Review
Agricultural Engineering
Octavio Garcia-Depraect, Roberto Castro-Munoz, Raill Munoz, Eldon R. Rene, Elizabeth Leon-Becerril, Idania Valdez-Vazquez, Gopalakrishnan Kumar, Luis C. Reyes-Alvarado, Leonardo J. Martinez-Mendoza, Julian Carrillo-Reyes, German Buitron
Summary: Dark fermentation is a promising biological method to produce bio-hydrogen and other value added bio-products, but faces challenges like process instability and low hydrogen production yields. Inhibitory activity of lactate-producing bacteria against hydrogen producers has been highlighted as a major bottleneck, although lactate based metabolic pathways are considered prevalent in hydrogen production.
BIORESOURCE TECHNOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Dragomir Yankov
Summary: This review summarizes the research and progress in lactic acid production from inexpensive and renewable resources over the past 5 years, covering topics such as raw materials, pretreatment and detoxification methods, lactic acid-producers, separation techniques, process organization approaches, and optimization challenges and solutions.
FRONTIERS IN CHEMISTRY
(2022)
Article
Biotechnology & Applied Microbiology
Line D. Hansen, Vincent G. H. Eijsink, Svein J. Horn, Aniko Varnai
Summary: Simultaneous saccharification and fermentation (SSF) is a commonly used strategy for lignocellulosic biomass valorization. Adding small amounts of H2O2 during SSF can sustain the activity of lytic polysaccharide monooxygenases (LPMOs) and improve cellulose depolymerization efficiency, leading to increased lactic acid production.
BIOTECHNOLOGY AND BIOENGINEERING
(2023)
Review
Chemistry, Physical
Yang Chen, Yanan Yin, Jianlong Wang
Summary: Dark fermentative hydrogen production is an effective and feasible technology, but not commercially applied yet due to inhibitory factors limiting hydrogen production potential. This review systematically analyzed various inhibitory factors, including inorganic, organic, and bio-inhibitors, discussing strategies for mitigation and suggesting future research directions.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2021)
Article
Biotechnology & Applied Microbiology
Paola Monteiro de Oliveira, Larissa Provasi Santos, Luciana Fontes Coelho, Paulo Marcelo Avila Neto, Daiane Cristina Sass, Jonas Contiero
Summary: This study focuses on obtaining L(+)-lactic acid from sucrose using Lactobacillus casei Ke11 strain through different feeding strategies, which increases lactic acid production and productivity, while avoiding cellular stress caused by high osmotic pressure. The purification of the acid using charcoal and celite, followed by a cation exchange column, proved to be highly efficient, allowing for a high yield of lactic acid and removal of sugars and proteins. This study shows potential for large-scale fermentation of L. casei Ke11 for production of l-lactic acid.
FERMENTATION-BASEL
(2021)
Review
Energy & Fuels
Ashfaq Ahmad, Fawzi Banat, Habiba Alsafar, Shadi W. Hasan
Summary: PLA, a biodegradable biopolymer produced from fermentative lactic acid, has the potential to replace petroleum-based plastics. It finds applications in the biomedical field and disposable packaging materials. However, PLA is comparatively expensive and has inferior properties to petroleum-based plastics, requiring scientific and technical efforts for improvement.
BIOMASS CONVERSION AND BIOREFINERY
(2022)
Article
Biotechnology & Applied Microbiology
Shanmugaprakasham Selvamani, Solleh Ramli, Daniel Joe Dailin, Khairun Hani Natasya, Theodoros Varzakas, Bassam Abomoelak, Dalia Sukmawati, Muktiningsih Nurjayadi, Siqing Liu, Vijai Kumar Gupta, Hesham Ali El Enshasy
Summary: This study presents a novel technique to enhance the cell mass and viable cell counts of Limosilactobacillus reuteri using anion-exchange resins. The use of IRA 67 resin in batch fermentation and fed-batch cultivation resulted in a higher number of viable cells. An external and integrated resin column system was proposed to overcome the shear stress caused by in situ application of the resin. The integrated resin column significantly improved the viable cell count by 71 times compared to control batch fermentation, due to the high adsorption rate of lactic acid.
FERMENTATION-BASEL
(2022)
Article
Biotechnology & Applied Microbiology
Nisa Saelee
Summary: Using squeezed sap from old oil palm trunks as a substrate, the LA yield and productivity can be improved by employing a modified constant feed fermentation mode.
FERMENTATION-BASEL
(2022)
Article
Environmental Sciences
Zengshuai Zhang, Panagiotis Tsapekos, Merlin Alvarado-Morales, Xinyu Zhu, Athanasios Zervas, Carsten S. Jacobsen, Irini Angelidaki
Summary: The study investigated lactic acid production at low pH using source-sorted organic household waste. By controlling the pH at 5.0 and bio-augmenting with Pedincoccus acidilactici, a high concentration of lactic acid was achieved, leading to reduced production costs. Subsequent batch fermentations and adaptation processes further improved lactic acid concentration and productivity, offering a promising method to utilize residual resources for cost-effective production.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Agricultural Engineering
Nirakar Pradhan, Giuliana d'Ippolito, Laura Dipasquale, Giovanni Esposito, Antonio Panico, Piet N. L. Lens, Angelo Fontana
Summary: This study investigated the feasibility of hydrogen and L-lactic acid production from starch using Thermotoga neapolitana under capnophilic lactic fermentation conditions. Different yields of H2 and lactic acid were achieved from potato and wheat starch, with higher lactic acid production observed in the presence of CO2. A kinetic model was applied to simulate the metabolic profile and bioreactor performance, suggesting a new direction towards transforming agricultural food waste into biofuels and valuable biochemicals.
BIORESOURCE TECHNOLOGY
(2021)
Article
Chemistry, Physical
Grazia Policastro, Marco Giugliano, Vincenzo Luongo, Raffaele Napolitano, Massimiliano Fabbricino
Summary: The study demonstrates the feasibility of a two-phase biorefinery process applied to waste substrates for producing ethanol rich effluents. It involves dark fermentation followed by photo fermentation to optimize hydrogen production from waste biomass. Using winery wastewater as feedstock, no additional treatments are required, and good hydrogen production results are obtained during the photo fermentative stage.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2022)
Article
Agricultural Engineering
Yanan Yin, Weize Song, Jianlong Wang
Summary: This study examined the working mechanisms of acetic acid inhibition on dark fermentative hydrogen production. The results showed that undissociated acetic acid concentration was the critical factor in acetic acid inhibition. Acetic acid inhibited hydrogen production by altering the dominant microbial community and regulating the metabolic pathways. Controlling the undissociated acetic acid concentration would be an effective strategy to alleviate acetic acid inhibition.
BIORESOURCE TECHNOLOGY
(2022)
Article
Food Science & Technology
Katherine Lobeda, Qing Jin, Jian Wu, Wencai Zhang, Haibo Huang
Summary: This study aims to maximize lactic acid production from food waste fermentation by investigating key fermentation variables. The results show that supplementation of yeast extract and peptone significantly improves fermentation titer and productivity, while increasing the initial sugar concentration also increases fermentation titer and productivity. pH 6.0 is found to be the optimal pH for fermentation. The high fermentation yield of 1.12 g/g can be explained by additional lactic acid production from unidentified compounds in food waste hydrolysates. Fed-batch fermentation can further increase the lactic acid concentration. A total of 251 kg lactic acid can be produced from 1000 kg food waste.
JOURNAL OF FOOD SCIENCE
(2022)
Article
Chemistry, Physical
Ikbal Oren, Ayse Calkaya, Handan Han, Nurce Keskin, Zeynep Karaoglan, Muhammed Enes Miynat, Ismail Gorgul, Hidayet Argun
Summary: This study presents the production of hydrogen gas from molasses by hot spring microflora in three stages. The most suitable temperature and inoculation percentage were determined through suspended culture, and promising hydrogen production was achieved using biofilm culture.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2022)
Article
Chemistry, Physical
Yang Chen, Yanan Yin, Jianlong Wang
Summary: The addition of butyric acid can inhibit hydrogen production and decrease substrate utilization rate in dark fermentative hydrogen production system, leading to an increase in the proportion of non-hydrogen-producing bacteria in the microbial community.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2021)
Article
Engineering, Environmental
Shahram Amirnia, Madhumita B. Ray, Argyrios Margaritis
CHEMICAL ENGINEERING JOURNAL
(2015)
Article
Pharmacology & Pharmacy
Christoph Hoennscheidt, Argyrios Margaritis, Rainer Krull
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2015)
Article
Pharmacology & Pharmacy
Landi Cheng, Cody Bulmer, Argyrios Margaritis
CURRENT DRUG DELIVERY
(2015)
Article
Engineering, Environmental
Shahram Amirnia, Madhumita B. Ray, Argyrios Margaritis
CHEMICAL ENGINEERING JOURNAL
(2016)
Review
Biotechnology & Applied Microbiology
Isabela Reiniati, Andrew N. Hrymak, Argyrios Margaritis
CRITICAL REVIEWS IN BIOTECHNOLOGY
(2017)
Article
Chemistry, Applied
Shahram Amirnia, Argyrios Margaritis, Madhumita B. Ray
ADSORPTION SCIENCE & TECHNOLOGY
(2012)
Article
Biotechnology & Applied Microbiology
Cody Bulmer, Argyrios Margaritis, Anargyros Xenocostas
BIOCHEMICAL ENGINEERING JOURNAL
(2012)
Article
Biotechnology & Applied Microbiology
Christoph Hoennscheidt, Dirk Kreyenschulte, Argyrios Margaritis, Rainer Krull
BIOCHEMICAL ENGINEERING JOURNAL
(2013)
Article
Biotechnology & Applied Microbiology
Frank Hellmers, Peter Ferguson, James Koropatnick, Rainer Krull, Argyrios Margaritis
BIOCHEMICAL ENGINEERING JOURNAL
(2013)
Article
Agricultural Engineering
Peter Kilonzo, Argyrios Margaritis, Maurice Bergougnou
BIORESOURCE TECHNOLOGY
(2011)
Article
Engineering, Chemical
Shahram Amirnia, John R. de Bruyn, Maurice A. Bergougnou, Argyrios Margaritis
CHEMICAL ENGINEERING SCIENCE
(2013)
Review
Biotechnology & Applied Microbiology
Dirk Kreyenschulte, Rainer Krull, Argyrios Margaritis
CRITICAL REVIEWS IN BIOTECHNOLOGY
(2014)
Review
Biotechnology & Applied Microbiology
David Hudson, Argyrios Margaritis
CRITICAL REVIEWS IN BIOTECHNOLOGY
(2014)
Article
Chemistry, Physical
Bita Baghchehsaraee, George Nakhla, Dimitre Karamanev, Argyrios Margaritis
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2011)
Review
Pharmacology & Pharmacy
Cody Bulmer, Argyrios Margaritis, Anargyros Xenocostas
CURRENT DRUG DELIVERY
(2012)
