Journal
INTERNATIONAL JOURNAL OF HEMATOLOGY
Volume 94, Issue 3, Pages 224-229Publisher
SPRINGER JAPAN KK
DOI: 10.1007/s12185-011-0923-7
Keywords
MiR-146a; Pathophysiological pathway; Hematopoiesis disease
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Funding
- Shanghai Municipal Commission of Sciences and Technology [09ZR1418400]
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MicroRNAs (MiRNAs) are a class of small non-coding regulatory RNAs that repress protein expression at the posttranscriptional level and play important roles in hematopoiesis processes. MiR-146a is a miRNA that is thought to regulate physiological and pathophysiological pathways in hematopoietic cells. In this review, we focus on recent progress in analyzing the functional roles of miR-146a in normal hematopoiesis and hematopoietic disease. We suggest that manipulation of miR-146a expression may represent a potential new therapy for several hematopoietic diseases, and may further serve as a biomarker for diagnosis, prevention, and treatment of such disease.
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