Article
Public, Environmental & Occupational Health
Kai-Wei Liao, Wei-Hsiang Chang, Wei-Chun Chou, Han-Bin Huang, Alexander Waits, Pau-Chung Chen, Po-Chin Huang
Summary: The study investigated the phthalate exposure levels in the Taiwanese population and found variations in exposure levels among different age groups and regions. Reference values (RVs) for phthalate metabolites in Taiwan were established in the current study, aiding in further monitoring and investigation of food safety and environmental protection in the region.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2021)
Article
Public, Environmental & Occupational Health
Kai -Wei Liao, Pau-Chung Chen, Wei -Chun Chou, Ivy Shiue, Hsin- Huang, Wan -Ting Chang, Po-Chin Huang
Summary: Human biomonitoring identifies chemicals that may pose health risks to human populations. This study aimed to establish urinary reference levels for metals in the general population of Taiwan. Exposure to arsenic, cadmium, lead, and manganese was found to be important in the Taiwanese population. Urinary levels of metal exposure varied by sex, age, region, and urbanization level.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Article
Chemistry, Medicinal
Zifang Ding, Xu Wang, Ning Zhang, Chen Sun, Guode Zhao, Ying Peng, Jiang Zheng
Summary: This study investigated the in vitro and in vivo metabolic activation of PRP. The results showed that PRP was metabolized to GSH and NAC conjugates, and CYP1A2 was the key enzyme involved. The metabolites formed by PRP may contribute to its cytotoxicity.
CHEMICAL RESEARCH IN TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
E. Piva, A. Giorgetti, P. Ioime, L. Morini, F. Freni, F. Lo Faro, F. Pirani, M. Montisci, P. Fais, J. P. Pascali
Summary: There are geographical differences in the presence and prevalence of PFAS in the hair of the Italian population, with hair analysis being a useful tool for assessing PFAS exposure on a regional scale. However, no significant differences in the amount of PFAS were observed based on gender or age groups.
Article
Public, Environmental & Occupational Health
Denise S. Tevis, Sharon R. Flores, Brandon M. Kenwood, Deepak Bhandari, Peyton Jacob, Jia Liu, Pawel K. Lorkiewicz, Daniel J. Conklin, Stephen S. Hecht, Maciej L. Goniewicz, Benjamin C. Blount, Victor R. De Jesus
Summary: The increasing interest in VOC exposure has highlighted the need for consistent naming of VOC metabolites, which currently lacks standardization. This study aims to establish a systematic acronym naming system to provide consistency in current usage and guide future acronyms for VOC metabolites. Despite the well-established measurement of VOC metabolites for investigating exposure, harmonizing acronyms among investigators has not been formally attempted.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2021)
Article
Health Care Sciences & Services
Ole Marten, Wolfgang Greiner
Summary: The study analyzed a subset of data from the German EQ-5D-5L valuation study, examining severity levels per dimension, means, standard deviations, and confidence intervals of index and EQ VAS values by age groups and gender. Health problems were reported more frequently with higher age, leading to decreasing index and EQ VAS values. Men reported fewer problems than women, particularly beyond the age of 80.
HEALTH AND QUALITY OF LIFE OUTCOMES
(2021)
Article
Environmental Sciences
Kavita Singh, Scott Blechinger, Luc Pelletier, Subramanian Karthikeyan, Annie St-Amand, Eric N. Liberda, Hing Man Chan
Summary: The study analyzed the hair and blood mercury levels in the Canadian population and explored factors associated with higher/lower ratios. The results showed that the average hair:blood mercury ratio among Canadians exceeded the default ratio of 250:1 recommended by the WHO. Shellfish consumption was found to be the most important factor associated with the ratio.
ENVIRONMENTAL RESEARCH
(2023)
Article
Oncology
Nisha A. Mohindra, John Devin Peipert, Steven I. Blum, James W. Shaw, John R. Penrod, David Cella
Summary: This study calculated the reference values for the Functional Assessment of Cancer Therapy-Lung (FACT-L) tool in the US general population. The results showed that COVID-19 patients had lower quality of life scores, especially in social and functional domains. These reference values are important for future clinical research.
Article
Public, Environmental & Occupational Health
Michael Hoopmann, Aline Murawski, Michael Schuemann, Thomas Goeen, Petra Apel, Nina Vogel, Marike Kolossa-Gehring, Claudia Roehl
Summary: HBM reference values are statistically derived values that provide information on population exposure. A revision is needed to improve the standardization and transparency of the process. It is recommended to use the 95th percentile of the reference distribution as the HBM reference value.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Article
Environmental Sciences
Audrey Catteau, Antoine Le Guernic, Melissa Palos Ladeiroa, Odile Dedourge-Geffard, Marc Bonnard, Isabelle Bonnard, Laurence Delahaut, Anne Bado-Nilles, Jean -Marc Porcher, Christelle Lopes, Olivier Geffard, Alain Geffard
Summary: The Integrated Biomarker Response (IBR) is commonly used in biomonitoring, but it has limitations for routine and large-scale use. To overcome these limitations, a new index called IBR-T was proposed, which considers the threshold values of biomarkers and calculates the IBR value only for significantly modulated biomarkers. The comparison between IBR-T and IBRv2 showed that IBR-T has a better correlation with the percentage of significantly modulated biomarkers and provides a more ecologically relevant ranking of sites. IBR-T is important for biomonitoring as it simplifies data interpretation, directly indicates the contamination status of a site, aids in decision-making, and facilitates communication of results to the general public.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Geriatrics & Gerontology
Sung Woo Moon, Sang Hoon Lee, Ala Woo, Ah Young Leem, Su Hwan Lee, Kyung Soo Chung, Eun Young Kim, Ji Ye Jung, Young Ae Kang, Moo Suk Park, Young Sam Kim, Chang Oh Kim, Song Yee Kim
Summary: This study aimed to establish reference values for sarcopenia of thoracic skeletal muscles acquired from chest CT scans and analyze variables related to sarcopenia. The findings provide sex-specific standardized methods for quantifying thoracic muscle mass and assessing sarcopenia.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Medicine, General & Internal
Ugne Krenz, Sven Greving, Marina Zeldovich, Juanita Haagsma, Suzanne Polinder, Nicole von Steinbuechel
Summary: Traumatic brain injury (TBI) can negatively impact the lives of individuals and their relatives in various aspects. Health-related quality of life (HRQoL) is a comprehensive concept that assesses satisfaction with many areas of life and health. The QOLIBRI questionnaire is commonly used to measure HRQoL after TBI, but reference values for a general population in Italy have been lacking until now.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Environmental Sciences
Jeong Weon Choi, Yoon Chae Song, Nam-Yong Cheong, Kiyoung Lee, Sunmi Kim, Kyoung-Mu Lee, Kyunghee Ji, Mi-Yeon Shin, Sungkyoon Kim
Summary: This study investigated the levels and distributions of arsenic species in urine and blood in the Korean population. It found that blood arsenic concentration cannot represent urinary arsenic, but different compositions of urine and blood may reflect distinct information about arsenic exposure. Further investigations on exposure factors and health are needed for low-exposure groups.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Elisa Gallo, Claudio Barbiellini Amidei, Giulia Barbieri, Aline S. C. Fabricio, Massimo Gion, Gisella Pitter, Francesca Dapra, Francesca Russo, Dario Gregori, Tony Fletcher, Cristina Canova
Summary: The study found no association between TSH and any type of PFAS among adolescents or women. However, in male adults, there was a decrease in TSH concentration associated with an IQR increase in PFHxS and a mild decrease in TSH at low levels of PFOA, PFOS, and PFHxS. Self-reported thyroid disease was more common among women with higher levels of PFNA concentrations, while other PFAS were not associated with thyroid diseases regardless of sex or age.
ENVIRONMENTAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Sharad S. Singhal, Rachana Garg, David Horne, Sulabh Singhal, Sanjay Awasthi, Ravi Salgia
Summary: Studies have shown that RLIP-deficient mice are resistant to chemical carcinogenesis, inflammation, and metabolic syndrome, as well as obesity caused by a high-fat diet. These findings highlight the role of RLIP in regulating obesity-inducing signaling pathways through CDE. Recent research has also demonstrated that suppression of tumor growth can be achieved through depletion of RLIP.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Article
Environmental Sciences
Hans G. J. Mol, Ingrid Elbers, Claudia Paelmke, Daniel Bury, Thomas Goeen, Marta Esteban Lopez, Stefanie Nuebler, Vincent Vaccher, Jean-Philippe Antignac, Darina Dvorakova, Jana Hajslova, Amrit Kaur Sakhi, Cathrine Thomsen, Katrin Vorkamp, Argelia Castano, Holger M. Koch
Summary: A quality assurance/quality control program was implemented in the HBM4EU project, which included four rounds of proficiency tests and involved 28 laboratories. The program resulted in a significant improvement in performance and the establishment of a network of competent laboratories capable of generating comparable and accurate data for biomarker analysis.
Article
Chemistry, Analytical
Corinna Fischer, Thomas Goeen
Summary: 2-(5-Chloro-benzotriazol-2-yl)-4,6-di-(tert-butyl)phenol (UV-327) is a compound used as an ultraviolet (UV) absorber in plastic materials and coatings. This study presents a method for the determination of UV-327 and its metabolites in human blood using protein precipitation, dispersive liquid-liquid microextraction (DLLME) and derivatization. The method has been validated and shown to have high sensitivity and reliability, allowing for the analysis of UV-327 and its metabolites and the assessment of exposure in potentially exposed individuals.
JOURNAL OF ANALYTICAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Kate Jones, Karen S. Galea, Bernice Scholten, Marika Loikala, Simo P. Porras, Radia Bousoumah, Sophie Ndaw, Elizabeth Leese, Henriqueta Louro, Maria Joao Silva, Susana Viegas, Lode Godderis, Jelle Verdonck, Katrien Poels, Thomas Goeen, Radu-Corneliu Duca, Tiina Santonen
Summary: This study aims to assess occupational exposure to diisocyanates in five European countries and test the usability of different biomarkers in the assessment of exposure. It also aims to provide background data for regulatory purposes.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Ana Maria Tavares, Susana Viegas, Henriqueta Louro, Thomas Goeen, Tiina Santonen, Mirjam Luijten, Andreas Kortenkamp, Maria Joao Silva
Summary: This study conducted a mixture risk assessment (MRA) based on human biomonitoring (HBM) data in Europe to evaluate the co-exposure of hexavalent chromium, nickel, and polycyclic aromatic hydrocarbons. The results indicate that there is concern regarding the occupational health risk of co-exposure to these substances, particularly in welding activities and waste incineration settings. It highlights the importance of considering exposure to the mixture rather than the individual components to manage workplace risk and protect workers' health.
Article
Environmental Sciences
Michael Poteser, Federica Laguzzi, Thomas Schettgen, Nina Vogel, Till Weber, Aline Murawski, Phillipp Schmidt, Maria Ruther, Marike Kolossa-Gehring, Sonia Namorado, An Van Nieuwenhuyse, Brice Appenzeller, Edda Dufthaksdottir, Kristin Olafsdottir, Line Smastuen Haug, Cathrine Thomsen, Fabio Barbone, Valentina Rosolen, Loic Rambaud, Margaux Riou, Thomas Goen, Stefanie Nuebler, Moritz Schaefer, Karin H. A. Zarrabi, Liese Gilles, Laura Rodriguez Martin, Greet Schoeters, Ovnair Sepai, Eva Govarts, Hanns Moshammer
Summary: This report summarizes the results of the HBM4EU project and associated studies regarding acrylamide exposure levels. The findings show an increasing trend in acrylamide exposure in children, while the trend is less significant in adults and smokers. The average acrylamide exposure still exceeds suggested benchmark levels, raising specific concerns for children. Further research is needed to confirm the declining trend observed in recent years.
Article
Multidisciplinary Sciences
Caroline Fortmann, Thomas Goeen, Norman Zinne, Soeren Wiesner, Benno M. Ure, Claus Petersen, Joachim F. Kuebler
Summary: An analysis of the kinetics of metal contamination after minimally-invasive repair of pectus excavatum (MIRPE) and after bar removal revealed a rapid systemic increase of nickel and chromium in patients' blood, urine, and local tissue. These elevated levels of trace metals could cause irritative symptoms, and the prolonged elevated systemic nickel levels beyond bar removal require further investigation of the long-term side effects of MIRPE.
Review
Environmental Sciences
Henriqueta Louro, Bruno Costa Gomes, Anne Thoustrup Saber, Anna Laura Iamiceli, Thomas Goen, Kate Jones, Andromachi Katsonouri, Christiana M. Neophytou, Ulla Vogel, Celia Ventura, Axel Oberemm, Radu Corneliu Duca, Mariana F. Fernandez, Nicolas Olea, Tiina Santonen, Susana Viegas, Maria Joao Silva
Summary: This comprehensive review aims to provide regulators and policymakers with a comprehensive overview of occupational exposure to polycyclic aromatic hydrocarbons (PAHs), including the use of exposure and effect biomarkers, as well as the knowledge needs for regulation. The review highlights the importance of advancing harmonized approaches in data and sample collection, as well as the use of appropriate biomarkers in occupational studies to obtain reliable and comparable data on PAH exposure.
Article
Biochemical Research Methods
Heike Denghel, Thomas Goeen
Summary: A simple, reliable, and highly sensitive method for simultaneous monitoring of multiple endocrine disruptors in urine was developed. The method showed good sensitivity and accuracy, making it suitable for exploring the exposome of these disruptors in the general population.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Toxicology
Corinna Fischer, Edgar Leibold, Julia Hiller, Thomas Goeen
Summary: This study provides initial information on the human in vivo metabolism of UV-327 by administering it orally to volunteers. The results show that UV-327 is well-absorbed from the intestine but only partially metabolized. Biliary excretion may be the major route of elimination for UV-327 and its hydroxylated metabolites.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Environmental Sciences
Julia Hiller, Thomas Goeen, Nina Seibold-Wulf, Sebastian Meyer, Hans Drexler
Summary: This study investigates whether a diet highly exposed to aluminum-containing food-contact materials (Al-FCM) leads to an increased aluminum load in humans. The results show that under real-world conditions, there is a measurable but fully reversible additional aluminum burden. The estimated increase from Al-FCM corresponds to 8% of the baseline concentration.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Public, Environmental & Occupational Health
Michael Hoopmann, Aline Murawski, Michael Schuemann, Thomas Goeen, Petra Apel, Nina Vogel, Marike Kolossa-Gehring, Claudia Roehl
Summary: HBM reference values are statistically derived values that provide information on population exposure. A revision is needed to improve the standardization and transparency of the process. It is recommended to use the 95th percentile of the reference distribution as the HBM reference value.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Article
Multidisciplinary Sciences
Caroline Fortmann, Thomas Goeen, Soeren Wiesner, Jan Hegermann, Rim Kiblawi, Martha Dohna, Benno M. Ure, Diane Miriam Renz, Claus Petersen, Joachim F. Kuebler
Summary: This study investigated the impact of titanium nitride coating on metal release and exposure in patients undergoing minimally invasive repair of pectus excavatum (MIRPE). The results showed that the use of titanium nitride coated pectus bars led to a significant increase in trace metal levels after MIRPE, compared to stainless steel bars, possibly due to wear of the coating and inter-component mobilization processes.
Article
Public, Environmental & Occupational Health
Katharina Schwarz, Katharina Bluemlein, Thomas Goeen, Stefan Hahn, Ralph Hebisch, Wolfgang Koch, Ulrich Poppek, Anja Schaeferhenrich, Urs Schlueter, Monika Krug
Summary: The application of biocidal products by foam as an alternative to droplet spraying has inhalation exposure to aerosols as a concern. The study quantified the formation of inhalable aerosols during foaming and measured the aerosol release fractions of the active substance. The results showed that the aerosol release fractions varied and could be correlated to the process and foam parameters.
ANNALS OF WORK EXPOSURES AND HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Anja Schaeferhenrich, Katharina Bluemlein, Wolfgang Koch, Stefan Hahn, Katharina Schwarz, Ulrich Poppek, Ralph Hebisch, Urs Schlueter, Monika Krug, Thomas Goeen
Summary: This study provides comparative exposure data for foam and spray applications of biocidal products in occupational settings, showing that potential dermal exposure is higher than inhalation exposure. While foam application reduces inhalation exposure, it does not significantly affect potential dermal exposure.
ANNALS OF WORK EXPOSURES AND HEALTH
(2023)
Article
Chemistry, Analytical
Laura Kuhlmann, Frank Muench, Thomas Goeen, Elisabeth Eckert
Summary: An online SPE-LC-MS/MS method was developed for the simultaneous determination of DEHP and alternative plasticizers in urine samples. The method showed high sensitivity and a simple sample preparation procedure, making it suitable for analyzing background levels of plasticizer exposure in the general population and for monitoring studies.
ANALYTICAL METHODS
(2022)
Article
Public, Environmental & Occupational Health
Dewan Muhammad Shoaib, Tanvir Ahmed, Kazy Farhat Tabassum, Mehedi Hasan, Fazle Sharior, Mahbubur Rahman, Makfie Farah, Md Azizur Rahman, Alauddin Ahmed, James B. Tidwell, Mahbub-Ul Alam
Summary: An intervention was implemented in Bangladesh during COVID-19 to reduce occupational health risks for waste and sanitation workers. The intervention involved training and distribution of personal protective equipment (PPE). The study found that the intervention improved workers' knowledge, attitude, and practice regarding PPE usage.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2024)
Article
Public, Environmental & Occupational Health
Andreas Kortenkamp, Olwenn Martin, Eleni Iacovidou, Martin Scholze
Summary: The European Food Safety Authority's downward revision of the Health-based Guidance Value for bisphenol A (BPA) has led to disagreements with other regulatory agencies, particularly the German Federal Institute for Risk Assessment. The differing views between EFSA and BfR are driven by their respective selection of endpoints and study evaluation systems, as well as their acceptance or refusal of immunotoxic effects as a basis for establishing a Health-based Guidance Value.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2024)
Article
Public, Environmental & Occupational Health
Shizhen He, Bjorn Lundberg, Jenny Hallberg, Susanna Klevebro, Goran Pershagen, Kristina Eneroth, Erik Melen, Matteo Bottai, Olena Gruzieva
Summary: Early life air pollution exposure and abnormal inflammation-related protein profiles may interact synergistically towards lower lung function in infants.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2024)
Article
Public, Environmental & Occupational Health
Paulien Cleys, Emilie Hardy, Yu Ait Bamai, Giulia Poma, Adam Cseresznye, Govindan Malarvannan, Paul T. J. Scheepers, Susana Viegas, Simo P. Porras, Tiina Santonen, Lode Godderis, Jelle Verdonck, Katrien Poels, Carla Martins, Maria Joao Silva, Henriqueta Louro, Inese Martinsone, Lasma Akulova, An van Nieuwenhuyse, Martien Graumans, Selma Mahiout, Radu Corneliu Duca, Adrian Covaci
Summary: The aim of this study was to assess the exposure of e-waste workers to phthalates and alternative plasticizers. The results showed that e-waste workers had higher urinary concentrations of phthalates and metabolites compared to non-occupationally exposed controls. However, no significant differences were found between pre-and post-shift concentrations in the e-waste workers.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2024)
Article
Public, Environmental & Occupational Health
Karolina Bralewska
Summary: This review study examines the concentrations of various air pollutants in fire stations, identifies the limitations and strengths of existing research, identifies research gaps and challenges, and suggests potential solutions for reducing firefighter exposure to air pollution at fire stations.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2024)
