Article
Hematology
Abdulrahman Alsultan, Rodaina Abujoub, Reem Alsudairy, Shahbaz Memon, Mohammad S. Jarrar, Sameera Alafghani, Saad Aldaama, Walid Ballourah, Fahd Almanjomi, Mohammed F. Essa
Summary: This study investigated the efficacy of a unified HSCT conditioning protocol consisting of low-dose Cy, fludarabine, and ATG in children with severe aplastic anaemia. The data reviewed from Saudi institutions showed a successful engraftment in all 32 patients who received the HSCT. The 3-year event-free survival rate was 93% and the overall survival rate was 95%.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Immunology
Dimitrios Filioglou, Muhammad Husnain, Sharad Khurana, Richard J. Simpson, Emmanuel Katsanis
Summary: The most common lymphodepletion regimen used before CAR-T cell infusion is a combination of cyclophosphamide and fludarabine. However, this regimen may affect the efficacy of CAR-T cells and is linked to neurotoxicity. Due to the shortage of fludarabine, alternative lymphodepleting agents are needed. This review focuses on the use of bendamustine as a lymphodepleting agent and suggests that it may have comparable efficacy and a more favorable toxicity profile compared to cyclophosphamide-fludarabine.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biophysics
Ryszard Swoboda, Myriam Labopin, Sebastian Giebel, Emanuele Angelucci, Mutlu Arat, Mahmoud Aljurf, Simona Sica, Jiri Pavlu, Gerard Socie, Paolo Bernasconi, Luigi Rigacci, Johanna Tischer, Antonio Risitano, Montserrat Rovira, Riccardo Saccardi, Pietro Pioltelli, Gwendolyn Van Gorkom, Antonin Vitek, Bipin N. Savani, Alexandros Spyridonidis, Zinaida Peric, Arnon Nagler, Mohamad Mohty
Summary: This study compared the outcomes of two conditioning regimens for adult acute lymphoblastic leukemia patients undergoing haploidentical hematopoietic cell transplantation. The results showed that the use of fludarabine + total body irradiation (Flu-TBI) reduced the risk of non-relapse mortality, while the use of thiotepa + iv. busulfan + fludarabine (TBF) may reduce the risk of relapse.
BONE MARROW TRANSPLANTATION
(2022)
Article
Thermodynamics
Denes Lorinczy, David Szatmari
Summary: Actin is an essential protein in the cytoskeleton and muscle sarcomeres. The nucleotide-binding cleft plays an important role in the development of actin functions. Cyclophosphamide has a less significant impact on actin filaments than monomers.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2022)
Article
Hematology
Riad El Fakih, Saud Alhayli, Syed Osman Ahmed, Marwan Shaheen, Naeem Chaudhri, Fahad Alsharif, Amr Hanbali, Feras Alfraih, Alfadel Alshaibani, Ali Assiri, Hadeel Samarkandi, Fatima Babiker, Ahmad Alshomar, Anas Alhakim, Emad Ghabashi, Ahmed Kotb, Tusneem Elhassan, Ahmed Balbaid, Husam Alsadi, Walid Rasheed, Ali Alahmari, Hazzaa Alzahrani, Fahad Almohareb, Mahmoud Aljurf
Summary: This study is a retrospective analysis of 82 consecutive patients with severe aplastic anemia who underwent allogeneic hematopoietic cell transplantation with a matched sibling donor. The results show that using mobilized bone marrow grafts and fludarabine-cyclophosphamide conditioning is an effective and safe approach for treating these patients.
TRANSPLANTATION AND CELLULAR THERAPY
(2021)
Article
Medicine, Research & Experimental
Elisa Zaghi, Michela Calvi, Simone Puccio, Gianmarco Spata, Sara Terzoli, Clelia Peano, Alessandra Roberto, Federica De Paoli, Jasper J. P. van Beek, Jacopo Mariotti, Chiara De Philippis, Barbara Sarina, Rossana Mineri, Stefania Bramanti, Armando Santoro, Vu Thuy Khanh Le-Trilling, Mirko Trilling, Emanuela Marcenaro, Luca Castagna, Clara Di Vito, Enrico Lugli, Domenico Mavilio
Summary: This study shows that HCMV accelerates NK cell immune reconstitution and expands NK cells with adaptive traits. These NK cells are characterized by downmodulation of gene pathways associated with cell migration, the cell cycle, and effector-functions, as well as metabolic/cellular exhaustion, due to the viral-induced expression of checkpoint inhibitors LAG-3 and PD-1.
Article
Chemistry, Medicinal
Thomas Desmettre, Martin A. Mainster, Gerardo Ledesma-Gil
Summary: This study presents the clinical findings and multimodal imaging of three patients who developed bacillary layer detachments (BALADs) shortly after half-fluence, half-dose verteporfin photodynamic therapy (PDT). The BALADs resolved over 6-8 weeks and did not cause photoreceptor damage over a 6-month follow-up period. The reduced-impact HFHD protocol may decrease direct tissue damage but increase proinflammatory cytokines.
Article
Hematology
Wenli Zhang, Ruirui Gui, Yingling Zu, Binglei Zhang, Zhen Li, Yanli Zhang, Xianjing Wang, Shuli Guo, Xinrong Zhan, Yuewen Fu, Yongping Song, Jian Zhou
Summary: This study demonstrates that the combination of reduced-dose post-transplant cyclophosphamide (PTCy) and low-dose post-transplant anti-thymocyte globulin (ATG) in haploidentical peripheral blood stem cell transplantation (haplo-PBSCT) significantly reduces the incidence of graft-versus-host disease (GVHD) and improves overall survival and disease-free survival.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Oncology
Nitin Jain, Philip Thompson, Jan Burger, Alessandra Ferrajoli, Koichi Takahashi, Zeev Estrov, Gautam Borthakur, Prithviraj Bose, Tapan Kadia, Naveen Pemmaraju, Koji Sasaki, Marina Konopleva, Elias Jabbour, Naveen Garg, Xuemei Wang, Rashmi Kanagal-Shamanna, Keyur Patel, Wei Wang, Jeffrey Jorgensen, Sa Wang, Wanda Lopez, Ana Ayala, William Plunkett, Varsha Gandhi, Hagop Kantarjian, Susan O'Brien, Michael Keating, William G. Wierda
Summary: The iFCG regimen with only 3 cycles of chemotherapy is an effective, time-limited regimen for patients with CLL with mutated IGHV and without del(17p)/TP53 mutation. The treatment resulted in high rates of complete remission and undetectable measurable residual disease in the marrow, with excellent 3-year progression-free and overall survival rates.
Article
Rheumatology
Miao Shao, Miao Miao, Xia Zhang, Xiaoying Zhang, Yuan An, Huifang Guo, Lingyan Lei, Qing Zhao, Yanjie Ding, Jin Lin, Rui Wu, Feng Yu, Yucui Li, Huali Miao, Liyun Zhang, Yan Du, Ruiying Jiao, Lixia Pang, Li Long, Xueming Yao, Xiaofei Shi, Fei Wang, Luping Cui, Lei Zhang, Shengyun Liu, Fuai Lu, Kangkai Luo, Simeng Zhao, Yongfu Wang, Xiao Wu, Qingwen Wang, Hongjiang Liu, Shulin Song, Xiaoyuan Zhou, Xiaoping Zhang, Shumei Shi, Hong Zhu, Yao Chen, Honglian Yu, Jie Wu, Ruiyun Yu, Wenqiang Fan, Shuang Liu, Jian Xu, Zhibin Chen, Lianjie Shi, Jing He, Xuewu Zhang, Zhanguo Li, Ru Li
Summary: Infection is a major cause of death in patients with SLE. This study found that patients receiving low-dose IV-CYC had a significantly lower infection rate compared to high-dose IV-CYC. Respiratory tract and skin/soft tissue infections were notably decreased in the low-dose group, with infections more likely in SLE patients with leucopenia, pulmonary arterial hypertension, and higher doses of glucocorticoid.
LUPUS SCIENCE & MEDICINE
(2022)
Article
Medicine, General & Internal
David I. Marks, Anna Castleton, Eduardo Olavarria, Maria Gilleece, Adele Fielding, George Mikhaeel, Matthew Beasley, Patricia Diez, Aimee Jackson, Andrea Hodgkinson, Mohamed Elhanied, Ronjon Chakraverty
Summary: This study examines the usage of T-cell depleted, reduced intensity conditioning (RIC) approach to haematopoietic cell transplantation (HCT) in adult patients with acute lymphoblastic leukaemia (ALL). The results show encouraging survival rates but high relapse rates, suggesting the need for more powerful conditioning approaches.
Review
Hematology
Mohammad Vaezi, Maryam Souri, Seyed Amin Setarehdan, Amir Ali Hamidieh, Mohammad Reza Fazlollahi, Zahra Pourpak, Mohsen Badalzadeh, Shaghayegh Tajik, Seyed Alireza Mahdaviani, Kamran Alimoghaddam, Ardeshir Ghavamzadeh
Summary: Chronic granulomatous disease (CGD) is a life-threatening immunodeficiency condition. Hematopoietic stem cell transplantation (HSCT) with fludarabine, melphalan, and anti-thymocyte globulin (ATG) has shown relatively favorable outcomes in CGD patients.
ANNALS OF HEMATOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Christiane Kuhl, Tibor Csoszi, Wojciech Piskorski, Tomasz Miszalski, Jeong-Min Lee, Pamela M. Otto
Summary: This study compared the effectiveness of Gadopiclenol and Gadobutrol for lesion visualization in body MRI. The results showed that Gadopiclenol at a dose of 0.05 mmol/kg was comparable to Gadobutrol at a dose of 0.1 mmol/kg in terms of lesion evaluation, and both had a similar safety profile.
Article
Medicine, General & Internal
Shunsuke Furuta, Daiki Nakagomi, Yoshihisa Kobayashi, Masaki Hiraguri, Takao Sugiyama, Koichi Amano, Takeshi Umibe, Hajime Kono, Kazuhiro Kurasawa, Yasuhiko Kita, Ryutaro Matsumura, Yuko Kaneko, Keita Ninagawa, Keiju Hiromura, Shin-ichiro Kagami, Yosuke Inaba, Hideki Hanaoka, Kei Ikeda, Hiroshi Nakajima
Summary: The study compared the efficacy and safety between a reduced-dose glucocorticoid plus rituximab regimen and a standard high-dose glucocorticoid plus rituximab regimen for the remission induction of ANCA-associated vasculitis. Results showed that the reduced-dose regimen was noninferior to the high-dose regimen in terms of inducing disease remission at 6 months, while having lower rates of adverse events.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Genetics & Heredity
Rongmu Luo, Xiaomei Zhang, Ya Wang, Qihang Man, Wenjing Gu, Zhengqin Tian, Jingbo Wang
Summary: Our findings suggest that PTCy may be an alternative choice for the prevention of GVHD among CAEBV patients treated with haplo-HSCT.
ORPHANET JOURNAL OF RARE DISEASES
(2022)
Letter
Hematology
Naokazu Nakamura, Yasuyuki Arai, Toshio Kitawaki, Tomoyasu Jo, Chisaki Mizumoto, Junya Kanda, Momoko Nishikori, Kouhei Yamashita, Akifumi Takaori-Kondo
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Infectious Diseases
Nozomu Yoshino, Shun-ichi Kimura, Akari Matsuoka, Tomohiro Meno, Takuto Ishikawa, Yuhei Nakamura, Masakatsu Kawamura, Junko Takeshita, Shunto Kawamura, Yukiko Misaki, Kazuki Yoshimura, Ayumi Gomyo, Yosuke Okada, Masaharu Tamaki, Yu Akahoshi, Machiko Kusuda, Kazuaki Kameda, Aki Tanihara, Hidenori Wada, Hideki Nakasone, Shinichi Kako, Yoshinobu Kanda
Summary: In autologous hematopoietic cell transplantation, there is a high incidence of febrile neutropenia, possibly due to mucosal damage. However, the rate of bloodstream infection is lower compared to AML consolidation chemotherapy.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2023)
Article
Hematology
Yu Akahoshi, Hideki Nakasone, Katsuto Takenaka, Satoshi Yamasaki, Momoko Nakamura, Noriko Doki, Masatsugu Tanaka, Yukiyasu Ozawa, Naoyuki Uchida, Takahide Ara, Hirohisa Nakamae, Shuichi Ota, Makoto Onizuka, Shingo Yano, Junji Tanaka, Takahiro Fukuda, Yoshinobu Kanda, Yoshiko Atsuta, Shinichi Kako, Masamitsu Yanada, Yasuyuki Arai
Summary: A nationwide retrospective study revealed that cytomegalovirus reactivation (CMVR) is associated with a lower relapse risk in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) patients after allogeneic hematopoietic cell transplantation (HCT). This finding suggests important implications for CMV prophylaxis strategies after HCT.
Article
Cell & Tissue Engineering
Masaharu Tamaki, Yu Akahoshi, Yosuke Okada, Naoyuki Uchida, Masatsugu Tanaka, Noriko Doki, Masashi Sawa, Yumiko Maruyama, Yasunori Ueda, Shigesaburo Miyakoshi, Yuta Katayama, Toshiro Kawakita, Takafumi Kimura, Makoto Onizuka, Takahiro Fukuda, Yoshiko Atsuta, Ryu Yanagisawa, Kimikazu Yakushijin, Junya Kanda, Hideki Nakasone
Summary: This study compared the survival outcomes between unrelated cord blood transplantation (UCBT) and unrelated female-to-male bone marrow transplantation (UFMBMT) groups. The results showed that HLA-mismatched UFMBMT was associated with a decreased risk of relapse, and HLA-matched UFMBMT had a tendency of decreased relapse risk. HLA-matched UFMBMT was also associated with favorable overall survival.
Article
Multidisciplinary Sciences
Masaharu Tamaki, Yu Akahoshi, Masahiro Ashizawa, Yukiko Misaki, Satoshi Koi, Sung-Won Kim, Yukiyasu Ozawa, Shin-ichiro Fujiwara, Shinichi Kako, Ken-ichi Matsuoka, Masashi Sawa, Yuta Katayama, Makoto Onizuka, Yoshinobu Kanda, Takahiro Fukuda, Yoshiko Atsuta, Kimikazu Yakushijin, Hideki Nakasone
Summary: Allogeneic hematopoietic cell transplantation between female donors and male recipients is a known risk factor for inferior survival outcomes. This study found that the use of anti-thymocyte globulin (ATG) in female-to-male allo-HCT did not reduce the risk of graft-versus-host disease (GVHD), but was associated with improved overall survival and decreased non-relapse mortality. The use of ATG in female-to-male allo-HCT resulted in survival outcomes similar to those in male-to-male allo-HCT, suggesting that ATG may overcome the inferiority of survival outcomes in female-to-male allo-HCT.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Shun-ichi Kimura, Yu Akahoshi, Souichi Shiratori, Keiji Okinaka, Kaito Harada, Naoyuki Uchida, Noriko Doki, Kazuhiro Ikegame, Hirohisa Nakamae, Masatsugu Tanaka, Satoru Takada, Toshiro Kawakita, Ken-ichi Matsuoka, Takahide Ara, Shuichi Ota, Masashi Sawa, Makoto Onizuka, Takahiro Fukuda, Yoshiko Atsuta, Yoshinobu Kanda, Hideki Nakasone
Summary: This study found an association between candidemia and noninfectious interstitial pneumonia in allogeneic hematopoietic cell transplantation recipients. Candidemia was significantly associated with an increased incidence of noninfectious interstitial pneumonia, and the prognosis for patients with both conditions was extremely poor.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Hematology
Yu Akahoshi, Nikolaos Spyrou, William J. Hogan, Francis Ayuk, Zachariah DeFilipp, Daniela Weber, Hannah K. Choe, Elizabeth O. Hexner, Wolf Roesler, Aaron M. Etra, Karamjeet Sandhu, Gregory A. Yanik, Chantiya Chanswangphuwana, Carrie L. Kitko, Ran Reshef, Sabrina Kraus, Matthias Woelfl, Matthias Eder, Hannah Bertrand, Muna Qayed, Pietro Merli, Stephan A. Grupp, Paibel Aguayo-Hiraldo, Tal Schechter, Evelyn Ullrich, Janna Baez, Rahnuma Beheshti, Sigrun Gleich, Steven Kowalyk, George Morales, Rachel Young, Deukwoo Kwon, Ryotaro Nakamura, John E. Levine, James L. M. Ferrara, Yi-Bin Chen
Summary: This study aims to better describe the clinical progression and prognosis of late acute graft-versus-host disease (GVHD). Late acute GVHD was more severe than classic acute GVHD based on clinical and biomarker parameters, and had a lower overall response rate after treatment. Advanced age, female-to-male sex mismatch, and the use of reduced intensity conditioning were associated with the development of late acute GVHD. Overall outcomes were comparable between patients with classic and late acute GVHD, suggesting that treatment strategies based on clinical presentation are appropriate.
Letter
Hematology
Ryosuke Naka, Tadakazu Kondo, Masashi Nishikubo, Hiroyuki Muranushi, Yasunori Ueda, Tomomi Oka, Fumiya Wada, Junya Kanda, Shohei Yamamoto, Mitsumasa Watanabe, Shinri Okada, Kazunori Imada, Yukiharu Nakabo, Yu Mizutani, Yasuhito Nannya, Seishi Ogawa, Takayuki Ishikawa
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Biophysics
Yoshimitsu Shimomura, Sho Komukai, Tetsuhisa Kitamura, Tomotaka Sobue, Yu Akahoshi, Junya Kanda, Hiroyuki Ohigashi, Hirohisa Nakamae, Nobuhiro Hiramoto, Koji Nagafuji, Takashi Tanaka, Tetsuya Eto, Shuichi Ota, Yumiko Maruyama, Takashi Akasaka, Ken-ichi Matsuoka, Yasuo Mori, Takahiro Fukuda, Yoshiko Atsuta, Seitaro Terakura
Summary: There is no association between GVHD and reduced relapse rate or improved OS in patients who undergo haplo-HSCT using PTCY. However, grade III-IV acute GVHD and extensive chronic GVHD are associated with higher NRM.
BONE MARROW TRANSPLANTATION
(2023)
Letter
Biophysics
Shigeo Fuji, Akitoshi Hakoda, Junya Kanda, Takahiro Fukuda, Noriko Doki, Yuta Katayama, Naoyuki Uchida, Yukiyasu Ozawa, Yoshinobu Kanda, Masatsugu Tanaka, Keisuke Kataoka, Takahide Ara, Masashi Sawa, Makoto Onizuka, Yasushi Onishi, Takafumi Kimura, Tatsuo Ichinohe, Yoshiko Atsuta, Ayumi Shintani, Satoko Morishima
BONE MARROW TRANSPLANTATION
(2023)
Article
Hematology
Monzr M. Al Malki, Kaitlyn London, Janna Baez, Yu Akahoshi, William J. Hogan, Aaron Etra, Hannah Choe, Elizabeth Hexner, Amelia Langston, Sunil Abhyankar, Doris M. Ponce, Zachariah Defilipp, Carrie L. Kitko, Kehinde Adekola, Ran Reshef, Francis Ayuk, Alexandra Capellini, Chantiya Chanswangphuwana, Matthias Eder, Gilbert Eng, Isha Gandhi, Stephan Grupp, Sigrun Gleich, Ernst Holler, Nora Rebeka Javorniczky, Stelios Kasikis, Steven Kowalyk, George Morales, Umut Oezbek, Wolf Roesler, Nikolaos Spyrou, Gregory Yanik, Rachel Young, Yi-Bin Chen, Ryotaro Nakamura, James L. M. Ferrara, John E. Levine
Summary: The combination of natalizumab and corticosteroids did not improve outcomes for patients with newly diagnosed high-risk GVHD.
Article
Cell & Tissue Engineering
Fumiya Wada, Junya Kanda, Kimimori Kamijo, Masashi Nishikubo, Satoshi Yoshioka, Takayuki Ishikawa, Yasunori Ueda, Takashi Akasaka, Yasuyuki Arai, Kiyotaka Izumi, Hirokazu Hirata, Takashi Ikeda, Akihito Yonezawa, Naoyuki Anzai, Mitsumasa Watanabe, Kazunori Imada, Kazuhiro Yago, Naoki Tamura, Mitsuru Itoh, Yuki Masuo, Akane Kunitomi, Tomoharu Takeoka, Toshiyuki Kitano, Nobuyoshi Arima, Masakatsu Hishizawa, Kohsuke Asagoe, Tadakazu Kondo, Akifumi Takaori-Kondo, Kyoto Stem Cell Transplantat Grp
Summary: Haploidentical-related donor transplantation and cord blood transplantation are valid alternatives when HLA-matched donor transplantation is unavailable for patients with hematological malignancies. However, the effects of graft-versus-host disease on outcomes after these transplants have not been fully elucidated. This study evaluated the effects of acute and chronic GVHD on transplant outcomes after PTCy-haplo transplants and compared them with CBT and MDT.
CELL TRANSPLANTATION
(2023)
Article
Hematology
Mari Morita-Fujita, Takero Shindo, Tomoki Iemura, Yasuyuki Arai, Junya Kanda, Kazuya Okada, Yasunori Ueda, Onda Yoshiyuki, Naoyuki Anzai, Takuto Mori, Takayuki Ishikawa, Yasuyuki Otsuka, Akihito Yonezawa, Naoki Yuhi, Kazunori Imada, Akifumi Oba, Mitsuru Itoh, Yoshio Okamoto, Toshiyuki Kitano, Takashi Ikeda, Shinichi Kotani, Takashi Akasaka, Kazuhiro Yago, Mitsumasa Watanabe, Masaharu Nohgawa, Masaaki Tsuji, Tomoharu Takeoka, Ryusuke Yamamoto, Nobuyoshi Arima, Noriyoshi Yoshinaga, Masakatsu Hishizawa, Kouhei Yamashita, Tadakazu Kondo, Akifumi Takaori-Kondo
Summary: Cord blood transplantation is an attractive option for treating hematologic malignancies. The association between HLA epitope mismatches and relapse following single-unit cord blood transplantation was investigated. Higher HLA epitope mismatches were associated with better disease-free survival in one group and increased nonrelapse mortality in another.
TRANSPLANTATION AND CELLULAR THERAPY
(2023)
Article
Hematology
Naokazu Nakamura, Fumiya Wada, Tadakazu Kondo, Kazunari Aoki, Yasuyuki Arai, Chisaki Mizumoto, Junya Kanda, Toshio Kitawaki, Kouhei Yamashita, Akifumi Takaori-Kondo
Summary: The combination of calcineurin inhibitors and short-term methotrexate is a standard prophylaxis for graft-versus-host disease (GVHD) in allogeneic hematopoietic stem cell transplantation. However, the omission of the day 11 methotrexate dose is associated with a higher risk of severe GVHD.
TRANSPLANTATION AND CELLULAR THERAPY
(2023)
Letter
Biophysics
Tomoyasu Jo, Yasuyuki Arai, Toshio Kitawaki, Naokazu Nakamura, Momoko Nishikori, Chisaki Mizumoto, Junya Kanda, Kouhei Yamashita, Miki Nagao, Akifumi Takaori-Kondo
BONE MARROW TRANSPLANTATION
(2023)
