Journal
INTERNATIONAL JOURNAL OF IMAGING SYSTEMS AND TECHNOLOGY
Volume 24, Issue 2, Pages 149-160Publisher
WILEY
DOI: 10.1002/ima.22089
Keywords
MRI; depression in the elderly; hippocampus; amygdala; prefrontal cortex; morphometry; volumetry
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Early-onset (EOD) and late-onset depression (LOD) are associated with different neuropsychological syndromes and structural brain changes. In this article, neuroimaging studies examining structural brain changes in elderly depressed patients are reviewed. The presented findings support current assumptions that depression in the elderly generally is associated with volume reductions in brain structures, notably in the hippocampus and the orbitofrontal cortex (OFC). Concerning structural cerebral differences between EOD and LOD, the review yielded conflicting resultsonly for OFC, but not for amygdala or hippocampus, pronounced effects in LOD than in EOD can be assumed. (c) 2014 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 24, 149-160, 2014
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