Article
Medicine, Research & Experimental
Erika S. Varady, L. Angel Ayala, Pauline U. Nguyen, Vanessa M. Scarfone, Alborz Karimzadeh, Cuiwen Zhou, Xiyu Chen, Scott A. Greilach, Craig M. Walsh, Matthew A. Inlay
Summary: Donor cell conditioning with the glucocorticoid fluticasone propionate (FLU) prior to transplantation increases HSC engraftment and reduces the severity and incidence of graft-versus-host disease (GvHD) in allogeneic hosts.
EMBO MOLECULAR MEDICINE
(2023)
Article
Immunology
Thomas Krueger, Rebekka Wehner, Maik Herbig, Martin Kraeter, Michael Kramer, Jan Moritz Middeke, Friedrich Stoelzel, Catrin List, Katharina Egger-Heidrich, Raphael Teipel, Uta Oelschlaegel, Martin Wermke, Helena Jambor, Manja Wobus, Johannes Schetelig, Korinna Joehrens, Torsten Tonn, Julien Subburayalu, Marc Schmitz, Martin Bornhauser, Malte von Bonin
Summary: Functional impairment of the bone marrow niche, particularly a decrease in mesenchymal stromal cells (MSCs), is associated with cytopenia and graft failure after hematopoietic cell transplantation. Acute graft-versus-host disease (aGvHD) is shown to significantly reduce MSC numbers, and this reduction can be observed before clinical onset of aGvHD. The different phenotypic and functional characteristics of MSCs depending on the occurrence of aGvHD suggest that they may contribute to alloreactivity after transplantation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Konradin F. Muskens, Caroline A. Lindemans, Mirjam E. Belderbos
Summary: GvHD is a major complication of HCT, causing severe hematopoietic dysfunction. Immune activation during GvHD damages hematopoietic stem cells and their niche in the bone marrow, leading to reduced functionality. Complications and treatments associated with HCT exacerbate hematopoietic dysfunction.
Article
Surgery
Cecile Chague, Thomas Gautier, Ludivine Dal Zuffo, Jean-Paul Pais de Barros, Audrey Wetzel, Georges Tarris, Gaetan Pallot, Laurent Martin, Severine Valmary-Degano, Valerie Deckert, Laurent Lagrost, Etienne Daguindau, Philippe Saas
Summary: This study found that HDL deficiency leads to LPS accumulation and exacerbates aGVHD. However, administration of HDL isolated from human plasma significantly decreases the mortality and severity of aGVHD. HDL infusion also plays an important role in mitigating liver aGVHD by reducing immune infiltration and inflammation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Martin H. Cherk, Robert Khor, Thomas W. Barber, Kenneth S. K. Yap, Sushrut Patil, Patricia Walker, Sharon Avery, Stuart Roberts, William Kemp, Alan Pham, Michael Bailey, Victor Kalff
Summary: This study evaluated the diagnostic utility of 18F-FDG PET/CT for acute GIT-GVHD. The results showed that 18F-FDG PET/CT is a useful noninvasive diagnostic test, with high sensitivity and specificity for detecting acute GIT-GVHD. It was also found that acute GIT-GVHD typically involves the colon and can be confirmed by colonic biopsy obtained by sigmoidoscopy. However, 18F-FDG PET cannot distinguish acute GIT-GVHD from non-GVHD inflammatory changes in the colon.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Immunology
Pooja Khandelwal, Rosa F. Yeh, Louie Yu, Adam Lane, Christopher E. Dandoy, Javier El-Bietar, Stella M. Davies, Michael S. Grimley
Summary: The addition of abatacept to standard acute GVHD prophylaxis effectively reduced the incidence of severe acute GVHD in children with beta-thalassemia major undergoing HSCT, without affecting engraftment. Thalassemia-free survival was significantly higher in the abatacept group compared to the standard group.
Article
Immunology
Raghavan Chinnadurai, Paul D. Bates, Keith A. Kunugi, Kwangok P. Nickel, Larry A. DeWerd, Christian M. Capitini, Jacques Galipeau, Randall J. Kimple
Summary: MSCs are being tested as a cell therapy in clinical trials for inflammatory disorders, but suitable preclinical animal models are rare. In this study, two robust animal models of immune pathology were introduced to study the effect of IFN gamma primed bone marrow derived MSCs in acute radiation syndrome and graft versus host disease. The results showed that infused IFN gamma primed allogeneic MSCs protect against lethality from ARS, but not GvHD.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Qianqian Wang, Xiuhua Su, Yi He, Mei Wang, Donglin Yang, Rongli Zhang, Jialin Wei, Qiaoling Ma, Weihua Zhai, Aiming Pang, Yong Huang, Sizhou Feng, Christie M. Ballantyne, Huaizhu Wu, Xiaolei Pei, Xiaoming Feng, Mingzhe Han, Erlie Jiang
Summary: Blocking CD11c inhibits T cell proliferation and differentiation into Th1 cells, playing crucial roles in aGVHD pathogenesis. CD11c deficiency alleviates aGVHD symptoms by affecting antigen presentation of DCs.
Article
Biophysics
David Michonneau, Nadia Quignot, Heng Jiang, Dawn Reichenbach, Maebh Kelly, Anita Burrell, Xiang Zhang, Kris Thiruvillakkat, Mohamad Mohty
Summary: This study comprehensively investigates the clinical and economic burden of graft-versus-host disease (GVHD) following allogeneic hematopoietic stem cell transplantation in France. The results demonstrate that patients with GVHD have a higher risk of severe infection, higher mortality rates, higher hospital admission rates, and higher direct costs compared to patients without GVHD.
BONE MARROW TRANSPLANTATION
(2023)
Review
Immunology
Kilian Kelly, John E. J. Rasko
Summary: GvHD is a life-threatening complication of hematopoietic stem cell transplantation, often requiring high-dose corticosteroid treatment. MSCs show promise as a potential therapy due to their immunosuppressive and immunoregulatory effects, but their efficacy may be influenced by donor variability and manufacturing processes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Hui Li, Qi Liu, Xiaofeng Gao, Di Zhang, Shengjun Mao, Yongqian Jia
Summary: The study explored the potential of human umbilical mesenchymal stem cells transfected with IFN-γ gene and found that this treatment significantly reduced the incidence and severity of GVHD in vivo, providing a significant survival benefit.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Barbara Betonico Berg, Jaqueline Silva Soares, Isabela Ribeiro Paiva, Barbara Maximino Rezende, Milene Alvarenga Rachid, Stefany Bruno de Assis Cau, Thiago Roberto Lima Romero, Vanessa Pinho, Mauro Martins Teixeira, Marina Gomes Miranda e Castor
Summary: Cannabidiol (CBD) treatment in mice with acute graft-versus-host disease (aGVHD) successfully reduced inflammation levels and increased survival rates by enhancing intestinal cannabinoid receptor type 2 (CB2) receptor expression, demonstrating its potential therapeutic applications in patients undergoing bone marrow transplantation.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2021)
Article
Biophysics
Yoshimitsu Shimomura, Sho Komukai, Tetsuhisa Kitamura, Tomotaka Sobue, Yu Akahoshi, Junya Kanda, Hiroyuki Ohigashi, Hirohisa Nakamae, Nobuhiro Hiramoto, Koji Nagafuji, Takashi Tanaka, Tetsuya Eto, Shuichi Ota, Yumiko Maruyama, Takashi Akasaka, Ken-ichi Matsuoka, Yasuo Mori, Takahiro Fukuda, Yoshiko Atsuta, Seitaro Terakura
Summary: There is no association between GVHD and reduced relapse rate or improved OS in patients who undergo haplo-HSCT using PTCY. However, grade III-IV acute GVHD and extensive chronic GVHD are associated with higher NRM.
BONE MARROW TRANSPLANTATION
(2023)
Article
Biochemistry & Molecular Biology
Andrei Mircea Vacaru, Ana-Maria Mazilu, Madalina Dumitrescu, Ioana Madalina Fenyo, Anca Violeta Gafencu, Ana-Maria Vacaru
Summary: This study found that treatment with FasL-overexpressing MSC can improve GvHD and increase survival in mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Shota Shimizu, Shinri Sato, Hiroko Taniguchi, Eisuke Shimizu, Jingliang He, Shunsuke Hayashi, Kazuno Negishi, Yoko Ogawa, Shigeto Shimmura
Summary: The study observed the dynamics of inflammatory cells in the cornea of chronic GVHD model mice, discovering that neovascularization occurred in all eyes at 1 week after BMT but almost all vessels disappeared at 2 weeks after BMT. Additionally, infiltration of globular cells and tortuosity and branching of nerves were found in both cGVHD mice and human cGVHD patients.
Article
Peripheral Vascular Disease
Shohei Chatani, Ryota Tsukii, Kyohei Nagasawa, Takaaki Hasegawa, Shinichi Murata, Mina Kato, Hidekazu Yamaura, Hiroaki Onaya, Keitaro Matsuo, Yoshiyuki Watanabe, Yoshitaka Inaba
Summary: This study investigated the difficulty in removing totally implantable venous access devices (TIVADs) and identified associated risk factors. Interventional radiology (IR) approaches for difficult removal were also explored. The results showed that indwelling duration and subcutaneous leakage of fluid were significant risk factors for difficult removal. IR techniques were found to be minimally invasive and useful in some cases.
JOURNAL OF VASCULAR ACCESS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Neerav Goyal, Max Hennessy, Erik Lehman, Wenxue Lin, Antonio Agudo, Wolfgang Ahrens, Stefania Boccia, Paul Brennan, Hermann Brenner, Gabriella Cadoni, Cristina Canova, Chu Chen, David Conway, Maria Paula Curado, Luigino Dal Maso, Alexander W. Daudt, Valeria Edefonti, Eleonora Fabianova, Leticia Fernandez, Silvia Franceschi, Werner Garavello, Maura Gillison, Richard B. Hayes, Claire Healy, Rolando Herrero, Ivana Holcatova, Jossy L. Kanda, Karl Kelsey, Bo T. Hansen, Rosalina Koifman, Pagona Lagiou, Carlo La Vecchia, Fabio Levi, Guojun Li, Jolanta Lissowska, Rossana Mendoza Lopez, Daniele Luce, Gary Macfarlane, Dana Mates, Keitaro Matsuo, Michael McClean, Ana Menezes, Gwenn Menvielle, Hal Morgenstern, Kirsten Moysich, Eva Negri, Andrew F. Olshan, Tamas Pandics, Jerry Polesel, Mark Purdue, Loredana Radoi, Heribert Ramroth, Lorenzo Richiardi, Stimson Schantz, Stephen M. Schwartz, Diego Serraino, Oxana Shangina, Elaine Smith, Erich M. Sturgis, Beata Swiatkowska, Peter Thomson, Thomas L. Vaughan, Marta Vilensky, Deborah M. Winn, Victor Wunsch-Filho, Guo-Pei Yu, Jose P. Zevallos, Zuo-Feng Zhang, Tongzhang Zheng, Ariana Znaor, Paolo Boffetta, Mia Hashibe, Yuan-Chin A. Lee, Joshua E. Muscat
Summary: This study analyzed the relationship between cigarette smoking, alcohol consumption, and head and neck cancer risk factors in less developed and more developed countries. The results showed that the duration of smoking and alcohol consumption had different effects on the risk of specific cancer sites depending on the country's level of development. These findings suggest that the degree of industrialization and economic development affects the relationship between smoking, alcohol, and head and neck cancer.
Article
Ophthalmology
Akiko Hanyuda, Atsushi Goto, Masahiro Nakatochi, Yoichi Sutoh, Akira Narita, Shiori Nakano, Ryoko Katagiri, Kenji Wakai, Naoyuki Takashima, Teruhide Koyama, Kokichi Arisawa, Issei Imoto, Yukihide Momozawa, Kozo Tanno, Atsushi Shimizu, Atsushi Hozawa, Kengo Kinoshita, Taiki Yamaji, Norie Sawada, Masao Iwagami, Kenya Yuki, Kazuo Tsubota, Kazuno Negishi, Keitaro Matsuo, Masayuki Yamamoto, Makoto Sasaki, Shoichiro Tsugane, Motoki Iwasaki
Summary: This study conducted a Mendelian randomization analysis to assess the causal association between genetically predicted glycemic traits and the risk of primary open-angle glaucoma (POAG). The results did not provide strong evidence to support the association between genetically predicted glycemic traits and POAG in the Japanese population.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Takaaki Hasegawa, Haruyuki Takaki, Hiroshi Kodama, Keitaro Matsuo, Takashi Yamanaka, Atsuhiro Nakatsuka, Motoshi Takao, Hideo Gobara, Sadao Hayashi, Yoshitaka Inaba, Koichiro Yamakado
Summary: The purpose of this study was to explore the impact of ablative margin depicted by CT immediately after RF ablation on reducing LTP for CRC lung metastases. A retrospective study was conducted on 70 patients who underwent RF ablation for CRC lung metastases. The results indicated that an ablative margin of at least 2 mm is important to reduce LTP after RF ablation for CRC lung metastases.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2023)
Letter
Rheumatology
Yu Toyoda, Masahiro Nakatochi, Akiyoshi Nakayama, Yusuke Kawamura, Hirofumi Nakaoka, Kenji Wakai, Keitaro Matsuo, Hirotaka Matsuo
Article
Rheumatology
Ai Yaku, Yuki Ishikawa, Takeshi Iwasaki, Ryosuke Hiwa, Keitaro Matsuo, Hiroh Saji, Kimiko Yurugi, Yasuo Miura, Moritoshi Furu, Hiromu Ito, Takao Fujii, Taira Maekawa, Motomu Hashimoto, Koichiro Ohmura, Tsuneyo Mimori, Chikashi Terao
Summary: Objective HLA-DRB1 alleles, particularly the shared epitope (SE) alleles, are strongly associated with RA. Different genetic structures underlie the production of the various autoantibodies in RA. However, the genetic architecture underlying IgG-RF, which is associated with rheumatoid vasculitis, is not well understood.
Article
Oncology
Yukari Taniyama, Isao Oze, Yuriko N. Koyanagi, Yukino Kawakatsu, Yuri Ito, Tomohiro Matsuda, Keitaro Matsuo, Tetsuya Mitsudomi, Hidemi Ito
Summary: Introduction of EGFR-TKIs and EGFR mutation testing has led to improved survival in NSCLC patients, particularly in women with adenocarcinoma and at advanced stages.
Article
Oncology
Takaaki Ono, Naoto Takahashi, Masahiro Kizaki, Tatsuya Kawaguchi, Ritsuro Suzuki, Kazuhito Yamamoto, Kazunori Ohnishi, Tomoki Naoe, Itaru Matsumura
Summary: Age and comorbidities should be taken into consideration when selecting TKIs for first-line treatment in CML-CP patients. This study found that the choice between imatinib and second-generation TKIs did not significantly impact treatment outcomes, regardless of age. However, older patients had lower overall survival rates compared to younger patients.
Article
Oncology
Zhuxuan Fu, Maria Mori Brooks, Sarah Irvin, Susan Jordan, Katja K. H. Aben, Hoda Anton-Culver, Elisa Bandera, Matthias W. Beckmann, Andrew Berchuck, Angela Brooks-Wilson, Jenny Chang-Claude, Linda S. Cook, Daniel W. Cramer, Kara L. Cushing-Haugen, Jennifer A. Doherty, Arif B. Ekici, Peter A. Fasching, Renee T. Fortner, Simon A. Gayther, Aleksandra Gentry-Maharaj, Graham G. Giles, Ellen L. Goode, Marc T. Goodman, Holly R. Harris, Alexander Hein, Rudolf Kaaks, Lambertus A. Kiemeney, Martin Koebel, Joanne Kotsopoulos, Nhu D. Le, Alice W. Lee, Keitaro Matsuo, Valerie McGuire, John R. McLaughlin, Usha Menon, Roger L. Milne, Kirsten B. Moysich, Celeste Leigh Pearce, Malcolm C. Pike, Bo Qin, Susan J. Ramus, Marjorie J. Riggan, Joseph H. Rothstein, Joellen M. Schildkraut, Weiva Sieh, Rebecca Sutphen, Kathryn L. Terry, Pamela J. Thompson, Linda Titus, Anne M. van Altena, Emily White, Alice S. Whittemore, Anna H. Wu, Wei Zheng, Argyrios Ziogas, Sarah E. Taylor, Lu Tang, Thomas Songer, Nicolas Wentzensen, Penelope M. Webb, Harvey A. Risch, Francesmary Modugno
Summary: The lifetime ovulatory years (LOY) are positively associated with nonmucinous epithelial ovarian cancer (EOC) risk, implicating factors beyond ovulation in the development of EOC. The protective effects of parity and oral contraceptive use may not solely depend on anovulation.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Oncology
Tomoharu Mori, Yusuke Okamoto, Anfeng Mu, Yoshimi Ide, Akiyo Yoshimura, Noriko Senda, Yukiko Inagaki-Kawata, Masahiro Kawashima, Hiroyuki Kitao, Eriko Tokunaga, Yasuo Miyoshi, Shozo Ohsumi, Koichiro Tsugawa, Tomohiko Ohta, Toyomasa Katagiri, Shigeru Ohtsuru, Kaoru Koike, Seishi Ogawa, Masakazu Toi, Hiroji Iwata, Seigo Nakamura, Keitaro Matsuo, Minoru Takata
Summary: The ALDH2 enzyme's ability to break down aldehydes is impaired by a specific gene polymorphism, leading to alcohol flushing and an increased risk of esophageal cancer in East Asians. Recent studies suggest that this gene variant may result in higher levels of DNA damage caused by naturally occurring aldehydes. However, in breast epithelial cells, this loss of function does not appear to have an impact on the initiation and development of cancer.
Article
Oncology
Yuriko Koyanagi, Keitaro Matsuo, Hidemi Ito, Chaochen Wang, Akiko Tamakoshi, Yumi Sugawara, Ichiro Tsuji, Ayami Ono, Shoichiro Tsugane, Norie Sawada, Keiko Wada, Chisato Nagata, Taro Takeuchi, Tetsuhisa Kitamura, Mai Utada, Ritsu Sakata, Tetsuya Mizoue, Sarah Krull Abe, Manami Inoue
Summary: The effect of body mass index (BMI) on esophageal and gastric carcinogenesis varies depending on subtype or subsite. In this study, a pooled analysis of 10 population-based cohort studies in Japan, we observed an inverse association between BMI and esophageal squamous cell carcinoma, but a positive association with gastric cardia cancer. Additionally, a positive association was found for overweight or obese individuals with esophageal adenocarcinoma and gastric cardia cancer. The study highlights the subtype- or subsite-specific impact of BMI on upper gastrointestinal cancer in the Japanese population.
Letter
Biophysics
Risa Koresawa-Shimizu, Ritsuro Suzuki, Yasufumi Uehara, Nobuhiro Hiramoto, Masashi Sawa, Takahiro Fukuda, Keisuke Kataoka, Yoshinobu Kanda, Tatsuo Oyake, Yasushi Kubota, Naoyuki Uchida, Shingo Yano, Hikaru Kobayashi, Junji Tanaka, Yoshiko Atsuta, Eisei Kondo
BONE MARROW TRANSPLANTATION
(2023)
Article
Oncology
Yoshiaki Usui, Hidemi Ito, Kota Katanoda, Tomohiro Matsuda, Yoshinobu Maeda, Keitaro Matsuo
Summary: The introduction of rituximab has led to a decline in mortality rates of non-Hodgkin lymphoma in both Japan and the United States, despite an increase in incidence. However, the trends in mortality rates have differed between the two countries, with the mortality rate declining continuously in the United States but stopping in Japan.
Article
Multidisciplinary Sciences
Yasushi Kojima, Emi Mishiro-Sato, Teruaki Fujishita, Kiyotoshi Satoh, Rie Kajino-Sakamoto, Isao Oze, Kazuki Nozawa, Yukiya Narita, Takatsugu Ogata, Keitaro Matsuo, Kei Muro, Makoto Mark Taketo, Tomoyoshi Soga, Masahiro Aoki
Summary: Cancer cachexia is a metabolic disorder characterized by a decrease in B vitamin-related liver enzymes. The relationship between enzymes and their associated metabolites may depend on protein abundance and cofactor subtype. These metabolic/proteomic changes can be utilized for the diagnosis of cancer cachexia through blood samples.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Michi Sawabe, Daisuke Kawakita, Isao Oze, Shinichi Iwasaki, Yasuhisa Hasegawa, Shingo Murakami, Hidemi Ito, Nobuhiro Hanai, Keitaro Matsuo
Summary: This study is the first to suggest an association between prediagnostic folate intake and head and neck squamous cell carcinoma (HNSCC) survival that differs based on fluorouracil (FU)-containing chemotherapy. In the FU-containing chemotherapy group, higher folate intake is associated with better overall survival, while no clear association is observed in the non-FU-containing chemotherapy group. This finding indicates that the folate status affects the heterogeneity of one-carbon metabolism in HNSCC.