Article
Food Science & Technology
Johannes Grosch, Antoine Lesur, Stephanie Kler, Francois Bernardin, Gunnar Dittmar, Elisabetta Francescato, Simon J. Hewings, Constanze A. Jakwerth, Ulrich M. Zissler, Matthew D. Heath, Markus Ollert, Matthias F. Kramer, Christiane Hilger, Maria Beatrice Bilo, Carsten B. Schmidt-Weber, Simon Blank
Summary: Allergy to Polistes dominula venom is a significant issue in Southern Europe and may become a threat in other regions. Venom immunotherapy (VIT) is an effective treatment for this allergy. This study compared five different VIT preparations for P. dominula venom allergy in Spain and found that the majority of samples contained comparable levels of major allergens.
Article
Immunology
Mahvash Sadeghi, Sanaz Keshavarz Shahbaz, Sajad Dehnavi, Khadijeh Koushki, Mojtaba Sankian
Summary: For allergen-specific sublingual immunotherapy (SLIT), utilizing appropriate allergen-presentation platforms can improve allergen efficacy, target immune cells, induce regulatory immune responses, enhancing treatment outcomes.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
W. Urbanska, L. Szymanski, M. Ciepelak, A. Cios, W. Stankiewicz, E. Klimaszewska, Krystyna Lieto, Rafal Skopek, A. Chcialowski, S. Lewicki
Summary: Venom immunotherapy (VIT) aims to modify the immune response to venom allergens and enhance its precision. This study found that VIT induced a shift in T helper cell responses from Th2 to Th1, as characterized by the production of IL-2 and interferon-gamma. It also revealed increased levels of IL-12, IL-9, and TGF-beta, indicating their potential role in the immune response and desensitization process associated with VIT.
SCIENTIFIC REPORTS
(2023)
Article
Microbiology
Fabiana Furci, Luisa Ricciardi
Summary: The study observed significant improvement in respiratory and plant food allergies in 15 female patients after undergoing sublingual immunotherapy with a five-grass pollen tablet.
Review
Pharmacology & Pharmacy
Juan L. Paris, Lalitkumar K. Vora, Maria Jose Torres, Cristobalina Mayorga, Ryan F. Donnelly
Summary: The incidence of allergies has been increasing recently. Allergen-specific immunotherapy (AIT) is the only approach that can induce long-term immune tolerance towards allergens. However, its clinical success is limited by efficacy and safety concerns related to the administration route. Microneedles have been proposed to improve therapeutic delivery into the skin, but the stratum corneum poses a challenge. This review discusses recent developments in the use of microneedles for AIT and suggests future research directions.
DRUG DISCOVERY TODAY
(2023)
Review
Food Science & Technology
Aida Abd El-Wahed, Nermeen Yosri, Hanem H. Sakr, Ming Du, Ahmed F. M. Algethami, Chao Zhao, Ahmed H. Abdelazeem, Haroon Elrasheid Tahir, Saad H. D. Masry, Mohamed M. Abdel-Daim, Syed Ghulam Musharraf, Islam El-Garawani, Guoyin Kai, Yahya Al Naggar, Shaden A. M. Khalifa, Hesham R. El-Seedi
Summary: Wasps can be solitary or social, with social wasps using venom to protect their colonies and solitary wasps using it to capture prey. The bioactive constituents in wasp venom have anticancer, antimicrobial, and anti-inflammatory effects, but challenges remain in synthesizing these compounds.
Article
Allergy
Syuji Yonekura, Minoru Gotoh, Shinya Kaneko, Yuriko Maekawa, Kimihiro Okubo, Yoshitaka Okamoto
Summary: Japanese cedar pollen SLIT tablets demonstrated sustained clinical efficacy over 5 years, with the AA group showing the largest relative reduction in total nasal symptom and medication score. The treatment also exhibited disease-modifying effects for at least 2 years post-cessation.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Allergy
Tomas Clive Barker-Tejeda, Raphaelle Bazire, David Obeso, Leticia Mera-Berriatua, Domenico Rosace, Sonia Vazquez-Cortes, Tania Ramos, Maria del Pilar Rico, Tomas Chivato, Coral Barbas, Alma Villasenor, Maria M. Escribese, Montserrat Fernandez-Rivas, Carlos Blanco, Domingo Barber
Summary: This study investigated the immunological changes in grass-pollen-allergic patients undergoing SLIT treatment, revealing that Mono-sensitized patients showed suppression of effector cells after two years of treatment, while Poly-sensitized patients exhibited higher inflammation levels at baseline.
Article
Agriculture, Dairy & Animal Science
Ana Rostaher, Nina Maria Fischer, Alessio Vigani, Barbara Steblaj, Franco Martini, Salina Brem, Claude Favrot, Mitja Kosnik
Summary: This study aimed to demonstrate that venom immunotherapy (VIT) is not only safe, but also effective in treating dogs allergic to bee or wasp stings. Out of the 10 dogs treated with VIT, all of them tolerated the therapy and were able to tolerate subsequent stings.
Article
Food Science & Technology
Johannes Grosch, Bernadette Eberlein, Sebastian Waldherr, Mariona Pascal, Clara San Bartolome, Federico De La Roca Pinzon, Michael Dittmar, Christiane Hilger, Markus Ollert, Tilo Biedermann, Ulf Darsow, Maria Beatrice Bilo, Carsten B. Schmidt-Weber, Simon Blank
Summary: Differentiating between Polistes dominula and Vespula spp. venom allergies is crucial, with potential new allergens identified from P. dominula venom to improve diagnostic accuracy for Hymenoptera venom allergies. The characterization of these venom proteins contributes to a better understanding of molecular mechanisms and allergenic potential.
Article
Immunology
Ewa Czerwinska, Marita Nittner-Marszalska, Robert Pawlowicz, Leszek Szenborn
Summary: Simultaneous administration of allergen immunotherapy and seasonal influenza vaccines is safe and well-tolerated, with no increase in adverse reactions. This procedure is feasible in patients with a history of systemic allergic reactions after Hymenoptera stings, and does not lead to an increase in adverse reactions.
Article
Immunology
Luis Alfredo Gonzalez Guzman, Jose Carlos Garcia Robaina, Javier Barrios Recio, Elena Escudero Arias, Tania Linares Mata, Raquel Cervera Aznar, Federico de la Roca Pinzon, Lissette del Carmen Miguel Polo, Luis Arenas Villarroel, Veronica P. Lopez Couso, Javier Alcover Diaz, David Rodriguez Gil, Ricardo Palacios Pelaez, Francisco Javier Carballada Gonzalez
Summary: The aim of this study was to investigate the safety and effectiveness of bee venom immunotherapy without HSA in real-life patients. A total of 108 patients from seven hospitals in Spain were included in this retrospective observational study. The results showed that different protocols had varying incidences of systemic adverse reactions, and demographic data did not directly influence the appearance of adverse reactions.
Editorial Material
Allergy
Karna Gendo, Tony Orden, Allyson Tevrizian, Joshua Jacobs, Nancy Mozelsio, Katherine Gilbert, Matthew Lodewick
Summary: Food SLIT is a desensitization method using a daily maintenance dose of <10 mg for up to 5 years, often utilizing commercially available skin test extracts. OIT treatment solutions, with consistent protein concentrations and cheaper costs, have been adapted for use in published SLIT dosing schedules.
JOURNAL OF ASTHMA AND ALLERGY
(2021)
Article
Allergy
Wojciech Francuzik, Franziska Rueeff, Andrea Bauer, Maria Beatrice Bilo, Victoria Cardona, George Christoff, Sabine Doelle-Bierke, Luis Ensina, Montserrat Fernandez Rivas, Thomas Hawranek, Jonathan O'b Hourihane, Thilo Jakob, Nicos G. Papadopoulos, Claudia Pfoehler, Iwona Poziomkowska-Gesicka, Xavier Van der Brempt, Kathrin Scherer Hofmeier, Regina Treudler, Nicola Wagner, Bettina Wedi, Margitta Worm
Summary: The study evaluated the phenotype and risk factors of venom-induced anaphylaxis (VIA) using data from the European Anaphylaxis Registry. VIA more frequently involved multiple organ systems and was associated with cardiovascular symptoms, while the absence of skin symptoms during anaphylaxis was correlated with a higher risk of severe reactions. Patients with intermediate baseline serum tryptase levels and without skin involvement had a higher risk of severe VIA. Patients receiving beta-blockers or angiotensin-converting enzyme inhibitors had a higher risk of developing severe cardiovascular symptoms in VIA and non-VIA cases, where patients experiencing VIA received epinephrine less frequently than cases with non-VIA.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Otorhinolaryngology
Sharmila Dhulipalla
Summary: This systematic review examines the effectiveness and safety of sublingual immunotherapy for allergic rhinoconjunctivitis caused by Ragweed. The results suggest that sublingual immunotherapy can improve symptoms, but more high-quality studies are needed to determine optimal dosing strategies.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Editorial Material
Allergy
E. Nucera, S. Urbani, A. Buonomo, G. Andriollo, A. Aruanno
JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
(2020)
Article
Clinical Neurology
M. Luigetti, R. Iorio, A. R. Bentivoglio, L. Tricoli, V Riso, J. Marotta, C. Piano, G. Primiano, L. Zileri Del Verme, M. R. Lo Monaco, P. Calabresi
EUROPEAN JOURNAL OF NEUROLOGY
(2020)
Article
Oncology
Marta Benedetta Brumana, Massimo Milani, Mario Puviani
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2020)
Letter
Gastroenterology & Hepatology
Gianluca Ianiro, Serena Porcari, Carlo Romano Settanni, Stefano Bibbo, Francesca Romana Ponziani, Lorenzo Zileri dal Verme, Francesco Franceschi, Giovanni Cammarota, Antonio Gasbarrini
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2020)
Article
Dermatology
Federica Dall'Oglio, Mario Puviani, Massimo Milani, Giuseppe Micali
Summary: The study evaluated the efficacy and tolerability of E-AR cream in treating mild to moderate rosacea subjects for 8 weeks. The results showed that E-AR cream was effective in relieving symptoms in these patients, and local tolerability was in line with other anti-rosacea treatments.
JOURNAL OF COSMETIC DERMATOLOGY
(2021)
Article
Dermatology
Maria Beatrice Bertolani, Eleonora Rodighiero, Marco Gandolfi, Torello Lotti, Giuseppe Pedrazzi, Mario Puviani, Massimo Milani, Claudio Feliciani, Francesca Satolli
Summary: Retinoids and antibiotics are commonly used as topical treatments for mild to moderate acne, with irritant contact dermatitis being a common side effect. Short contact therapy (SCT) may improve local tolerability, and a gel containing tretinoin, clindamycin, and glycolic acid has shown to be effective in acne treatment. The SCT approach could potentially improve skin tolerability and adherence to treatment.
DERMATOLOGIC THERAPY
(2021)
Article
Geriatrics & Gerontology
Marcello Covino, Giuseppe De Matteis, Maria Livia Burzo, Andrea Russo, Evelina Forte, Annamaria Carnicelli, Andrea Piccioni, Benedetta Simeoni, Antonio Gasbarrini, Francesco Franceschi, Claudio Sandroni
Summary: The study compared several COVID-19 scoring systems for predicting in-hospital death in older patients, with ISARIC-4C and COVID-GRAM showing the best performance at ED admission. NEWS, a widely validated score in clinical practice, also had similar efficacy in predicting outcomes for older COVID-19 patients.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Dermatology
Elisabetta Caprari, Maria Teresa Viciguerra, Massimo Milani
Summary: The application of L/T pC 7%/7% peel cream before a fractional laser resurfacing session significantly reduces the procedure-associated pain with good tolerability and safety profile.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Article
Pathology
Giorgio Durante, Elisabetta Broseghini, Francesca Comito, Maria Naddeo, Massimo Milani, Irene Salamon, Elena Campione, Emi Dika, Manuela Ferracin
Summary: Skin cancer is the most common type of cancer, with specific microRNAs dysregulated in each skin cancer type, serving as potential biomarkers for disease presence, stage, evolution, or therapy efficacy. The development of methodological guidelines and standardized protocols for circulating miRNA quantification in clinical settings is expected.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2022)
Article
Dermatology
Massimo Milani, Liboria Adamo
Summary: Lichen planus is a chronic inflammatory mucocutaneous disease. Nail involvement could be the only manifestation or associated with other skin and mucous localizations. A nail lacquer containing urea, keratinase, and a retinoid molecule has shown good efficacy in the treatment of moderate nail lichen planus (NLP).
CASE REPORTS IN DERMATOLOGY
(2022)
Editorial Material
Allergy
Alessandro Buonomo, Stefano Pucci, Tiziana Maria Angela De Pasquale
CONTACT DERMATITIS
(2023)
Letter
Allergy
Eleonora Nucera, Arianna Aruanno, Alessandro Buonomo, Giuseppe Parrinello, Angela Rizzi
POSTEPY DERMATOLOGII I ALERGOLOGII
(2020)
Letter
Gastroenterology & Hepatology
Veronica Ojetti, Angela Saviano, Marcello Covino, Nicola Acampora, Eliana Troiani, Francesco Franceschi
DIGESTIVE AND LIVER DISEASE
(2020)
Letter
Allergy
Eleonora Nucera, Raffaella Chini, Alessandro Buonomo, Michele Centrone, Arianna Aruanno, Domenico Schiavino
POSTEPY DERMATOLOGII I ALERGOLOGII
(2020)
Article
Immunology
Angela Rizzi, Alessia Di Rienzo, Alessandro Buonomo, Arianna Aruanno, Valentina Carusi, Anna Giulia Ricci, Michele Centrone, Simona Mezzacappa, Lilli Romeo, Domenico Schiavino, Riccardo Inchingolo, Antonio Gasbarrini, Eleonora Nucera
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2020)