The role of PML in hematopoietic and leukemic stem cell maintenance

DNA damage response, redox status and hematopoiesis

(2013) Cary N. Weiss et al.   BLOOD CELLS MOLECULES AND DISEASES

Regulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells

(2013) Keiyo Takubo et al.   Cell Stem Cell

Mechanisms of action and resistance to all-trans retinoic acid (ATRA) and arsenic trioxide (As2O3) in acute promyelocytic leukemia

(2013) Akihiro Tomita et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

All-trans-retinoic acid, idarubicin, and IV arsenic trioxide as initial therapy in acute promyelocytic leukemia (APML4)

(2012) H. J. Iland et al.   BLOOD

Cellular Metabolism and Disease: What Do Metabolic Outliers Teach Us?

(2012) Ralph J. DeBerardinis et al.   CELL

Roles of the hypoxia response system in hematopoietic and leukemic stem cells

(2012) Keiyo Takubo et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Effects of hypoxia and HIFs on cancer metabolism

(2012) Vera Mucaj et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

A metabolic prosurvival role for PML in breast cancer

(2012) Arkaitz Carracedo et al.   JOURNAL OF CLINICAL INVESTIGATION

A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance

(2012) Keisuke Ito et al.   NATURE MEDICINE

Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche

(2011) Toshio Suda et al.   Cell Stem Cell

DNA damage response in adult stem cells: pathways and consequences

(2011) Pankaj K. Mandal et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Rethinking the Warburg Effect with Myc Micromanaging Glutamine Metabolism

(2010) C. V. Dang   CANCER RESEARCH

mTOR Activation Induces Tumor Suppressors that Inhibit Leukemogenesis and Deplete Hematopoietic Stem Cells after Pten Deletion

(2010) Jae Y. Lee et al.   Cell Stem Cell

The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche

(2010) Tugba Simsek et al.   Cell Stem Cell

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells

(2010) Daisuke Nakada et al.   NATURE

The Lkb1 metabolic sensor maintains haematopoietic stem cell survival

(2010) Sushma Gurumurthy et al.   NATURE

Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells

(2010) Boyi Gan et al.   NATURE

Arsenic Trioxide Controls the Fate of the PML-RAR  Oncoprotein by Directly Binding PML

(2010) X. W. Zhang et al.   SCIENCE

Changing nuclear landscape and unique PML structures during early epigenetic transitions of human embryonic stem cells

(2009) John T. Butler et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Pten Deletion in Adult Neural Stem/Progenitor Cells Enhances Constitutive Neurogenesis

(2009) C. Gregorian et al.   JOURNAL OF NEUROSCIENCE

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

(2009) Zachary T. Schafer et al.   NATURE

The tumor suppressor Pml regulates cell fate in the developing neocortex

(2009) Tarik Regad et al.   NATURE NEUROSCIENCE

Long-term efficacy and safety of all-trans retinoic acid/arsenic trioxide-based therapy in newly diagnosed acute promyelocytic leukemia

(2009) J. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PML depletion disrupts normal mammary gland development and skews the composition of the mammary luminal cell progenitor pool

(2009) W. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stems Cells and the Pathways to Aging and Cancer

(2008) Derrick J. Rossi et al.   CELL

The deubiquitinylation and localization of PTEN are regulated by a HAUSP–PML network

(2008) Min Sup Song et al.   NATURE

PML targeting eradicates quiescent leukaemia-initiating cells

(2008) Keisuke Ito et al.   NATURE

Arsenic degrades PML or PML–RARα through a SUMO-triggered RNF4/ubiquitin-mediated pathway

(2008) Valérie Lallemand-Breitenbach et al.   NATURE CELL BIOLOGY

PI3K pathway alterations in cancer: variations on a theme

(2008) T L Yuan et al.   ONCOGENE

Retinoic acid-stimulated sequential phosphorylation, PML recruitment, and SUMOylation of nuclear receptor TR2 to suppress Oct4 expression

(2008) P. Gupta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA