4.1 Article

Toll-like receptors 2 and 4 gene polymorphisms in a southeastern Chinese population with tuberculosis

Journal

INTERNATIONAL JOURNAL OF IMMUNOGENETICS
Volume 37, Issue 2, Pages 135-138

Publisher

WILEY
DOI: 10.1111/j.1744-313X.2009.00892.x

Keywords

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Funding

  1. National Found for Fostering Talents of Basic Science (NFFTBS) [J0730856, J0830833]
  2. National Sci-tech Important Special Projects [2008ZX10005-010]

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P>Polymorphisms of the toll-like receptor 2 (TLR2) gene (Arg677Trp, Arg753Gln) and the TLR4 gene (Asp299Gly, Thr399Ile) were investigated in 205 tuberculosis (TB) patients and 203 controls. Genetic variations were analysed by DNA sequencing. We revealed that these polymorphisms were rare in the southeastern Chinese population and were not associated with susceptibility to TB.

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