Article
Biochemistry & Molecular Biology
Jung Sun Kim, Sak Lee, Jeong Yee, Kyemyung Park, Eun Jeong Jang, Byung Chul Chang, Hye Sun Gwak
Summary: This study aimed to investigate novel genetic variants associated with the variability of warfarin dose in the Korean population. The results showed that VKORC1, NKX2-6 rs310279, FRAS1 rs4386623, and FAM201A rs1890109 were associated with stable warfarin dose requirement. The study highlighted the importance of both genetic and non-genetic factors in the variability of warfarin dose.
Article
Clinical Neurology
Huihui Liu, Mengxing Wang, Xianglong Xiang, Yuesong Pan, Jiejie Li, Xia Meng, Hao Li, Zixiao Li, Jing Jing, Yongjun Wang
Summary: This study found that persistent high residual inflammatory risk (RIR) increased the risks of stroke recurrence, composite vascular events, mortality, and poor functional outcome in patients with acute ischemic stroke or transient ischemic attack.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Gun Ho Choi, Sung Hwan Cho, Hui Jeong An, Han Sung Park, Jeong Yong Lee, Eun Ju Ko, Seung Hun Oh, Ok Joon Kim, Nam Keun Kim
Summary: Stroke is the second leading cause of death globally, with most cases being ischemic. Increased levels of plasminogen activator inhibitor-1 (PAI-1) have been linked to higher risk of stroke. A case-control study in South Korea identified specific variations in the PAI-1 gene that are significantly associated with higher prevalence of ischemic stroke. These genetic variations could potentially serve as clinical biomarkers for stroke and improve patient prognosis and management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Li Song, Hao Li, Miaomiao Suo, Yingying Sun, Ming Su, Yan Song, Ning Xiao, Rutai Hui, Chunchang Qin, Jingzhou Chen
Summary: This study suggests that AL110200 may have a proinflammatory effect on atherosclerosis, while the variant rs901681 could be a strong predictor of stroke prognosis in ischemic stroke patients.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Critical Care Medicine
Richard J. Allen, Justin M. Oldham, David A. Jenkins, Olivia C. Leavy, Beatriz Guillen-Guio, Carl A. Melbourne, Shwu-Fan Ma, Jonathan Jou, John S. Kim, William A. Fahy, Eunice Oballa, Richard B. Hubbard, Vidya Navaratnam, Rebecca Braybrooke, Gauri Saini, Katy M. Roach, Martin D. Tobin, Nik Hirani, Moira K. B. Whyte, Naftali Kaminski, Yingze Zhang, Fernando J. Martinez, Angela L. Linderholm, Ayodeji Adegunsoye, Mary E. Strek, Toby M. Maher, Philip L. Molyneaux, Carlos Flores, Imre Noth, R. Gisli Jenkins, Louise Wain
Summary: In this study, a genetic variant associated with disease progression in idiopathic pulmonary fibrosis (IPF) was identified, and the PKN2 gene was proposed as a potential target for novel therapeutic approaches. This finding provides insights into the biological mechanisms underlying IPF and offers potential implications for its treatment.
LANCET RESPIRATORY MEDICINE
(2023)
Article
Multidisciplinary Sciences
Muhammad Imran Qadeer, Ali Amar, Yung-Yu Huang, Eli Min, Hanga Galfalvy, Shahida Hasnain, J. John Mann
Summary: The study identified an association between the serotonin transporter gene SLC6A4 HTTLPR polymorphism and criminal aggression in Pakistani prisoners, with the L/L and L-A/L-A genotypes being linked to higher aggression scores. Functional effects were demonstrated for the rs25531 polymorphism in HTTLPR and other serotonergic polymorphisms in different brain regions and peripheral tissues. Further research is needed to replicate and understand the biological mechanisms underlying this relationship.
SCIENTIFIC REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Xu Liu, Qianwen Wang, Ruixia Zhu
Summary: The PDE4D rs966221 polymorphism is significantly associated with recurrent stroke risk, with GA + GG genotype having 1.399 times the risk. The other five SNPs showed no significant association with recurrent ischemic stroke risk.
JOURNAL OF GENE MEDICINE
(2021)
Article
Clinical Neurology
Yin-Hua Weng, Wen-Tao Yu, Yan-Ping Luo, Chao Liu, Xi-Xi Gu, Huo-Ying Chen, Hong-Bo Liu
Summary: The miR-365 rs30230 polymorphism may be associated with susceptibility to IS in the Chinese population. The TC/TT genotypes of rs30230 may be protective factors against IS.
FRONTIERS IN NEUROLOGY
(2023)
Article
Medicine, General & Internal
Tao You, Yi Li, Xiaoguang Wu, Siyi Wu, Yanlin Zhang, Xiang Zhou
Summary: The study found that preferences for fruits and soy products are negatively associated with the risk of IS, while lower life satisfaction is positively associated with the risk of IS. Adding these factors to a basic CVD risk model can improve the discriminative ability and reclassification for IS.
POSTGRADUATE MEDICAL JOURNAL
(2022)
Article
Genetics & Heredity
Yi-ying Jiang, Jian-li Li, Liu-yu Liu, Guo-qiu Zhou, Dong-can Mo, Dong-dong Jiang, Man Luo
Summary: The study investigated the association between two SNPs in the ABO gene and the risk of small artery occlusion stroke in the southern Chinese Han population. The results showed that the rs532436 polymorphism was significantly associated with SAO, while the rs505922 polymorphism showed no significant association. This suggests a potential genetic influence on SAO in this population.
Article
Medicine, Research & Experimental
Jiayong Wang, Zujun Sun, Yibao Yang, Junlu Wu, Wenqiang Quan, Xingcai Chen, Peihua Ni, Dong Li
Summary: This study found associations between certain clinical laboratory parameters and genetic polymorphisms such as ACE I/D, β-Fg-455 A/G, and PAI-1 4G/5G, which are closely related to the risk of IS. The D allele of ACE I/D may be associated with elevated levels of total cholesterol and LDL-C. Elevated levels of blood glucose, triglycerides, and LDL-C are risk factors for IS.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Genetics & Heredity
Hye-Rim Kim, Hyun-Seok Jin, Yong-Bin Eom
Summary: The study revealed a significant association between variants in the MACROD2 gene and obesity, phenotypic traits, and physical activity in the Korean population. Carriers of the minor allele of rs6079275 may have a reduced risk of obesity, especially with high levels of physical activity.
MOLECULAR GENETICS & GENOMIC MEDICINE
(2021)
Article
Multidisciplinary Sciences
Jeong Hee Chi, Bum Ju Lee
Summary: This study examined the associations of obesity and biochemical indices with myocardial infarction or angina pectoris risk in the Korean population. The study found a significant association between obesity and MIAP in men, but not in women. Additionally, total cholesterol, creatinine, and platelets were associated with MIAP in both men and women.
SCIENTIFIC REPORTS
(2022)
Review
Clinical Neurology
Christoph Stretz, Teddy Y. Wu, Duncan Wilson, David J. Seiffge, Eric E. Smith, M. Edip Gurol, Shadi Yaghi
Summary: Although anticoagulation significantly reduces the risk of stroke in patients with atrial fibrillation, a proportion of patients on anticoagulation still experience ischaemic stroke. Understanding the potential mechanisms of stroke despite anticoagulation is crucial in order to tailor individualized treatment strategies for secondary prevention.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Article
Genetics & Heredity
Hyeon Woo Park, Young Ran Kim, Jeong Yong Lee, Eun Ju Ko, Min Jung Kwon, Ji Hyang Kim, Nam Keun Kim
Summary: This study analyzed the impact of HOTAIR polymorphisms on RPL in Korean women and found that rs4759314A>G and rs920778T>C were significantly associated with increased risk of RPL.
Review
Clinical Neurology
Jung Hwan Lee, Kyoung Hyo Choi, Seok Kang, Dong Hwan Kim, Du Hwan Kim, Bo Ryun Kim, Won Kim, Jung Hwan Kim, Kyung Hee Do, Jong Geol Do, Ju Seok Ryu, Kyunghoon Min, Sung Gin Bahk, Yun Hee Park, Heui Je Bang, Kyoung-ho Shin, Seoyon Yang, Hee Seung Yang, Seung Don Yoo, Ji Sung Yoo, Kyung Jae Yoon, Se Jin Yoon, Goo Joo Lee, Sang Yoon Lee, Sang Chul Lee, Seung Yeol Lee, In-Sik Lee, Jung-Soo Lee, Chang-Hyung Lee, Jae-Young Lim, Jae-Young Han, Seung Hoon Han, Duk Hyun Sung, Kang Hee Cho, Soo Young Kim, Hyun Jung Kim, Woong Ju
Article
Clinical Neurology
Eo Jin Park, Seung Don Yoo, Hee-Sang Kim, Jong Ha Lee, Dong Hwan Yun, Dong Hwan Kim, Jin Mann Chon, Seung Ah Lee, Yun Soo Soh, Yong Kim, Young Rok Han, Myung Chul Yoo, Kwang Min Choi, Yun Kyung Seo, Do Hun Lee, Young Hwa Choi, Kwi Hyun Jeong, Jung Eun Son
NEUROREHABILITATION
(2019)
Article
Otorhinolaryngology
Tae Hoon Kim, Young Chan Lee, Seung Don Yoo, Seung Ah Lee, Young-Gyu Eun
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
(2020)
Article
Medicine, General & Internal
Jinmann Chon, Seung Don Yoo, Seung Ah Lee
Article
Medicine, General & Internal
Eo Jin Park, Jae Hoon Kim, Young Hwa Choi, Jung Eun Son, Seung Ah Lee, Seung Don Yoo
Article
Environmental Sciences
Seon A. Chae, Hee-Sang Kim, Jong Ha Lee, Dong Hwan Yun, Jinmann Chon, Myung Chul Yoo, Yeocheon Yun, Seung Don Yoo, Dong Hwan Kim, Seung Ah Lee, Sung Joon Chung, Yunsoo Soh, Chang Won Won
Summary: The study found a relationship between vitamin B12 insufficiency and sarcopenia, especially in terms of appendicular skeletal muscle mass. However, B12 insufficiency did not significantly affect muscle strength or physical performance.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Review
Geriatrics & Gerontology
Hyung Eun Shin, Miji Kim, Daehyun Lee, Jae Young Jang, Yunsoo Soh, Dong Hwan Yun, Sunyoung Kim, Jisoo Yang, Maeng Kyu Kim, Hooman Lee, Chang Won Won
Summary: This review focuses on the therapeutic effects of functional electrical stimulation (FES) on physical performance and skeletal muscle function in post-stroke older adults. FES has been found to restore muscle strength, support weight-bearing and upright posture, and improve balance. It may also be effective in preventing muscle atrophy. However, further studies are needed to confirm these findings in this specific population.
ANNALS OF GERIATRIC MEDICINE AND RESEARCH
(2022)
Article
Environmental Sciences
Min Gyun Kim, Seung Ah Lee, Eo Jin Park, Min Kyu Choi, Ji Min Kim, Min Kyun Sohn, Sung Ju Jee, Yeong Wook Kim, Jung Eun Son, Seo Jun Lee, Keum Sun Hwang, Seung Don Yoo
Summary: This study compared the effects of two different shoulder orthoses on shoulder subluxation distance, pain, and upper extremity function in patients with hemiplegia. The results showed that the elastic dynamic sling had better outcomes in shoulder subluxation distance, while both orthoses had similar improvements in upper extremity movements and independence in daily living.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Min Kyu Choi, Seung Don Yoo, Eo Jin Park
Summary: This study investigated the correlation between vowel space destruction and dysphagia in stroke patients, and found that vowel space destruction is associated with reduced swallowing function.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Nutrition & Dietetics
Ji Min Kim, Seung Don Yoo, Eo Jin Park
Summary: This study aimed to investigate whether nutritional biomarkers transferrin, albumin, and prealbumin could be predictors of dysphonia severity. The results showed significant correlations between these biomarkers and the severity of dysphonia.
Article
Nutrition & Dietetics
Eo Jin Park, Seung Don Yoo
Summary: This study aimed to examine the relationship between nutritional biomarkers and heart rate variability (HRV) parameters in stroke patients. The results showed that HRV parameters were significantly lower in the nutritional biomarker-deficient groups. Serum albumin, prealbumin, and transferrin levels were associated with autonomic nervous system (ANS) function, as measured by HRV, and their deficiency may be a predictive factor for the severity of ANS dysfunction in stroke patients.
Article
Medicine, General & Internal
Seung Don Yoo, Eo Jin Park
Summary: Depressive and somatic symptoms are commonly observed in patients with traumatic brain injury (TBI). This study aimed to investigate the relationship between autonomic nervous system (ANS) dysfunction, depression, and somatic symptoms in TBI patients. The results showed a significant association between reduced HRV, indicative of ANS dysfunction, and the severity of depressive and somatic symptoms. These findings suggest that autonomic dysfunction may contribute to the development and severity of depressive and somatic symptoms in patients with TBI.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Eo Jin Park, Seung Don Yoo
Summary: Dysarthria and dysphonia are common in TBI patients. This study investigated the relationship between vowel quadrilateral parameters and DSI, finding that resonance frequency is positively correlated with dysphonia severity, while the second formant ratio is negatively correlated.
Article
Medicine, General & Internal
Eo Jin Park, Seung Don Yoo
Summary: This study evaluated the correlation between serum vitamin D level and phonetic function in subacute stroke patients. The results showed a positive correlation between vitamin D levels and the severity of phonation, and vitamin D deficiency may be a factor in predicting phonation severity in stroke patients.
Article
Cardiac & Cardiovascular Systems
Chul Kim, Jidong Sung, Jong Hwa Lee, Won-Seok Kim, Goo Joo Lee, Sungju Jee, Il-Young Jung, Ueon Woo Rah, Byung Ok Kim, Kyoung Hyo Choi, Bum Sun Kwon, Seung Don Yoo, Heui Je Bang, Hyung-Ik Shin, Yong Wook Kim, Heeyoune Jung, Eung Ju Kim, Jung Hwan Lee, In Hyun Jung, Jae-Seung Jung, Jong-Young Lee, Jae-Young Han, Eun Young Han, Yu Hui Won, Woosik Han, Sora Baek, Kyung-Lim Joa, Sook Joung Lee, Ae Ryoung Kim, So Young Lee, Jihee Kim, Hee Eun Choi, Byeong-Ju Lee, Soon Kim
KOREAN CIRCULATION JOURNAL
(2019)
