase of Chagas disease. In mice with acute oral infection, the bone marrow cells are highly parasitized, particularly in the perivascular, intravascular, and near bone regions. The infection leads to a decrease in hematopoietic cells in the bone marrow, except for an increase in hematopoietic stem and progenitor cells. The study also suggests that the spleen may play a role in emergency hematopoiesis during acute T. cruzi infection. Overall, this research provides important insights into the impact of T. cruzi infection on the hematopoietic system.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Shilpa Naik, Mallika Alexander, Pavan Kumar, Vandana Kulkarni, Prasad Deshpande, Su Yadana, Cheng-Shiun Leu, Mariana Araujo-Pereira, Bruno B. Andrade, Ramesh Bhosale, Subash Babu, Amita Gupta, Jyoti S. Mathad, Rupak Shivakoti
Summary: This study investigated the differences in systemic inflammation markers between pregnant women with and without latent tuberculosis infection (LTBI), revealing a distinct immune profile in LTBI+ pregnant women. Interestingly, the study suggests a negative association between this immune profile and tuberculosis progression, which could potentially help target high-risk pregnant women for preventative therapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Tucker J. Piergallini, Julia M. Scordo, Paula A. Pino, Larry S. Schlesinger, Jordi B. Torrelles, Joanne Turner
Summary: The study demonstrates that an early and transient inflammatory environment induced by lipopolysaccharide treatment enhances protection against Mycobacterium tuberculosis infection in mice for up to 6 months postinfection. Neutrophils from lipopolysaccharide-treated mice exhibited increased association with M. tuberculosis and had a greater innate capacity for killing the bacteria. The results suggest that acute inflammation at the time of M. tuberculosis infection can positively alter disease outcome by potentially improving immune responses.
MICROBIOLOGY SPECTRUM
(2021)
Article
Multidisciplinary Sciences
Daria Szkwarko, Steven Kim, E. Jane Carter, Roberta E. Goldman
Summary: This qualitative study aimed to evaluate the knowledge, attitudes, and skills of primary care team members regarding the LTBI care cascade, and to identify barriers limiting primary care teams in following the USPSTF recommendations.
Article
Immunology
Monalisa Martins Trentini, Alex Issamu Kanno, Dunia Rodriguez, Lazaro Moreira Marques-Neto, Silas Fernandes Eto, Ana Marisa Chudzinki-Tavassi, Luciana Cezar de Cerqueira Leite
Summary: This study evaluated the immunotherapeutic potential of recombinant BCG expressing LTAK63 (rBCG-LTAK63) against tuberculosis (TB). The results showed that mice treated with rBCG-LTAK63 had reduced bacillary load and lung inflammation compared to those treated with BCG, especially when administered intravenously. Furthermore, intravenous administration of rBCG-LTAK63 induced a higher inflammatory response of CD4(+) T cells in the spleen and an increased presence of CD4(+)IL-10(+) and regulatory T cells in the lungs. When combined with short-term chemotherapy, subcutaneous or intravenous administration of rBCG-LTAK63 decreased the bacillary load, increased the anti-inflammatory response, and reduced tissue inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Olivier Tabone, Raman Verma, Akul Singhania, Probir Chakravarty, William J. Branchett, Christine M. Graham, Jo Lee, Tran Trang, Frederic Reynier, Philippe Leissner, Karine Kaiser, Marc Rodrigue, Gerrit Woltmann, Pranabashis Haldar, Anne O'Garra
Summary: The study indicates that gene expression in household contacts of active TB patients gradually changes as TB progresses, peaking at 30 days before diagnosis. Blood signatures can also differentiate between early and late responders to anti-TB treatment.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Microbiology
Maya Gough, Dhiraj K. Singh, Chivonne Moodley, Tianhua Niu, Nadia A. Golden, Deepak Kaushal, Smriti Mehra
Summary: This study analyzes peripheral blood samples from experimentally infected rhesus macaques, and identifies biomarkers that are associated with the activity and latency of tuberculosis. These biomarkers can predict bacterial load and differentiate between different states of tuberculosis infection.
Article
Virology
A. Dusty Miller, Marcelo De las Heras, Jingyou Yu, Fushun Zhang, Shan-Lu Liu, Andrew E. Vaughan, Thomas L. Vaughan, Raul Rosadio, Stefano Rocca, Giuseppe Palmieri, James J. Goedert, Junya Fujimoto, Ignacio I. Wistuba
Article
Immunology
Tiziana Cubeddu, Carla Cacciotto, Salvatore Pisanu, Vittorio Tedde, Alberto Alberti, Marco Pittau, Simone Dore, Agnese Cannas, Sergio Uzzau, Stefano Rocca, Maria Filippa Addis
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
(2017)
Article
Veterinary Sciences
S. Pisanu, T. Cubeddu, S. Uzzau, S. Rocca, M. F. Addis
VETERINARY JOURNAL
(2017)
Article
Pathology
Veronica Vitiello, Giovanni P. Burrai, Mariagrazia Agus, Antonio G. Anfossi, Alberto Alberti, Elisabetta Antuofermo, Stefano Rocca, Tiziana Cubeddu, Salvatore Pirino
VETERINARY PATHOLOGY
(2017)
Article
Veterinary Sciences
Susanna Pilichi, Stefano Rocca, Maria Dattena, Roy Ransom Pool, Laura Mara, Daniela Sanna, Gerolamo Masala, Maria Lucia Manunta, Simone Dore, Andrea Manunta, Eraldo Sanna Passino
BMC VETERINARY RESEARCH
(2018)
Article
Multidisciplinary Sciences
Michela Sali, Flavio De Maio, Michela Tarantino, Giuliano Garofolo, Manuela Tittarelli, Lorena Sacchini, Katiuscia Zilli, Paolo Pasquali, Paola Petrucci, Cinzia Marianelli, Massimiliano Francia, Maurizio Sanguinetti, Rosanna Adone
Review
Immunology
Roberto Nisini, Noemi Poerio, Sabrina Mariotti, Federica De Santis, Maurizio Fraziano
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Elisabetta Volpe, Eleonora Cesari, Neri Mercatelli, Rosella Cicconi, Marco De Bardi, Alessia Capone, Davide Bonvissuto, Maurizio Fraziano, Maurizio Mattei, Luca Battistini, Maria Paola Paronetto, Claudio Sette
CELL DEATH AND DIFFERENTIATION
(2019)
Article
Virology
Nagaia Ciacci, Marco Maria D'Andrea, Pasquale Marmo, Elisa Dematte, Francesco Amisano, Vincenzo Di Pilato, Maurizio Fraziano, Pietro Lupetti, Gian Maria Rossolini, Maria Cristina Thaller
Article
Substance Abuse
Brunella Posteraro, Francesco Paroni Sterbini, Valentina Petito, Stefano Rocca, Tiziana Cubeddu, Cristina Graziani, Vincenzo Arena, Gabriele A. Vassallo, Carolina Mosoni, Loris Lopetuso, Irene Lorrai, Paola Maccioni, Luca Masucci, Cecilia Martini, Antonio Gasbarrini, Maurizio Sanguinetti, Giancarlo Colombo, Giovanni Addolorato
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2018)
Article
Multidisciplinary Sciences
Federica De Santis, Noemi Poerio, Angelo Gismondi, Valentina Nanni, Gabriele Di Marco, Roberto Nisini, Maria Cristina Thaller, Antonella Canini, Maurizio Fraziano
Article
Immunology
Noemi Poerio, Nadia R. Caccamo, Marco P. La Manna, Tommaso Olimpieri, Lucia Henrici De Angelis, Marco M. D'Andrea, Francesco Dieli, Maurizio Fraziano
Summary: This study demonstrated the therapeutic potential of phosphatidylserine-liposome (PS-L) in the treatment of Mycobacterium tuberculosis-human immunodeficiency virus (HIV) coinfection. PS-L reduced inflammation and cytokine production, leading to a significant decrease in intracellular M. tuberculosis viability and HIV replication.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Maria Chiriaco, Gigliola Di Matteo, Francesca Conti, Davide Petricone, Maia De Luca, Silvia Di Cesare, Cristina Cifaldi, Rita De Vito, Matteo Zoccolillo, Jessica Serafinelli, Noemi Poerio, Maurizio Fraziano, Immacolata Brigida, Fabio Cardinale, Paolo Rossi, Alessandro Aiuti, Caterina Cancrini, Andrea Finocchi
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Virology
S. Dei Giudici, T. Cubeddu, A. Giagu, G. Sanna, S. Rocca, A. Oggiano
ARCHIVES OF VIROLOGY
(2017)
Article
Veterinary Sciences
Salvatore Pisanu, Tiziana Cubeddu, Carla Cacciotto, Ylenia Pilicchi, Daniela Pagnozzi, Sergio Uzzau, Stefano Rocca, Maria Filippa Addis
VETERINARY RESEARCH
(2018)
