Article
Biochemistry & Molecular Biology
Kirill Nazarov, Roman Perik-Zavodskii, Olga Perik-Zavodskaia, Saleh Alrhmoun, Marina Volynets, Julia Shevchenko, Sergey Sennikov
Summary: This study found that placental erythroid cells are mainly represented by CD45(+) erythroid cells, and the secretomes of CD71(+) placental erythroid cells differ from those in syngeneic pregnancy. In addition, CCL2, CCL3, CCL4, and CXCL1 chemokines are secreted at different stages of embryonic development and in different types of pregnancy. The researchers believe that these chemokines attract placental immune cells towards erythroid cells, and erythroid cells induce anergy in these immune cells through cell-bound ligands such as PD-L1, enzymes such as ARG1, and secreted factors such as TGF beta-1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Public, Environmental & Occupational Health
Yuvaraj Krishnamoorthy, Komala Ezhumalai, Sharan Murali, Sathish Rajaa, Marie Gilbert Majella, Sonali Sarkar, Subitha Lakshminarayanan, Noyal Mariya Joseph, Govindarajan Soundappan, Senbagavalli Prakash Babu, Charles Horsburgh, Natasha Hochberg, W. Evan Johnson, Selby Knudsen, Sri Ram Pentakota, Padmini Salgame, Gautam Roy, Jerrold Ellner
Summary: A prognostic-scoring model was developed to predict death among newly diagnosed drug sensitive pulmonary TB patients in South India. The model, which had a discriminative power of 0.81, could aid clinicians and policy makers in devising targeted interventions to reduce TB mortality.
JOURNAL OF PUBLIC HEALTH
(2023)
Article
Immunology
Weijun Fang, Hua Liu, Lianhua Qin, Jie Wang, Xiaochen Huang, Sha Pan, Ruijuan Zheng
Summary: In this study, Notch4 gene polymorphisms were found to be associated with susceptibility to pulmonary tuberculosis, and the expression level of Notch4 was correlated with the severity of tuberculosis. Furthermore, it was discovered that Notch4 and its ligand Jagged1 were regulated by Mycobacterium tuberculosis infection through TLR2/P38 and TLR2/ERK signaling pathways, respectively. These findings highlight the important role of Notch4 in the pathogenesis of tuberculosis and suggest it as a potential target for host-directed therapy of tuberculosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pathology
Qi Guo, Zengliang Liu, Moxue Wang, Shanqiang Guo, Haibo Cong, Lei Liu
Summary: This study investigated the clinical value of CCL2 and CCL3 in OA, finding that their levels were elevated in the peripheral blood of OA patients and had good predictive value for the occurrence, efficacy, and prognosis of OA recurrence. This suggests that they may serve as excellent markers for the diagnosis and treatment of OA in the future.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Jayashree Kalva, Senbagavalli P. Babu, Prakash B. Narasimhan, Kalaivani Raghupathy, Komala Ezhumalai, Selby Knudsen, Charles R. Horsburgh, Natasha Hochberg, Padmini Salgame, Gautam Roy, Jerrold Ellner, Sonali Sarkar
Summary: This study aimed to assess the predictors of weight loss during the intensive treatment phase of tuberculosis (TB) and found that alcohol use was the major predictor for weight loss.
JOURNAL OF PUBLIC HEALTH
(2022)
Article
Immunology
Shuyuan Liu, Nannan Liu, Hui Wang, Xinwen Zhang, Yufeng Yao, Shuqiong Zhang, Li Shi
Summary: The study found an association between CCR5 promoter polymorphisms and pulmonary TB and TB progression in the Chinese Han population.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sun Myoung Kim, Ga Yeon Song, Aeri Shim, Jee Hyung Lee, Cheol Bin Eom, Cheng Liu, Yoon Mee Yang, Ekihiro Seki
Summary: Liver fibrosis is a disease characterized by excessive extracellular matrix deposition during wound healing after repeated liver injury. Recent research has identified hyaluronan synthase 2 (HAS2) as a driver of liver fibrosis and hepatic stellate cell (HSC) activation. This study reveals that miR-200c negatively regulates HAS2 and contributes to the development of acute liver injury and chronic liver inflammation. Additionally, hyaluronidase-2 (HYAL2) is found to be overexpressed in fibrotic livers, which indicates its potential involvement in liver fibrosis.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Noha A. Hassuna, Mohamed El Feky, Aliae A. R. Mohamed Hussein, Manal A. Mahmoud, Naglaa K. Idriss, Sayed F. Abdelwahab, Maggie A. Ibrahim
Summary: This study evaluated the role of IL-18 and IFN-γ polymorphisms in susceptibility to tuberculosis infection among Egyptian patients. Results showed a protective effect against TB with IL-18 -137G/C CC genotype, a higher risk with GG and GC genotypes, and a significant risk with INF-γ+874 AA genotype.
Article
Medicine, General & Internal
Sathish Rajaa, Yuvaraj Krishnamoorthy, Selby Knudsen, Gautam Roy, Jerrold Ellner, C. Robert Horsburgh, Natasha S. Hochberg, Padmini Salgame, S. Govindarajan, Senbagavalli Prakash Babu, Sonali Sarkar
Summary: The study revealed that one in three TB patients had concurrent diabetes mellitus. Marital status and body mass index category were found to be significant determinants of diabetes. The number of TB patients needed to be screened to find a new diabetes mellitus case was determined to be 12.
Article
Microbiology
Xingshan Cai, Yang Luo, Yuanliang Zhang, Yuan Lin, Bitong Wu, Zhizhong Cao, Zuqiong Hu, Xingyi Wu, Shouyong Tan
Summary: This study investigated the respiratory microbiota composition of 30 tuberculosis patients compared to 30 healthy controls using high-throughput 16S rRNA gene sequencing. The results showed that pulmonary tuberculosis can cause disorders of the respiratory tract microbial flora, with a significant difference in the relative abundance of Streptococcus between rifampicin-sensitive and rifampicin-resistant patients.
Article
Infectious Diseases
Ahmed Kabir Refaya, Harini Ramanujam, Mahaprabhu Ramalingam, Ganne Venkata Sudhakar Rao, Dhandapani Ravikumar, Devi Sangamithrai, Sivakumar Shanmugam, Kannan Palaniyandi
Summary: We isolated Mycobacterium orygis from black bucks and a spotted deer in a national park in India, and confirmed their identity using genetic sequencing. The exact source of infection is unknown, but due to increased human-animal interaction, it is important to strengthen surveillance and screening.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Infectious Diseases
Wenpei Shi, Yi Hu, Zhu Ning, Fan Xia, Meiying Wu, Yue O. O. Hu, Cheng Chen, Stefanie Prast-Nielsen, Biao Xu
Summary: There were significant differences in gut microbiota composition and metabolic pathways between tuberculosis patients and healthy controls. Antibiotic exposure was found to further reduce diversity and deplete beneficial bacteria in the gut microbiota of TB patients. Microbial functional analysis showed lower biosynthesis capacity of amino acids and fatty acids in TB patients compared to healthy controls.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Microbiology
Ajay Vir Singh, Suman Singh, Anjali Yadav, Shweta Kushwah, Rajbala Yadav, Davuluri Kushma Sai, Devendra Singh Chauhan
Summary: Background information on the genetic variability of drug resistant isolates of Mycobacterium tuberculosis is crucial for understanding disease transmission dynamics and improving TB control strategies. Despite having the highest number of MDR tuberculosis cases globally, the strains responsible for drug-resistant TB in India have been poorly characterized. This study in North India found high genetic diversity among MDR isolates, with the most common spoligotypes being SIT141/CAS1_Del and SIT26/Beijing lineage, indicating locally evolved strains play an important role in transmission within the community. The presence of unique and shared spoligotype patterns underscores the epidemiological significance of locally evolved strains in ongoing transmission of MDR-TB.
Article
Public, Environmental & Occupational Health
Yuvaraj Krishnamoorthy, Komala Ezhumalai, Sharan Murali, Sathish Rajaa, Maria Jose, Abilasha Sathishkumar, Govindarajan Soundappan, Charles Horsburgh, Natasha Hochberg, William Evan Johnson, Selby Knudsen, Padmini Salgame, Jerrold Ellner, Senbagavalli Prakash Babu, Sonali Sarkar
Summary: The study aimed to determine the prevalence and risk factors of latent tuberculosis infection (LTBI) among household contacts of pulmonary TB patients. A total of 1523 household contacts were included, with the prevalence of LTBI being 52.6%. Factors such as age group and sharing the same bed with the index case were independently associated with LTBI among the household contacts. Effective contact tracing and testing are needed in high TB burden settings.
TROPICAL MEDICINE & INTERNATIONAL HEALTH
(2021)
Article
Immunology
Hong-Miao Li, Li-Jun Wang, Qian Huang, Hai-Feng Pan, Tian-Ping Zhang
Summary: Th17 cells are important in immunity against Mycobacterium tuberculosis. The study found that the IL-23R rs11805303 polymorphism may contribute to the genetic underpinnings of pulmonary tuberculosis in the Chinese population, while genetic variations in IL-17A, IL-17F, and IL-21 are associated with various clinical manifestations of PTB patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ramakrishna Edukulla, Brijendra Singh, Anil G. Jegga, Vishwaraj Sontake, Stacey R. Dillon, Satish K. Madala
JOURNAL OF BIOLOGICAL CHEMISTRY
(2015)
Article
Immunology
Brijendra Singh, Selvaraj Anbalagan, Paramasivam Selvaraj
Article
Biochemistry & Molecular Biology
P. Selvaraj, M. Harishankar, Brijendra Singh, V. V. Banurekha, M. S. Jawahar
Article
Genetics & Heredity
P. Selvaraj, K. Alagarasu, B. Singh
INTERNATIONAL JOURNAL OF IMMUNOGENETICS
(2012)
Article
Genetics & Heredity
P. Selvaraj, K. Alagarasu, B. Singh, K. Afsal
INTERNATIONAL JOURNAL OF IMMUNOGENETICS
(2011)
Article
Multidisciplinary Sciences
Brijendra Singh, Anil G. Jegga, Kumar S. Shanmukhappa, Ramakrishna Edukulla, Gurjit H. Khurana, Mario Medvedovic, Stacey R. Dillon, Satish K. Madala
Article
Immunology
P. Selvaraj, M. Harishankar, Brijendra Singh, M. S. Jawahar, V. V. Banurekha
Article
Multidisciplinary Sciences
Joanna Balcerek, Jing Jiang, Yang Li, Qinqin Jiang, Nicholas Holdreith, Brijendra Singh, Vemika Chandra, Kaosheng Lv, Jian-gang Ren, Krasimira Rozenova, Weihua Li, Roger A. Greenberg, Wei Tong
NATURE COMMUNICATIONS
(2018)
Article
Physiology
Brijendra Singh, Rajesh K. Kasam, Vishwaraj Sontake, Thomas A. Wynn, Satish K. Madala
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2017)